IT1274480B - Procedimento migliorato per la preparazione della lercanidipina cloridrato - Google Patents

Procedimento migliorato per la preparazione della lercanidipina cloridrato

Info

Publication number
IT1274480B
IT1274480B ITMI950957A ITMI950957A IT1274480B IT 1274480 B IT1274480 B IT 1274480B IT MI950957 A ITMI950957 A IT MI950957A IT MI950957 A ITMI950957 A IT MI950957A IT 1274480 B IT1274480 B IT 1274480B
Authority
IT
Italy
Prior art keywords
preparation
improved procedure
lercanidipine hydrochloride
lercanidipine
hydrochloride
Prior art date
Application number
ITMI950957A
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of ITMI950957A0 publication Critical patent/ITMI950957A0/it
Priority to ITMI950957A priority Critical patent/IT1274480B/it
Priority to IL11814396A priority patent/IL118143A/en
Priority to IN822CA1996 priority patent/IN188486B/en
Priority to MA24223A priority patent/MA23858A1/fr
Priority to DZ960075A priority patent/DZ2032A1/fr
Priority to PCT/EP1996/002122 priority patent/WO1996035668A1/en
Priority to CZ19973567A priority patent/CZ288634B6/cs
Priority to EP96916111A priority patent/EP0824517B1/en
Priority to ES96916111T priority patent/ES2179942T3/es
Priority to JP53379796A priority patent/JP4038622B2/ja
Priority to PL96323236A priority patent/PL185260B1/pl
Priority to AU58985/96A priority patent/AU694046B2/en
Priority to PT96916111T priority patent/PT824517E/pt
Priority to BR9608374A priority patent/BR9608374A/pt
Priority to DE69622552T priority patent/DE69622552T2/de
Priority to CA002217849A priority patent/CA2217849C/en
Priority to EA199700374A priority patent/EA000346B1/ru
Priority to MYPI96001751A priority patent/MY113802A/en
Priority to HU9801913A priority patent/HU226709B1/hu
Priority to NZ309059A priority patent/NZ309059A/xx
Priority to KR1019970707905A priority patent/KR100395441B1/ko
Priority to DK96916111T priority patent/DK0824517T3/da
Priority to SI9630493T priority patent/SI0824517T1/xx
Priority to CN96193842A priority patent/CN1101810C/zh
Priority to RO97-02101A priority patent/RO119616B1/ro
Priority to EG40296A priority patent/EG21755A/xx
Priority to AT96916111T priority patent/ATE221050T1/de
Priority to EE9700303A priority patent/EE03351B1/xx
Priority to UA97125981A priority patent/UA46769C2/uk
Priority to SK1514-97A priority patent/SK283321B6/sk
Priority to TW085105567A priority patent/TW404940B/zh
Priority to ZA963716A priority patent/ZA963716B/xx
Priority to ARP960102528A priority patent/AR002739A1/es
Priority to US08/645,964 priority patent/US5767136A/en
Priority to US08/645,963 priority patent/US5912351A/en
Priority to TNTNSN96069A priority patent/TNSN96069A1/fr
Priority to SA96170216A priority patent/SA96170216B1/ar
Publication of ITMI950957A1 publication Critical patent/ITMI950957A1/it
Application granted granted Critical
Publication of IT1274480B publication Critical patent/IT1274480B/it
Priority to BG102034A priority patent/BG62400B1/bg
Priority to NO975176A priority patent/NO309423B1/no
Priority to MX9708662A priority patent/MX9708662A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ITMI950957A 1995-05-12 1995-05-12 Procedimento migliorato per la preparazione della lercanidipina cloridrato IT1274480B (it)

Priority Applications (40)

Application Number Priority Date Filing Date Title
ITMI950957A IT1274480B (it) 1995-05-12 1995-05-12 Procedimento migliorato per la preparazione della lercanidipina cloridrato
IL11814396A IL118143A (en) 1995-05-12 1996-05-03 Preparation of recanidipine hydrochloride
IN822CA1996 IN188486B (it) 1995-05-12 1996-05-06
MA24223A MA23858A1 (fr) 1995-05-12 1996-05-07 Un procede pour la preparation de hydrochlorure de lercanidipine
DZ960075A DZ2032A1 (fr) 1995-05-12 1996-05-08 Un procédé pour la préparation de l'hydrochlorure de lercanidipine.
KR1019970707905A KR100395441B1 (ko) 1995-05-12 1996-05-09 레르카니다핀하이드로클로라이드의제조공정
RO97-02101A RO119616B1 (ro) 1995-05-12 1996-05-09 Procedeu de preparare a clorhidratului de lercanidipină
EP96916111A EP0824517B1 (en) 1995-05-12 1996-05-09 A process for the preparation of lercanidipine hydrochloride
ES96916111T ES2179942T3 (es) 1995-05-12 1996-05-09 Un proceso para la preparacion de clorhidrato de lercanidipino.
JP53379796A JP4038622B2 (ja) 1995-05-12 1996-05-09 レルカニジピン・ハイドロクロリドの調製方法
PL96323236A PL185260B1 (pl) 1995-05-12 1996-05-09 Sposób wytwarzania chlorowodorku lerkanidypiny
AU58985/96A AU694046B2 (en) 1995-05-12 1996-05-09 A process for the preparation of lercanidipine hydrochloride
PT96916111T PT824517E (pt) 1995-05-12 1996-05-09 Processo para a preparacao de cloridrato de lercanidipina
BR9608374A BR9608374A (pt) 1995-05-12 1996-05-09 Processo para a prepara-Æo de cloridrato de lercanidipina
DE69622552T DE69622552T2 (de) 1995-05-12 1996-05-09 Verfahren zur herstellung von lercanidipin hydrochlorid
CA002217849A CA2217849C (en) 1995-05-12 1996-05-09 A process for the preparation of lercanidipine hydrochloride
EA199700374A EA000346B1 (ru) 1995-05-12 1996-05-09 Способ получения гидрохлорида лерканидипина
MYPI96001751A MY113802A (en) 1995-05-12 1996-05-09 A process for the preparation of lercanidipine hydrochloride
HU9801913A HU226709B1 (en) 1995-05-12 1996-05-09 Process for the preparation of lercanidipine hydrochloride
NZ309059A NZ309059A (en) 1995-05-12 1996-05-09 A process for the preparation of lercanidipine hydrochloride
PCT/EP1996/002122 WO1996035668A1 (en) 1995-05-12 1996-05-09 A process for the preparation of lercanidipine hydrochloride
DK96916111T DK0824517T3 (da) 1995-05-12 1996-05-09 Fremgangsmåde til fremstilling af lercanidipinhydrochlorid
SI9630493T SI0824517T1 (en) 1995-05-12 1996-05-09 A process for the preparation of lercanidipine hydrochloride
CN96193842A CN1101810C (zh) 1995-05-12 1996-05-09 盐酸乐卡地平的制备方法
CZ19973567A CZ288634B6 (cs) 1995-05-12 1996-05-09 Způsob výroby lercanidipinhydrochloridu
EG40296A EG21755A (en) 1995-05-12 1996-05-09 Process for preparing of lercanidipine hydrochloride and their use for the treatment of angina and coronary disease
AT96916111T ATE221050T1 (de) 1995-05-12 1996-05-09 Verfahren zur herstellung von lercanidipin hydrochlorid
EE9700303A EE03351B1 (et) 1995-05-12 1996-05-09 Meetod lerkanidipiinhüdrokloriidi valmistamiseks
UA97125981A UA46769C2 (uk) 1995-05-12 1996-05-09 Спосіб одержання метил-1,1,n-триметил-n-(3,3-дифенілпропіл)-2-аміноетил-1,4-дигідро-2,6-диметил-4-(3-нітрофеніл)-піридин-3,5- дикарбоксилату (лерканідипіну) гідрохлориду
SK1514-97A SK283321B6 (sk) 1995-05-12 1996-05-09 Spôsob prípravy lerkanidipínhydrochloridu
TW085105567A TW404940B (en) 1995-05-12 1996-05-10 A process for the preparation of lercanidipine hydrochloride
ZA963716A ZA963716B (en) 1995-05-12 1996-05-10 A process for the preparation of lercanidipine hydrochloride
ARP960102528A AR002739A1 (es) 1995-05-12 1996-05-10 Un procedimiento para la preparacion de hidrocloruro de lercanidipino y el clorhidrato de metiloanhidro 1,1,n-trimetil-n-(3,3-difenilpropil)-2-aminoetilo-1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)-piridino-3,5-dicarboxilato obtenido mediante dicho procedimiento.
US08/645,964 US5767136A (en) 1995-05-12 1996-05-10 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls
US08/645,963 US5912351A (en) 1995-05-12 1996-05-10 Anhydrous 1,4-Dihydropyridines and salts thereof
TNTNSN96069A TNSN96069A1 (fr) 1995-05-12 1996-05-10 Un procede pour la preparation de l'hydrochlorure de lercanidipine
SA96170216A SA96170216B1 (ar) 1995-05-12 1996-08-07 Lercanidipine hudrochloride طريقة لتحضير هيدروكلوريد ليركانيديبين
BG102034A BG62400B1 (bg) 1995-05-12 1997-11-07 Метод за получаване на лерканидипин хидрохлорид
NO975176A NO309423B1 (no) 1995-05-12 1997-11-11 Fremgangsmåte ved fremstilling av lercanidipinhydroklorid
MX9708662A MX9708662A (es) 1995-05-12 1997-11-11 Un procedimiento para la preparacion de clorhidrato de lercanidipino.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI950957A IT1274480B (it) 1995-05-12 1995-05-12 Procedimento migliorato per la preparazione della lercanidipina cloridrato

Publications (3)

Publication Number Publication Date
ITMI950957A0 ITMI950957A0 (it) 1995-05-12
ITMI950957A1 ITMI950957A1 (it) 1996-11-12
IT1274480B true IT1274480B (it) 1997-07-17

Family

ID=11371581

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI950957A IT1274480B (it) 1995-05-12 1995-05-12 Procedimento migliorato per la preparazione della lercanidipina cloridrato

Country Status (37)

Country Link
EP (1) EP0824517B1 (it)
JP (1) JP4038622B2 (it)
KR (1) KR100395441B1 (it)
CN (1) CN1101810C (it)
AR (1) AR002739A1 (it)
AT (1) ATE221050T1 (it)
AU (1) AU694046B2 (it)
BG (1) BG62400B1 (it)
BR (1) BR9608374A (it)
CA (1) CA2217849C (it)
CZ (1) CZ288634B6 (it)
DE (1) DE69622552T2 (it)
DK (1) DK0824517T3 (it)
DZ (1) DZ2032A1 (it)
EA (1) EA000346B1 (it)
EE (1) EE03351B1 (it)
EG (1) EG21755A (it)
ES (1) ES2179942T3 (it)
HU (1) HU226709B1 (it)
IL (1) IL118143A (it)
IN (1) IN188486B (it)
IT (1) IT1274480B (it)
MA (1) MA23858A1 (it)
MX (1) MX9708662A (it)
MY (1) MY113802A (it)
NO (1) NO309423B1 (it)
NZ (1) NZ309059A (it)
PL (1) PL185260B1 (it)
PT (1) PT824517E (it)
RO (1) RO119616B1 (it)
SA (1) SA96170216B1 (it)
SK (1) SK283321B6 (it)
TN (1) TNSN96069A1 (it)
TW (1) TW404940B (it)
UA (1) UA46769C2 (it)
WO (1) WO1996035668A1 (it)
ZA (1) ZA963716B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US6852737B2 (en) 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
WO2004035051A1 (en) * 2002-10-16 2004-04-29 Recordati Ireland Limited Lisinopril/lercanidipine combination therapy
AR052918A1 (es) * 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
KR100713136B1 (ko) * 2005-05-04 2007-05-02 주식회사 대희화학 무수 레르카니디핀 염화수소 결정다형의 개선된 신규결정화 방법
ES2335026T3 (es) 2005-06-15 2010-03-18 Hetero Drugs Limited Nuevo procedimiento de preparacion de lercanipidina.
KR20080048065A (ko) 2005-09-16 2008-05-30 그렌마크 파머수티칼스 엘티디. 다형 형태의 염산 레르카니디핀 및 이것의 제조방법
KR100811497B1 (ko) * 2005-10-19 2008-03-07 신풍제약주식회사 무수 염산 1,4-디하이드로피리딘 유도체의 제조 방법
EP1860102B1 (en) * 2006-05-24 2008-11-26 CF Pharma Ltd. Process for Producing Lercanidipine
KR100808281B1 (ko) * 2006-06-30 2008-03-03 주식회사 하원정밀화학 레르카니디핀 및 그 산부가염의 제조방법
CN102020602B (zh) * 2009-09-18 2013-12-25 深圳信立泰药业股份有限公司 盐酸乐卡地平晶型及其制备方法和含有该晶型的药物组合物
WO2011161223A2 (en) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
EA023996B1 (ru) 2010-12-24 2016-08-31 КРКА, д.д., НОВО МЕСТО Гомогенные фармацевтические пероральные лекарственные формы, содержащие лерканидипин и эналаприл или их фармацевтически приемлемые соли совместно с органической кислотой
CN102516160B (zh) * 2011-12-16 2014-04-02 华润赛科药业有限责任公司 一种高纯盐酸乐卡地平的合成工艺
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102584682A (zh) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 盐酸乐卡地平的制备方法
CN109956943B (zh) * 2019-04-18 2021-07-20 合肥合源药业有限公司 一种二氢吡啶类药物中脱羧缩合杂质及其制备、控制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters

Also Published As

Publication number Publication date
ES2179942T3 (es) 2003-02-01
TW404940B (en) 2000-09-11
MA23858A1 (fr) 1996-12-31
UA46769C2 (uk) 2002-06-17
JP4038622B2 (ja) 2008-01-30
AU694046B2 (en) 1998-07-09
ZA963716B (en) 1996-11-20
EP0824517A1 (en) 1998-02-25
AR002739A1 (es) 1998-04-29
CN1184468A (zh) 1998-06-10
DZ2032A1 (fr) 2002-07-21
EA000346B1 (ru) 1999-04-29
JPH11504932A (ja) 1999-05-11
MX9708662A (es) 1998-08-30
NO975176D0 (no) 1997-11-11
IL118143A0 (en) 1996-09-12
KR19990008378A (ko) 1999-01-25
TNSN96069A1 (fr) 2005-03-15
EG21755A (en) 2002-02-27
CZ288634B6 (cs) 2001-08-15
MY113802A (en) 2002-05-31
DK0824517T3 (da) 2002-11-18
EP0824517B1 (en) 2002-07-24
RO119616B1 (ro) 2005-01-28
AU5898596A (en) 1996-11-29
DE69622552T2 (de) 2003-01-23
CA2217849A1 (en) 1996-11-14
EA199700374A1 (ru) 1998-10-29
HUP9801913A3 (en) 1999-01-28
BG62400B1 (bg) 1999-10-29
CN1101810C (zh) 2003-02-19
BG102034A (en) 1998-04-30
SK151497A3 (en) 1998-05-06
PT824517E (pt) 2002-12-31
DE69622552D1 (de) 2002-08-29
SA96170216B1 (ar) 2005-12-21
HU226709B1 (en) 2009-07-28
CA2217849C (en) 2007-09-11
CZ356797A3 (cs) 1998-04-15
SK283321B6 (sk) 2003-06-03
KR100395441B1 (ko) 2004-02-05
ITMI950957A0 (it) 1995-05-12
ITMI950957A1 (it) 1996-11-12
HUP9801913A2 (hu) 1998-12-28
WO1996035668A1 (en) 1996-11-14
BR9608374A (pt) 1999-08-24
ATE221050T1 (de) 2002-08-15
IN188486B (it) 2002-10-05
PL323236A1 (en) 1998-03-16
IL118143A (en) 2001-06-14
PL185260B1 (pl) 2003-04-30
EE03351B1 (et) 2001-02-15
NO309423B1 (no) 2001-01-29
NO975176L (no) 1997-11-11
NZ309059A (en) 1998-10-28

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