ECSP078055A - Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas - Google Patents

Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas

Info

Publication number
ECSP078055A
ECSP078055A EC2007008055A ECSP078055A ECSP078055A EC SP078055 A ECSP078055 A EC SP078055A EC 2007008055 A EC2007008055 A EC 2007008055A EC SP078055 A ECSP078055 A EC SP078055A EC SP078055 A ECSP078055 A EC SP078055A
Authority
EC
Ecuador
Prior art keywords
crystalline
tigecicline
solid forms
prepare
methods
Prior art date
Application number
EC2007008055A
Other languages
English (en)
Inventor
Mannching Sherry Ku
Subodh S Deshmukh
Anthony F Hadfield
Lalitha Krishnan
James W Huang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37026996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP078055(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP078055A publication Critical patent/ECSP078055A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Se describen en la presente las formas sólidas cristalinas de tigeciclina, Forma I, Forma II, Forma III, Forma IV y Forma V, composiciones que comprenden estas formas sólidas cristalinas, y procesos para preparar estas formas sólidas cristalinas
EC2007008055A 2005-05-27 2007-12-26 Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas ECSP078055A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68495505P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
ECSP078055A true ECSP078055A (es) 2008-01-23

Family

ID=37026996

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007008055A ECSP078055A (es) 2005-05-27 2007-12-26 Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas

Country Status (27)

Country Link
US (1) US8372995B2 (es)
EP (1) EP1890996B1 (es)
JP (2) JP2008545717A (es)
KR (1) KR20080016890A (es)
CN (1) CN101248038B (es)
AR (1) AR057649A1 (es)
AU (1) AU2006251954A1 (es)
BR (1) BRPI0610653A2 (es)
CA (1) CA2609875C (es)
CL (1) CL2006001266A1 (es)
CR (1) CR9540A (es)
DK (1) DK1890996T3 (es)
EC (1) ECSP078055A (es)
ES (1) ES2415518T3 (es)
GT (1) GT200600227A (es)
IL (1) IL187359A (es)
MX (1) MX2007014735A (es)
NO (1) NO20076005L (es)
PE (1) PE20070024A1 (es)
PL (1) PL1890996T3 (es)
PT (1) PT1890996E (es)
RU (1) RU2478612C2 (es)
SI (1) SI1890996T1 (es)
SV (1) SV2008002542A (es)
TW (1) TWI421232B (es)
WO (1) WO2006128150A2 (es)
ZA (1) ZA200710151B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101489987A (zh) * 2006-04-17 2009-07-22 特瓦制药工业有限公司 四环素衍生物的分离
TW200812943A (en) * 2006-04-24 2008-03-16 Teva Pharma Processes for preparation of tigecycline crystalline forms I and II
US8198470B2 (en) 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2251320A1 (en) 2006-11-29 2010-11-17 Teva Pharmaceutical Industries Ltd. Crystalline form of tigecycline and processes for preparation thereof
EP2084126A1 (en) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
PT103661B (pt) * 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
US20080214869A1 (en) * 2007-03-01 2008-09-04 Sergei Fine Processes for purification of tigecycline
AT13157U1 (de) * 2007-04-24 2013-07-15 Teva Pharma Tigecyclin, kristalline Formen und Herstellungsverfahren dafür
EP2178827A1 (en) 2007-06-21 2010-04-28 Sandoz AG Crystalline solid forms
JP5574967B2 (ja) 2007-11-14 2014-08-20 サンド・アクチエンゲゼルシヤフト チゲサイクリン塩酸塩の結晶型
US20100256402A1 (en) * 2007-11-14 2010-10-07 Sandoz Ag Novel solvate
WO2009070799A1 (en) * 2007-11-29 2009-06-04 Teva Pharmaceutical Industries Ltd. Processes for preparation of crystalline tigecycline form ii
EP2252579A2 (en) * 2008-01-23 2010-11-24 Sandoz AG Antibiotic compounds
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202216656A (zh) * 2008-05-19 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
ES2528490T3 (es) 2008-12-18 2015-02-10 Sandoz Ag Forma cristalina C de dihidrocloruro de tigeciclina y métodos para su preparación
PT104350A (pt) 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
CN102746183B (zh) * 2011-04-20 2014-12-17 胡梨芳 替加环素结晶水合物及其制备方法和用途
CN102295576A (zh) * 2011-06-29 2011-12-28 赵军旭 替加环素的晶型及其制备方法
CN102898325B (zh) * 2011-07-29 2015-07-08 江苏奥赛康药业股份有限公司 替加环素晶体及其制备方法
CN102924322B (zh) * 2012-11-05 2014-09-17 赵军旭 一种替加环素的新晶型及其制备方法
CN103833590A (zh) * 2012-11-26 2014-06-04 石药集团中奇制药技术（石家庄）有限公司 替加环素晶型及其制备方法
KR102205843B1 (ko) * 2016-06-22 2021-01-22 케이비피 바이오사이언시즈 씨오., 엘티디. 9-아미노메틸 치환된 테트라사이클린 화합물의 결정형 및 그것의 제조 방법
US11492342B2 (en) 2020-11-03 2022-11-08 Landos Biopharma, Inc. Crystalline forms of piperazine-1,4-diylbis((6-(1H-benzo[d]imidazo-2-yl)pyridin-2yl)methanone)
CN116917009A (zh) 2021-02-19 2023-10-20 美国迈胜医疗系统有限公司 用于粒子治疗系统的机架

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
DE122006000058I2 (de) 1991-10-04 2007-09-13 Wyeth Corp 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
AU2930501A (en) * 2000-01-07 2001-07-24 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
PE20061107A1 (es) * 2005-03-14 2006-12-08 Wyeth Corp Composiciones de tigeciclina y metodos para su preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina

Also Published As

Publication number Publication date
KR20080016890A (ko) 2008-02-22
SV2008002542A (es) 2008-02-22
US20070123497A1 (en) 2007-05-31
US8372995B2 (en) 2013-02-12
JP2008545717A (ja) 2008-12-18
IL187359A0 (en) 2008-04-13
ZA200710151B (en) 2010-05-26
CN101248038A (zh) 2008-08-20
WO2006128150A3 (en) 2007-03-08
PT1890996E (pt) 2013-06-24
NO20076005L (no) 2008-02-22
GT200600227A (es) 2007-01-12
PE20070024A1 (es) 2007-02-06
RU2007143160A (ru) 2009-07-10
CA2609875A1 (en) 2006-11-30
TWI421232B (zh) 2014-01-01
EP1890996A2 (en) 2008-02-27
TW200720232A (en) 2007-06-01
SI1890996T1 (sl) 2013-06-28
IL187359A (en) 2013-04-30
WO2006128150A2 (en) 2006-11-30
RU2478612C2 (ru) 2013-04-10
JP2013100354A (ja) 2013-05-23
MX2007014735A (es) 2008-02-15
DK1890996T3 (da) 2013-05-13
CN101248038B (zh) 2014-03-05
HK1113786A1 (en) 2008-10-17
EP1890996B1 (en) 2013-04-24
CL2006001266A1 (es) 2008-05-16
AU2006251954A1 (en) 2006-11-30
AR057649A1 (es) 2007-12-12
CR9540A (es) 2008-02-21
BRPI0610653A2 (pt) 2010-07-13
ES2415518T3 (es) 2013-07-25
CA2609875C (en) 2014-01-07
PL1890996T3 (pl) 2013-08-30

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