ES2089993T1 - Procedimiento y productos intermediarios para la preparacion de clorhidrato de terazosin dihidrato. - Google Patents

Procedimiento y productos intermediarios para la preparacion de clorhidrato de terazosin dihidrato.

Info

Publication number
ES2089993T1
ES2089993T1 ES95103188T ES95103188T ES2089993T1 ES 2089993 T1 ES2089993 T1 ES 2089993T1 ES 95103188 T ES95103188 T ES 95103188T ES 95103188 T ES95103188 T ES 95103188T ES 2089993 T1 ES2089993 T1 ES 2089993T1
Authority
ES
Spain
Prior art keywords
preparation
chlorhydrate
terazosin
dihydrate
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES95103188T
Other languages
English (en)
Other versions
ES2089993T3 (es
Inventor
Anthony Mannino
Wayne R Heitmann
Rodger F Henry
Bruce W Horrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23264439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2089993(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES2089993T1 publication Critical patent/ES2089993T1/es
Application granted granted Critical
Publication of ES2089993T3 publication Critical patent/ES2089993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE 1-(4-AMINO-6-7-DIMETOXI-2QUINAZOLINIL)-4-(2-TETRAHIDROFUROILO)PIPERACINA HIDROCLORURO (DIHIDRATO DE HIDROCLORURO DE TERAZOSINA COMPRENDE LOS PASOS DE REACCIONAR 4-AMINO-2-CLORO-6,7-DIMETOXI-QUINAZOLINA CON N-(2TETRAHIDROFUROIL)PIPERACINA EN UN SOLVENTE ORGANICO POLAR ANHIDROSO EN AUSENCIA DE UN DEPURADOR DE ACIDO AÑADIDO PARA PRODUCIR HIDROCLORURO 1-(4-AMINO-6,7-DIMETOXI-2-QUIONAZOLINIL)4-(2-TETRAHIDROFUROIL)PIPERACINA ANHIDROSO (FORMA IV) Y A CONTINUACION CONVERTIR EL PRODUCTO DE ESTE PASO EN 1-(4-AMINO6,7-DIMETOXI-2-QUINAZOLINIL)-4-(2-TETRAHIDROFUROIL)DEHIDRATADO DE HIDROCLORURO PIPERACINA.
ES95103188T 1994-10-18 1995-03-06 Procedimiento y productos intermedios para la preparacion de clorhidrato de terazosina dihidrato. Expired - Lifetime ES2089993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/324,635 US5504207A (en) 1994-10-18 1994-10-18 Process and intermediate for the preparation of terazosin hydrochloride dihydrate

Publications (2)

Publication Number Publication Date
ES2089993T1 true ES2089993T1 (es) 1996-10-16
ES2089993T3 ES2089993T3 (es) 1997-02-16

Family

ID=23264439

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95103188T Expired - Lifetime ES2089993T3 (es) 1994-10-18 1995-03-06 Procedimiento y productos intermedios para la preparacion de clorhidrato de terazosina dihidrato.

Country Status (11)

Country Link
US (1) US5504207A (es)
EP (1) EP0708104B1 (es)
JP (1) JP2711230B2 (es)
AT (1) ATE143959T1 (es)
BR (1) BR1100705A (es)
CA (1) CA2143971C (es)
DE (1) DE69500064T2 (es)
DK (1) DK0708104T3 (es)
ES (1) ES2089993T3 (es)
GR (2) GR960300047T1 (es)
HK (1) HK130297A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587377A (en) * 1995-10-24 1996-12-24 Invamed, Inc. Terazosin crystalline polymorph and pharmaceutical compositions thereof
DE19546573A1 (de) * 1995-12-13 1997-06-19 Uetikon Chemie Gmbh Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung
US5952003A (en) * 1996-08-01 1999-09-14 Novartis Corporation Terazosin capsules
EP0849266B8 (de) * 1996-12-20 2007-10-03 Heumann PCS GmbH Neue polymorphe Form von Doxazosinmesylat (Form III)
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
US6248888B1 (en) * 1997-11-14 2001-06-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of terazosin hydrochloride dihydrate
US6200573B1 (en) 1999-12-03 2001-03-13 Starcor Pharmaceuticals, Inc. Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia
US20070161791A1 (en) * 2006-01-09 2007-07-12 Narsimha Reddy Penthala Process for the preparation of terazosin hydrocloride dihydrate
EP2049117A4 (en) * 2006-08-08 2010-08-25 Auspex Pharmaceuticals Inc PREPARATION AND USE OF SUBSTITUTED CHINAZOLIN COMPOUNDS WITH ALPHA-ADRENERGER BLOKING EFFECT

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
DE3683760D1 (de) * 1986-03-21 1992-03-12 Heumann Pharma Gmbh & Co Kristalline, wasserfreie sigma -form von 2-(4-(2-furoyl-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung.
US5212176A (en) * 1990-06-29 1993-05-18 Abbott Laboratories R(+)-terazosin
AU644895B2 (en) * 1990-08-23 1993-12-23 Dainippon Ink And Chemicals Inc. Antiviral agent
JP2652272B2 (ja) * 1990-12-31 1997-09-10 住化ファインケム株式会社 １−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
US5294615A (en) * 1993-04-29 1994-03-15 Abbott Laboratories Terazosin polymorph and pharmaceutical composition

Also Published As

Publication number Publication date
ATE143959T1 (de) 1996-10-15
GR960300047T1 (en) 1996-08-31
JPH08134066A (ja) 1996-05-28
DE69500064D1 (de) 1996-11-14
US5504207A (en) 1996-04-02
ES2089993T3 (es) 1997-02-16
GR3021319T3 (en) 1997-01-31
DK0708104T3 (da) 1997-03-10
CA2143971A1 (en) 1996-04-19
HK130297A (en) 1997-09-19
BR1100705A (pt) 1999-10-13
CA2143971C (en) 1997-06-03
DE69500064T2 (de) 1997-04-10
EP0708104A1 (en) 1996-04-24
EP0708104B1 (en) 1996-10-09
JP2711230B2 (ja) 1998-02-10

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