AU2001271556A1 - 7,8 and 9-substituted tetracycline compounds - Google Patents

7,8 and 9-substituted tetracycline compounds

Info

Publication number
AU2001271556A1
AU2001271556A1 AU2001271556A AU7155601A AU2001271556A1 AU 2001271556 A1 AU2001271556 A1 AU 2001271556A1 AU 2001271556 A AU2001271556 A AU 2001271556A AU 7155601 A AU7155601 A AU 7155601A AU 2001271556 A1 AU2001271556 A1 AU 2001271556A1
Authority
AU
Australia
Prior art keywords
doxycycline
compound
phenyl
hydrogen
tetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001271556A
Other languages
English (en)
Inventor
Darrell Koza
Mark L Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/021366 external-priority patent/WO2002012170A1/en
Application filed by Tufts University filed Critical Tufts University
Publication of AU2001271556A1 publication Critical patent/AU2001271556A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
AU2001271556A 2000-07-07 2001-06-29 7,8 and 9-substituted tetracycline compounds Abandoned AU2001271556A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21665600P 2000-07-07 2000-07-07
US60216656 2000-07-07
WOUS00/21366 2000-08-04
PCT/US2000/021366 WO2002012170A1 (en) 2000-08-04 2000-08-04 8-substituted tetracycline compounds
PCT/US2001/020558 WO2002004404A2 (en) 2000-07-07 2001-06-29 7,8 and 9-substituted tetracycline compounds

Publications (1)

Publication Number Publication Date
AU2001271556A1 true AU2001271556A1 (en) 2002-01-21

Family

ID=26680300

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001271556A Abandoned AU2001271556A1 (en) 2000-07-07 2001-06-29 7,8 and 9-substituted tetracycline compounds

Country Status (8)

Country Link
US (1) US6624168B2 (de)
EP (2) EP2166000A1 (de)
JP (1) JP4963771B2 (de)
AT (1) ATE504562T1 (de)
AU (1) AU2001271556A1 (de)
CA (1) CA2415086A1 (de)
DE (1) DE60144375D1 (de)
WO (1) WO2002004404A2 (de)

Families Citing this family (63)

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US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
DE60027465T2 (de) * 1999-09-14 2007-02-01 The Trustees Of Tufts College, Medford Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2001052858A1 (en) * 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
MXPA02009482A (es) * 2000-03-31 2004-05-14 Tufts College Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino.
AU2001259701A1 (en) * 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US6846939B2 (en) * 2000-07-07 2005-01-25 Paratek Pharmaceuticals, Inc. 9-substituted minocycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
CA2415718C (en) * 2000-07-07 2012-08-28 Trustees Of Tufts College 7-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
BR0116935A (pt) * 2001-03-13 2005-04-12 Paratek Pharm Innc Composto de tetraciclina, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica
EP1241160A1 (de) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
WO2002072031A2 (en) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2332546A1 (de) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclinverbindungen zur Behandlung von Schlaganfall
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
EP2311796A1 (de) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-Dedimethylamin-Tetracyclinverbindungen
AU2003220123B2 (en) * 2002-03-08 2009-05-07 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
WO2004006850A2 (en) * 2002-07-12 2004-01-22 Paratek Pharmaceuticals, Inc 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
US8173624B2 (en) * 2002-10-24 2012-05-08 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate RNA
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CN101786991A (zh) * 2003-07-09 2010-07-28 帕拉特克药品公司 取代的四环素化合物
JP5010284B2 (ja) 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
AU2012202559B2 (en) * 2004-05-21 2014-07-17 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
AU2014250722B2 (en) * 2004-05-21 2016-05-26 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
ES2607453T3 (es) 2004-05-21 2017-03-31 President And Fellows Of Harvard College Síntesis de tetraciclinas y sus análogos
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2284150A3 (de) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
AU2005299294B2 (en) 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US8088755B2 (en) 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AU2006214543A1 (en) * 2005-02-15 2006-08-24 Wyeth 9-substituted tetracyclines
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
WO2007014154A2 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
EP2016044B1 (de) * 2006-04-07 2020-06-10 President and Fellows of Harvard College Pentacylin-derivate zur behandlung von infektionen
EP2026776A2 (de) * 2006-05-15 2009-02-25 Paratek Pharmaceuticals, Inc. Verfahren zur regelung der genexpression oder genprodukte mithilfe von substituierten tetracyclinverbindungen
EP3056487B1 (de) * 2006-10-11 2018-02-21 President and Fellows of Harvard College Synthese eines enon-zwischenprodukts
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
PT2120963T (pt) 2006-12-21 2018-12-17 Paratek Pharm Innc Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele
ES2463457T3 (es) 2006-12-21 2014-05-28 Paratek Pharmaceuticals, Inc. Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
EP2144614A1 (de) * 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Verfahren zur behandlung von spinaler muskelatrophie mittels tetracyclinverbindungen
CA2688662A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
ES2386926T3 (es) 2007-07-06 2012-09-06 Paratek Pharmaceuticals, Inc. Métodos para sintetizar minociclina9-sustituida
ES2388958T3 (es) 2007-11-29 2012-10-22 Actelion Pharmaceuticals Ltd. Derivados de acido fosfonico y su uso como antagonista del receptor P2Y12
WO2009111064A2 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
RS54485B1 (en) 2008-08-08 2016-06-30 Tetraphase Pharmaceuticals, Inc. C7-FLUORO SUBSTITUTED TETRACYCLINE UNITS
AP2011005631A0 (en) * 2008-09-19 2011-04-30 Paratek Pharmaceuticals Ind Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment.
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
US9315451B2 (en) 2009-05-08 2016-04-19 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
DK2470500T3 (en) 2009-08-28 2018-01-08 Tetraphase Pharmaceuticals Inc tetracycline
AR082633A1 (es) * 2010-08-12 2012-12-19 Tetraphase Pharmaceuticals Inc Analogos de tetraciclina
CA2883238C (en) 2012-08-31 2021-11-23 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
RU2668535C2 (ru) * 2016-09-22 2018-10-01 Федеральное государственное бюджетное научное учреждение "Уральский федеральный аграрный научно-исследовательский центр Уральского отделения Российской академии наук" (ФГБНУ УрФАНИЦ УрО РАН) Способ профилактики маститов у высокопродуктивных коров
CN110582486B (zh) 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式
SG10201913599RA (en) 2016-11-01 2020-02-27 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)

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US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
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US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
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US3388162A (en) * 1966-03-14 1968-06-11 American Cyanamid Co 7-and/or 9-nitro or amino tetracyclines
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DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
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SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
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Also Published As

Publication number Publication date
WO2002004404A3 (en) 2002-06-13
CA2415086A1 (en) 2002-01-17
ATE504562T1 (de) 2011-04-15
US6624168B2 (en) 2003-09-23
EP1303479B1 (de) 2011-04-06
EP2166000A1 (de) 2010-03-24
JP4963771B2 (ja) 2012-06-27
EP1303479A2 (de) 2003-04-23
JP2004502750A (ja) 2004-01-29
US20020111335A1 (en) 2002-08-15
WO2002004404A2 (en) 2002-01-17
DE60144375D1 (de) 2011-05-19

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