GB867273A - Piperazine derivatives - Google Patents

Piperazine derivatives

Info

Publication number
GB867273A
GB867273A GB3681/60A GB368160A GB867273A GB 867273 A GB867273 A GB 867273A GB 3681/60 A GB3681/60 A GB 3681/60A GB 368160 A GB368160 A GB 368160A GB 867273 A GB867273 A GB 867273A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
heptylpiperazine
carbethoxy
alkanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3681/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Filter Wallace and Tiernan Inc
Original Assignee
Wallace and Tiernan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallace and Tiernan Inc filed Critical Wallace and Tiernan Inc
Publication of GB867273A publication Critical patent/GB867273A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals

Abstract

867,273. Nitro-thiazolyl-piperazines. WALLA CE & TIERNAN Inc. Feb. 2, 1960 [Feb. 20, 1959; Jan. 13, 1960], No. 3681/60. Class 2 (3). The invention comprises compounds of the formula: wherein R 1 and R 2 are each hydrogen or alkyl C 1 - 8 and R 3 is hydrogen, alkyl C 1-8 , hydroxyalkyl C 1-8 , alkanoyl C 1-8 , phenylalkanoyl C 7-14 , benzoyl, halogeno-alkanoyl C 1-8 , carbamyl, carboalkoxy C 2-9 , alkyl C 1-8 sulphonyl, alkanoyl C 1-8 amino-phenylene-sulphonyl, and acid-addition salts of the compounds in which R 3 is hydrogen, alkyl C 1-8 or hydroxyalkyl C 1-8 , and the preparation thereof by condensing 2-bromo- 5-nitrothiazole with appropriately substituted piperazines or by appropriate N-alkylations or N-acylations or, in the case where R 3 is hydrogen, by hydrolysing corresponding N-acyl derivatives and, if desired, converting basic products into their acid-addition salts. The products have trichomonacidal properties. 1-Carbethoxy-4-heptylpiperazine is prepared by treating N-carbethoxy-piperazine with heptyl bromide. N-Heptylpiperazine is prepared by hydrolysing 1-carbethoxy-4-heptylpiperazine. 1-Acetyl-2, 5-dimethylpiperazine is prepared by appropriate acetylation.
GB3681/60A 1959-02-20 1960-02-02 Piperazine derivatives Expired GB867273A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US867273XA 1959-02-20 1959-02-20

Publications (1)

Publication Number Publication Date
GB867273A true GB867273A (en) 1961-05-03

Family

ID=22200488

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3681/60A Expired GB867273A (en) 1959-02-20 1960-02-02 Piperazine derivatives

Country Status (2)

Country Link
DE (1) DE1136705B (en)
GB (1) GB867273A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006072436A1 (en) * 2005-01-07 2006-07-13 F. Hoffmann-La Roche Ag [4-(heteroaryl) piperazin-1-yl]-(2,5-substituted -phenyl)methanone derivatives as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1292646B (en) * 1966-03-08 1969-04-17 Giulini Gmbh Geb 2-Alkyl-3, 3-diphenylacrylic acids, their alkali metal salts and a process for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2735798A (en) * 1956-02-21 Acyl amevo-nitrothiazole compositions
NL72956C (en) * 1947-11-12

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006072436A1 (en) * 2005-01-07 2006-07-13 F. Hoffmann-La Roche Ag [4-(heteroaryl) piperazin-1-yl]-(2,5-substituted -phenyl)methanone derivatives as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
US7220744B2 (en) 2005-01-07 2007-05-22 Hoffman-La Roche Inc. Monocyclic substituted phenyl methanones
KR100895752B1 (en) * 2005-01-07 2009-04-30 에프. 호프만-라 로슈 아게 [4-heteroarylpiperazin-1-yl]-2,5-substituted-phenylmethanone derivatives as glycine transporter 1glyt-1 inhibitors for the treatment of neurological and neuropsychiatric disorders
CN101137363B (en) * 2005-01-07 2010-09-15 弗·哈夫曼-拉罗切有限公司 [4-(heteroaryl)piperazin-1-yl]-(2,5-substituted -phenyl)methanone derivatives as glycine transporter 1 (Glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders

Also Published As

Publication number Publication date
DE1136705B (en) 1962-09-20

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