CR9538A - Tigeciclina y metodos para preparar 9-aminominociclina - Google Patents

Tigeciclina y metodos para preparar 9-aminominociclina

Info

Publication number
CR9538A
CR9538A CR9538A CR9538A CR9538A CR 9538 A CR9538 A CR 9538A CR 9538 A CR9538 A CR 9538A CR 9538 A CR9538 A CR 9538A CR 9538 A CR9538 A CR 9538A
Authority
CR
Costa Rica
Prior art keywords
methods
tigecicline
aminominocicline
prepare
disclosed
Prior art date
Application number
CR9538A
Other languages
English (en)
Inventor
Krishnan Lalitha
Sum Phaik-Eng
Daigneault Sylvain
Bernatchez Michel
Scott Pilcher Anthonny
Marshall Horne Jeffrey
Joseph Tuper Adam
James Mccauley Joseph
P Michaud Adam
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9538A publication Critical patent/CR9538A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se revelan metodos para preparar y purificar tetraciclinas tales como tigeciclina. Tambien se revelan composiciones de tetraciclinas, tales como composiciones de tigeclina, preparadas por estos metodos.
CR9538A 2005-05-27 2007-11-22 Tigeciclina y metodos para preparar 9-aminominociclina CR9538A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68514605P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
CR9538A true CR9538A (es) 2008-02-20

Family

ID=37025920

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9538A CR9538A (es) 2005-05-27 2007-11-22 Tigeciclina y metodos para preparar 9-aminominociclina

Country Status (21)

Country Link
US (1) US20070049563A1 (es)
EP (1) EP1885686A2 (es)
JP (1) JP2008545707A (es)
KR (1) KR20080016894A (es)
CN (1) CN101228113A (es)
AR (1) AR057324A1 (es)
AU (1) AU2006252686A1 (es)
BR (1) BRPI0610649A2 (es)
CA (1) CA2609649A1 (es)
CR (1) CR9538A (es)
EC (1) ECSP078056A (es)
GT (1) GT200600222A (es)
IL (1) IL187358A0 (es)
MX (1) MX2007014734A (es)
NI (1) NI200700300A (es)
NO (1) NO20075998L (es)
PE (1) PE20061447A1 (es)
RU (1) RU2007143159A (es)
TW (1) TW200716515A (es)
WO (1) WO2006130500A2 (es)
ZA (1) ZA200710154B (es)

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AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
EP2857386B1 (en) * 2006-04-24 2017-02-22 Teva Pharmaceutical Industries Ltd Tigecycline crystalline forms and processes for preparation thereof
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
WO2008066935A2 (en) * 2006-11-29 2008-06-05 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
MX2008009727A (es) * 2006-11-30 2009-01-09 Teva Pharma Procesos para la preparacion de 9-haloacetamidominociclinas.
EP2114865A1 (en) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
WO2009052152A2 (en) * 2007-10-16 2009-04-23 Wyeth Tigecycline and methods of preparing intermediates
US8252946B2 (en) 2007-11-14 2012-08-28 Sandoz Ag Crystalline forms of tigecycline hydrochloride
ES2528490T3 (es) 2008-12-18 2015-02-10 Sandoz Ag Forma cristalina C de dihidrocloruro de tigeciclina y métodos para su preparación
EP2406213A1 (en) 2009-03-12 2012-01-18 Wyeth LLC Nitration of tetracyclines
IT1393350B1 (it) * 2009-03-16 2012-04-20 Antibioticos Spa Processo di preparazione di tigeciclina
ES2469829T3 (es) * 2009-11-26 2014-06-20 Sandoz Ag Reacción de compuestos orgánicos con bajas cantidades de hidrógeno
CN101919816B (zh) * 2010-07-02 2012-07-25 赵军旭 一种含有替加环素的注射用无菌分装制剂
CN101973906B (zh) * 2010-09-27 2014-03-19 重庆福安药业(集团)股份有限公司 一种替加环素无定形态的制备方法
CN101955443B (zh) * 2010-09-30 2012-05-23 浙江大学 一种替加环素中间体及其盐的制备方法
CN102617395B (zh) * 2011-01-29 2014-06-11 正大天晴药业集团股份有限公司 一种甘氨酰环素类抗生素的制备方法
CN103044280B (zh) * 2012-12-20 2015-04-22 安徽悦康凯悦制药有限公司 替加环素的制备方法
WO2015071299A2 (en) 2013-11-12 2015-05-21 Galenicum Health S.L. Stable pharmaceutical compositions
CN111855857B (zh) * 2020-07-30 2022-07-26 武汉药品医疗器械检验所 一种盐酸米诺环素及其杂质的高效液相色谱检测方法

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US3250809A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives
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Also Published As

Publication number Publication date
RU2007143159A (ru) 2009-07-10
US20070049563A1 (en) 2007-03-01
CA2609649A1 (en) 2006-12-07
ZA200710154B (en) 2009-05-27
NO20075998L (no) 2008-02-19
NI200700300A (es) 2008-07-03
EP1885686A2 (en) 2008-02-13
ECSP078056A (es) 2008-01-23
IL187358A0 (en) 2008-04-13
BRPI0610649A2 (pt) 2010-07-13
AR057324A1 (es) 2007-11-28
WO2006130500A2 (en) 2006-12-07
GT200600222A (es) 2007-01-12
TW200716515A (en) 2007-05-01
WO2006130500A8 (en) 2008-01-10
AU2006252686A1 (en) 2006-12-07
MX2007014734A (es) 2008-02-15
WO2006130500A3 (en) 2007-01-18
KR20080016894A (ko) 2008-02-22
JP2008545707A (ja) 2008-12-18
CN101228113A (zh) 2008-07-23
PE20061447A1 (es) 2007-01-22

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)