ZA200710154B - Tigecycline and methods of preparing 9-aminominocycline - Google Patents

Tigecycline and methods of preparing 9-aminominocycline

Info

Publication number
ZA200710154B
ZA200710154B ZA200710154A ZA200710154A ZA200710154B ZA 200710154 B ZA200710154 B ZA 200710154B ZA 200710154 A ZA200710154 A ZA 200710154A ZA 200710154 A ZA200710154 A ZA 200710154A ZA 200710154 B ZA200710154 B ZA 200710154B
Authority
ZA
South Africa
Prior art keywords
aminominocycline
tigecycline
preparing
methods
Prior art date
Application number
ZA200710154A
Other languages
English (en)
Inventor
Krishnan Lalitha
Daigneault Sylvain
Anthony Scott Pilcher
Tuper Adam Joseph
Adam P Michaud
Sum Phaik-Eng
Bernatchez Michel
Home Jeffrey Marshall
Mccauley Iii Joseph James
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200710154B publication Critical patent/ZA200710154B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200710154A 2005-05-27 2007-11-26 Tigecycline and methods of preparing 9-aminominocycline ZA200710154B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68514605P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
ZA200710154B true ZA200710154B (en) 2009-05-27

Family

ID=37025920

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710154A ZA200710154B (en) 2005-05-27 2007-11-26 Tigecycline and methods of preparing 9-aminominocycline

Country Status (21)

Country Link
US (1) US20070049563A1 (xx)
EP (1) EP1885686A2 (xx)
JP (1) JP2008545707A (xx)
KR (1) KR20080016894A (xx)
CN (1) CN101228113A (xx)
AR (1) AR057324A1 (xx)
AU (1) AU2006252686A1 (xx)
BR (1) BRPI0610649A2 (xx)
CA (1) CA2609649A1 (xx)
CR (1) CR9538A (xx)
EC (1) ECSP078056A (xx)
GT (1) GT200600222A (xx)
IL (1) IL187358A0 (xx)
MX (1) MX2007014734A (xx)
NI (1) NI200700300A (xx)
NO (1) NO20075998L (xx)
PE (1) PE20061447A1 (xx)
RU (1) RU2007143159A (xx)
TW (1) TW200716515A (xx)
WO (1) WO2006130500A2 (xx)
ZA (1) ZA200710154B (xx)

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AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
ES2528202T3 (es) * 2006-04-24 2015-02-05 Teva Pharmaceutical Industries Ltd. Una forma cristalina de tigeciclina y procesos para su preparación
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
MX2008009520A (es) * 2006-11-29 2009-02-26 Teva Pharma Formas cristalinas de tigeciclina y procesos de preparacion de ellas.
WO2008066908A1 (en) * 2006-11-30 2008-06-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
US20090099376A1 (en) * 2007-10-16 2009-04-16 Wyeth Tigecycline and methods of preparing intermediates
WO2009062963A1 (en) * 2007-11-14 2009-05-22 Sandoz Ag Crystalline forms of tigecycline hydrochloride
WO2010070093A1 (en) 2008-12-18 2010-06-24 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
JP2012520305A (ja) 2009-03-12 2012-09-06 ワイス・エルエルシー テトラサイクリンのニトロ化
IT1393350B1 (it) * 2009-03-16 2012-04-20 Antibioticos Spa Processo di preparazione di tigeciclina
PL2327676T3 (pl) * 2009-11-26 2014-08-29 Sandoz Ag Reakcja związków organicznych z małymi ilościami wodoru
CN101919816B (zh) * 2010-07-02 2012-07-25 赵军旭 一种含有替加环素的注射用无菌分装制剂
CN101973906B (zh) * 2010-09-27 2014-03-19 重庆福安药业(集团)股份有限公司 一种替加环素无定形态的制备方法
CN101955443B (zh) * 2010-09-30 2012-05-23 浙江大学 一种替加环素中间体及其盐的制备方法
CN102617395B (zh) * 2011-01-29 2014-06-11 正大天晴药业集团股份有限公司 一种甘氨酰环素类抗生素的制备方法
CN103044280B (zh) * 2012-12-20 2015-04-22 安徽悦康凯悦制药有限公司 替加环素的制备方法
US20160143925A1 (en) 2013-11-12 2016-05-26 Galenicum Health S.L. Stable pharmaceutical compositions
CN111855857B (zh) * 2020-07-30 2022-07-26 武汉药品医疗器械检验所 一种盐酸米诺环素及其杂质的高效液相色谱检测方法

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Also Published As

Publication number Publication date
JP2008545707A (ja) 2008-12-18
PE20061447A1 (es) 2007-01-22
US20070049563A1 (en) 2007-03-01
AU2006252686A1 (en) 2006-12-07
WO2006130500A3 (en) 2007-01-18
BRPI0610649A2 (pt) 2010-07-13
IL187358A0 (en) 2008-04-13
NI200700300A (es) 2008-07-03
WO2006130500A8 (en) 2008-01-10
NO20075998L (no) 2008-02-19
CA2609649A1 (en) 2006-12-07
AR057324A1 (es) 2007-11-28
ECSP078056A (es) 2008-01-23
EP1885686A2 (en) 2008-02-13
KR20080016894A (ko) 2008-02-22
GT200600222A (es) 2007-01-12
WO2006130500A2 (en) 2006-12-07
CR9538A (es) 2008-02-20
MX2007014734A (es) 2008-02-15
CN101228113A (zh) 2008-07-23
RU2007143159A (ru) 2009-07-10
TW200716515A (en) 2007-05-01

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