DE60144375D1 - 7-, 8- und 9-substitutierte tetracyclinverbindungen - Google Patents
7-, 8- und 9-substitutierte tetracyclinverbindungenInfo
- Publication number
- DE60144375D1 DE60144375D1 DE60144375T DE60144375T DE60144375D1 DE 60144375 D1 DE60144375 D1 DE 60144375D1 DE 60144375 T DE60144375 T DE 60144375T DE 60144375 T DE60144375 T DE 60144375T DE 60144375 D1 DE60144375 D1 DE 60144375D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- compounds
- tetracyclin
- tetracycline compounds
- substituted tetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21665600P | 2000-07-07 | 2000-07-07 | |
PCT/US2000/021366 WO2002012170A1 (en) | 2000-08-04 | 2000-08-04 | 8-substituted tetracycline compounds |
PCT/US2001/020558 WO2002004404A2 (en) | 2000-07-07 | 2001-06-29 | 7,8 and 9-substituted tetracycline compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60144375D1 true DE60144375D1 (de) | 2011-05-19 |
Family
ID=26680300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60144375T Expired - Lifetime DE60144375D1 (de) | 2000-07-07 | 2001-06-29 | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
Country Status (8)
Country | Link |
---|---|
US (1) | US6624168B2 (de) |
EP (2) | EP2166000A1 (de) |
JP (1) | JP4963771B2 (de) |
AT (1) | ATE504562T1 (de) |
AU (1) | AU2001271556A1 (de) |
CA (1) | CA2415086A1 (de) |
DE (1) | DE60144375D1 (de) |
WO (1) | WO2002004404A2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
DE60027465T2 (de) * | 1999-09-14 | 2007-02-01 | The Trustees Of Tufts College, Medford | Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
WO2001052858A1 (en) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
MXPA02009482A (es) * | 2000-03-31 | 2004-05-14 | Tufts College | Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino. |
AU2001259701A1 (en) * | 2000-05-15 | 2001-11-26 | Paratek Pharmaceuticals, Inc | 7-substituted fused ring tetracycline compounds |
US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US6846939B2 (en) * | 2000-07-07 | 2005-01-25 | Paratek Pharmaceuticals, Inc. | 9-substituted minocycline compounds |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
CA2415718C (en) * | 2000-07-07 | 2012-08-28 | Trustees Of Tufts College | 7-substituted tetracycline compounds |
WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
BR0116935A (pt) * | 2001-03-13 | 2005-04-12 | Paratek Pharm Innc | Composto de tetraciclina, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica |
EP1241160A1 (de) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracyclinderivate und ihre Verwendung als Antibiotica |
WO2002072031A2 (en) | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
EP2332546A1 (de) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclinverbindungen zur Behandlung von Schlaganfall |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
AU2002365120A1 (en) | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
EP2311796A1 (de) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-Dedimethylamin-Tetracyclinverbindungen |
AU2003220123B2 (en) * | 2002-03-08 | 2009-05-07 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
WO2003079984A2 (en) | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
WO2004006850A2 (en) * | 2002-07-12 | 2004-01-22 | Paratek Pharmaceuticals, Inc | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS |
US8173624B2 (en) * | 2002-10-24 | 2012-05-08 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate RNA |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
CN101786991A (zh) * | 2003-07-09 | 2010-07-28 | 帕拉特克药品公司 | 取代的四环素化合物 |
JP5010284B2 (ja) | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族a環誘導体 |
AU2012202559B2 (en) * | 2004-05-21 | 2014-07-17 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
AU2014250722B2 (en) * | 2004-05-21 | 2016-05-26 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
ES2607453T3 (es) | 2004-05-21 | 2017-03-31 | President And Fellows Of Harvard College | Síntesis de tetraciclinas y sus análogos |
TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
EP2284150A3 (de) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
AU2005299294B2 (en) | 2004-10-25 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
US8088755B2 (en) | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
AU2006214543A1 (en) * | 2005-02-15 | 2006-08-24 | Wyeth | 9-substituted tetracyclines |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
WO2007014154A2 (en) * | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
EP2016044B1 (de) * | 2006-04-07 | 2020-06-10 | President and Fellows of Harvard College | Pentacylin-derivate zur behandlung von infektionen |
EP2026776A2 (de) * | 2006-05-15 | 2009-02-25 | Paratek Pharmaceuticals, Inc. | Verfahren zur regelung der genexpression oder genprodukte mithilfe von substituierten tetracyclinverbindungen |
EP3056487B1 (de) * | 2006-10-11 | 2018-02-21 | President and Fellows of Harvard College | Synthese eines enon-zwischenprodukts |
US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
PT2120963T (pt) | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
ES2463457T3 (es) | 2006-12-21 | 2014-05-28 | Paratek Pharmaceuticals, Inc. | Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias |
EP2144614A1 (de) * | 2007-04-12 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Verfahren zur behandlung von spinaler muskelatrophie mittels tetracyclinverbindungen |
CA2688662A1 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
ES2386926T3 (es) | 2007-07-06 | 2012-09-06 | Paratek Pharmaceuticals, Inc. | Métodos para sintetizar minociclina9-sustituida |
ES2388958T3 (es) | 2007-11-29 | 2012-10-22 | Actelion Pharmaceuticals Ltd. | Derivados de acido fosfonico y su uso como antagonista del receptor P2Y12 |
WO2009111064A2 (en) | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
US20100022483A1 (en) * | 2008-04-14 | 2010-01-28 | Paratek Pharmaceuticals, Inc. | Substituted Tetracycline Compounds |
RS54485B1 (en) | 2008-08-08 | 2016-06-30 | Tetraphase Pharmaceuticals, Inc. | C7-FLUORO SUBSTITUTED TETRACYCLINE UNITS |
AP2011005631A0 (en) * | 2008-09-19 | 2011-04-30 | Paratek Pharmaceuticals Ind | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment. |
WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
US9315451B2 (en) | 2009-05-08 | 2016-04-19 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
DK2470500T3 (en) | 2009-08-28 | 2018-01-08 | Tetraphase Pharmaceuticals Inc | tetracycline |
AR082633A1 (es) * | 2010-08-12 | 2012-12-19 | Tetraphase Pharmaceuticals Inc | Analogos de tetraciclina |
CA2883238C (en) | 2012-08-31 | 2021-11-23 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
RU2668535C2 (ru) * | 2016-09-22 | 2018-10-01 | Федеральное государственное бюджетное научное учреждение "Уральский федеральный аграрный научно-исследовательский центр Уральского отделения Российской академии наук" (ФГБНУ УрФАНИЦ УрО РАН) | Способ профилактики маститов у высокопродуктивных коров |
CN110582486B (zh) | 2016-10-19 | 2024-01-12 | 四相制药公司 | 艾若威四环素的结晶形式 |
SG10201913599RA (en) | 2016-11-01 | 2020-02-27 | Paratek Pharm Innc | 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp) |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
US3388162A (en) * | 1966-03-14 | 1968-06-11 | American Cyanamid Co | 7-and/or 9-nitro or amino tetracyclines |
NL6607516A (de) | 1966-05-31 | 1967-12-01 | ||
DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
CA2103189C (en) | 1992-11-17 | 2005-05-03 | Lorne M. Golub | Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes |
EP0745065A1 (de) | 1994-02-17 | 1996-12-04 | Pfizer Inc. | 9-(substituiertes amino)-alpha-6-desoxy-5-oxytetracyclin derivate, deren herstellung und deren verwendung als antibiotika |
US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
AU766200B2 (en) * | 1998-11-18 | 2003-10-09 | Collagenex Pharmaceuticals, Inc. | Novel 4-dedimethy laminotetra cycline derivatives |
-
2001
- 2001-06-29 WO PCT/US2001/020558 patent/WO2002004404A2/en active Application Filing
- 2001-06-29 EP EP09175818A patent/EP2166000A1/de not_active Withdrawn
- 2001-06-29 AT AT01950582T patent/ATE504562T1/de not_active IP Right Cessation
- 2001-06-29 DE DE60144375T patent/DE60144375D1/de not_active Expired - Lifetime
- 2001-06-29 US US09/894,805 patent/US6624168B2/en not_active Expired - Lifetime
- 2001-06-29 EP EP01950582A patent/EP1303479B1/de not_active Expired - Lifetime
- 2001-06-29 CA CA002415086A patent/CA2415086A1/en not_active Abandoned
- 2001-06-29 JP JP2002509072A patent/JP4963771B2/ja not_active Expired - Fee Related
- 2001-06-29 AU AU2001271556A patent/AU2001271556A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002004404A3 (en) | 2002-06-13 |
CA2415086A1 (en) | 2002-01-17 |
ATE504562T1 (de) | 2011-04-15 |
US6624168B2 (en) | 2003-09-23 |
EP1303479B1 (de) | 2011-04-06 |
AU2001271556A1 (en) | 2002-01-21 |
EP2166000A1 (de) | 2010-03-24 |
JP4963771B2 (ja) | 2012-06-27 |
EP1303479A2 (de) | 2003-04-23 |
JP2004502750A (ja) | 2004-01-29 |
US20020111335A1 (en) | 2002-08-15 |
WO2002004404A2 (en) | 2002-01-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60144375D1 (de) | 7-, 8- und 9-substitutierte tetracyclinverbindungen | |
DE69711640D1 (de) | Naphthopyrane, zusammensetzungen und artikel die diese enthalten | |
DE60044069D1 (de) | Chromenverbindung und diese enthaltende Artikel | |
DE69431121T2 (de) | Anti-rauch riechstoffe und kompositionen | |
DK0960107T3 (da) | 6-Thiosubstituerede paclitaxeler | |
FI943749A (fi) | Taksaanijohdannaisten fosfono-oksimetyylieetterit | |
DE69425879D1 (de) | Taxolformulierung | |
DE60235083D1 (de) | Substituierte tetracyclin-verbindungen zur behandlung von malaria | |
MX9102407A (es) | 4 arilpiperazinas y 4-arilpiperidinas novedosas. | |
FI920023A0 (fi) | Heteroarylpiperazinfoereningar som antipsykotiska aemnen. | |
DE69842237D1 (de) | Azeotropische Zusammensetzungen enthaltend 1,1,1,2,3,3,3-Heptafluorpropan und Verfahren, die diese Zusammensetzungen verwenden | |
IT1293968B1 (it) | Produzione ed utilizzo di composizioni comprendenti alte concentrazioni di attivita' di vitamina b12. | |
DE69421172D1 (de) | Synthetises detergensstueck und herstellung davon | |
DE69818516D1 (de) | Phenylaminoalkylcarbonsäure-derivate und medizinische zusammensetzungen, die diese enthalten | |
DE69706146T2 (de) | Taxoide, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen | |
GB0112312D0 (en) | Novel photoresist polymers and photoresist compositions containing the same | |
DK1204659T3 (da) | Serotonerge benzofuraner | |
ATE240099T1 (de) | Taxane, die eine alkyl-substituierte seitenkette haben, und diese enthaltende pharmazeutische zusammensetzungen | |
GB2324091A (en) | Metalloproteinase inhibitors | |
DK1011329T3 (da) | 7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler | |
ATE526308T1 (de) | 13-substituierte methacyclinverbindungen | |
EE9600197A (et) | Uudsed 1,1-bis(heteroasolüül)alkaani derivaadid ja nende kasutamine neuroprotektiivsete ainetena | |
ATE251619T1 (de) | 1,4-dioxacycloalkan-2-one und 1,4-dioxacycloalken-2-one | |
IT1275594B1 (it) | Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide | |
NO20005856D0 (no) | Anvendelse av 1,1-diokso-perhydro-1,2,4-tiadiaziner |