HK130297A - Process and intermediate for the preparation of terazosin hydrochloride dihydrate - Google Patents
Process and intermediate for the preparation of terazosin hydrochloride dihydrateInfo
- Publication number
- HK130297A HK130297A HK130297A HK130297A HK130297A HK 130297 A HK130297 A HK 130297A HK 130297 A HK130297 A HK 130297A HK 130297 A HK130297 A HK 130297A HK 130297 A HK130297 A HK 130297A
- Authority
- HK
- Hong Kong
- Prior art keywords
- tetrahydrofuroyl
- dimethoxy
- amino
- preparation
- hydrochloride dihydrate
- Prior art date
Links
- KKCIOUWDFWQUBT-UHFFFAOYSA-N thyronine Chemical compound C1=CC(CC(N)C(O)=O)=CC=C1OC1=CC=C(O)C=C1 KKCIOUWDFWQUBT-UHFFFAOYSA-N 0.000 title abstract 2
- IWSWDOUXSCRCKW-UHFFFAOYSA-N [6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-yl]azanium;chloride Chemical compound Cl.N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 IWSWDOUXSCRCKW-UHFFFAOYSA-N 0.000 abstract 2
- UKESBLFBQANJHH-UHFFFAOYSA-N 1-(Tetrahydro-2-furoyl)piperazine Chemical compound C1CNCCN1C(=O)C1CCCO1 UKESBLFBQANJHH-UHFFFAOYSA-N 0.000 abstract 1
- HWIIAAVGRHKSOJ-UHFFFAOYSA-N 2-chloro-6,7-dimethoxyquinazolin-4-amine Chemical compound ClC1=NC(N)=C2C=C(OC)C(OC)=CC2=N1 HWIIAAVGRHKSOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 239000002516 radical scavenger Substances 0.000 abstract 1
- NZMOFYDMGFQZLS-UHFFFAOYSA-N terazosin hydrochloride dihydrate Chemical compound [H+].O.O.[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 NZMOFYDMGFQZLS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/324,635 US5504207A (en) | 1994-10-18 | 1994-10-18 | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK130297A true HK130297A (en) | 1997-09-19 |
Family
ID=23264439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK130297A HK130297A (en) | 1994-10-18 | 1997-06-26 | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5504207A (es) |
| EP (1) | EP0708104B1 (es) |
| JP (1) | JP2711230B2 (es) |
| AT (1) | ATE143959T1 (es) |
| BR (1) | BR1100705A (es) |
| CA (1) | CA2143971C (es) |
| DE (1) | DE69500064T2 (es) |
| DK (1) | DK0708104T3 (es) |
| ES (1) | ES2089993T3 (es) |
| GR (2) | GR960300047T1 (es) |
| HK (1) | HK130297A (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
| US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
| EP0849266B8 (de) * | 1996-12-20 | 2007-10-03 | Heumann PCS GmbH | Neue polymorphe Form von Doxazosinmesylat (Form III) |
| EP0849264A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| US6248888B1 (en) * | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
| US6200573B1 (en) | 1999-12-03 | 2001-03-13 | Starcor Pharmaceuticals, Inc. | Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia |
| US20070161791A1 (en) * | 2006-01-09 | 2007-07-12 | Narsimha Reddy Penthala | Process for the preparation of terazosin hydrocloride dihydrate |
| EP2049117A4 (en) * | 2006-08-08 | 2010-08-25 | Auspex Pharmaceuticals Inc | PREPARATION AND USE OF SUBSTITUTED CHINAZOLIN COMPOUNDS WITH ALPHA-ADRENERGER BLOKING EFFECT |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| DE3683760D1 (de) * | 1986-03-21 | 1992-03-12 | Heumann Pharma Gmbh & Co | Kristalline, wasserfreie sigma -form von 2-(4-(2-furoyl-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung. |
| US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
| AU644895B2 (en) * | 1990-08-23 | 1993-12-23 | Dainippon Ink And Chemicals Inc. | Antiviral agent |
| JP2652272B2 (ja) * | 1990-12-31 | 1997-09-10 | 住化ファインケム株式会社 | １−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法 |
| US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
-
1994
- 1994-10-18 US US08/324,635 patent/US5504207A/en not_active Expired - Fee Related
-
1995
- 1995-03-06 DK DK95103188.9T patent/DK0708104T3/da active
- 1995-03-06 CA CA002143971A patent/CA2143971C/en not_active Expired - Fee Related
- 1995-03-06 AT AT95103188T patent/ATE143959T1/de not_active IP Right Cessation
- 1995-03-06 EP EP95103188A patent/EP0708104B1/en not_active Revoked
- 1995-03-06 DE DE69500064T patent/DE69500064T2/de not_active Revoked
- 1995-03-06 ES ES95103188T patent/ES2089993T3/es not_active Expired - Lifetime
- 1995-03-16 JP JP7057435A patent/JP2711230B2/ja not_active Expired - Fee Related
-
1996
- 1996-08-31 GR GR960300047T patent/GR960300047T1/el unknown
- 1996-10-10 GR GR960402604T patent/GR3021319T3/el unknown
-
1997
- 1997-05-08 BR BR1100705-2A patent/BR1100705A/pt active Search and Examination
- 1997-06-26 HK HK130297A patent/HK130297A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE143959T1 (de) | 1996-10-15 |
| GR960300047T1 (en) | 1996-08-31 |
| JPH08134066A (ja) | 1996-05-28 |
| DE69500064D1 (de) | 1996-11-14 |
| US5504207A (en) | 1996-04-02 |
| ES2089993T3 (es) | 1997-02-16 |
| GR3021319T3 (en) | 1997-01-31 |
| DK0708104T3 (da) | 1997-03-10 |
| ES2089993T1 (es) | 1996-10-16 |
| CA2143971A1 (en) | 1996-04-19 |
| BR1100705A (pt) | 1999-10-13 |
| CA2143971C (en) | 1997-06-03 |
| DE69500064T2 (de) | 1997-04-10 |
| EP0708104A1 (en) | 1996-04-24 |
| EP0708104B1 (en) | 1996-10-09 |
| JP2711230B2 (ja) | 1998-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20050306 |
|
| ARF | Application filed for restoration |
Effective date: 20060620 |
|
| ARG | Restoration of standard patent granted |
Effective date: 20060809 |
|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20140306 |