YU48602B - Postupak za dobijanje stabilne formulacije soli enalaprila - Google Patents

Postupak za dobijanje stabilne formulacije soli enalaprila

Info

Publication number
YU48602B
YU48602B YU184291A YU184291A YU48602B YU 48602 B YU48602 B YU 48602B YU 184291 A YU184291 A YU 184291A YU 184291 A YU184291 A YU 184291A YU 48602 B YU48602 B YU 48602B
Authority
YU
Yugoslavia
Prior art keywords
sodium
stable formulation
enalaprile
salts
procedure
Prior art date
Application number
YU184291A
Other languages
English (en)
Other versions
YU184291A (sh
Inventor
Marjo dr. Merslavič
Jožica dipl. ing. Ražen
Aleš mag. Rotar
Original Assignee
Krka Tovarna Zdravil P.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25555813&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48602(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Krka Tovarna Zdravil P.O. filed Critical Krka Tovarna Zdravil P.O.
Priority to SI9111842A priority Critical patent/SI9111842A/sl
Priority to YU184291A priority patent/YU48602B/sh
Priority to DE69218557T priority patent/DE69218557T2/de
Priority to AT92119896T priority patent/ATE150650T1/de
Priority to DK92119896.6T priority patent/DK0545194T3/da
Priority to EP92119896A priority patent/EP0545194B1/en
Priority to ES92119896T priority patent/ES2101004T3/es
Priority to US07/980,956 priority patent/US5350582A/en
Priority to CA002083683A priority patent/CA2083683C/en
Priority to HRP-1842/91A priority patent/HRP921482B1/xx
Publication of YU184291A publication Critical patent/YU184291A/sh
Priority to GR970401299T priority patent/GR3023655T3/el
Publication of YU48602B publication Critical patent/YU48602B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Postupak za dobijanje stabilne formulacije soli enalaprila formule I, naznačen time, što jedinjenja formule II suspendujemo u demineralizovanoj vodi i dodamo stehiometrisku količinu odgovarajućeg natrijumovog jedinjenja, kao što su natrijum karbonat, natrijum hidrogenkarbonat ili natrijum hidroksid, pa toj IN SITU pripremljenoj natrijumovoj soli enalaprila formule I dodamo formulisane dodatke, homogenizujemo i formulišemo.
YU184291A 1991-11-25 1991-11-25 Postupak za dobijanje stabilne formulacije soli enalaprila YU48602B (sh)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SI9111842A SI9111842A (sl) 1991-11-25 1991-11-25 Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba
YU184291A YU48602B (sh) 1991-11-25 1991-11-25 Postupak za dobijanje stabilne formulacije soli enalaprila
ES92119896T ES2101004T3 (es) 1991-11-25 1992-11-23 Formulacion estable de sales del enalapril, procedimiento para su preparacion y su uso.
DK92119896.6T DK0545194T3 (da) 1991-11-25 1992-11-23 Stabil formulering af enaprilsalt, fremgangsmåde til fremstilling deraf og anvendelse deraf.
AT92119896T ATE150650T1 (de) 1991-11-25 1992-11-23 Stabile zusammensetzung die ein enalapril-salz enthält, verfahren zu ihrer herstellung und ihre verwendung
DE69218557T DE69218557T2 (de) 1991-11-25 1992-11-23 Stabile Zusammensetzung die ein Enalapril-Salz enthält, Verfahren zu ihrer Herstellung und ihre Verwendung
EP92119896A EP0545194B1 (en) 1991-11-25 1992-11-23 Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof
US07/980,956 US5350582A (en) 1991-11-25 1992-11-24 Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof
CA002083683A CA2083683C (en) 1991-11-25 1992-11-24 Stable formulation of analapril salt, a process for the preparation thereof and the use thereof
HRP-1842/91A HRP921482B1 (en) 1991-11-25 1992-12-30 Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof
GR970401299T GR3023655T3 (en) 1991-11-25 1997-06-04 Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU184291A YU48602B (sh) 1991-11-25 1991-11-25 Postupak za dobijanje stabilne formulacije soli enalaprila

Publications (2)

Publication Number Publication Date
YU184291A YU184291A (sh) 1994-04-05
YU48602B true YU48602B (sh) 1998-12-23

Family

ID=25555813

Family Applications (1)

Application Number Title Priority Date Filing Date
YU184291A YU48602B (sh) 1991-11-25 1991-11-25 Postupak za dobijanje stabilne formulacije soli enalaprila

Country Status (11)

Country Link
US (1) US5350582A (sh)
EP (1) EP0545194B1 (sh)
AT (1) ATE150650T1 (sh)
CA (1) CA2083683C (sh)
DE (1) DE69218557T2 (sh)
DK (1) DK0545194T3 (sh)
ES (1) ES2101004T3 (sh)
GR (1) GR3023655T3 (sh)
HR (1) HRP921482B1 (sh)
SI (1) SI9111842A (sh)
YU (1) YU48602B (sh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5562921A (en) * 1994-07-15 1996-10-08 Sherman; Bernard C. Stable solid pharmaceutical compositions containing enalapril maleate
US5573780A (en) * 1995-08-04 1996-11-12 Apotex Usa Inc. Stable solid formulation of enalapril salt and process for preparation thereof
GB9521781D0 (en) * 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
ES2125198B1 (es) * 1997-05-13 1999-11-16 Vita Invest Sa Asociacion a dosis fija de un inhibidor de la enzima convertidora de angiotensina y de un antagonista de los canales de calcio, procedimiento para su preparacion y su utilizacion para el tratamiento de enfermees cardiovasculares.
CN1154654C (zh) * 1998-07-21 2004-06-23 钟渊化学工业株式会社 N-(1(s)-乙氧基羰基-3-苯丙基)-l-丙氨酰-l-脯氨酸马来酸盐的结晶方法
NZ333206A (en) 1998-12-08 2000-07-28 Bernard Charles Sherman Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
US6637359B1 (en) * 1998-12-15 2003-10-28 Maritrans Inc. System and method for internally fitting a new inner hull to an existing outer hull to form a rebuilt double hull vessel
US20040157911A1 (en) * 1999-08-31 2004-08-12 Spiridon Spireas Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof
US6555551B1 (en) 1999-08-31 2003-04-29 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
US6764694B1 (en) * 1999-08-31 2004-07-20 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
HU226950B1 (en) * 1999-11-03 2010-03-29 Richter Gedeon Nyrt The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it
US20030215526A1 (en) * 2002-03-08 2003-11-20 Scott Stofik Stable formulations of angiotensin converting enzyme (ACE) inhibitors
DK1729739T3 (en) * 2004-03-29 2016-10-31 Servier Lab PROCESS FOR THE PREPARATION OF A solid pharmaceutical composition.
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
PT1948224E (pt) 2005-11-17 2014-06-12 Silverstone Pharma Est Preparação industrial, e a sua utilização na terapêutica da hipertensão
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
WO2011161223A2 (en) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
EP2654729B1 (en) 2010-12-24 2016-05-04 KRKA, d.d., Novo mesto Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts together with an organic acid
EP3039432B1 (en) 2013-08-28 2019-10-09 Psychemedics Corporation Integrity testing of hair samples
ES2705610T3 (es) 2014-07-31 2019-03-26 Pharmathen Sa Composición de película orodispersable que comprende enalapril para el tratamiento de la hipertensión en una población pediátrica

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4830853A (en) * 1986-10-20 1989-05-16 Warner-Lambert Company Drug compositions stabilized against oxidation
US4743450A (en) * 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
EP0391462A1 (en) * 1989-04-05 1990-10-10 Janssen Pharmaceutica N.V. Synergistic compositions containing ketanserin

Also Published As

Publication number Publication date
DE69218557D1 (de) 1997-04-30
ATE150650T1 (de) 1997-04-15
YU184291A (sh) 1994-04-05
DE69218557T2 (de) 1997-11-13
HRP921482B1 (en) 2000-04-30
CA2083683C (en) 2000-09-05
CA2083683A1 (en) 1993-05-26
US5350582A (en) 1994-09-27
DK0545194T3 (da) 1997-07-28
EP0545194A1 (en) 1993-06-09
GR3023655T3 (en) 1997-09-30
SI9111842A (sl) 1998-04-30
ES2101004T3 (es) 1997-07-01
EP0545194B1 (en) 1997-03-26
HRP921482A2 (en) 1996-12-31

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