CR10230A - Proceso para la síntesis convergente de los derivados de caliqueamicina - Google Patents

Proceso para la síntesis convergente de los derivados de caliqueamicina

Info

Publication number
CR10230A
CR10230A CR10230A CR10230A CR10230A CR 10230 A CR10230 A CR 10230A CR 10230 A CR10230 A CR 10230A CR 10230 A CR10230 A CR 10230A CR 10230 A CR10230 A CR 10230A
Authority
CR
Costa Rica
Prior art keywords
derivatives
caliqueamycin
convergent synthesis
convergent
synthesis
Prior art date
Application number
CR10230A
Other languages
English (en)
Inventor
Justin Moran
Jianxin Gu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38437933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR10230(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR10230A publication Critical patent/CR10230A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esta invención describe procesos para la síntesis convergente de derivados de caliqueamicina, y análogos similares que utilizan intermedios de ligador bifuncional y trifuncional.
CR10230A 2006-02-21 2008-08-21 Proceso para la síntesis convergente de los derivados de caliqueamicina CR10230A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77537006P 2006-02-21 2006-02-21

Publications (1)

Publication Number Publication Date
CR10230A true CR10230A (es) 2008-10-03

Family

ID=38437933

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10230A CR10230A (es) 2006-02-21 2008-08-21 Proceso para la síntesis convergente de los derivados de caliqueamicina

Country Status (32)

Country Link
US (6) US20070197455A1 (es)
EP (2) EP1987048B1 (es)
JP (4) JP5179383B2 (es)
KR (1) KR101454489B1 (es)
CN (1) CN101389639B (es)
AR (1) AR059592A1 (es)
AU (1) AU2007217795B2 (es)
BR (1) BRPI0708149B1 (es)
CA (1) CA2642194C (es)
CL (1) CL2009001487A1 (es)
CR (1) CR10230A (es)
CY (1) CY1120206T1 (es)
DK (2) DK2799441T3 (es)
EC (1) ECSP088691A (es)
ES (2) ES2670709T3 (es)
GT (1) GT200800161A (es)
HK (1) HK1203515A1 (es)
HU (1) HUE037880T2 (es)
IL (1) IL193343A (es)
MX (1) MX2008010768A (es)
NO (1) NO20083698L (es)
PE (1) PE20071229A1 (es)
PL (2) PL2799441T3 (es)
PT (2) PT1987048E (es)
RU (1) RU2436790C2 (es)
SG (1) SG170013A1 (es)
SI (2) SI2799441T1 (es)
SV (1) SV2009003002A (es)
TR (1) TR201808220T4 (es)
TW (1) TW200806685A (es)
WO (1) WO2007098124A2 (es)
ZA (1) ZA200807196B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806685A (en) * 2006-02-21 2008-02-01 Wyeth Corp Processes for the convergent synthesis of calicheamicin derivatives
WO2011080739A2 (en) 2009-12-29 2011-07-07 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives
WO2014027302A1 (en) 2012-08-16 2014-02-20 Pfizer Inc. Glycoconjugation processes and compositions
SI3066074T1 (sl) 2013-11-04 2020-03-31 Pfizer Inc. Intermediati in postopki za sintetizacijo derivatov kaliheamicina
AU2014342610A1 (en) 2013-11-04 2016-06-02 Abbvie Stemcentrx Llc Anti-EFNA4 antibody-drug conjugates
PL3137114T3 (pl) 2014-04-30 2021-06-28 Pfizer Inc. Koniugaty przeciwciało anty-ptk7-lek
US10464442B2 (en) * 2016-10-11 2019-11-05 Honda Motor Co., Ltd. Non-contact power supply system and power transmission apparatus, and designing method and installing method of power transmission apparatus
US20190048073A1 (en) 2017-07-20 2019-02-14 Pfizer Inc. Anti-gd3 antibodies and antibody-drug conjugates
WO2019109188A1 (en) * 2017-12-06 2019-06-13 Ontario Institute For Cancer Research (Oicr) Acyl hydrazone linkers, methods and uses thereof
WO2019119141A1 (en) 2017-12-22 2019-06-27 Ontario Institute For Cancer Research (Oicr) Heterocyclic acyl hydrazone linkers, methods and uses thereof
CN111647865B (zh) * 2020-08-06 2020-11-24 北京卓立汉光仪器有限公司 溅射镀膜方法、装置及系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970198A (en) 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5108912A (en) * 1987-01-30 1992-04-28 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5770701A (en) * 1987-10-30 1998-06-23 American Cyanamid Company Process for preparing targeted forms of methyltrithio antitumor agents
US5053394A (en) 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US5773001A (en) * 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
TW200806685A (en) * 2006-02-21 2008-02-01 Wyeth Corp Processes for the convergent synthesis of calicheamicin derivatives

Also Published As

Publication number Publication date
ES2670709T3 (es) 2018-05-31
US20140081010A1 (en) 2014-03-20
US8546549B2 (en) 2013-10-01
ES2527107T3 (es) 2015-01-20
RU2436790C2 (ru) 2011-12-20
JP2013040213A (ja) 2013-02-28
CA2642194C (en) 2015-12-08
US20090312530A1 (en) 2009-12-17
AR059592A1 (es) 2008-04-16
CY1120206T1 (el) 2018-12-12
EP2799441A1 (en) 2014-11-05
WO2007098124A3 (en) 2007-12-27
US20070197455A1 (en) 2007-08-23
WO2007098124A2 (en) 2007-08-30
SV2009003002A (es) 2009-01-28
TW200806685A (en) 2008-02-01
BRPI0708149A2 (pt) 2011-05-17
JP2009527557A (ja) 2009-07-30
JP2014196352A (ja) 2014-10-16
KR20080094925A (ko) 2008-10-27
US20130018179A1 (en) 2013-01-17
AU2007217795B2 (en) 2012-09-13
DK1987048T3 (en) 2014-12-15
PT2799441T (pt) 2018-05-29
HK1203515A1 (en) 2015-10-30
US8273862B2 (en) 2012-09-25
EP2799441B1 (en) 2018-04-18
EP1987048B1 (en) 2014-11-19
IL193343A0 (en) 2009-08-03
CN101389639A (zh) 2009-03-18
IL193343A (en) 2017-03-30
JP5179383B2 (ja) 2013-04-10
CN101389639B (zh) 2012-07-18
US9802890B2 (en) 2017-10-31
PL2799441T3 (pl) 2018-08-31
SG170013A1 (en) 2011-04-29
AU2007217795A1 (en) 2007-08-30
JP2016011316A (ja) 2016-01-21
ZA200807196B (en) 2009-05-27
US10343989B2 (en) 2019-07-09
EP1987048A2 (en) 2008-11-05
RU2008132777A (ru) 2010-03-27
NO20083698L (no) 2008-11-12
GT200800161A (es) 2009-01-15
MX2008010768A (es) 2008-11-28
DK2799441T3 (en) 2018-05-28
ECSP088691A (es) 2008-09-29
PT1987048E (pt) 2015-01-14
PE20071229A1 (es) 2007-11-30
KR101454489B1 (ko) 2014-10-27
CA2642194A1 (en) 2007-08-30
CL2009001487A1 (es) 2009-10-16
TR201808220T4 (tr) 2018-07-23
US20150315138A1 (en) 2015-11-05
PL1987048T3 (pl) 2015-03-31
BRPI0708149B1 (pt) 2022-01-25
HUE037880T2 (hu) 2018-09-28
SI1987048T1 (sl) 2015-01-30
US20180016228A1 (en) 2018-01-18
SI2799441T1 (en) 2018-07-31

Similar Documents

Publication Publication Date Title
CR10230A (es) Proceso para la síntesis convergente de los derivados de caliqueamicina
CR8929A (es) Polimorfo ii de rapamicina y usos del mismo
CR10530A (es) Anticuerpos anti-dlla4 y metodos que los usan
NI201000005A (es) Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico.
CR20150088A (es) Anticuerpos anti-notch1 nrr
CR10149A (es) Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico
ECSP099619A (es) Anticuerpos anti-robo4 y sus usos
CU20110029A7 (es) Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
PA8667201A1 (es) Nuevos compuestos farmaceuticos
ECSP10010095A (es) 2'-fluoro-2'-desoxitetrahidrouridinas como inhibidores de citidina desaminasa
CR20110028A (es) Derivados de pirimidina como inhibidores de cinasa
ECSP088733A (es) Anticuerpos anti-5t4 y usos de los mismos
HN2006037713A (es) Compuestos utiles en terapia
CL2008002295A1 (es) Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
BRPI0820043A8 (pt) Atividades do receptor de vitamina d e seus usos
EA201000258A1 (ru) Новые гербициды
ECSP11011344A (es) Nuevos anticuerpos anti-?5?1 y sus usos
HN2009000566A (es) Nuevos derivados de diosmetina, su procedimiento de prearacion y las composiciones farmaceuticas que lo contienen.
CR10280A (es) Anticuerpos de la efgl7 y metodos de uso
ECSP088383A (es) Tetrahidroquinolinas, su síntesis e intermediarios campo de la invención
EA201000069A1 (ru) Новые гербициды
PA8659601A1 (es) Procedimiento para la preparacion de alcoholes aminoetoxibencilicos
CR10651A (es) Derivados de feniloxianilina
ECSP066818A (es) Proceso para la preparacion de inhibidores de triptasa

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)