AR053890A1 - Proceso para la sintesis de derivados de piridinil-pirimidinilo - Google Patents

Proceso para la sintesis de derivados de piridinil-pirimidinilo

Info

Publication number
AR053890A1
AR053890A1 ARP060102369A ARP060102369A AR053890A1 AR 053890 A1 AR053890 A1 AR 053890A1 AR P060102369 A ARP060102369 A AR P060102369A AR P060102369 A ARP060102369 A AR P060102369A AR 053890 A1 AR053890 A1 AR 053890A1
Authority
AR
Argentina
Prior art keywords
piridinil
synthesis
lower alkyl
pyrimidinyl derivatives
phenyl
Prior art date
Application number
ARP060102369A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR053890A1 publication Critical patent/AR053890A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Reivindicacion 1: Un proceso para la preparacion de compuestos de la formula (1) el cual comprende hacer reaccionar el compuesto de la formula (2) con R1-NH-R2, en donde: R1 es arilo sustituido o insustituido; R2 es H, alquilo inferior, o arilo; R4 es H, alquilo inferior, o halogeno; y R3 es alquilo inferior, fenilo, fenil-alquilo inferior, o fenilo sustituido, y en donde el proceso se cataliza mediante una base en un solvente orgánico.
ARP060102369A 2005-06-09 2006-06-07 Proceso para la sintesis de derivados de piridinil-pirimidinilo AR053890A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68897705P 2005-06-09 2005-06-09
US70559005P 2005-08-04 2005-08-04

Publications (1)

Publication Number Publication Date
AR053890A1 true AR053890A1 (es) 2007-05-23

Family

ID=37091153

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102369A AR053890A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de derivados de piridinil-pirimidinilo

Country Status (32)

Country Link
US (2) US8124763B2 (es)
EP (1) EP1924574B1 (es)
JP (1) JP5118024B2 (es)
KR (3) KR101514593B1 (es)
AR (1) AR053890A1 (es)
AT (1) ATE487709T1 (es)
AU (1) AU2006258051B2 (es)
BR (1) BRPI0611663A2 (es)
CA (1) CA2610105C (es)
CY (1) CY1111428T1 (es)
DE (1) DE602006018156D1 (es)
DK (1) DK1924574T3 (es)
EC (1) ECSP077982A (es)
EG (1) EG25039A (es)
GT (1) GT200600217A (es)
HK (1) HK1117524A1 (es)
IL (1) IL187421A (es)
JO (1) JO2636B1 (es)
MA (1) MA29599B1 (es)
MX (1) MX2007015423A (es)
MY (1) MY147436A (es)
NO (1) NO340743B1 (es)
NZ (1) NZ563740A (es)
PE (1) PE20070015A1 (es)
PL (1) PL1924574T3 (es)
PT (1) PT1924574E (es)
RU (1) RU2444520C2 (es)
SA (1) SA06270147B1 (es)
SI (1) SI1924574T1 (es)
TN (1) TNSN07463A1 (es)
TW (1) TWI430999B (es)
WO (1) WO2006135641A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
CA2689989A1 (en) 2007-06-04 2008-12-11 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
US20100016590A1 (en) 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
PL2262793T3 (pl) 2008-11-05 2013-01-31 Teva Pharma Formy krystaliczne nilotynibu HCL
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) * 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
MX2013010977A (es) 2011-03-31 2013-10-30 Procter & Gamble Sistema, modelos y metodos para identificar y evaluar agentes dermoactivos eficaces para tratar la caspa/dermatitis seborreica.
AR086913A1 (es) * 2011-06-14 2014-01-29 Novartis Ag 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
WO2013120852A1 (en) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
MX2014014898A (es) 2012-06-06 2015-03-04 Procter & Gamble Sistemas y metodos de identificacion de agentes cosmeticos para composiciones para el cuidado del cabello/cuero cabelludo.
WO2015092624A1 (en) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Nilotinib mono-oxalate and its crystalline form
CN103694176B (zh) 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
EP3806858A4 (en) 2018-06-15 2022-03-09 Handa Pharmaceuticals, Inc. SALTS OF KINASE INHIBITORS AND ASSOCIATED COMPOSITIONS
JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136082A (en) * 1990-08-03 1992-08-04 Himont Incorporated Process for preparing organic esters and amides and catalyst system therefor
WO1994014415A1 (en) 1992-12-24 1994-07-07 Hemagen/Pfc Fluorocarbon emulsions
TW406020B (en) 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5597829A (en) 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
AR013261A1 (es) 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina
US20030059465A1 (en) 1998-05-11 2003-03-27 Unger Evan C. Stabilized nanoparticle formulations of camptotheca derivatives
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
DE69901379T2 (de) 1999-03-09 2002-11-07 Sigma Tau Ind Farmaceuti Camptothecin-Derivate mit Antitumor-Wirkung
IT1306129B1 (it) 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
DE19926056B4 (de) 1999-06-08 2004-03-25 Gkss-Forschungszentrum Geesthacht Gmbh Einrichtung zur Analyse atomarer und/oder molekularer Elemente mittels wellenlängendispersiver, röntgenspektrometrischer Einrichtungen
GB9918885D0 (en) 1999-08-10 1999-10-13 Pharmacia & Upjohn Spa Pharmaceutical formulations in hydroxypropymethycellulose capsules
GB9925127D0 (en) 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
US20040009229A1 (en) 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US20020150615A1 (en) 2001-02-12 2002-10-17 Howard Sands Injectable pharmaceutical composition comprising microdroplets of a camptothecin
US6629598B2 (en) 2001-08-10 2003-10-07 Vinod K. Narula Flexible ribbed splint system
US6653319B1 (en) 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
ES2625340T3 (es) 2001-10-15 2017-07-19 Crititech, Inc. Composiciones y métodos para la administración de fármacos escasamente solubles en agua y métodos de tratamiento
AU2002353118A1 (en) 2001-12-11 2003-07-24 Dor Biopharma, Inc. Lipid particles and suspensions and uses thereof
JP2003267891A (ja) 2002-03-13 2003-09-25 Mitsubishi-Kagaku Foods Corp Ｗ／ｏ／ｗ型エマルション製剤
US7202367B2 (en) 2002-05-31 2007-04-10 Rhodia Chimie Process for arylating or vinylating or alkynating a nucleophilic compound
CZ294371B6 (cs) 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
EP1393719A1 (en) 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-carboxylate formulations
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
JP4426749B2 (ja) 2002-07-11 2010-03-03 株式会社産学連携機構九州 Ｏ／ｗ型エマルション製剤
US20040171560A1 (en) 2002-12-23 2004-09-02 Dabur Research Foundation Stabilized pharmaceutical composition
JP2006199590A (ja) 2003-09-04 2006-08-03 Nano Career Kk 水溶性の塩基性薬物内包ナノ粒子含有組成物
DE602004027936D1 (de) 2003-10-29 2010-08-12 Sonus Pharmaceutical Inc Tocopherolmodifizierte therapeutische arzneimittelverbindung
WO2005060871A1 (en) 2003-12-17 2005-07-07 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos

Also Published As

Publication number Publication date
EG25039A (en) 2011-07-06
GT200600217A (es) 2007-03-28
RU2444520C2 (ru) 2012-03-10
US20080188656A1 (en) 2008-08-07
ATE487709T1 (de) 2010-11-15
EP1924574A2 (en) 2008-05-28
JO2636B1 (en) 2012-06-17
AU2006258051A1 (en) 2006-12-21
TW200726756A (en) 2007-07-16
MX2007015423A (es) 2008-02-21
RU2007148231A (ru) 2009-07-20
US8946416B2 (en) 2015-02-03
JP5118024B2 (ja) 2013-01-16
BRPI0611663A2 (pt) 2010-09-28
DK1924574T3 (da) 2011-02-14
IL187421A0 (en) 2008-02-09
NZ563740A (en) 2011-03-31
EP1924574B1 (en) 2010-11-10
PL1924574T3 (pl) 2011-04-29
HK1117524A1 (en) 2009-01-16
KR101514593B1 (ko) 2015-04-22
KR20130118394A (ko) 2013-10-29
SA06270147B1 (ar) 2009-12-22
US8124763B2 (en) 2012-02-28
SI1924574T1 (sl) 2011-02-28
CA2610105C (en) 2014-03-25
MA29599B1 (fr) 2008-07-01
NO20080157L (no) 2008-01-09
MY147436A (en) 2012-12-14
TNSN07463A1 (en) 2009-03-17
CA2610105A1 (en) 2006-12-21
WO2006135641A3 (en) 2007-03-29
TWI430999B (zh) 2014-03-21
AU2006258051B2 (en) 2010-09-09
PT1924574E (pt) 2011-02-08
KR20080022093A (ko) 2008-03-10
IL187421A (en) 2011-11-30
US20120116081A1 (en) 2012-05-10
CY1111428T1 (el) 2015-08-05
NO340743B1 (no) 2017-06-12
WO2006135641A2 (en) 2006-12-21
DE602006018156D1 (de) 2010-12-23
KR20120066067A (ko) 2012-06-21
KR101216249B1 (ko) 2012-12-28
JP2008545786A (ja) 2008-12-18
PE20070015A1 (es) 2007-02-06
ECSP077982A (es) 2008-01-23

Similar Documents

Publication Publication Date Title
AR053890A1 (es) Proceso para la sintesis de derivados de piridinil-pirimidinilo
ME01992B (me) Jedinjenje diarilhidantoina
RS51341B (en) INTERMEDIATE COMPOUNDS FOR THE TRANS-5-CHLOR-2-METHYL-2,3A, 12B-TETRAHYDRO-1H-DIBENZE [2,3; 6,7] OXEPINO [4,5-C] Pyrrole
RS52534B (en) MACROCYCLIC COMPOUNDS OF HINOXALINE AS HCV NS3 PROTEASE INHIBITORS
GT200500286A (es) Analogos de anilino-pirimidina
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
PE20061450A1 (es) Proceso para la preparacion de derivados de sulfamida
TN2011000286A1 (en) Spiroheterocyclic n-oxypiperidines as pesticides
EA200701738A1 (ru) Способ получения транс-1-((1r,3s)-6-хлор-3-фенилиндан-1-ил)-3,3-диметилпиперазина
MX2007005933A (es) Compuestos de acetamida como fungicidas.
AR057894A1 (es) Derivados de tiofeno
DE50311885D1 (de) Kohlenstoffhaltiges Material
ECSP099091A (es) Profarmaco de compuesto de cinamida
ES2308299T3 (es) Tiadiazoles como ligandos de receptores de cxc-y cc-quimioquinas.
TW200628583A (en) Compound and organic light emitting diode and display comprising the compound
ATE496044T1 (de) Indolylmaleimidderivate
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
NO20075734L (no) Tiofenforbindelser og trombopoietin reseptoractivatorer
AR048876A1 (es) Un proceso para preparar montelukast y compuestos intermedios para el mismo
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
CR10637A (es) Fungicidas
TW200619213A (en) A process for the preparation of organic compounds
DE602006009290D1 (de) Organische verbindungen
ZA201003751B (en) Process for the synthesis of propargylated aminoindan derivatives
ITMI20050550A1 (it) Procedimento per la preparazione di adapalene

Legal Events

Date Code Title Description
FC Refusal