SI2654729T1 - Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino - Google Patents

Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino

Info

Publication number
SI2654729T1
SI2654729T1 SI201130833A SI201130833A SI2654729T1 SI 2654729 T1 SI2654729 T1 SI 2654729T1 SI 201130833 A SI201130833 A SI 201130833A SI 201130833 A SI201130833 A SI 201130833A SI 2654729 T1 SI2654729 T1 SI 2654729T1
Authority
SI
Slovenia
Prior art keywords
lercanidipine
enalapril
pharmaceutically acceptable
acceptable salts
dosage forms
Prior art date
Application number
SI201130833A
Other languages
English (en)
Inventor
Gregor Sedmak
Vesna Kroselj
Maja Kincl Skube
Urska Jursic
Original Assignee
Krka, D.D., Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, D.D., Novo Mesto filed Critical Krka, D.D., Novo Mesto
Publication of SI2654729T1 publication Critical patent/SI2654729T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SI201130833A 2010-12-24 2011-12-22 Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino SI2654729T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SI201000451 2010-12-24
SI201100142 2011-04-21
EP11805851.0A EP2654729B1 (en) 2010-12-24 2011-12-22 Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts together with an organic acid
PCT/EP2011/073884 WO2012085249A2 (en) 2010-12-24 2011-12-22 Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts

Publications (1)

Publication Number Publication Date
SI2654729T1 true SI2654729T1 (sl) 2016-08-31

Family

ID=45464548

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201130833A SI2654729T1 (sl) 2010-12-24 2011-12-22 Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino

Country Status (4)

Country Link
EP (1) EP2654729B1 (sl)
EA (1) EA023996B1 (sl)
SI (1) SI2654729T1 (sl)
WO (1) WO2012085249A2 (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8568747B1 (en) 2012-10-05 2013-10-29 Silvergate Pharmaceuticals, Inc. Enalapril compositions
CN103222960B (zh) * 2013-05-15 2016-06-15 中国药科大学 一种马来酸依那普利口服定时释放微丸及其制备方法
US9463183B1 (en) 2015-10-30 2016-10-11 Silvergate Pharmaceuticals, Inc. Lisinopril formulations
US9669008B1 (en) 2016-03-18 2017-06-06 Silvergate Pharmaceuticals, Inc. Enalapril formulations
CN105796490B (zh) * 2016-04-01 2019-12-10 广东药科大学 一种含氨基酸的尼莫地平注射液组合物及其制备方法
TR201907094A2 (tr) * 2019-05-10 2020-11-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Lerkani̇di̇pi̇n ve enalapri̇l i̇çeren tablet formülasyonu

Family Cites Families (27)

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Publication number Priority date Publication date Assignee Title
IL58849A (en) 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4510083A (en) 1982-05-07 1985-04-09 Merck & Co., Inc. Process for preparing polypeptides
US4442089A (en) 1982-07-06 1984-04-10 E. R. Squibb & Sons, Inc. Method for treating glaucoma with topical or systemic ACE inhibitor compositions
GB8403866D0 (en) 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US4830853A (en) * 1986-10-20 1989-05-16 Warner-Lambert Company Drug compositions stabilized against oxidation
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
DE3936053A1 (de) 1989-10-28 1991-05-02 Basf Ag Verfahren zur verbesserung der bioverfuegbarkeit von pharmazeutischen wirkstoffen mit peptidbindungen
YU48602B (sh) 1991-11-25 1998-12-23 Krka Tovarna Zdravil P.O. Postupak za dobijanje stabilne formulacije soli enalaprila
CA2128199C (en) 1994-07-15 1997-02-04 Bernard Charles Sherman Stable solid pharmaceutical compositions containing enalapril maleate
IT1274480B (it) 1995-05-12 1997-07-17 Recordati Chem Pharm Procedimento migliorato per la preparazione della lercanidipina cloridrato
IT1275532B (it) 1995-07-14 1997-08-07 Recordati Chem Pharm Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
US5912351A (en) 1995-05-12 1999-06-15 Recordati, S.A. Chemical And Pharmaceutical Company Anhydrous 1,4-Dihydropyridines and salts thereof
US5696139A (en) 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
US5573780A (en) 1995-08-04 1996-11-12 Apotex Usa Inc. Stable solid formulation of enalapril salt and process for preparation thereof
HU222497B1 (hu) 1996-12-18 2003-07-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Enalapril-maleátot tartalmazó stabilizált gyógyszerkészítmény és eljárás előállítására
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
MY121470A (en) * 1999-05-03 2006-01-28 Ranbaxy Lab Ltd Stable solid pharmaceutical compositions containing enalapril maleate
US6555551B1 (en) 1999-08-31 2003-04-29 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
AU7580000A (en) * 1999-09-17 2001-04-17 Mylan Pharmaceuticals, Inc. Stabilization of enalapril maleate with maleic acid
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
ITMI20011727A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi
US20030180355A1 (en) 2001-10-16 2003-09-25 Amedeo Leonardi Combination therapy for hypertension
EP1694305B1 (en) * 2003-12-01 2019-10-16 Recordati Ireland Limited Pharmaceutical compositions comprising lercanidipine
RU2425033C2 (ru) 2005-09-16 2011-07-27 Гленмарк Фармасьютикалз Лимитед Полиморфная форма гидрохлорида лерканидипина и способ ее получения
EP2101771A2 (en) 2006-12-06 2009-09-23 Torrent Pharmaceuticals Ltd Stable lercanidipine formulation
ES2397570T3 (es) 2008-07-02 2013-03-07 Recordati Ireland Limited Un procedimiento para la producción de la forma V de HCI de lercanidipina
CN101836982A (zh) * 2010-05-27 2010-09-22 北京德众万全药物技术开发有限公司 一种治疗高血压的药用组合物

Also Published As

Publication number Publication date
EA201390950A1 (ru) 2014-06-30
WO2012085249A3 (en) 2012-08-23
WO2012085249A2 (en) 2012-06-28
EA023996B1 (ru) 2016-08-31
EP2654729B1 (en) 2016-05-04
EP2654729A2 (en) 2013-10-30

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