PE20071229A1 - Procesos para la sintesis convergente de los derivados de caliqueamicida - Google Patents
Procesos para la sintesis convergente de los derivados de caliqueamicidaInfo
- Publication number
- PE20071229A1 PE20071229A1 PE2007000151A PE2007000151A PE20071229A1 PE 20071229 A1 PE20071229 A1 PE 20071229A1 PE 2007000151 A PE2007000151 A PE 2007000151A PE 2007000151 A PE2007000151 A PE 2007000151A PE 20071229 A1 PE20071229 A1 PE 20071229A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- formula
- alk1
- acid
- dimethylformed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UN PROCESO PARA PREPARAR UN COMPUESTO DERIVADO DE CALIQUEAMICINA DE FORMULA: Z-C(=O)-Alk1-Sp1-Ar-C(Z1)=Q-Sp-S-S-W', DONDE Z ES -O-TETRAFLUORFENILO, -O-PENTAFLUORFENILO, ENTRE OTROS; AlK1 ES ALQUILENO DE 2 A 6 ATOMOS DE CARBONO; Sp1 ES S, O, CONH, NHCO O NR'; Z1 ES H O ALQUILO C1-C5; Ar ES 1,2-FENILENO, 1,3-FENILENO, ENTRE OTROS; R' ES ALQUILO C1-C5 OPCIONALMENTE SUSTITUIDO CON OH, ALCOXI C1-C4, ENTRE OTROS; Sp ES ALQUILO C1-C18, ARILO O HETEROARILO DE 3 A 18 ATOMOS, CICLOALQUILO C1-C18, ENTRE OTROS; R5 ES CH3, -C2H5 O CH(CH3)2; R5' ES H O UN GRUPO RCO; R ES H, ALQUILO C1-C10, ALQUILENO C2-C10, ENTRE OTROS; Q ES -NNHCO-, NNHCS-, ENTRE OTROS; DONDE DICHO PROCESO COMPRENDE: A) HACER REACCIONAR ACIDO CARBOXILICO DE FORMULA HO-C(=O)-Alk1-Sp1-Ar-C(=O)-Z1 CON EL COMPUESTO MERCAPTO DE FORMULA H2Q-Sp-SH EN UN DISOLVENTE DE ALCOHOL EN LA PRESENCIA DE UN ACIDO ALQUILCARBOXILICO alq2CO2H DONDE alq2 ES ALQUILO C1-C4, A UNA TEMPERATURA DE ENTRE 20ºC A 70ºC DE 1 A 24 HORAS, PARA PRODUCIR UN ACIDO CARBOXILICO BILIGADOR; b) AISLAR EL ACIDO CARBOXILICO BILIGADOR Y HACERLO REACCIONAR CON CON N-HIDROXISULFOSUCCINIMIDA, 2,4--DINITROFENOL, ENTRE OTROS, EN UN DISOLVENTE INERTE QUE CONTIENE 0-50% DE N,N-DIMETILFORMAMIDA PARA GENERAR UN ESTER ACTIVADO TRILIGADOR, EL CUAL SE HACE REACCIONAR CON UN ANTIBIOTICO ANTITUMOR METIL TRITIO CH3-S-S-S-W' EN LA PRESENCIA DE UNA BASE Y SE OBTIENE UN ESTER ACTIVADO TRILIGADOR QUE SE AISLA Y SE PURIFICA PARA PRODUCIR COMPUESTOS DE FORMULA (I)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77537006P | 2006-02-21 | 2006-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071229A1 true PE20071229A1 (es) | 2007-11-30 |
Family
ID=38437933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000151A PE20071229A1 (es) | 2006-02-21 | 2007-02-13 | Procesos para la sintesis convergente de los derivados de caliqueamicida |
Country Status (32)
| Country | Link |
|---|---|
| US (6) | US20070197455A1 (es) |
| EP (2) | EP1987048B1 (es) |
| JP (4) | JP5179383B2 (es) |
| KR (1) | KR101454489B1 (es) |
| CN (1) | CN101389639B (es) |
| AR (1) | AR059592A1 (es) |
| AU (1) | AU2007217795B2 (es) |
| BR (1) | BRPI0708149B1 (es) |
| CA (1) | CA2642194C (es) |
| CL (1) | CL2009001487A1 (es) |
| CR (1) | CR10230A (es) |
| CY (1) | CY1120206T1 (es) |
| DK (2) | DK1987048T3 (es) |
| EC (1) | ECSP088691A (es) |
| ES (2) | ES2670709T3 (es) |
| GT (1) | GT200800161A (es) |
| HK (1) | HK1203515A1 (es) |
| HU (1) | HUE037880T2 (es) |
| IL (1) | IL193343A (es) |
| MX (1) | MX2008010768A (es) |
| NO (1) | NO20083698L (es) |
| PE (1) | PE20071229A1 (es) |
| PL (2) | PL1987048T3 (es) |
| PT (2) | PT1987048E (es) |
| RU (1) | RU2436790C2 (es) |
| SG (1) | SG170013A1 (es) |
| SI (2) | SI1987048T1 (es) |
| SV (1) | SV2009003002A (es) |
| TR (1) | TR201808220T4 (es) |
| TW (1) | TW200806685A (es) |
| WO (1) | WO2007098124A2 (es) |
| ZA (1) | ZA200807196B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200806685A (en) * | 2006-02-21 | 2008-02-01 | Wyeth Corp | Processes for the convergent synthesis of calicheamicin derivatives |
| WO2011080739A2 (en) | 2009-12-29 | 2011-07-07 | Yeda Research And Development Co. Ltd. | Synergistic antibiotic combinations and derivatives |
| SG11201500566XA (en) | 2012-08-16 | 2015-04-29 | Pfizer | Glycoconjugation processes and compositions |
| PE20161413A1 (es) | 2013-11-04 | 2017-01-10 | Stemcentrx Inc | Conjugados de anticuerpo anti-efna4-farmaco |
| CA3131631A1 (en) | 2013-11-04 | 2015-05-07 | Pfizer Inc. | Intermediates and methods for synthesizing calicheamicin derivatives |
| KR102238032B1 (ko) | 2014-04-30 | 2021-04-08 | 화이자 인코포레이티드 | 항-ptk7 항체-약물 접합체 |
| US10464442B2 (en) * | 2016-10-11 | 2019-11-05 | Honda Motor Co., Ltd. | Non-contact power supply system and power transmission apparatus, and designing method and installing method of power transmission apparatus |
| WO2019018647A1 (en) | 2017-07-20 | 2019-01-24 | Pfizer Inc. | ANTI-GD3 ANTIBODIES AND CONJUGATES ANTIBODY-MEDICATION |
| US11576981B2 (en) | 2017-12-06 | 2023-02-14 | Ontario Institute For Cancer Research (Oicr) | Acyl hydrazone linkers, methods and uses thereof |
| WO2019119141A1 (en) | 2017-12-22 | 2019-06-27 | Ontario Institute For Cancer Research (Oicr) | Heterocyclic acyl hydrazone linkers, methods and uses thereof |
| CN111647865B (zh) * | 2020-08-06 | 2020-11-24 | 北京卓立汉光仪器有限公司 | 溅射镀膜方法、装置及系统 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| US5079233A (en) * | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
| US5108912A (en) * | 1987-01-30 | 1992-04-28 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5053394A (en) | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
| US5773001A (en) * | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| TW200806685A (en) * | 2006-02-21 | 2008-02-01 | Wyeth Corp | Processes for the convergent synthesis of calicheamicin derivatives |
-
2007
- 2007-02-08 TW TW096104537A patent/TW200806685A/zh unknown
- 2007-02-13 PE PE2007000151A patent/PE20071229A1/es not_active Application Discontinuation
- 2007-02-16 BR BRPI0708149-9A patent/BRPI0708149B1/pt active IP Right Grant
- 2007-02-16 WO PCT/US2007/004301 patent/WO2007098124A2/en active Application Filing
- 2007-02-16 HU HUE14171872A patent/HUE037880T2/hu unknown
- 2007-02-16 TR TR2018/08220T patent/TR201808220T4/tr unknown
- 2007-02-16 CN CN2007800062025A patent/CN101389639B/zh active Active
- 2007-02-16 PL PL07751087T patent/PL1987048T3/pl unknown
- 2007-02-16 PT PT77510873T patent/PT1987048E/pt unknown
- 2007-02-16 CA CA2642194A patent/CA2642194C/en not_active Expired - Fee Related
- 2007-02-16 JP JP2008556378A patent/JP5179383B2/ja active Active
- 2007-02-16 DK DK07751087.3T patent/DK1987048T3/en active
- 2007-02-16 PT PT141718726T patent/PT2799441T/pt unknown
- 2007-02-16 DK DK14171872.6T patent/DK2799441T3/en active
- 2007-02-16 ES ES14171872.6T patent/ES2670709T3/es active Active
- 2007-02-16 SG SG201101229-1A patent/SG170013A1/en unknown
- 2007-02-16 PL PL14171872T patent/PL2799441T3/pl unknown
- 2007-02-16 AU AU2007217795A patent/AU2007217795B2/en active Active
- 2007-02-16 ES ES07751087.3T patent/ES2527107T3/es active Active
- 2007-02-16 MX MX2008010768A patent/MX2008010768A/es active IP Right Grant
- 2007-02-16 SI SI200731560T patent/SI1987048T1/sl unknown
- 2007-02-16 EP EP07751087.3A patent/EP1987048B1/en active Active
- 2007-02-16 RU RU2008132777/04A patent/RU2436790C2/ru active
- 2007-02-16 KR KR1020087020367A patent/KR101454489B1/ko not_active Application Discontinuation
- 2007-02-16 EP EP14171872.6A patent/EP2799441B1/en active Active
- 2007-02-16 SI SI200732034T patent/SI2799441T1/en unknown
- 2007-02-20 AR ARP070100723A patent/AR059592A1/es unknown
- 2007-02-20 US US11/708,849 patent/US20070197455A1/en not_active Abandoned
-
2008
- 2008-08-10 IL IL193343A patent/IL193343A/en active IP Right Grant
- 2008-08-20 ZA ZA200807196A patent/ZA200807196B/xx unknown
- 2008-08-20 GT GT200800161A patent/GT200800161A/es unknown
- 2008-08-21 SV SV2008003002A patent/SV2009003002A/es unknown
- 2008-08-21 CR CR10230A patent/CR10230A/es not_active Application Discontinuation
- 2008-08-21 EC EC2008008691A patent/ECSP088691A/es unknown
- 2008-08-27 NO NO20083698A patent/NO20083698L/no not_active Application Discontinuation
-
2009
- 2009-06-25 CL CL2009001487A patent/CL2009001487A1/es unknown
- 2009-08-17 US US12/583,237 patent/US8273862B2/en active Active
-
2012
- 2012-09-21 US US13/624,118 patent/US8546549B2/en active Active
- 2012-11-27 JP JP2012258265A patent/JP2013040213A/ja not_active Withdrawn
-
2013
- 2013-09-12 US US14/025,588 patent/US20140081010A1/en not_active Abandoned
-
2014
- 2014-07-15 JP JP2014144737A patent/JP2014196352A/ja active Pending
-
2015
- 2015-04-24 HK HK15104003.0A patent/HK1203515A1/xx unknown
- 2015-05-13 US US14/711,267 patent/US9802890B2/en active Active
- 2015-10-19 JP JP2015205319A patent/JP2016011316A/ja not_active Withdrawn
-
2017
- 2017-09-28 US US15/719,504 patent/US10343989B2/en active Active
-
2018
- 2018-05-15 CY CY20181100495T patent/CY1120206T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |