AR064658A1 - Proceso para preparar duloxetina y sus compuestos relacionados, asi como tambien intermediarios utiles en la misma - Google Patents
Proceso para preparar duloxetina y sus compuestos relacionados, asi como tambien intermediarios utiles en la mismaInfo
- Publication number
- AR064658A1 AR064658A1 ARP070105826A ARP070105826A AR064658A1 AR 064658 A1 AR064658 A1 AR 064658A1 AR P070105826 A ARP070105826 A AR P070105826A AR P070105826 A ARP070105826 A AR P070105826A AR 064658 A1 AR064658 A1 AR 064658A1
- Authority
- AR
- Argentina
- Prior art keywords
- well
- same
- related compounds
- duloxetine
- prepare
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Abstract
Reivindicacion 18: Un proceso caracterizado porque comprende hacer reaccionar un acetiltiofeno de formula (1) con formaldehído y N-hidroximetilamina para formar un compuesto de formula (2) o una sal de adicion de ácido del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87162606P | 2006-12-22 | 2006-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064658A1 true AR064658A1 (es) | 2009-04-15 |
Family
ID=39183198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105826A AR064658A1 (es) | 2006-12-22 | 2007-12-21 | Proceso para preparar duloxetina y sus compuestos relacionados, asi como tambien intermediarios utiles en la misma |
Country Status (6)
Country | Link |
---|---|
US (1) | US7928250B2 (es) |
EP (1) | EP2114912B1 (es) |
CN (1) | CN101657438A (es) |
AR (1) | AR064658A1 (es) |
AT (1) | ATE552250T1 (es) |
WO (1) | WO2008077645A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009019719A2 (en) * | 2007-08-09 | 2009-02-12 | Ind-Swift Laboratories Limited | Process for the preparation of 3-aryloxy-3-arylpropanamines |
US8168805B2 (en) | 2007-10-29 | 2012-05-01 | Sci Pharmtech, Inc | Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol |
US7829731B2 (en) | 2007-10-29 | 2010-11-09 | Sci Pharmtech, Inc. | Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL |
US20110275836A1 (en) * | 2009-01-06 | 2011-11-10 | Alembic Pharmaceuticals Limited | Process for the preparation of duloxetine and salts thereof |
US8148549B2 (en) * | 2009-03-12 | 2012-04-03 | Sci Pharmtech, Inc. | Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate |
CN103214452B (zh) * | 2013-05-07 | 2014-08-06 | 浙江丽晶化学有限公司 | N-甲基-3-羟基-3-(2-噻吩基)-丙胺的制备方法 |
CN108341797B (zh) * | 2017-01-25 | 2021-04-27 | 重庆常捷医药有限公司 | 一种度洛西汀中间体的合成方法 |
WO2020035040A1 (zh) * | 2018-08-17 | 2020-02-20 | 上海璃道医药科技有限公司 | 3-芳氧基-3-五元杂芳基-丙胺类化合物及其用途 |
JP7429998B2 (ja) * | 2019-05-16 | 2024-02-09 | シャンハイ リード ファーマテック カンパニー リミテッド | 3―アリールオキシル―3―5員ヘテロアリール―プロピルアミン化合物およびその結晶形態ならびに用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR880007433A (ko) | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
CA2042346A1 (en) | 1990-05-17 | 1991-11-18 | Michael Alexander Staszak | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
US5508276A (en) | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
AU3877500A (en) | 1999-04-09 | 2000-11-14 | Eli Lilly And Company | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
EP1478641A1 (en) | 2002-01-24 | 2004-11-24 | Eli Lilly And Company | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine |
DE10207586A1 (de) * | 2002-02-22 | 2003-09-11 | Degussa | Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte |
DE10212301A1 (de) * | 2002-03-20 | 2003-10-02 | Bayer Ag | Verfahren zur Herstellung von Aryl-aminopropanolen |
WO2003097632A1 (fr) | 2002-05-20 | 2003-11-27 | Mitsubishi Rayon Co., Ltd. | Derives de propanolamine, procede de preparation de 3-n-methylamino-1-(2-thienyl)-1-propanols et procede de preparation de derives de propanolamine |
CA2491472C (en) | 2002-07-09 | 2011-09-27 | Lonza Ag | Process for the preparation of n-monosubstituted .beta.-amino alcohols |
WO2004005307A1 (en) | 2002-07-09 | 2004-01-15 | Lonza Ag | Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol |
DE10235206A1 (de) | 2002-08-01 | 2004-02-19 | Basf Ag | Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol |
GB0221438D0 (en) | 2002-09-16 | 2002-10-23 | Avecia Ltd | Processes and compounds |
JP4483165B2 (ja) | 2002-10-01 | 2010-06-16 | 山川薬品工業株式会社 | 光学活性な3−(メチルアミノ)−1−(2−チエニル)プロパン−1−オールの製造方法および製造の中間体 |
AU2003276066A1 (en) * | 2002-10-07 | 2004-04-23 | Lonza Ag | Processes and intermediates for the preparation of optically active 3-amino-1-(2-thienyl)-1-propanol derivatives |
GB0229583D0 (en) | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
DE10302595A1 (de) | 2003-01-22 | 2004-07-29 | Basf Ag | 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung |
CZ297560B6 (cs) | 2004-10-26 | 2007-02-07 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu) |
-
2007
- 2007-12-19 CN CN200780050077A patent/CN101657438A/zh active Pending
- 2007-12-19 WO PCT/EP2007/011485 patent/WO2008077645A1/en active Application Filing
- 2007-12-19 AT AT07857175T patent/ATE552250T1/de active
- 2007-12-19 EP EP07857175A patent/EP2114912B1/en not_active Not-in-force
- 2007-12-20 US US12/004,294 patent/US7928250B2/en not_active Expired - Fee Related
- 2007-12-21 AR ARP070105826A patent/AR064658A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20080171887A1 (en) | 2008-07-17 |
WO2008077645A1 (en) | 2008-07-03 |
EP2114912A1 (en) | 2009-11-11 |
CN101657438A (zh) | 2010-02-24 |
EP2114912B1 (en) | 2012-04-04 |
US7928250B2 (en) | 2011-04-19 |
ATE552250T1 (de) | 2012-04-15 |
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