PE20070015A1 - Proceso para la sintesis de compuestos pirimidinilaminobenzamidas - Google Patents

Proceso para la sintesis de compuestos pirimidinilaminobenzamidas

Info

Publication number
PE20070015A1
PE20070015A1 PE2006000631A PE2006000631A PE20070015A1 PE 20070015 A1 PE20070015 A1 PE 20070015A1 PE 2006000631 A PE2006000631 A PE 2006000631A PE 2006000631 A PE2006000631 A PE 2006000631A PE 20070015 A1 PE20070015 A1 PE 20070015A1
Authority
PE
Peru
Prior art keywords
methyl
alkyl
phenyl
compounds
formula
Prior art date
Application number
PE2006000631A
Other languages
English (en)
Inventor
Joseph Mckenna
Wen-Chung Shieh
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20070015A1 publication Critical patent/PE20070015A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

SE REFIERE A UN PROCESO DE PREPARACION DE COMPUESTOS DE LA FORMULA (I) DONDE R1 ES ARILO(C6-C14) OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C6), FENILO, NITRO, ENTRE OTROS; R2 ES H, ALQUILO(C1-C6) O ARILO(C6-C14); R4 ES H, HALOGENO O ALQUILO(C1-C6); UN COMPUESTO PREFERIDO ES 4-METIL-3-[[4-(3-PIRIDINIL)-2-PIRIMIDINIL]-AMINO]-N-[5-(4-METIL-1H-IMIDAZOL-1-IL)-3-(TRIFLUORO-METIL)-FENIL]-BENZAMIDA. DICHO PROCESO COMPRENDE: A) HACER REACCIONAR EL COMPUESTO DE FORMULA (II) CON EL COMPUESTO DE FORMULA R1-NH-R2 TAL COMO 5-(4-METIL-1H-IMIDAZOL-1-IL)-3-(TRIFLUORO-METIL)-BENCENAMINA, DONDE R3 ES ALQUILO(C1-C6), FENILO OPCIONALMENTE SUSTITUIDO O FENIL-ALQUILO(C1-C6), DICHA REACCION SE CATALIZA CON UNA BASE TAL COMO HIDRURO DE METAL, BIS-(TRIMETIL-SILIL)-AMIDA DE METAL, DIALQUIL-AMIDA DE LITIO, TERBUTOXIDO DE POTASIO, ENTRE OTROS, EN UN SOLVENTE ORGANICO TAL COMO TETRAHIDROFURANO, DIMETIL-FORMAMIDA, TOLUENO O N-METIL-PIRROLIDONA. EL PROCESO SE LLEVA A CABO A UNA TEMPERATURA DE -50°C A 50°C. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASAS DE TIROSINA SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES NEOPLASICAS TAL COMO LEUCEMIA
PE2006000631A 2005-06-09 2006-06-07 Proceso para la sintesis de compuestos pirimidinilaminobenzamidas PE20070015A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68897705P 2005-06-09 2005-06-09
US70559005P 2005-08-04 2005-08-04

Publications (1)

Publication Number Publication Date
PE20070015A1 true PE20070015A1 (es) 2007-02-06

Family

ID=37091153

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000631A PE20070015A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de compuestos pirimidinilaminobenzamidas

Country Status (32)

Country Link
US (2) US8124763B2 (es)
EP (1) EP1924574B1 (es)
JP (1) JP5118024B2 (es)
KR (3) KR101514593B1 (es)
AR (1) AR053890A1 (es)
AT (1) ATE487709T1 (es)
AU (1) AU2006258051B2 (es)
BR (1) BRPI0611663A2 (es)
CA (1) CA2610105C (es)
CY (1) CY1111428T1 (es)
DE (1) DE602006018156D1 (es)
DK (1) DK1924574T3 (es)
EC (1) ECSP077982A (es)
EG (1) EG25039A (es)
GT (1) GT200600217A (es)
HK (1) HK1117524A1 (es)
IL (1) IL187421A (es)
JO (1) JO2636B1 (es)
MA (1) MA29599B1 (es)
MX (1) MX2007015423A (es)
MY (1) MY147436A (es)
NO (1) NO340743B1 (es)
NZ (1) NZ563740A (es)
PE (1) PE20070015A1 (es)
PL (1) PL1924574T3 (es)
PT (1) PT1924574E (es)
RU (1) RU2444520C2 (es)
SA (1) SA06270147B1 (es)
SI (1) SI1924574T1 (es)
TN (1) TNSN07463A1 (es)
TW (1) TWI430999B (es)
WO (1) WO2006135641A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
TWI433677B (zh) 2007-06-04 2014-04-11 Avila Therapeutics Inc 雜環化合物及其用途
WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
ES2394258T3 (es) 2008-11-05 2013-01-30 Teva Pharmaceutical Industries Ltd. Formas cristalinas de Nilotinib HCL
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
MX2013010977A (es) 2011-03-31 2013-10-30 Procter & Gamble Sistema, modelos y metodos para identificar y evaluar agentes dermoactivos eficaces para tratar la caspa/dermatitis seborreica.
AR086913A1 (es) * 2011-06-14 2014-01-29 Novartis Ag 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
WO2013120852A1 (en) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
EP2859486A2 (en) 2012-06-06 2015-04-15 The Procter & Gamble Company Systems and methods for identifying cosmetic agents for hair/scalp care compositions
WO2015092624A1 (en) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Nilotinib mono-oxalate and its crystalline form
CN103694176B (zh) 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
WO2019152977A2 (en) 2018-02-05 2019-08-08 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
TWI815137B (zh) 2018-06-15 2023-09-11 漢達生技醫藥股份有限公司 尼洛替尼十二烷基硫酸鹽之結晶
JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136082A (en) * 1990-08-03 1992-08-04 Himont Incorporated Process for preparing organic esters and amides and catalyst system therefor
AU5539294A (en) 1992-12-24 1994-07-19 Hemagen/Pfc Fluorocarbon emulsions
TW406020B (en) 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5597829A (en) 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
AR013261A1 (es) 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina
US20030059465A1 (en) 1998-05-11 2003-03-27 Unger Evan C. Stabilized nanoparticle formulations of camptotheca derivatives
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
PT1044977E (pt) 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral
IT1306129B1 (it) 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
DE19926056B4 (de) 1999-06-08 2004-03-25 Gkss-Forschungszentrum Geesthacht Gmbh Einrichtung zur Analyse atomarer und/oder molekularer Elemente mittels wellenlängendispersiver, röntgenspektrometrischer Einrichtungen
GB9918885D0 (en) 1999-08-10 1999-10-13 Pharmacia & Upjohn Spa Pharmaceutical formulations in hydroxypropymethycellulose capsules
GB9925127D0 (en) 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
US20040009229A1 (en) 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US20020150615A1 (en) 2001-02-12 2002-10-17 Howard Sands Injectable pharmaceutical composition comprising microdroplets of a camptothecin
US6629598B2 (en) 2001-08-10 2003-10-07 Vinod K. Narula Flexible ribbed splint system
US6653319B1 (en) 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
JP2005508354A (ja) 2001-10-15 2005-03-31 クリチテック インコーポレーテッド 水に溶けにくい薬物の送込み用組成物および方法並びに治療方法
WO2003057128A2 (en) 2001-12-11 2003-07-17 Dor Biopharma, Inc. Lipid particles and suspensions and uses thereof
JP2003267891A (ja) 2002-03-13 2003-09-25 Mitsubishi-Kagaku Foods Corp Ｗ／ｏ／ｗ型エマルション製剤
FR2840303B1 (fr) 2002-05-31 2005-07-15 Rhodia Chimie Sa Procede d'arylation ou de vinylation ou d'alcylynation d'un compose nucleophile
CZ294371B6 (cs) 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
EP1393719A1 (en) 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-carboxylate formulations
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
JP4426749B2 (ja) 2002-07-11 2010-03-03 株式会社産学連携機構九州 Ｏ／ｗ型エマルション製剤
US20040171560A1 (en) 2002-12-23 2004-09-02 Dabur Research Foundation Stabilized pharmaceutical composition
JP2006199590A (ja) 2003-09-04 2006-08-03 Nano Career Kk 水溶性の塩基性薬物内包ナノ粒子含有組成物
CA2543722C (en) 2003-10-29 2011-01-04 Sonus Pharmaceuticals, Inc. Tocopherol-modified therapeutic drug compounds
WO2005060871A1 (en) 2003-12-17 2005-07-07 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos

Also Published As

Publication number Publication date
EP1924574A2 (en) 2008-05-28
CA2610105A1 (en) 2006-12-21
GT200600217A (es) 2007-03-28
AU2006258051B2 (en) 2010-09-09
JP5118024B2 (ja) 2013-01-16
TWI430999B (zh) 2014-03-21
MA29599B1 (fr) 2008-07-01
CY1111428T1 (el) 2015-08-05
WO2006135641A2 (en) 2006-12-21
HK1117524A1 (en) 2009-01-16
JO2636B1 (en) 2012-06-17
DE602006018156D1 (de) 2010-12-23
TNSN07463A1 (en) 2009-03-17
MY147436A (en) 2012-12-14
KR20120066067A (ko) 2012-06-21
RU2007148231A (ru) 2009-07-20
US20080188656A1 (en) 2008-08-07
JP2008545786A (ja) 2008-12-18
KR101216249B1 (ko) 2012-12-28
EG25039A (en) 2011-07-06
US8124763B2 (en) 2012-02-28
KR101514593B1 (ko) 2015-04-22
US20120116081A1 (en) 2012-05-10
SI1924574T1 (sl) 2011-02-28
WO2006135641A3 (en) 2007-03-29
DK1924574T3 (da) 2011-02-14
AU2006258051A1 (en) 2006-12-21
IL187421A (en) 2011-11-30
NO340743B1 (no) 2017-06-12
KR20130118394A (ko) 2013-10-29
TW200726756A (en) 2007-07-16
NZ563740A (en) 2011-03-31
RU2444520C2 (ru) 2012-03-10
NO20080157L (no) 2008-01-09
AR053890A1 (es) 2007-05-23
ECSP077982A (es) 2008-01-23
US8946416B2 (en) 2015-02-03
EP1924574B1 (en) 2010-11-10
BRPI0611663A2 (pt) 2010-09-28
PT1924574E (pt) 2011-02-08
IL187421A0 (en) 2008-02-09
MX2007015423A (es) 2008-02-21
SA06270147B1 (ar) 2009-12-22
ATE487709T1 (de) 2010-11-15
PL1924574T3 (pl) 2011-04-29
CA2610105C (en) 2014-03-25
KR20080022093A (ko) 2008-03-10

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