AR052866A1 - Fenil-metanonas monociclicas sustituidas - Google Patents

Fenil-metanonas monociclicas sustituidas

Info

Publication number
AR052866A1
AR052866A1 ARP060100050A ARP060100050A AR052866A1 AR 052866 A1 AR052866 A1 AR 052866A1 AR P060100050 A ARP060100050 A AR P060100050A AR P060100050 A ARP060100050 A AR P060100050A AR 052866 A1 AR052866 A1 AR 052866A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
phenyl
substituted
halogen
monociclic
Prior art date
Application number
ARP060100050A
Other languages
English (en)
Inventor
Synese Jolidon
Robert Narquizian
Roger David Norcross
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR052866A1 publication Critical patent/AR052866A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se refiere a compuestos de la formula general (1), en la que: R1 es -OR1', -SR1' o es un grupo heterocicloalquilo; R1' es alquilo inferior, alquilo inferior sustituido por halogeno o es -(CH2)n-cicloalquilo; R2 es -S(O)2-alquilo inferior, -S(O)2NH- alquilo inferior, NO2 o CN; X1 es CR3 o N; X2 es CR3' o N; R3/R3' con independencia entre si son hidrogeno, halogeno, alquilo inferior, CN, NO2, -S(O)2)- fenilo, -S(O)2-alquilo inferior, -S(O)2-piridin-2-, -3- o -4-ilo, fenilo, opcionalmente sustituido por uno o dos sustituyentes elegidos entre el grupo formado por NO2 o halogeno, o es alquilo inferior sustituido por halogeno o es -C(O)-alquilo inferior; n es 0, 1 o 2; y a sales de adicion de ácido farmacéuticamente aceptable de los mismos. Se ha encontrado que los compuestos de la formula (1) son buenos inhibidores del transportador de glicina 1 (GlyT-1). Pueden utilizarse para el tratamiento de la esquizofrenia.
ARP060100050A 2005-01-07 2006-01-06 Fenil-metanonas monociclicas sustituidas AR052866A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05100077 2005-01-07

Publications (1)

Publication Number Publication Date
AR052866A1 true AR052866A1 (es) 2007-04-11

Family

ID=35998949

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060100050A AR052866A1 (es) 2005-01-07 2006-01-06 Fenil-metanonas monociclicas sustituidas

Country Status (19)

Country Link
US (1) US7220744B2 (es)
EP (1) EP1838308B1 (es)
JP (1) JP5006799B2 (es)
KR (1) KR100895752B1 (es)
CN (1) CN101137363B (es)
AR (1) AR052866A1 (es)
AT (1) ATE472327T1 (es)
AU (1) AU2005324024B2 (es)
BR (1) BRPI0519794A2 (es)
CA (1) CA2593463C (es)
DE (1) DE602005022113D1 (es)
ES (1) ES2346335T3 (es)
IL (1) IL184353A (es)
MX (1) MX2007008189A (es)
NO (1) NO20073667L (es)
RU (1) RU2396270C2 (es)
TW (1) TWI313174B (es)
WO (1) WO2006072436A1 (es)
ZA (1) ZA200705472B (es)

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US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
WO2006034312A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd)
US7951805B2 (en) * 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051202A1 (es) 2004-09-20 2006-12-27 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
WO2006034315A2 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
CN101622000B (zh) * 2007-03-05 2012-07-04 弗·哈夫曼-拉罗切有限公司 合成glyt-1抑制剂的方法
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WO2011082660A1 (zh) * 2010-01-08 2011-07-14 中国科学院上海有机化学研究所 5-多氟烷基取代的2-氨基噻唑类化合物、合成方法及其应用
CN101885708B (zh) * 2010-07-07 2013-03-06 中国科学院上海有机化学研究所 5-多氟烷基取代的2-氨基噻唑类化合物、合成方法及其应用
NZ604035A (en) * 2010-06-04 2015-02-27 Albany Molecular Res Inc Glycine transporter-1 inhibitors, methods of making them, and uses thereof
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US9266838B2 (en) 2011-08-15 2016-02-23 University Of Utah Research Foundation Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
EP2744798B1 (en) 2011-08-17 2016-03-30 reMynd NV Piperazine thiazole derivatives useful in the treatment of tauopathies such as alzheimer's disease
CN104119343A (zh) * 2013-04-25 2014-10-29 苏州科捷生物医药有限公司 2-三氟甲基噻二唑类化合物及其用途
AU2014281398B2 (en) * 2013-06-19 2018-10-04 University Of Utah Research Foundation Substituted (E)-N'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors
US9708334B2 (en) 2014-04-24 2017-07-18 Dart Neuroscience (Cayman) Ltd. Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors
EP3215500A1 (en) 2014-11-05 2017-09-13 Dart NeuroScience (Cayman) Ltd. Substituted azetidinyl compounds as glyt1 inhibitors
CN105712945B (zh) * 2014-12-22 2020-12-01 上海翰森生物医药科技有限公司 2-取代氧基-5-甲砜基芳基哌嗪酰胺类似物及其制备方法和用途
CN105712952B (zh) * 2014-12-22 2021-03-26 上海翰森生物医药科技有限公司 2-取代氧基-5-甲砜基苯基哌嗪酰胺类似物及其制备方法和用途
WO2018081167A1 (en) * 2016-10-24 2018-05-03 Yumanity Therapeutics Compounds and uses thereof
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Also Published As

Publication number Publication date
TW200635585A (en) 2006-10-16
CN101137363A (zh) 2008-03-05
US20060167009A1 (en) 2006-07-27
RU2396270C2 (ru) 2010-08-10
US7220744B2 (en) 2007-05-22
JP5006799B2 (ja) 2012-08-22
AU2005324024B2 (en) 2011-02-17
ZA200705472B (en) 2008-09-25
IL184353A0 (en) 2007-10-31
WO2006072436A1 (en) 2006-07-13
CA2593463A1 (en) 2006-07-13
IL184353A (en) 2012-06-28
KR100895752B1 (ko) 2009-04-30
JP2008526796A (ja) 2008-07-24
CN101137363B (zh) 2010-09-15
TWI313174B (en) 2009-08-11
KR20070092759A (ko) 2007-09-13
BRPI0519794A2 (pt) 2009-03-17
CA2593463C (en) 2013-10-08
DE602005022113D1 (de) 2010-08-12
RU2007124545A (ru) 2009-02-20
ES2346335T3 (es) 2010-10-14
MX2007008189A (es) 2007-08-07
AU2005324024A1 (en) 2006-07-13
ATE472327T1 (de) 2010-07-15
EP1838308B1 (en) 2010-06-30
NO20073667L (no) 2007-07-24
EP1838308A1 (en) 2007-10-03

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