RU2011115572A - Группа аминозамещенных бензоилпроизводных, их получение и применение - Google Patents

Группа аминозамещенных бензоилпроизводных, их получение и применение Download PDF

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RU2011115572A
RU2011115572A RU2011115572/04A RU2011115572A RU2011115572A RU 2011115572 A RU2011115572 A RU 2011115572A RU 2011115572/04 A RU2011115572/04 A RU 2011115572/04A RU 2011115572 A RU2011115572 A RU 2011115572A RU 2011115572 A RU2011115572 A RU 2011115572A
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pharmaceutically acceptable
lower alkyl
compounds
substituted
antiviral drugs
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Цзяньдун ЦЗЯН (CN)
Цзяньдун ЦЗЯН
Лиянь ЮЙ (CN)
Лиянь ЮЙ
Шань ЦЭНЬ (CN)
Шань ЦЭНЬ
Чжожун ЛИ (CN)
Чжожун ЛИ
Яньпин ЛИ (CN)
Яньпин ЛИ
Цзянь СЮЙ (CN)
Цзянь СЮЙ
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Инститьют Оф Медишинал Биотекнолоджи, Чайниз Академи Оф Медикал Сайенс (Cn)
Инститьют Оф Медишинал Биотекнолоджи, Чайниз Академи Оф Медикал Сайенс
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Abstract

1. Группа аминобензоилпроизводных, структуры которых выражены формулой (I): ! ! причем ! R1 - это H или одна или более из следующих групп в бензольном кольце: нитро-, галогено-, циано-, сложный эфир, амидо-, гидрокси-, меркапто-, замещенный или незамещенный низший алкил-, низшие алкокси- или арилокси-, низшие алкилтио- или арилтио-, амино- или замещенные аминогруппы и т.п., ! R2, R3 могут быть одинаковыми или различными, каждая может быть H, низшим алкилом, карбонильной или сульфонильной группой, ! X - это O, S, NH, NR5, CH2 или CHR6, ! Y - это С, S или SO, ! R4 и R5 каждая - это H, низший алкил, гидроксил, арил или замещенный арил. ! 2. Способ получения упомянутых соединений, показанных формулой (I), при этом процедура получения заключается в следующем: защищенное или ацилированное соединение A смешивают с 1-гидроксибензотриазолом и N,N'-диизопропилкарбодиимидом, смесь растворяют в DMF (диметилформамид) в мольном соотношении 1:0,5-3, затем через 0,5 ч в смесь добавляют B и ведут реакцию в течение 24 ч при комнатной температуре, продукт выделяют и очищают методом колоночной хроматографии ! ! где ! Х=O, S или NH, ! Y=C, S или SO, ! R1, R2, R3 и R4 такие же, как указано в п.1. ! 3. Фармацевтически приемлемые соли упомянутых соединений по п.1. ! 4. Фармацевтические композиции соединений по п.1, при этом композиции содержат упомянутые соединения в терапевтически эффективных количествах в качестве активных компонентов и один или больше фармацевтически приемлемых носителей. ! 5. Применение соединений по п.1 для получения противовирусных препаратов. ! 6. Фармацевтически приемлемые соли по п.3 для получения противовирусных препаратов. !7. Фармацевтические композиции по п.4, для получения прот

Claims (7)

1. Группа аминобензоилпроизводных, структуры которых выражены формулой (I):
Figure 00000001
причем
R1 - это H или одна или более из следующих групп в бензольном кольце: нитро-, галогено-, циано-, сложный эфир, амидо-, гидрокси-, меркапто-, замещенный или незамещенный низший алкил-, низшие алкокси- или арилокси-, низшие алкилтио- или арилтио-, амино- или замещенные аминогруппы и т.п.,
R2, R3 могут быть одинаковыми или различными, каждая может быть H, низшим алкилом, карбонильной или сульфонильной группой,
X - это O, S, NH, NR5, CH2 или CHR6,
Y - это С, S или SO,
R4 и R5 каждая - это H, низший алкил, гидроксил, арил или замещенный арил.
2. Способ получения упомянутых соединений, показанных формулой (I), при этом процедура получения заключается в следующем: защищенное или ацилированное соединение A смешивают с 1-гидроксибензотриазолом и N,N'-диизопропилкарбодиимидом, смесь растворяют в DMF (диметилформамид) в мольном соотношении 1:0,5-3, затем через 0,5 ч в смесь добавляют B и ведут реакцию в течение 24 ч при комнатной температуре, продукт выделяют и очищают методом колоночной хроматографии
Figure 00000002
где
Х=O, S или NH,
Y=C, S или SO,
R1, R2, R3 и R4 такие же, как указано в п.1.
3. Фармацевтически приемлемые соли упомянутых соединений по п.1.
4. Фармацевтические композиции соединений по п.1, при этом композиции содержат упомянутые соединения в терапевтически эффективных количествах в качестве активных компонентов и один или больше фармацевтически приемлемых носителей.
5. Применение соединений по п.1 для получения противовирусных препаратов.
6. Фармацевтически приемлемые соли по п.3 для получения противовирусных препаратов.
7. Фармацевтические композиции по п.4, для получения противовирусных препаратов.
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