ECSP088691A - Procesos para la síntesis convergente de los derivados de caliqueamicina - Google Patents

Procesos para la síntesis convergente de los derivados de caliqueamicina

Info

Publication number
ECSP088691A
ECSP088691A EC2008008691A ECSP088691A ECSP088691A EC SP088691 A ECSP088691 A EC SP088691A EC 2008008691 A EC2008008691 A EC 2008008691A EC SP088691 A ECSP088691 A EC SP088691A EC SP088691 A ECSP088691 A EC SP088691A
Authority
EC
Ecuador
Prior art keywords
derivatives
processes
caliqueamycin
convergent synthesis
convergent
Prior art date
Application number
EC2008008691A
Other languages
English (en)
Inventor
Justin Keith Moran
Jianxin Gu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38437933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088691(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP088691A publication Critical patent/ECSP088691A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esta invención describe procesos para la síntesis convergente de derivados de caliqueamicina, y análogos similares que utilizan intermedios de ligador bifuncional y trifuncional.
EC2008008691A 2006-02-21 2008-08-21 Procesos para la síntesis convergente de los derivados de caliqueamicina ECSP088691A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77537006P 2006-02-21 2006-02-21

Publications (1)

Publication Number Publication Date
ECSP088691A true ECSP088691A (es) 2008-09-29

Family

ID=38437933

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008691A ECSP088691A (es) 2006-02-21 2008-08-21 Procesos para la síntesis convergente de los derivados de caliqueamicina

Country Status (32)

Country Link
US (6) US20070197455A1 (es)
EP (2) EP1987048B1 (es)
JP (4) JP5179383B2 (es)
KR (1) KR101454489B1 (es)
CN (1) CN101389639B (es)
AR (1) AR059592A1 (es)
AU (1) AU2007217795B2 (es)
BR (1) BRPI0708149B1 (es)
CA (1) CA2642194C (es)
CL (1) CL2009001487A1 (es)
CR (1) CR10230A (es)
CY (1) CY1120206T1 (es)
DK (2) DK2799441T3 (es)
EC (1) ECSP088691A (es)
ES (2) ES2670709T3 (es)
GT (1) GT200800161A (es)
HK (1) HK1203515A1 (es)
HU (1) HUE037880T2 (es)
IL (1) IL193343A (es)
MX (1) MX2008010768A (es)
NO (1) NO20083698L (es)
PE (1) PE20071229A1 (es)
PL (2) PL1987048T3 (es)
PT (2) PT1987048E (es)
RU (1) RU2436790C2 (es)
SG (1) SG170013A1 (es)
SI (2) SI2799441T1 (es)
SV (1) SV2009003002A (es)
TR (1) TR201808220T4 (es)
TW (1) TW200806685A (es)
WO (1) WO2007098124A2 (es)
ZA (1) ZA200807196B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806685A (en) * 2006-02-21 2008-02-01 Wyeth Corp Processes for the convergent synthesis of calicheamicin derivatives
WO2011080739A2 (en) 2009-12-29 2011-07-07 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives
RU2724840C2 (ru) * 2012-08-16 2020-06-25 Пфайзер Инк. Способы гликоконъюгирования и композиции
RU2640197C1 (ru) * 2013-11-04 2017-12-27 Пфайзер Инк. Промежуточные соединения и способы синтеза производных калихеамицина
US9381205B2 (en) 2013-11-04 2016-07-05 Pfizer, Inc. Anti-EFNA4 antibody-drug conjugates
PL3137114T3 (pl) 2014-04-30 2021-06-28 Pfizer Inc. Koniugaty przeciwciało anty-ptk7-lek
US10464442B2 (en) * 2016-10-11 2019-11-05 Honda Motor Co., Ltd. Non-contact power supply system and power transmission apparatus, and designing method and installing method of power transmission apparatus
WO2019018647A1 (en) 2017-07-20 2019-01-24 Pfizer Inc. ANTI-GD3 ANTIBODIES AND CONJUGATES ANTIBODY-MEDICATION
EP3720842A4 (en) 2017-12-06 2021-11-03 Ontario Institute For Cancer Research ACYLHYDRAZONE LINKERS, METHODS, AND USES THEREOF
CA3086366A1 (en) 2017-12-22 2019-06-27 Ontario Institute For Cancer Research (Oicr) Heterocyclic acyl hydrazone linkers, methods and uses thereof
CN111647865B (zh) * 2020-08-06 2020-11-24 北京卓立汉光仪器有限公司 溅射镀膜方法、装置及系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970198A (en) 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5108912A (en) * 1987-01-30 1992-04-28 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5053394A (en) 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US5770701A (en) * 1987-10-30 1998-06-23 American Cyanamid Company Process for preparing targeted forms of methyltrithio antitumor agents
US5773001A (en) * 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
TW200806685A (en) * 2006-02-21 2008-02-01 Wyeth Corp Processes for the convergent synthesis of calicheamicin derivatives

Also Published As

Publication number Publication date
NO20083698L (no) 2008-11-12
CN101389639B (zh) 2012-07-18
AR059592A1 (es) 2008-04-16
US20180016228A1 (en) 2018-01-18
JP2009527557A (ja) 2009-07-30
CA2642194A1 (en) 2007-08-30
EP2799441B1 (en) 2018-04-18
SI1987048T1 (sl) 2015-01-30
US9802890B2 (en) 2017-10-31
JP2013040213A (ja) 2013-02-28
SV2009003002A (es) 2009-01-28
BRPI0708149A2 (pt) 2011-05-17
EP2799441A1 (en) 2014-11-05
JP5179383B2 (ja) 2013-04-10
DK2799441T3 (en) 2018-05-28
EP1987048B1 (en) 2014-11-19
PT2799441T (pt) 2018-05-29
JP2014196352A (ja) 2014-10-16
CA2642194C (en) 2015-12-08
ES2527107T3 (es) 2015-01-20
PT1987048E (pt) 2015-01-14
CN101389639A (zh) 2009-03-18
US8546549B2 (en) 2013-10-01
IL193343A (en) 2017-03-30
KR20080094925A (ko) 2008-10-27
DK1987048T3 (en) 2014-12-15
US20130018179A1 (en) 2013-01-17
WO2007098124A2 (en) 2007-08-30
ES2670709T3 (es) 2018-05-31
RU2436790C2 (ru) 2011-12-20
ZA200807196B (en) 2009-05-27
US10343989B2 (en) 2019-07-09
HUE037880T2 (hu) 2018-09-28
PL2799441T3 (pl) 2018-08-31
CL2009001487A1 (es) 2009-10-16
WO2007098124A3 (en) 2007-12-27
CR10230A (es) 2008-10-03
HK1203515A1 (en) 2015-10-30
MX2008010768A (es) 2008-11-28
PE20071229A1 (es) 2007-11-30
AU2007217795A1 (en) 2007-08-30
IL193343A0 (en) 2009-08-03
SI2799441T1 (en) 2018-07-31
EP1987048A2 (en) 2008-11-05
JP2016011316A (ja) 2016-01-21
GT200800161A (es) 2009-01-15
SG170013A1 (en) 2011-04-29
BRPI0708149B1 (pt) 2022-01-25
AU2007217795B2 (en) 2012-09-13
TW200806685A (en) 2008-02-01
US8273862B2 (en) 2012-09-25
US20070197455A1 (en) 2007-08-23
PL1987048T3 (pl) 2015-03-31
US20150315138A1 (en) 2015-11-05
RU2008132777A (ru) 2010-03-27
CY1120206T1 (el) 2018-12-12
TR201808220T4 (tr) 2018-07-23
US20140081010A1 (en) 2014-03-20
KR101454489B1 (ko) 2014-10-27
US20090312530A1 (en) 2009-12-17

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