BR9715045A - Novos derivados de pentaeritritol, processo de produção e uso e formas intermediárias para sìntese - Google Patents
Novos derivados de pentaeritritol, processo de produção e uso e formas intermediárias para sìnteseInfo
- Publication number
- BR9715045A BR9715045A BR9715045-2A BR9715045A BR9715045A BR 9715045 A BR9715045 A BR 9715045A BR 9715045 A BR9715045 A BR 9715045A BR 9715045 A BR9715045 A BR 9715045A
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- production
- use process
- intermediate forms
- new
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 title 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C06—EXPLOSIVES; MATCHES
- C06B—EXPLOSIVES OR THERMIC COMPOSITIONS; MANUFACTURE THEREOF; USE OF SINGLE SUBSTANCES AS EXPLOSIVES
- C06B25/00—Compositions containing a nitrated organic compound
-
- C—CHEMISTRY; METALLURGY
- C06—EXPLOSIVES; MATCHES
- C06B—EXPLOSIVES OR THERMIC COMPOSITIONS; MANUFACTURE THEREOF; USE OF SINGLE SUBSTANCES AS EXPLOSIVES
- C06B25/00—Compositions containing a nitrated organic compound
- C06B25/10—Compositions containing a nitrated organic compound the compound being nitroglycerine
-
- C—CHEMISTRY; METALLURGY
- C06—EXPLOSIVES; MATCHES
- C06B—EXPLOSIVES OR THERMIC COMPOSITIONS; MANUFACTURE THEREOF; USE OF SINGLE SUBSTANCES AS EXPLOSIVES
- C06B25/00—Compositions containing a nitrated organic compound
- C06B25/32—Compositions containing a nitrated organic compound the compound being nitrated pentaerythritol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
<B>"NOVOS DERIVADOS DE PENTAERITRITOL, PROCESSO DE PRODUçãO E USO E FORMAS INTERMEDIáRIAS PARA SìNTESE''<D>. A presente invenção refere se a novos compostos derivados de pentaentritol de formulas estruturais (I), (XIV), (XVI) e (XXm), cujos substituintes possuam as significações definidas na memória descrita, que podem ser utilizados enquanto substâncias farmacêuticas ativas, em especial para o tratamento de doenças cardíacas e circulatórias.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19641667A DE19641667A1 (de) | 1996-10-10 | 1996-10-10 | Neue Ester der Salpetersäure sowie deren Herstellung und Verwendung |
DE1996152345 DE19652345A1 (de) | 1996-12-17 | 1996-12-17 | Neue Salpetersäureester, deren Herstellung und Verwendung |
DE19726812A DE19726812A1 (de) | 1997-06-25 | 1997-06-25 | Neue Derivate des Pentaerythrits, deren Herstellung und Verwendung sowie Intermediate zur Synthese derselben |
PCT/DE1997/002328 WO1998015521A1 (de) | 1996-10-10 | 1997-10-10 | Neue derivate des pentaerythrits, deren herstellung und verwendung sowie intermediate zur synthese derselben |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9715045A true BR9715045A (pt) | 2001-01-16 |
Family
ID=27216719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9715045-2A BR9715045A (pt) | 1996-10-10 | 1997-10-10 | Novos derivados de pentaeritritol, processo de produção e uso e formas intermediárias para sìntese |
Country Status (20)
Country | Link |
---|---|
US (1) | US6180664B1 (pt) |
EP (1) | EP1009730A1 (pt) |
JP (1) | JP2001501627A (pt) |
CN (1) | CN1239944A (pt) |
AU (1) | AU736253B2 (pt) |
BG (1) | BG103303A (pt) |
BR (1) | BR9715045A (pt) |
CA (1) | CA2267129A1 (pt) |
CZ (1) | CZ9901223A3 (pt) |
EA (1) | EA001959B1 (pt) |
EE (1) | EE9900116A (pt) |
HR (1) | HRP970546A2 (pt) |
IL (1) | IL129339A0 (pt) |
NO (1) | NO991622L (pt) |
NZ (1) | NZ335057A (pt) |
PL (1) | PL332594A1 (pt) |
SK (1) | SK43499A3 (pt) |
TR (1) | TR199900791T2 (pt) |
WO (1) | WO1998015521A1 (pt) |
YU (1) | YU17999A (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6365611B1 (en) | 1997-06-11 | 2002-04-02 | Isis Pharma Gmbh | Pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same |
WO1999067430A2 (de) * | 1998-06-24 | 1999-12-29 | Alpharma-Isis Gmbh & Co. Kg | Analytische substrate und antioxidative mittel |
DE19950483A1 (de) * | 1999-10-19 | 2001-05-10 | Isis Pharma Gmbh | Verfahren zur Herstellung von 3-Nitryloxy-2,2-bis(nitryloxymethyl)-propanal |
US20040087558A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
US20050203142A1 (en) * | 2002-10-24 | 2005-09-15 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
US20050065184A1 (en) * | 2003-08-29 | 2005-03-24 | Aaipharma Inc. | Method of reducing the risk of oxidative stress |
CN103848704A (zh) * | 2012-11-30 | 2014-06-11 | 陕西省汉阴华能新材料研究有限公司 | 回收油的应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1883045A (en) | 1931-11-20 | 1932-10-18 | Du Pont | Explosive composition |
GB442850A (en) | 1934-05-14 | 1936-02-17 | Bombrini Parodi Delfino | Improvements in and relating to the production of explosives |
US2389228A (en) | 1943-04-14 | 1945-11-20 | Trojan Powder Co | Preparation of tripentaerythritol octanitrate |
NL110701C (pt) | 1960-03-14 | |||
US3419571A (en) * | 1966-04-06 | 1968-12-31 | Warner Lambert Pharmaceutical | Method for relieving coronary insufficiency |
US4394329A (en) * | 1979-06-26 | 1983-07-19 | Thiokol Corporation | 2-Hydroxymethyl-1,3-propanediol nitrate ester |
CS221031B1 (en) * | 1981-12-28 | 1983-04-29 | Svatopluk ZEMAN | Method of making the nitrates,derivatives of the trimethylmethane |
-
1997
- 1997-10-10 CA CA002267129A patent/CA2267129A1/en not_active Abandoned
- 1997-10-10 YU YU17999A patent/YU17999A/sh unknown
- 1997-10-10 CN CN97180509A patent/CN1239944A/zh active Pending
- 1997-10-10 AU AU51155/98A patent/AU736253B2/en not_active Ceased
- 1997-10-10 EP EP97945736A patent/EP1009730A1/de not_active Withdrawn
- 1997-10-10 SK SK434-99A patent/SK43499A3/sk unknown
- 1997-10-10 WO PCT/DE1997/002328 patent/WO1998015521A1/de not_active Application Discontinuation
- 1997-10-10 NZ NZ335057A patent/NZ335057A/xx unknown
- 1997-10-10 HR HR19726812.9A patent/HRP970546A2/hr not_active Application Discontinuation
- 1997-10-10 IL IL12933997A patent/IL129339A0/xx unknown
- 1997-10-10 EE EEP199900116A patent/EE9900116A/xx unknown
- 1997-10-10 TR TR1999/00791T patent/TR199900791T2/xx unknown
- 1997-10-10 EA EA199900363A patent/EA001959B1/ru not_active IP Right Cessation
- 1997-10-10 JP JP10517083A patent/JP2001501627A/ja active Pending
- 1997-10-10 US US09/269,969 patent/US6180664B1/en not_active Expired - Fee Related
- 1997-10-10 BR BR9715045-2A patent/BR9715045A/pt not_active IP Right Cessation
- 1997-10-10 PL PL97332594A patent/PL332594A1/xx unknown
- 1997-10-10 CZ CZ19991223A patent/CZ9901223A3/cs unknown
-
1999
- 1999-04-02 BG BG103303A patent/BG103303A/bg unknown
- 1999-04-06 NO NO991622A patent/NO991622L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6180664B1 (en) | 2001-01-30 |
AU5115598A (en) | 1998-05-05 |
IL129339A0 (en) | 2000-02-17 |
YU17999A (sh) | 2002-03-18 |
AU736253B2 (en) | 2001-07-26 |
SK43499A3 (en) | 2000-02-14 |
PL332594A1 (en) | 1999-09-27 |
BG103303A (bg) | 2000-01-31 |
JP2001501627A (ja) | 2001-02-06 |
WO1998015521A1 (de) | 1998-04-16 |
CZ9901223A3 (cs) | 2002-10-16 |
EA001959B1 (ru) | 2001-10-22 |
CA2267129A1 (en) | 1998-04-16 |
NO991622D0 (no) | 1999-04-06 |
EA199900363A1 (ru) | 1999-12-29 |
TR199900791T2 (xx) | 1999-07-21 |
NZ335057A (en) | 2000-09-29 |
HRP970546A2 (en) | 1998-08-31 |
NO991622L (no) | 1999-06-04 |
CN1239944A (zh) | 1999-12-29 |
EP1009730A1 (de) | 2000-06-21 |
EE9900116A (et) | 1999-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1835 DE 07/03/2006. |