PE20070318A1 - Metodo para purificar tigeciclina - Google Patents

Metodo para purificar tigeciclina

Info

Publication number
PE20070318A1
PE20070318A1 PE2006000555A PE2006000555A PE20070318A1 PE 20070318 A1 PE20070318 A1 PE 20070318A1 PE 2006000555 A PE2006000555 A PE 2006000555A PE 2006000555 A PE2006000555 A PE 2006000555A PE 20070318 A1 PE20070318 A1 PE 20070318A1
Authority
PE
Peru
Prior art keywords
formula
compound
tanol
alkyl
refers
Prior art date
Application number
PE2006000555A
Other languages
English (en)
Inventor
Lalitha Krishnan
Phaik-Eng Sum
Michel Bernatchez
Jeffrey Marshall Horne
Joseph James Mccauley Iii
Adam P Michaud
Adam Joseph Tuper
Anthony Scott Pilcher
Sylvain Daigneault
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36997702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070318(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070318A1 publication Critical patent/PE20070318A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA PURIFICAR UN COMPUESTO DE FORMULA (1) DONDE R1 Y R2 SON H, ALQUILO(C1-C6), CICLOALQUILO, ENTRE OTROS; R ES NR3R4 DONDE R3 Y R4 SON H O ALQUILO(C1-C4); n ES DE 1 A 4; DICHO PROCEDIMIENTO COMPRENDE: A) COMBINAR UN COMPUESTO DE FORMULA (I) CON UN SOLVENTE APROTICO POLAR TAL COMO ACETONA, ACETATO DE METILO, CLORURO DE METILENO, ENTRE OTROS, Y UN SOLVENTE PROTICO POLAR TAL COMO METANOL, ETANOL, ISOPROPANOL O T-BUTANOL; B) MEZCLAR POR UN PERIODO DE 15 MINUTOS A 2 HORAS A UNA TEMPERATURA DE 0ºC A 40ºC PARA DAR UNA PRIMERA MEZCLA; C) OBTENER EL COMPUESTO PURIFICADO DE FORMULA (I). SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES COMO ANTIBIOTICOS
PE2006000555A 2005-05-27 2006-05-25 Metodo para purificar tigeciclina PE20070318A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68562605P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
PE20070318A1 true PE20070318A1 (es) 2007-04-11

Family

ID=36997702

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000555A PE20070318A1 (es) 2005-05-27 2006-05-25 Metodo para purificar tigeciclina

Country Status (22)

Country Link
US (1) US20070049561A1 (es)
EP (1) EP1890997A1 (es)
JP (1) JP2008545702A (es)
KR (1) KR20080016892A (es)
CN (1) CN101228114A (es)
AR (1) AR057034A1 (es)
AU (1) AU2006252796A1 (es)
BR (1) BRPI0610057A2 (es)
CA (1) CA2609307A1 (es)
CR (1) CR9542A (es)
EC (1) ECSP078050A (es)
GT (1) GT200600224A (es)
IL (1) IL187361A0 (es)
MX (1) MX2007014717A (es)
NI (1) NI200700302A (es)
NO (1) NO20075997L (es)
PA (1) PA8676401A1 (es)
PE (1) PE20070318A1 (es)
RU (1) RU2007143158A (es)
TW (1) TW200716516A (es)
WO (1) WO2006130431A1 (es)
ZA (1) ZA200710174B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600112A (es) 2005-03-14 2006-11-29 Composiciiones de tigeciclina y metodos de preparacion
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR055336A1 (es) 2005-06-16 2007-08-22 Wyeth Corp Proeso de elaboracion para la produccion de tigeciclina como un polvo reconstituible, polvo de tigeciclina liofilizado y producto hecho mediante el proceso
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
TW200812943A (en) 2006-04-24 2008-03-16 Teva Pharma Processes for preparation of tigecycline crystalline forms I and II
EP2086926A2 (en) * 2006-11-29 2009-08-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
US20080234504A1 (en) * 2006-11-30 2008-09-25 Evgeny Tsiperman Processes for preparation of 9-haloacetamidominocyclines
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
US9434680B2 (en) * 2007-04-27 2016-09-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2178827A1 (en) * 2007-06-21 2010-04-28 Sandoz AG Crystalline solid forms
US20090099376A1 (en) * 2007-10-16 2009-04-16 Wyeth Tigecycline and methods of preparing intermediates
WO2009062963A1 (en) * 2007-11-14 2009-05-22 Sandoz Ag Crystalline forms of tigecycline hydrochloride
CN101450916B (zh) * 2007-11-30 2012-11-21 上海来益生物药物研究开发中心有限责任公司 替加环素的合成方法
US20110124893A1 (en) * 2008-01-23 2011-05-26 Sandoz Ag Antibiotic compounds
ES2528490T3 (es) 2008-12-18 2015-02-10 Sandoz Ag Forma cristalina C de dihidrocloruro de tigeciclina y métodos para su preparación
CA2751238A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
PL2327676T3 (pl) * 2009-11-26 2014-08-29 Sandoz Ag Reakcja związków organicznych z małymi ilościami wodoru
CN102898325B (zh) * 2011-07-29 2015-07-08 江苏奥赛康药业股份有限公司 替加环素晶体及其制备方法
CN102952035A (zh) * 2011-09-15 2013-03-06 北京海步国际医药科技发展有限公司 替加环素新晶型及其制备方法
CN103091424B (zh) * 2013-01-31 2014-11-19 成都百裕科技制药有限公司 替加环素中杂质的检测方法
CN104515820B (zh) * 2013-10-06 2018-08-14 山东新时代药业有限公司 一种替加环素中间体的分析检测方法
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
PT108223B (pt) * 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
CN105085311A (zh) * 2015-08-13 2015-11-25 江苏豪森药业股份有限公司 替加环素或其盐的高效纯化方法
CN107304173A (zh) * 2016-04-25 2017-10-31 浙江医药股份有限公司新昌制药厂 一种替加环素的晶型及其制备方法
CN111978196A (zh) * 2020-08-03 2020-11-24 河北圣雪大成制药有限责任公司 一种替加环素的纯化方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) * 1967-09-26 Reductive alkylation process
US3502696A (en) * 1961-08-18 1970-03-24 Pfizer & Co C Antibacterial agents
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3433834A (en) * 1966-03-14 1969-03-18 American Cyanamid Co Nitration of 11a-chloro tetracyclines
US3849493A (en) * 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
JP2784847B2 (ja) * 1994-02-17 1998-08-06 ファイザー インク． ９−（置換アミノ）−アルファ−６−デオキシ−５−オキシテトラサイクリン誘導体、それらの製造及び、抗生物質としてのそれらの使用
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5843925A (en) * 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
AU2001271642B2 (en) * 2000-07-07 2006-01-05 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds

Also Published As

Publication number Publication date
BRPI0610057A2 (pt) 2010-05-25
KR20080016892A (ko) 2008-02-22
ZA200710174B (en) 2009-08-26
WO2006130431A1 (en) 2006-12-07
AR057034A1 (es) 2007-11-14
JP2008545702A (ja) 2008-12-18
AU2006252796A1 (en) 2006-12-07
US20070049561A1 (en) 2007-03-01
RU2007143158A (ru) 2009-07-10
PA8676401A1 (es) 2009-03-31
MX2007014717A (es) 2008-02-15
CA2609307A1 (en) 2006-12-07
NI200700302A (es) 2008-07-24
CN101228114A (zh) 2008-07-23
CR9542A (es) 2008-02-20
ECSP078050A (es) 2008-01-23
EP1890997A1 (en) 2008-02-27
TW200716516A (en) 2007-05-01
GT200600224A (es) 2007-01-12
NO20075997L (no) 2008-02-19
IL187361A0 (en) 2008-04-13

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