CR9540A - Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas - Google Patents
Formas solidas cristalinas de tigeciclina y metodos para preparar las mismasInfo
- Publication number
- CR9540A CR9540A CR9540A CR9540A CR9540A CR 9540 A CR9540 A CR 9540A CR 9540 A CR9540 A CR 9540A CR 9540 A CR9540 A CR 9540A CR 9540 A CR9540 A CR 9540A
- Authority
- CR
- Costa Rica
- Prior art keywords
- forms
- solid
- tigecicline
- crystaline
- prepare
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Se describen en la presente las formas solidas cristalinas de tigeciclina, Forma I, Forma II, Forma III, Forma IV, Forma V, composiciones que comprenden estas formas solidas cristalinas, y procesos para preparar estas formas solidas cristalinas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68495505P | 2005-05-27 | 2005-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR9540A true CR9540A (es) | 2008-02-21 |
Family
ID=37026996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR9540A CR9540A (es) | 2005-05-27 | 2007-11-22 | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
Country Status (28)
Country | Link |
---|---|
US (1) | US8372995B2 (es) |
EP (1) | EP1890996B1 (es) |
JP (2) | JP2008545717A (es) |
KR (1) | KR20080016890A (es) |
CN (1) | CN101248038B (es) |
AR (1) | AR057649A1 (es) |
AU (1) | AU2006251954A1 (es) |
BR (1) | BRPI0610653A2 (es) |
CA (1) | CA2609875C (es) |
CL (1) | CL2006001266A1 (es) |
CR (1) | CR9540A (es) |
DK (1) | DK1890996T3 (es) |
EC (1) | ECSP078055A (es) |
ES (1) | ES2415518T3 (es) |
GT (1) | GT200600227A (es) |
HK (1) | HK1113786A1 (es) |
IL (1) | IL187359A (es) |
MX (1) | MX2007014735A (es) |
NO (1) | NO20076005L (es) |
PE (1) | PE20070024A1 (es) |
PL (1) | PL1890996T3 (es) |
PT (1) | PT1890996E (es) |
RU (1) | RU2478612C2 (es) |
SI (1) | SI1890996T1 (es) |
SV (1) | SV2008002542A (es) |
TW (1) | TWI421232B (es) |
WO (1) | WO2006128150A2 (es) |
ZA (1) | ZA200710151B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070244335A1 (en) * | 2006-04-17 | 2007-10-18 | Teva Pharmaceutical Industries Ltd. | Isolation of tetracycline derivatives |
US8198470B2 (en) | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
PT2016045E (pt) | 2006-04-24 | 2015-02-05 | Teva Pharma | Forma cristalina de tigeciclina e processos para a sua preparação |
MX2008009520A (es) | 2006-11-29 | 2009-02-26 | Teva Pharma | Formas cristalinas de tigeciclina y procesos de preparacion de ellas. |
EP2084126A1 (en) * | 2006-11-30 | 2009-08-05 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of 9-haloacetamidominocyclines |
PT103661B (pt) * | 2007-02-23 | 2010-09-07 | Hovione Farmaciencia S A | Processo de preparação de minociclina base cristalina |
WO2008106234A1 (en) * | 2007-03-01 | 2008-09-04 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
AT13157U1 (de) * | 2007-04-24 | 2013-07-15 | Teva Pharma | Tigecyclin, kristalline Formen und Herstellungsverfahren dafür |
US20100160264A1 (en) | 2007-06-21 | 2010-06-24 | Josef Wieser | Crystalline solid forms |
WO2009062964A1 (en) * | 2007-11-14 | 2009-05-22 | Sandoz Ag | Novel solvate |
ES2532880T3 (es) * | 2007-11-14 | 2015-04-01 | Sandoz Ag | Formas cristalinas del Clorhidrato de Tigeciclina |
WO2009070799A1 (en) * | 2007-11-29 | 2009-06-04 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of crystalline tigecycline form ii |
WO2009092680A2 (en) * | 2008-01-23 | 2009-07-30 | Sandoz Ag | Antibiotic compounds |
ITMI20080807A1 (it) | 2008-05-05 | 2009-11-06 | Antibioticos Spa | Procedimento per la preparazione di tigeciclina in forma amorfa |
TW202216656A (zh) * | 2008-05-23 | 2022-05-01 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
EP2376433B1 (en) | 2008-12-18 | 2014-10-29 | Sandoz AG | Crystalline form c of tigecycline dihydrochloride and methods for its preparation |
PT104350A (pt) | 2009-01-23 | 2010-07-23 | Hovione Farmaci Ncia S A | Processo de isolamento de tigeciclina |
CN102746183B (zh) | 2011-04-20 | 2014-12-17 | 胡梨芳 | 替加环素结晶水合物及其制备方法和用途 |
CN102295576A (zh) * | 2011-06-29 | 2011-12-28 | 赵军旭 | 替加环素的晶型及其制备方法 |
CN102898325B (zh) * | 2011-07-29 | 2015-07-08 | 江苏奥赛康药业股份有限公司 | 替加环素晶体及其制备方法 |
CN102924322B (zh) * | 2012-11-05 | 2014-09-17 | 赵军旭 | 一种替加环素的新晶型及其制备方法 |
CN103833590A (zh) * | 2012-11-26 | 2014-06-04 | 石药集团中奇制药技术(石家庄)有限公司 | 替加环素晶型及其制备方法 |
US10633337B2 (en) * | 2016-06-22 | 2020-04-28 | Kbp Biosciences Co., Ltd. | Crystal forms of a 9-aminomethyl substituted tetracycline compound and a preparation method thereof |
WO2022098644A1 (en) | 2020-11-03 | 2022-05-12 | Landos Biopharma, Inc. | Crystalline forms of piperazine-1,4-diylbis((6-(1h-benzoi[d]imidazo-2-yl)pyridin-2yl)methanone) as lancl2 modulators |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG52361A1 (en) | 1991-10-04 | 1998-09-28 | American Cyanamid Co | Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5284963A (en) | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
US5328902A (en) | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5420272A (en) | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5675030A (en) * | 1994-11-16 | 1997-10-07 | American Cyanamid Company | Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound |
CZ20022332A3 (cs) * | 2000-01-07 | 2003-01-15 | Transform Pharmaceuticals, Inc. | Sestava vzorků |
EP1858488B2 (en) * | 2005-03-14 | 2022-07-20 | Wyeth LLC | Tigecycline compositions and methods of preparation |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
-
2006
- 2006-05-24 AR ARP060102152A patent/AR057649A1/es unknown
- 2006-05-25 US US11/440,032 patent/US8372995B2/en active Active
- 2006-05-25 AU AU2006251954A patent/AU2006251954A1/en not_active Abandoned
- 2006-05-25 BR BRPI0610653-6A patent/BRPI0610653A2/pt not_active Application Discontinuation
- 2006-05-25 CN CN200680027182.5A patent/CN101248038B/zh active Active
- 2006-05-25 GT GT200600227A patent/GT200600227A/es unknown
- 2006-05-25 WO PCT/US2006/020871 patent/WO2006128150A2/en active Application Filing
- 2006-05-25 SI SI200631580T patent/SI1890996T1/sl unknown
- 2006-05-25 TW TW095118573A patent/TWI421232B/zh active
- 2006-05-25 PL PL06760544T patent/PL1890996T3/pl unknown
- 2006-05-25 DK DK06760544.4T patent/DK1890996T3/da active
- 2006-05-25 CL CL200601266A patent/CL2006001266A1/es unknown
- 2006-05-25 CA CA2609875A patent/CA2609875C/en active Active
- 2006-05-25 PE PE2006000551A patent/PE20070024A1/es not_active Application Discontinuation
- 2006-05-25 ES ES06760544T patent/ES2415518T3/es active Active
- 2006-05-25 PT PT67605444T patent/PT1890996E/pt unknown
- 2006-05-25 EP EP06760544.4A patent/EP1890996B1/en not_active Revoked
- 2006-05-25 SV SV2006002542A patent/SV2008002542A/es unknown
- 2006-05-25 KR KR1020077030562A patent/KR20080016890A/ko not_active IP Right Cessation
- 2006-05-25 MX MX2007014735A patent/MX2007014735A/es active IP Right Grant
- 2006-05-25 RU RU2007143160/04A patent/RU2478612C2/ru active
- 2006-05-25 JP JP2008513821A patent/JP2008545717A/ja not_active Withdrawn
-
2007
- 2007-11-14 IL IL187359A patent/IL187359A/en active IP Right Grant
- 2007-11-22 CR CR9540A patent/CR9540A/es not_active Application Discontinuation
- 2007-11-23 NO NO20076005A patent/NO20076005L/no not_active Application Discontinuation
- 2007-11-26 ZA ZA200710151A patent/ZA200710151B/xx unknown
- 2007-12-26 EC EC2007008055A patent/ECSP078055A/es unknown
-
2008
- 2008-08-18 HK HK08109174.1A patent/HK1113786A1/xx unknown
-
2013
- 2013-02-15 JP JP2013028239A patent/JP2013100354A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal (granting procedure) |