BR1100705A - Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazina - Google Patents
Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazinaInfo
- Publication number
- BR1100705A BR1100705A BR1100705-2A BR1100705A BR1100705A BR 1100705 A BR1100705 A BR 1100705A BR 1100705 A BR1100705 A BR 1100705A BR 1100705 A BR1100705 A BR 1100705A
- Authority
- BR
- Brazil
- Prior art keywords
- dimethoxy
- amino
- quinazolinyl
- piperazine
- hydrochloride
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 4-amino-6,7-dimethoxy-quinazolinyl Chemical group 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- MSQACBWWAIBWIC-UHFFFAOYSA-N hydron;piperazine;chloride Chemical compound Cl.C1CNCCN1 MSQACBWWAIBWIC-UHFFFAOYSA-N 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- IWSWDOUXSCRCKW-UHFFFAOYSA-N [6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-yl]azanium;chloride Chemical compound Cl.N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 IWSWDOUXSCRCKW-UHFFFAOYSA-N 0.000 abstract 2
- UKESBLFBQANJHH-UHFFFAOYSA-N 1-(Tetrahydro-2-furoyl)piperazine Chemical compound C1CNCCN1C(=O)C1CCCO1 UKESBLFBQANJHH-UHFFFAOYSA-N 0.000 abstract 1
- HWIIAAVGRHKSOJ-UHFFFAOYSA-N 2-chloro-6,7-dimethoxyquinazolin-4-amine Chemical compound ClC1=NC(N)=C2C=C(OC)C(OC)=CC2=N1 HWIIAAVGRHKSOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 239000002516 radical scavenger Substances 0.000 abstract 1
- NZMOFYDMGFQZLS-UHFFFAOYSA-N terazosin hydrochloride dihydrate Chemical compound [H+].O.O.[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 NZMOFYDMGFQZLS-UHFFFAOYSA-N 0.000 abstract 1
- KKCIOUWDFWQUBT-UHFFFAOYSA-N thyronine Chemical compound C1=CC(CC(N)C(O)=O)=CC=C1OC1=CC=C(O)C=C1 KKCIOUWDFWQUBT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/324,635 US5504207A (en) | 1994-10-18 | 1994-10-18 | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR1100705A true BR1100705A (pt) | 1999-10-13 |
Family
ID=23264439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR1100705-2A BR1100705A (pt) | 1994-10-18 | 1997-05-08 | Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazina |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5504207A (pt) |
| EP (1) | EP0708104B1 (pt) |
| JP (1) | JP2711230B2 (pt) |
| AT (1) | ATE143959T1 (pt) |
| BR (1) | BR1100705A (pt) |
| CA (1) | CA2143971C (pt) |
| DE (1) | DE69500064T2 (pt) |
| DK (1) | DK0708104T3 (pt) |
| ES (1) | ES2089993T3 (pt) |
| GR (2) | GR960300047T1 (pt) |
| HK (1) | HK130297A (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
| US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
| EP0849264A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| EP0849266B8 (de) * | 1996-12-20 | 2007-10-03 | Heumann PCS GmbH | Neue polymorphe Form von Doxazosinmesylat (Form III) |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| US6248888B1 (en) | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
| US6200573B1 (en) | 1999-12-03 | 2001-03-13 | Starcor Pharmaceuticals, Inc. | Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia |
| US20070161791A1 (en) * | 2006-01-09 | 2007-07-12 | Narsimha Reddy Penthala | Process for the preparation of terazosin hydrocloride dihydrate |
| WO2008021891A2 (en) * | 2006-08-08 | 2008-02-21 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| ATE72244T1 (de) * | 1986-03-21 | 1992-02-15 | Heumann Pharma Gmbh & Co | Kristalline, wasserfreie sigma -form von 2-(4-(2furoyl-(2-piperazin)-1-yl>-4-amino-6,7- dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung. |
| US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
| WO1992003453A1 (fr) * | 1990-08-23 | 1992-03-05 | Dainippon Ink & Chemicals, Inc. | Agent antiviral |
| JP2652272B2 (ja) * | 1990-12-31 | 1997-09-10 | 住化ファインケム株式会社 | １−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法 |
| US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
-
1994
- 1994-10-18 US US08/324,635 patent/US5504207A/en not_active Expired - Fee Related
-
1995
- 1995-03-06 ES ES95103188T patent/ES2089993T3/es not_active Expired - Lifetime
- 1995-03-06 CA CA002143971A patent/CA2143971C/en not_active Expired - Fee Related
- 1995-03-06 AT AT95103188T patent/ATE143959T1/de not_active IP Right Cessation
- 1995-03-06 EP EP95103188A patent/EP0708104B1/en not_active Revoked
- 1995-03-06 DE DE69500064T patent/DE69500064T2/de not_active Revoked
- 1995-03-06 DK DK95103188.9T patent/DK0708104T3/da active
- 1995-03-16 JP JP7057435A patent/JP2711230B2/ja not_active Expired - Fee Related
-
1996
- 1996-08-31 GR GR960300047T patent/GR960300047T1/el unknown
- 1996-10-10 GR GR960402604T patent/GR3021319T3/el unknown
-
1997
- 1997-05-08 BR BR1100705-2A patent/BR1100705A/pt active Search and Examination
- 1997-06-26 HK HK130297A patent/HK130297A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3021319T3 (en) | 1997-01-31 |
| EP0708104A1 (en) | 1996-04-24 |
| CA2143971C (en) | 1997-06-03 |
| DK0708104T3 (da) | 1997-03-10 |
| ES2089993T1 (es) | 1996-10-16 |
| DE69500064T2 (de) | 1997-04-10 |
| JP2711230B2 (ja) | 1998-02-10 |
| GR960300047T1 (en) | 1996-08-31 |
| HK130297A (en) | 1997-09-19 |
| DE69500064D1 (de) | 1996-11-14 |
| CA2143971A1 (en) | 1996-04-19 |
| US5504207A (en) | 1996-04-02 |
| JPH08134066A (ja) | 1996-05-28 |
| EP0708104B1 (en) | 1996-10-09 |
| ES2089993T3 (es) | 1997-02-16 |
| ATE143959T1 (de) | 1996-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR1100705A (pt) | Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazina | |
| PT900240E (pt) | Processo para a producao de polialcenoaminas | |
| RS51013B (sr) | Indolinon supstituisan na poziciji 6, njegovo dobijanje i njegova upotreba kao leka | |
| EA200100554A1 (ru) | Замещенные пиразолы как ингибиторы p38 киназы | |
| EA200200510A1 (ru) | 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр | |
| TR200003056T2 (tr) | Heterosiklik olarak ikame edilmiş amidler, üretimi ve kullanımı | |
| DE602004025344D1 (de) | Biologisch abbaubare verzweigte polylactidderivate, die zur bildung von polymermicellen befähigt sind, herstellungsverfahren dafür und verwendung davon | |
| MX9306196A (es) | Nueva forma cristalina polimorfa de terazosina y composicion farmaceutica que la contiene. | |
| ATE347555T1 (de) | 6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung | |
| ATE440088T1 (de) | Verfahren zur herstellung von 4-(3'-chlor-4'- fluoranilino)-7-methoxy-6-(3- morpholinopropoxy)chinazolin | |
| BR0312593A (pt) | Aciluréias substituìdas por uréia e uretano, processo para a sua produção e sua aplicação | |
| IT1293777B1 (it) | Processo per la preparazione di tetraazamacrocicli | |
| MXPA02001406A (es) | Heterociclilos-2h-cromenos substituidos. | |
| CO5540298A2 (es) | Proceso para preparar un ligando de ppar de tiazol y polimorfos del mismo | |
| DE50003759D1 (de) | Verfahren zur herstellung von n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid | |
| BR9808047B1 (pt) | processo para a preparação de 2-nitroguanidinas 1,3-dissubstituìdas. | |
| SE0202930D0 (sv) | Register mark | |
| ATE372326T1 (de) | Verfahren zur herstellung von substituierten 5- amino-n-phenyl-1,2,4-triazol-3-sulfonamiden | |
| YU61503A (sh) | Nova so benzoilgvanidina | |
| ES2123599T3 (es) | Procedimiento para la produccion de 2-halogeno-4,6-dialcoxipirimidinas. | |
| BR0107648B1 (pt) | Processo para produção de compostos heterocíclicos | |
| ATE214366T1 (de) | S-(4-biphenyl)-thioschwefelsäuren und ihre salze, verfahren zu deren herstellung und die herstellung von 4-mercaptobiphenylen | |
| PT1286965E (pt) | Compostos de piperidina e processo para a sua producao | |
| BR0016521B1 (pt) | processo para produÇço de 2-nitroguanidinas 1,3-dissubstituÍdas. | |
| ATE266621T1 (de) | Erdalkalimetall-alkylendiamide, verfahren zu deren herstellung und deren verwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AN | Processing applications according to articles 230 and 231 of law 9279/96: notification of filing an application | ||
| HHFK | Processing applications according to articles 230 and 231 of law 9.279/96: republication | ||
| MT | Patent procedure suspended until requirement met - articles 230 and 231 of law 9279/96 | ||
| FGAN | Processing applications according to articles 230 and 231 of law 9.279/96: granting | ||
| NB | Patent issued - articles 230 and 231 of law 9279/96 | ||
| B23L | Information on processing applications according to articles 230 and 231 of law 9.279/96 modified |
Free format text: REFERENTE A RPI 1501 DE 13/10/1999 COD. 23.9, QUANTO AO PRAZO DE VALIDADE. |