CO5540298A2 - Proceso para preparar un ligando de ppar de tiazol y polimorfos del mismo - Google Patents

Proceso para preparar un ligando de ppar de tiazol y polimorfos del mismo

Info

Publication number
CO5540298A2
CO5540298A2 CO03104438A CO03104438A CO5540298A2 CO 5540298 A2 CO5540298 A2 CO 5540298A2 CO 03104438 A CO03104438 A CO 03104438A CO 03104438 A CO03104438 A CO 03104438A CO 5540298 A2 CO5540298 A2 CO 5540298A2
Authority
CO
Colombia
Prior art keywords
polymorphes
tiazol
prepare
same
ppar binding
Prior art date
Application number
CO03104438A
Other languages
English (en)
Inventor
Thierry Boyer
Caroline Jane Day
Andrew Jonathan Whitehead
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO5540298A2 publication Critical patent/CO5540298A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

1.- Un método para preparar un compuesto de fórmula (I)y sales y solvatos farmacéuticamente aceptables del mismo, que comprende la reacción de un compuesto de fórmula (II)en donde X es Me o Hcon un compuesto de fórmula (III)en donde X1 es cloro o imidazol.
CO03104438A 2001-05-31 2003-11-26 Proceso para preparar un ligando de ppar de tiazol y polimorfos del mismo CO5540298A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0113232.3A GB0113232D0 (en) 2001-05-31 2001-05-31 Chemical process

Publications (1)

Publication Number Publication Date
CO5540298A2 true CO5540298A2 (es) 2005-07-29

Family

ID=9915637

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03104438A CO5540298A2 (es) 2001-05-31 2003-11-26 Proceso para preparar un ligando de ppar de tiazol y polimorfos del mismo

Country Status (22)

Country Link
US (1) US7244849B2 (es)
EP (1) EP1395572B1 (es)
JP (1) JP2004532265A (es)
KR (1) KR20040007631A (es)
CN (1) CN1551871A (es)
AT (1) ATE315556T1 (es)
AU (1) AU2002317764B2 (es)
BR (1) BR0209892A (es)
CA (1) CA2448101A1 (es)
CO (1) CO5540298A2 (es)
CZ (1) CZ20033256A3 (es)
DE (1) DE60208682T2 (es)
ES (1) ES2256493T3 (es)
GB (1) GB0113232D0 (es)
HU (1) HUP0400117A3 (es)
IL (1) IL158641A0 (es)
MX (1) MXPA03010943A (es)
NO (1) NO20035313L (es)
NZ (1) NZ529486A (es)
PL (1) PL367114A1 (es)
WO (1) WO2002096893A1 (es)
ZA (1) ZA200308570B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105551B2 (en) * 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
AU2003241579B9 (en) 2002-06-19 2009-07-30 Eli Lilly And Company Amide linker peroxisome proliferator activated receptor modulators
TW200400816A (en) 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
CA2497901A1 (en) 2002-09-06 2004-03-18 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
CA2549025A1 (en) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indole-o-glucosides
US20070202179A1 (en) * 2004-04-09 2007-08-30 FAULKNER Patrick Low Dose Pharmaceutical Products
WO2007127502A2 (en) * 2006-01-10 2007-11-08 Smithkline Beecham Corporation Polymorphic form of { 2-methyl-4- [ 4-methyl-2- ( 4-triflu0r0methylphenyl) thiazol -5- ylmethylthiol phenoxy }-acetic acid
US20140112992A1 (en) * 2011-06-06 2014-04-24 Hetero Research Foundation Process for febuxostat

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100620337B1 (ko) 1998-03-10 2006-09-13 오노 야꾸힝 고교 가부시키가이샤 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP2004517100A (ja) * 2000-12-20 2004-06-10 グラクソ　グループ　リミテッド ｈＰＰＡＲアルファアゴニストとしての置換オキサゾールおよびチアゾール
GB0111523D0 (en) * 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
GB0113233D0 (en) * 2001-05-31 2001-07-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
CZ20033256A3 (en) 2004-04-14
IL158641A0 (en) 2004-05-12
ZA200308570B (en) 2005-02-03
BR0209892A (pt) 2004-06-08
HUP0400117A3 (en) 2005-09-28
JP2004532265A (ja) 2004-10-21
CA2448101A1 (en) 2002-12-05
DE60208682D1 (de) 2006-04-06
NO20035313D0 (no) 2003-11-28
MXPA03010943A (es) 2004-02-27
ATE315556T1 (de) 2006-02-15
CN1551871A (zh) 2004-12-01
US20040242657A1 (en) 2004-12-02
HUP0400117A2 (hu) 2005-03-29
NZ529486A (en) 2005-12-23
PL367114A1 (en) 2005-02-21
AU2002317764B2 (en) 2005-01-06
EP1395572B1 (en) 2006-01-11
ES2256493T3 (es) 2006-07-16
DE60208682T2 (de) 2006-08-24
WO2002096893A1 (en) 2002-12-05
NO20035313L (no) 2003-12-09
GB0113232D0 (en) 2001-07-25
KR20040007631A (ko) 2004-01-24
US7244849B2 (en) 2007-07-17
EP1395572A1 (en) 2004-03-10

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