NI200700302A - Métodos para purificar tigeciclina - Google Patents

Métodos para purificar tigeciclina

Info

Publication number
NI200700302A
NI200700302A NI200700302A NI200700302A NI200700302A NI 200700302 A NI200700302 A NI 200700302A NI 200700302 A NI200700302 A NI 200700302A NI 200700302 A NI200700302 A NI 200700302A NI 200700302 A NI200700302 A NI 200700302A
Authority
NI
Nicaragua
Prior art keywords
methods
tigecicline
purify
disclosed
tigecycline
Prior art date
Application number
NI200700302A
Other languages
English (en)
Inventor
Lalitha Krishnan
Phaik-Eng Sum
Sylvain Daigneault
Michel Bernatchez
Anthony Scott Pilcher
Jeffrey Marshall Horne
Adam Joseph Tuper
Iii Joseph James Mccauley
Adam P Michaud
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36997702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI200700302(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NI200700302A publication Critical patent/NI200700302A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se revelan métodos para preparar y purificar tetraciclinas, tales como tigeciclina. También se revelan composiciones de tetraciclinas, tales como composiciones de tigeciclina, preparadas por estos métodos.-
NI200700302A 2005-05-27 2007-11-22 Métodos para purificar tigeciclina NI200700302A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68562605P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
NI200700302A true NI200700302A (es) 2008-07-24

Family

ID=36997702

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200700302A NI200700302A (es) 2005-05-27 2007-11-22 Métodos para purificar tigeciclina

Country Status (22)

Country Link
US (1) US20070049561A1 (es)
EP (1) EP1890997A1 (es)
JP (1) JP2008545702A (es)
KR (1) KR20080016892A (es)
CN (1) CN101228114A (es)
AR (1) AR057034A1 (es)
AU (1) AU2006252796A1 (es)
BR (1) BRPI0610057A2 (es)
CA (1) CA2609307A1 (es)
CR (1) CR9542A (es)
EC (1) ECSP078050A (es)
GT (1) GT200600224A (es)
IL (1) IL187361A0 (es)
MX (1) MX2007014717A (es)
NI (1) NI200700302A (es)
NO (1) NO20075997L (es)
PA (1) PA8676401A1 (es)
PE (1) PE20070318A1 (es)
RU (1) RU2007143158A (es)
TW (1) TW200716516A (es)
WO (1) WO2006130431A1 (es)
ZA (1) ZA200710174B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2434944T5 (es) 2005-03-14 2022-10-20 Wyeth Llc Composiciones de tigeciclina y procedimientos de preparación
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR055336A1 (es) 2005-06-16 2007-08-22 Wyeth Corp Proeso de elaboracion para la produccion de tigeciclina como un polvo reconstituible, polvo de tigeciclina liofilizado y producto hecho mediante el proceso
EP2007713A2 (en) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolation of tetracycline derivatives
DK2016045T3 (en) 2006-04-24 2015-02-02 Teva Pharma TIGECYCLIN CRYSTAL FORM AND PROCEDURES FOR PREPARING IT
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2236491A3 (en) * 2006-11-29 2010-11-03 Teva Pharmaceutical Industries, Ltd. Crystalline form of tigecycline and processes for preparation thereof
US20080234504A1 (en) * 2006-11-30 2008-09-25 Evgeny Tsiperman Processes for preparation of 9-haloacetamidominocyclines
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
AU2008246119A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2178827A1 (en) * 2007-06-21 2010-04-28 Sandoz AG Crystalline solid forms
WO2009052152A2 (en) * 2007-10-16 2009-04-23 Wyeth Tigecycline and methods of preparing intermediates
US8252946B2 (en) 2007-11-14 2012-08-28 Sandoz Ag Crystalline forms of tigecycline hydrochloride
CN101450916B (zh) * 2007-11-30 2012-11-21 上海来益生物药物研究开发中心有限责任公司 替加环素的合成方法
US20110124893A1 (en) * 2008-01-23 2011-05-26 Sandoz Ag Antibiotic compounds
SI2376433T1 (sl) 2008-12-18 2015-03-31 Sandoz Ag Kristalna oblika C tigeciklin dihidroklorida in postopki za njeno pripravo
CA2751238A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
EP2327676B1 (en) * 2009-11-26 2014-03-05 Sandoz Ag Reaction of organic compounds with low amounts of hydrogen
CN102898325B (zh) * 2011-07-29 2015-07-08 江苏奥赛康药业股份有限公司 替加环素晶体及其制备方法
CN102952035A (zh) * 2011-09-15 2013-03-06 北京海步国际医药科技发展有限公司 替加环素新晶型及其制备方法
CN103091424B (zh) * 2013-01-31 2014-11-19 成都百裕科技制药有限公司 替加环素中杂质的检测方法
CN104515820B (zh) * 2013-10-06 2018-08-14 山东新时代药业有限公司 一种替加环素中间体的分析检测方法
WO2015071299A2 (en) 2013-11-12 2015-05-21 Galenicum Health S.L. Stable pharmaceutical compositions
PT108223B (pt) * 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
CN105085311A (zh) * 2015-08-13 2015-11-25 江苏豪森药业股份有限公司 替加环素或其盐的高效纯化方法
CN107304173A (zh) * 2016-04-25 2017-10-31 浙江医药股份有限公司新昌制药厂 一种替加环素的晶型及其制备方法
CN111978196A (zh) * 2020-08-03 2020-11-24 河北圣雪大成制药有限责任公司 一种替加环素的纯化方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) * 1967-09-26 Reductive alkylation process
US3502696A (en) * 1961-08-18 1970-03-24 Pfizer & Co C Antibacterial agents
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3433834A (en) * 1966-03-14 1969-03-18 American Cyanamid Co Nitration of 11a-chloro tetracyclines
US3849493A (en) * 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
MX9603508A (es) * 1994-02-17 1997-03-29 Pfizer Analogos de la doxiciclina.
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5843925A (en) * 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
HUP0301163A3 (en) * 2000-07-07 2008-08-28 Tufts College 7-substituted tetracycline dervatives, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
PE20070318A1 (es) 2007-04-11
MX2007014717A (es) 2008-02-15
ZA200710174B (en) 2009-08-26
TW200716516A (en) 2007-05-01
AR057034A1 (es) 2007-11-14
JP2008545702A (ja) 2008-12-18
CR9542A (es) 2008-02-20
GT200600224A (es) 2007-01-12
AU2006252796A1 (en) 2006-12-07
RU2007143158A (ru) 2009-07-10
WO2006130431A1 (en) 2006-12-07
NO20075997L (no) 2008-02-19
IL187361A0 (en) 2008-04-13
US20070049561A1 (en) 2007-03-01
CA2609307A1 (en) 2006-12-07
BRPI0610057A2 (pt) 2010-05-25
PA8676401A1 (es) 2009-03-31
ECSP078050A (es) 2008-01-23
CN101228114A (zh) 2008-07-23
EP1890997A1 (en) 2008-02-27
KR20080016892A (ko) 2008-02-22

Similar Documents

Publication Publication Date Title
CR9542A (es) Metodos para purificar tigeciclina
CR9543A (es) Tigeciclina y metodos para preparar 9-nitrominociclina
CR9538A (es) Tigeciclina y metodos para preparar 9-aminominociclina
CR9541A (es) Tigeciclina y metodos de preparacion
HN2006011218A (es) Composiciones de tigeciclina y métodos de preparación
CR9540A (es) Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
CO6480948A2 (es) Composición farmacéutica para la anticoncepción de emergencia
GT201000015A (es) Sulfonamidas como moduladores de trpms
MX2007013632A (es) Procedimientos para preparar derivados de bencil-benceno sustituidos con glucopiranosilo y sus productos intermedios.
UA99936C2 (en) Biaryl substituted azabicyclic alkane derivatives
EA201170356A1 (ru) Полиморфные и аморфные формы лакозамида и аморфные композиции
CR7876A (es) Forma cristalina alfa del ranelato de estroncio, procedimiento para su preparacion y composiciones farmaceuticas que la contienen
CU20090009A7 (es) Bencilaminas, un proceso para su producción y su uso como agentes anti-inflamatorios
MX2010004546A (es) Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina.
ECSP11011346A (es) 3-Amino-2-mercaptoquinolina sustituida como modulador de KCNQ2/3
ECSP088360A (es) Métodos para preparar derivados de ácido glutámico
EA201690467A1 (ru) Промышленный способ синтеза улипристала ацетата и его 4'-ацетильного аналога
CL2010000743A1 (es) Compuestos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
MX2010003056A (es) Polimorfos de valomaciclovir.
AR059418A1 (es) Metodo para la fabricacion de lantibioticos
CL2010000742A1 (es) Compuestos derivados de piperidin-3-il fenilcarbamato; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades de falla de la memoria por la edad, neurodegenerativas, entre otras enfermedades.
CL2011000932A1 (es) Proceso para la preparacion de 9-diclorometilen-1,2,3,3-tetrahidro-1,4-metano-naftalen-5-ilamina; compuesto intermedio y proceso para preparar 6,6-diclorfulveno.
UY30145A1 (es) Metodo para la fabricacion de lantibioticos