PE20061014A1 - Clorhidrato de lercanidipina amorfo - Google Patents
Clorhidrato de lercanidipina amorfoInfo
- Publication number
- PE20061014A1 PE20061014A1 PE2006000224A PE2006000224A PE20061014A1 PE 20061014 A1 PE20061014 A1 PE 20061014A1 PE 2006000224 A PE2006000224 A PE 2006000224A PE 2006000224 A PE2006000224 A PE 2006000224A PE 20061014 A1 PE20061014 A1 PE 20061014A1
- Authority
- PE
- Peru
- Prior art keywords
- solvent
- amorphous
- lercanidipine hydrochloride
- methor
- lercanidipine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
- C07B63/04—Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE AL COMPUESTO CLORHIDRATO DE LERCANIDIPINA AMORFO CON UNA PUREZA DEL 95% Y SUSTANCIALMENTE LIBLE DE CLORHIDRATO DE LERCANIDIPINA CRISTALINO, CUYO PROCESO COMPRENDE: A) DISOLVER EL CLORHIDRATO DE LERCANIDIPINA CRISTALINO EN UN SOLVENTE ORGANICO SELECCIONADO ENTRE METANOL, ACETONA, SOLVENTE CLORADO O AMIDA; B) AISLAR EL CLORHIDRATO DE LERCANIDIPINA AMORFO MEDIANTE 2 METODOS: 1) AGREGADO DE LA SOLUCION A AGUA PARA FORMAR UN PRECIPITADO Y RECOLECCION DEL PRECIPITADO O 2) SEPARACION POR EVAPORACION DEL SOLVENTE ORGANICO. DICHP PROCESO SE LLEVA CABO A UNA TEMPERATURA ENTRE 30 Y 50°C. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA DE LIBERACION MODIFICADA CONTENIENDO UNA SUSTANCIA CEROSA TAL COMO ESTER DE ACILO GRASO DE POLIALCOHOL O MEZCLA DE ESTOS. DICHO PROCESO PROPORCIONA PROPIEDADES FARMACOCINETICAS MEJORADAS EN EL TRATAMIENTO DE LA HIPERTENSION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65683605P | 2005-02-25 | 2005-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061014A1 true PE20061014A1 (es) | 2006-10-03 |
Family
ID=36585434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000224A PE20061014A1 (es) | 2005-02-25 | 2006-02-24 | Clorhidrato de lercanidipina amorfo |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7820701B2 (es) |
| EP (1) | EP1856051B1 (es) |
| JP (1) | JP2008531515A (es) |
| KR (1) | KR20070105979A (es) |
| CN (1) | CN101124204A (es) |
| AR (1) | AR052918A1 (es) |
| AU (1) | AU2006218026B9 (es) |
| BR (1) | BRPI0608138A2 (es) |
| CA (1) | CA2598016A1 (es) |
| CY (1) | CY1122429T1 (es) |
| DK (1) | DK1856051T3 (es) |
| EA (1) | EA014383B1 (es) |
| ES (1) | ES2339213T3 (es) |
| HR (1) | HRP20192302T1 (es) |
| HU (1) | HUE046910T2 (es) |
| IL (1) | IL184349A0 (es) |
| LT (1) | LT1856051T (es) |
| ME (1) | ME03659B (es) |
| MX (1) | MX2007010093A (es) |
| MY (1) | MY142129A (es) |
| NO (1) | NO344559B1 (es) |
| NZ (1) | NZ556667A (es) |
| PE (1) | PE20061014A1 (es) |
| PL (1) | PL1856051T3 (es) |
| PT (1) | PT1856051T (es) |
| RS (1) | RS59654B1 (es) |
| SI (1) | SI1856051T1 (es) |
| TW (1) | TW200640861A (es) |
| UA (1) | UA90130C2 (es) |
| UY (1) | UY29401A1 (es) |
| WO (1) | WO2006089787A1 (es) |
| ZA (1) | ZA200708127B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2493949C (en) | 2002-07-26 | 2015-06-02 | Chiron Corporation | Modified small interfering rna molecules and methods of use |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| RU2425033C2 (ru) | 2005-09-16 | 2011-07-27 | Гленмарк Фармасьютикалз Лимитед | Полиморфная форма гидрохлорида лерканидипина и способ ее получения |
| EP2046745B1 (en) * | 2006-08-04 | 2013-10-23 | Recordati Ireland Limited | Process for preparing amorphous lercanidipine hydrochloride |
| EP2101771A2 (en) * | 2006-12-06 | 2009-09-23 | Torrent Pharmaceuticals Ltd | Stable lercanidipine formulation |
| EP2121575A2 (en) * | 2007-03-05 | 2009-11-25 | Actavis Group PTC EHF | Lercanidipine hydrochloride polymorphs and an improved process for preparation of 1,1,n-trimethyl-n-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate |
| WO2010132445A1 (en) * | 2009-05-12 | 2010-11-18 | Corcept Therapeutics, Inc. | Solid forms and process for preparing |
| DE102010005124A1 (de) * | 2010-01-19 | 2012-03-01 | Stada Arzneimittel Ag | Feste pharmazeutische Zusammensetzung umfassend Lercanidipin |
| EP2444394A1 (en) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Process for the preparation of amorphous form of lercanidipine HCI |
| CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
| CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
| CN102600146B (zh) * | 2012-04-11 | 2014-10-08 | 兆科药业（合肥）有限公司 | 一种盐酸乐卡地平和氯沙坦钾复方制剂及其制备方法 |
| US9951009B2 (en) * | 2013-08-29 | 2018-04-24 | Cadila Healthcare Limited | Polymorphic form of pyrrole derivative and intermediate thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8403866D0 (en) | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
| US5767136A (en) * | 1995-05-12 | 1998-06-16 | Recordati, S.A. Chemical And Pharmaceutical Company | 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls |
| US5696139A (en) * | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
| IT1274480B (it) | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
| ITMI20011727A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi |
| ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| US6852737B2 (en) * | 2001-08-06 | 2005-02-08 | Recordati Ireland Limited | Crude and crystalline forms of lercanidipine hydrochloride |
| US20030069285A1 (en) * | 2001-08-06 | 2003-04-10 | Recordati Ireland Limited | Novel solvate and crystalline forms of lercanidipine hydrochloride |
| US20030180355A1 (en) * | 2001-10-16 | 2003-09-25 | Amedeo Leonardi | Combination therapy for hypertension |
| JP4749660B2 (ja) * | 2002-10-16 | 2011-08-17 | 武田薬品工業株式会社 | 安定な固形製剤 |
| US20040147566A1 (en) * | 2002-10-16 | 2004-07-29 | Amedeo Leonardi | Lisinopril/lercanidipine combination therapy |
| US20040198789A1 (en) * | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
| TW200613275A (en) * | 2004-08-24 | 2006-05-01 | Recordati Ireland Ltd | Lercanidipine salts |
| TW200616681A (en) * | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
| KR100651212B1 (ko) | 2004-10-27 | 2006-12-01 | 제일약품주식회사 | 무정형 레르카니디핀의 제조방법 |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| RU2425033C2 (ru) | 2005-09-16 | 2011-07-27 | Гленмарк Фармасьютикалз Лимитед | Полиморфная форма гидрохлорида лерканидипина и способ ее получения |
| WO2007054969A2 (en) | 2005-09-21 | 2007-05-18 | Torrent Pharmaceuticals Limited | Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride |
| EP2046745B1 (en) | 2006-08-04 | 2013-10-23 | Recordati Ireland Limited | Process for preparing amorphous lercanidipine hydrochloride |
-
2006
- 2006-02-22 AR ARP060100641A patent/AR052918A1/es not_active Application Discontinuation
- 2006-02-24 SI SI200632364T patent/SI1856051T1/sl unknown
- 2006-02-24 UA UAA200709786A patent/UA90130C2/ru unknown
- 2006-02-24 BR BRPI0608138-0A patent/BRPI0608138A2/pt not_active Application Discontinuation
- 2006-02-24 MY MYPI20060808A patent/MY142129A/en unknown
- 2006-02-24 NZ NZ556667A patent/NZ556667A/en not_active IP Right Cessation
- 2006-02-24 TW TW095106337A patent/TW200640861A/zh unknown
- 2006-02-24 AU AU2006218026A patent/AU2006218026B9/en not_active Ceased
- 2006-02-24 PL PL06723128T patent/PL1856051T3/pl unknown
- 2006-02-24 CA CA002598016A patent/CA2598016A1/en not_active Abandoned
- 2006-02-24 UY UY29401A patent/UY29401A1/es not_active Application Discontinuation
- 2006-02-24 RS RS20191591A patent/RS59654B1/sr unknown
- 2006-02-24 LT LTEP06723128.2T patent/LT1856051T/lt unknown
- 2006-02-24 ME MEP-2019-352A patent/ME03659B/me unknown
- 2006-02-24 PE PE2006000224A patent/PE20061014A1/es active IP Right Grant
- 2006-02-24 ES ES06723128T patent/ES2339213T3/es active Active
- 2006-02-24 KR KR1020077017758A patent/KR20070105979A/ko not_active Application Discontinuation
- 2006-02-24 EP EP06723128.2A patent/EP1856051B1/en not_active Revoked
- 2006-02-24 EA EA200701687A patent/EA014383B1/ru unknown
- 2006-02-24 WO PCT/EP2006/001782 patent/WO2006089787A1/en active Application Filing
- 2006-02-24 MX MX2007010093A patent/MX2007010093A/es not_active Application Discontinuation
- 2006-02-24 CN CNA2006800054950A patent/CN101124204A/zh active Pending
- 2006-02-24 JP JP2007556565A patent/JP2008531515A/ja active Pending
- 2006-02-24 PT PT67231282T patent/PT1856051T/pt unknown
- 2006-02-24 DK DK06723128.2T patent/DK1856051T3/da active
- 2006-02-24 HU HUE06723128A patent/HUE046910T2/hu unknown
- 2006-02-27 US US11/364,862 patent/US7820701B2/en active Active
-
2007
- 2007-07-02 IL IL184349A patent/IL184349A0/en active IP Right Grant
- 2007-09-21 ZA ZA200708127A patent/ZA200708127B/xx unknown
- 2007-09-25 NO NO20074874A patent/NO344559B1/no not_active IP Right Cessation
-
2019
- 2019-12-18 CY CY20191101332T patent/CY1122429T1/el unknown
- 2019-12-20 HR HRP20192302TT patent/HRP20192302T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |