ATE530531T1 - Verfahren zur herstellung von bosentan - Google Patents

Verfahren zur herstellung von bosentan

Info

Publication number
ATE530531T1
ATE530531T1 AT08170830T AT08170830T ATE530531T1 AT E530531 T1 ATE530531 T1 AT E530531T1 AT 08170830 T AT08170830 T AT 08170830T AT 08170830 T AT08170830 T AT 08170830T AT E530531 T1 ATE530531 T1 AT E530531T1
Authority
AT
Austria
Prior art keywords
compound
formula
hydroxy
salt
bosentan
Prior art date
Application number
AT08170830T
Other languages
English (en)
Inventor
Maurizio Taddei
Diletta Naldini
Pietro Allegrini
Gabriele Razzetti
Simone Mantegazza
Original Assignee
Dipharma Francis Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20072360 external-priority patent/ITMI20072360A1/it
Priority claimed from ITMI20080992 external-priority patent/ITMI20080992A1/it
Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl
Application granted granted Critical
Publication of ATE530531T1 publication Critical patent/ATE530531T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT08170830T 2007-12-18 2008-12-05 Verfahren zur herstellung von bosentan ATE530531T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20072360 ITMI20072360A1 (it) 2007-12-18 2007-12-18 Procedimento per la preparazione di bosentan
ITMI20080992 ITMI20080992A1 (it) 2008-05-28 2008-05-28 Procedimento per la preparazione di composti benzensolfonammidici

Publications (1)

Publication Number Publication Date
ATE530531T1 true ATE530531T1 (de) 2011-11-15

Family

ID=40404499

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08170830T ATE530531T1 (de) 2007-12-18 2008-12-05 Verfahren zur herstellung von bosentan

Country Status (5)

Country Link
US (1) US20090156811A1 (de)
EP (1) EP2072503B1 (de)
AT (1) ATE530531T1 (de)
CA (1) CA2646795A1 (de)
ES (1) ES2376375T3 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008272685B2 (en) 2007-06-29 2013-04-18 Generics [Uk] Limited Process for introduction of hydroxyethoxy side chain in bosentan
EP2222649A2 (de) 2007-10-24 2010-09-01 Generics (UK) Limited Neue kristalline formen
JP5683276B2 (ja) * 2008-02-08 2015-03-11 ジェネリクス・［ユーケー］・リミテッド ボセンタンの製造方法
EP2268634A2 (de) * 2008-03-13 2011-01-05 Actavis Group PTC EHF Verfahren zur herstellung von bosentan und verwandte verbindungen unter verwendung neuer zwischenprodukte
US8975402B2 (en) 2008-11-03 2015-03-10 Generics [Uk] Limited HPLC method for the analysis of bosetan and related substances and use of these substances as reference standards and markers
WO2011024056A2 (en) * 2009-08-27 2011-03-03 Aurobindo Pharma Limited An improved process for the preparation of bosentan
AU2010317410B9 (en) * 2009-11-12 2014-10-23 Sun Pharmaceutical Industries Limited Crystalline forms of bosentan salts and processes for their preparation
CA2811367C (en) * 2010-10-01 2019-03-26 Zach System S.P.A. Process for preparing bosentan monohydrate and its intermediates
WO2012056468A1 (en) * 2010-10-13 2012-05-03 Matrix Laboratories Ltd A process for the preparation of bosentan
ITMI20120701A1 (it) 2012-04-27 2013-10-28 Dipharma Francis Srl Procedimento per la purificazione di un composto benzensolfonammidico
KR102004422B1 (ko) * 2012-12-20 2019-07-26 제일약품주식회사 보센탄 일수화물의 제조방법, 이에 사용되는 신규 중간체 및 이의 제조방법
CN113173888A (zh) * 2021-04-28 2021-07-27 山东鲁抗医药股份有限公司 替格瑞洛杂质a及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US529740A (en) * 1894-11-27 lytten
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
WO1997017018A1 (en) 1995-11-09 1997-05-15 Brigham & Women's Hospital Aperiodic ultrasound phased array
US5883254A (en) * 1996-11-08 1999-03-16 Hoffmann-La Roche Inc. Process for making pyrimidine derivatives
US6136971A (en) 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides

Also Published As

Publication number Publication date
EP2072503A3 (de) 2009-07-15
US20090156811A1 (en) 2009-06-18
EP2072503A2 (de) 2009-06-24
ES2376375T3 (es) 2012-03-13
EP2072503B1 (de) 2011-10-26
CA2646795A1 (en) 2009-06-18

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Legal Events

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