JP2009528333A - 選択的アンドロゲン受容体モジュレーター - Google Patents
選択的アンドロゲン受容体モジュレーター Download PDFInfo
- Publication number
- JP2009528333A JP2009528333A JP2008556805A JP2008556805A JP2009528333A JP 2009528333 A JP2009528333 A JP 2009528333A JP 2008556805 A JP2008556805 A JP 2008556805A JP 2008556805 A JP2008556805 A JP 2008556805A JP 2009528333 A JP2009528333 A JP 2009528333A
- Authority
- JP
- Japan
- Prior art keywords
- cyano
- compounds
- hydroxy
- mmol
- androgen receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Description
2−シアノ−5−[(S)−3−(4−シアノ−3−フルオロフェノキシ)−2−ヒドロキシ−2−メチルプロピオニル−アミノ]安息香酸、
(S)−3−(4−シアノ−3−フルオロフェノキシ)−N−(4−シアノ−3−ヒドロキシメチルフェニル)−2−ヒドロキシ−2−メチルプロピオンアミド、および
(S)−3−(4−シアノ−3−フルオロフェノキシ)−N−(4−シアノ−3−ホルミルフェニル)−2−ヒドロキシ−2−メチルプロピオンアミド
が挙げられる。
2−シアノ−5−[(S)−3−(4−シアノ−3−フルオロフェノキシ)−2−ヒドロキシ−2−メチルプロピオニル−アミノ]安息香酸、
(S)−3−(4−シアノ−3−フルオロフェノキシ)−N−(4−シアノ−3−ヒドロキシメチルフェニル)−2−ヒドロキシ−2−メチルプロピオンアミド、および
(S)−3−(4−シアノ−3−フルオロフェノキシ)−N−(4−シアノ−3−ホルミルフェニル)−2−ヒドロキシ−2−メチルプロピオンアミド
が挙げられる。
Claims (4)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77841706P | 2006-03-03 | 2006-03-03 | |
US60/778,417 | 2006-03-03 | ||
PCT/FI2007/000055 WO2007099200A1 (en) | 2006-03-03 | 2007-03-02 | Selective androgen receptor modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009528333A true JP2009528333A (ja) | 2009-08-06 |
JP5373405B2 JP5373405B2 (ja) | 2013-12-18 |
Family
ID=37994519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008556805A Expired - Fee Related JP5373405B2 (ja) | 2006-03-03 | 2007-03-02 | 選択的アンドロゲン受容体モジュレーター |
Country Status (10)
Country | Link |
---|---|
US (1) | US8501814B2 (ja) |
EP (1) | EP1991523B1 (ja) |
JP (1) | JP5373405B2 (ja) |
AU (1) | AU2007220419B2 (ja) |
CA (1) | CA2642598C (ja) |
NO (1) | NO341158B1 (ja) |
NZ (1) | NZ570533A (ja) |
RU (1) | RU2435756C2 (ja) |
WO (1) | WO2007099200A1 (ja) |
ZA (1) | ZA200807551B (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US8067448B2 (en) | 2008-02-22 | 2011-11-29 | Radius Health, Inc. | Selective androgen receptor modulators |
US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
JP2011519916A (ja) * | 2008-07-02 | 2011-07-14 | ファーマコステック カンパニー リミテッド | アミド誘導体の製造方法 |
BR112012019551A2 (pt) | 2010-02-04 | 2016-08-09 | Radius Health Inc | moduladores seletivos do receptor de androgênio. |
LT2568806T (lt) | 2010-05-12 | 2016-09-26 | Radius Health, Inc. | Terapiniai režimai |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
FI20105806A0 (fi) * | 2010-07-15 | 2010-07-15 | Medeia Therapeutics Ltd | Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia |
WO2012047617A1 (en) | 2010-09-28 | 2012-04-12 | Radius Health, Inc. | Selective androgen receptor modulators |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP3834824A1 (en) | 2014-03-28 | 2021-06-16 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
HRP20220619T1 (hr) | 2016-06-22 | 2023-02-03 | Ellipses Pharma Ltd | Postupci za liječenje ar+ raka dojke |
US10385008B2 (en) | 2017-01-05 | 2019-08-20 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD1901-2HCL |
AU2019297421A1 (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD 1901-2HCL |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5933250A (ja) * | 1982-07-23 | 1984-02-23 | インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− | アシルアニリド、その製法及び抗アンドロゲン作用を有する医薬又は獣医薬組成物 |
JPS6330457A (ja) * | 1986-07-18 | 1988-02-09 | インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− | アシルアニリド、その製造法及びこれを含有し抗アンドロゲン作用又は月経前期作用を有する製薬組成物 |
WO2005000794A1 (en) * | 2003-06-27 | 2005-01-06 | Orion Corporation | Propionamide derivatives useful as androgen receptor modulators |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
-
2007
- 2007-03-02 EP EP07712597A patent/EP1991523B1/en active Active
- 2007-03-02 AU AU2007220419A patent/AU2007220419B2/en not_active Ceased
- 2007-03-02 CA CA2642598A patent/CA2642598C/en not_active Expired - Fee Related
- 2007-03-02 RU RU2008139315/04A patent/RU2435756C2/ru not_active IP Right Cessation
- 2007-03-02 NZ NZ570533A patent/NZ570533A/en not_active IP Right Cessation
- 2007-03-02 JP JP2008556805A patent/JP5373405B2/ja not_active Expired - Fee Related
- 2007-03-02 WO PCT/FI2007/000055 patent/WO2007099200A1/en active Application Filing
- 2007-03-02 US US12/280,026 patent/US8501814B2/en not_active Expired - Fee Related
-
2008
- 2008-09-02 ZA ZA200807551A patent/ZA200807551B/xx unknown
- 2008-09-26 NO NO20084114A patent/NO341158B1/no not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5933250A (ja) * | 1982-07-23 | 1984-02-23 | インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− | アシルアニリド、その製法及び抗アンドロゲン作用を有する医薬又は獣医薬組成物 |
JPS6330457A (ja) * | 1986-07-18 | 1988-02-09 | インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− | アシルアニリド、その製造法及びこれを含有し抗アンドロゲン作用又は月経前期作用を有する製薬組成物 |
WO2005000794A1 (en) * | 2003-06-27 | 2005-01-06 | Orion Corporation | Propionamide derivatives useful as androgen receptor modulators |
Also Published As
Publication number | Publication date |
---|---|
AU2007220419B2 (en) | 2012-03-15 |
JP5373405B2 (ja) | 2013-12-18 |
WO2007099200A1 (en) | 2007-09-07 |
NO341158B1 (no) | 2017-09-04 |
CA2642598C (en) | 2014-05-27 |
NZ570533A (en) | 2011-02-25 |
CA2642598A1 (en) | 2007-09-07 |
US20090054525A1 (en) | 2009-02-26 |
RU2008139315A (ru) | 2010-04-10 |
AU2007220419A1 (en) | 2007-09-07 |
RU2435756C2 (ru) | 2011-12-10 |
ZA200807551B (en) | 2009-06-24 |
US8501814B2 (en) | 2013-08-06 |
NO20084114L (no) | 2008-09-26 |
EP1991523B1 (en) | 2012-08-15 |
EP1991523A1 (en) | 2008-11-19 |
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