ES2179942T3 - Un proceso para la preparacion de clorhidrato de lercanidipino. - Google Patents

Un proceso para la preparacion de clorhidrato de lercanidipino.

Info

Publication number
ES2179942T3
ES2179942T3 ES96916111T ES96916111T ES2179942T3 ES 2179942 T3 ES2179942 T3 ES 2179942T3 ES 96916111 T ES96916111 T ES 96916111T ES 96916111 T ES96916111 T ES 96916111T ES 2179942 T3 ES2179942 T3 ES 2179942T3
Authority
ES
Spain
Prior art keywords
chlorhydrate
preparation
lercanidipino
acid
imetile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96916111T
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati Ireland Ltd
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Application granted granted Critical
Publication of ES2179942T3 publication Critical patent/ES2179942T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE METIL 1,1,N DIMETIL RO ACIDO DEL ACIDO 2,6 NITROFENIL) IMETIL TECNICAS DE CRISTALIZACION APLICABLES INDUSTRIALMENTE Y SE OBTIENE CON UN ALTO RENDIMIENTO EN FORMA DE SU CLORHIDRATO ANHIDRO, UNA FORMA QUE POSEE ALTA ESTABILIDAD Y BAJA HIGROSCOPICIDAD.
ES96916111T 1995-05-12 1996-05-09 Un proceso para la preparacion de clorhidrato de lercanidipino. Expired - Lifetime ES2179942T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI950957A IT1274480B (it) 1995-05-12 1995-05-12 Procedimento migliorato per la preparazione della lercanidipina cloridrato

Publications (1)

Publication Number Publication Date
ES2179942T3 true ES2179942T3 (es) 2003-02-01

Family

ID=11371581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96916111T Expired - Lifetime ES2179942T3 (es) 1995-05-12 1996-05-09 Un proceso para la preparacion de clorhidrato de lercanidipino.

Country Status (37)

Country Link
EP (1) EP0824517B1 (es)
JP (1) JP4038622B2 (es)
KR (1) KR100395441B1 (es)
CN (1) CN1101810C (es)
AR (1) AR002739A1 (es)
AT (1) ATE221050T1 (es)
AU (1) AU694046B2 (es)
BG (1) BG62400B1 (es)
BR (1) BR9608374A (es)
CA (1) CA2217849C (es)
CZ (1) CZ288634B6 (es)
DE (1) DE69622552T2 (es)
DK (1) DK0824517T3 (es)
DZ (1) DZ2032A1 (es)
EA (1) EA000346B1 (es)
EE (1) EE03351B1 (es)
EG (1) EG21755A (es)
ES (1) ES2179942T3 (es)
HU (1) HU226709B1 (es)
IL (1) IL118143A (es)
IN (1) IN188486B (es)
IT (1) IT1274480B (es)
MA (1) MA23858A1 (es)
MX (1) MX9708662A (es)
MY (1) MY113802A (es)
NO (1) NO309423B1 (es)
NZ (1) NZ309059A (es)
PL (1) PL185260B1 (es)
PT (1) PT824517E (es)
RO (1) RO119616B1 (es)
SA (1) SA96170216B1 (es)
SK (1) SK283321B6 (es)
TN (1) TNSN96069A1 (es)
TW (1) TW404940B (es)
UA (1) UA46769C2 (es)
WO (1) WO1996035668A1 (es)
ZA (1) ZA963716B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US6852737B2 (en) 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
AU2003274004A1 (en) * 2002-10-16 2004-05-04 Recordati Ireland Limited Lisinopril/lercanidipine combination therapy
AR052918A1 (es) * 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
KR100713136B1 (ko) * 2005-05-04 2007-05-02 주식회사 대희화학 무수 레르카니디핀 염화수소 결정다형의 개선된 신규결정화 방법
WO2006134606A1 (en) * 2005-06-15 2006-12-21 Hetero Drugs Limited A novel process for the preparation of lercanidipine
WO2007031865A2 (en) 2005-09-16 2007-03-22 Glenmark Pharmaceuticals Limited Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof
KR100811497B1 (ko) * 2005-10-19 2008-03-07 신풍제약주식회사 무수 염산 1,4-디하이드로피리딘 유도체의 제조 방법
EP1860102B1 (en) * 2006-05-24 2008-11-26 CF Pharma Ltd. Process for Producing Lercanidipine
KR100808281B1 (ko) * 2006-06-30 2008-03-03 주식회사 하원정밀화학 레르카니디핀 및 그 산부가염의 제조방법
CN102020602B (zh) * 2009-09-18 2013-12-25 深圳信立泰药业股份有限公司 盐酸乐卡地平晶型及其制备方法和含有该晶型的药物组合物
WO2011161223A2 (en) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
SI2654729T1 (sl) 2010-12-24 2016-08-31 Krka, D.D., Novo Mesto Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102516160B (zh) * 2011-12-16 2014-04-02 华润赛科药业有限责任公司 一种高纯盐酸乐卡地平的合成工艺
CN102584682A (zh) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 盐酸乐卡地平的制备方法
CN109956943B (zh) * 2019-04-18 2021-07-20 合肥合源药业有限公司 一种二氢吡啶类药物中脱羧缩合杂质及其制备、控制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters

Also Published As

Publication number Publication date
PL323236A1 (en) 1998-03-16
TNSN96069A1 (fr) 2005-03-15
DK0824517T3 (da) 2002-11-18
CZ356797A3 (cs) 1998-04-15
NO975176L (no) 1997-11-11
JPH11504932A (ja) 1999-05-11
ITMI950957A1 (it) 1996-11-12
WO1996035668A1 (en) 1996-11-14
HUP9801913A2 (hu) 1998-12-28
AU694046B2 (en) 1998-07-09
BG102034A (en) 1998-04-30
SK283321B6 (sk) 2003-06-03
UA46769C2 (uk) 2002-06-17
EP0824517A1 (en) 1998-02-25
IL118143A (en) 2001-06-14
CN1184468A (zh) 1998-06-10
AR002739A1 (es) 1998-04-29
EE03351B1 (et) 2001-02-15
TW404940B (en) 2000-09-11
AU5898596A (en) 1996-11-29
JP4038622B2 (ja) 2008-01-30
DE69622552T2 (de) 2003-01-23
CA2217849A1 (en) 1996-11-14
NO309423B1 (no) 2001-01-29
ITMI950957A0 (it) 1995-05-12
IN188486B (es) 2002-10-05
IL118143A0 (en) 1996-09-12
BG62400B1 (bg) 1999-10-29
KR19990008378A (ko) 1999-01-25
MA23858A1 (fr) 1996-12-31
CZ288634B6 (cs) 2001-08-15
PT824517E (pt) 2002-12-31
ATE221050T1 (de) 2002-08-15
NZ309059A (en) 1998-10-28
KR100395441B1 (ko) 2004-02-05
MX9708662A (es) 1998-08-30
PL185260B1 (pl) 2003-04-30
EA000346B1 (ru) 1999-04-29
EA199700374A1 (ru) 1998-10-29
IT1274480B (it) 1997-07-17
HU226709B1 (en) 2009-07-28
HUP9801913A3 (en) 1999-01-28
SA96170216B1 (ar) 2005-12-21
CA2217849C (en) 2007-09-11
BR9608374A (pt) 1999-08-24
NO975176D0 (no) 1997-11-11
SK151497A3 (en) 1998-05-06
EP0824517B1 (en) 2002-07-24
CN1101810C (zh) 2003-02-19
DZ2032A1 (fr) 2002-07-21
DE69622552D1 (de) 2002-08-29
MY113802A (en) 2002-05-31
ZA963716B (en) 1996-11-20
RO119616B1 (ro) 2005-01-28
EG21755A (en) 2002-02-27

Similar Documents

Publication Publication Date Title
ES2179942T3 (es) Un proceso para la preparacion de clorhidrato de lercanidipino.
EA199700186A1 (ru) Новые дипептидные амидины, используемые в качестве ингибиторов тромбина
BR9509269A (pt) Processo para tratar diabetes
BR9607060A (pt) Processos para inibição de crescimento de pelos em mamíferos uso de um inibidor não esteroidal de angiogénese processo para produção de uma composição para inibir o crescimento de pelos em mamíferos composição quando usada para inibir o crescimento de pelos em mamíferos
PT960109E (pt) Processo para preparacao de tolterodina
BR8903237A (pt) Processo para incrementar a estabilidade de armazenagem de um amidoperoxiacido,e composicao detergente
EA199700426A1 (ru) Промежуточные продукты для ассиметричного синтеза (-)6-хлор-4-циклопропилэтинил-4-трифторметил-1,4-дигидро-2н-3,1-бензоксазин-2-она и способ их получения
ES2090713T3 (es) Sales organicas de n,n'-diacetil-cistina.
EA200000891A1 (ru) Кристаллическая форма 4-[5-метил-3-фенилизоксазол-4-ил] бензолсульфонамида
BR9205163A (pt) Processo para a preparacao de protease alcalina altamente purificada a partir de um caldo de fermentacao,composicao e protease alcalina purificada
CO4761070A1 (es) Esfingolipidos novedosos y un proceso de preparacion de es- tos
ATE297564T1 (de) Forgeschrittes rezept - wissensbasiertes informationssystem für herstellungsprozesse
EA199900580A1 (ru) Фармацевтические производные аминофосфоновой кислоты
DE69423179T2 (de) Prozess zur Herstellung von optisch aktiven 2-Amino-1-phenylethanol Derivaten
ES2173241T3 (es) Procedimiento para la obtencion de 1,3-dimetil-5-fluoro-pirazol-4-carboxanilidas.
PT97049A (pt) Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados
ES2149543T3 (es) Composiciones para eliminar incrustaciones de cal.
ITRM930188A0 (it) Produzione di fogli polarizzatori.
BR9710015A (pt) Elemento estrutural e processo para a fabricação de um elemento estrutural
ES2089993T1 (es) Procedimiento y productos intermediarios para la preparacion de clorhidrato de terazosin dihidrato.
BR9007035A (pt) Processo para a producao de alcoois de guerbet
BR9715045A (pt) Novos derivados de pentaeritritol, processo de produção e uso e formas intermediárias para sìntese
PT775146E (pt) Novo processo para a preparacao de diisopinocanfeilcloroborano
IT7820295A0 (it) Processo per la produzione di una benzamide otticamente attiva, benzamide otticamente attiva cosi'ottenuta e composizioni farmaceutiche che la contengono.
BR9406352A (pt) Processo para a fabricição de ácido aminometanofosfonico