BR9814327A - Compostos de tiouréia e benzamida, composições e pro-cessos para tratamento ou prevenção de doenças infla-matórias e arteriosclerose - Google Patents
Compostos de tiouréia e benzamida, composições e pro-cessos para tratamento ou prevenção de doenças infla-matórias e arterioscleroseInfo
- Publication number
- BR9814327A BR9814327A BR9814327-1A BR9814327A BR9814327A BR 9814327 A BR9814327 A BR 9814327A BR 9814327 A BR9814327 A BR 9814327A BR 9814327 A BR9814327 A BR 9814327A
- Authority
- BR
- Brazil
- Prior art keywords
- processes
- arteriosclerosis
- compositions
- inflammatory diseases
- thiourea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Patente de Invenção: <B>"COMPOSTOS DE TIOURéIA E BENZAMIDA, COMPOSIçõES E PROCESSOS PARA TRATAMENTO OU PREVENçãO DE DOENçAS INFLAMATóRIAS E ARTERIOSCLEROSE"<D>. A presente invenção provê compostos da fórmula (I). A presente invenção também provê processos para tratamento ou prevenção de inflamação ou arteriosclerose, e uma composição farmacêutica que contém um composto da fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6860497P | 1997-12-23 | 1997-12-23 | |
PCT/US1998/024688 WO1999032433A1 (en) | 1997-12-23 | 1998-11-20 | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9814327A true BR9814327A (pt) | 2000-10-03 |
Family
ID=22083601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9814327-1A BR9814327A (pt) | 1997-12-23 | 1998-11-20 | Compostos de tiouréia e benzamida, composições e pro-cessos para tratamento ou prevenção de doenças infla-matórias e arteriosclerose |
Country Status (17)
Country | Link |
---|---|
US (2) | US6268387B1 (pt) |
EP (1) | EP1042276B1 (pt) |
JP (1) | JP2001526255A (pt) |
KR (1) | KR20010033470A (pt) |
AR (1) | AR024826A1 (pt) |
AT (1) | ATE282591T1 (pt) |
AU (1) | AU1529799A (pt) |
BR (1) | BR9814327A (pt) |
CA (1) | CA2300197A1 (pt) |
CO (1) | CO4990966A1 (pt) |
DE (1) | DE69827664T2 (pt) |
ES (1) | ES2234169T3 (pt) |
NZ (1) | NZ502963A (pt) |
PE (1) | PE20000064A1 (pt) |
UY (1) | UY25322A1 (pt) |
WO (1) | WO1999032433A1 (pt) |
ZA (1) | ZA9811805B (pt) |
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ATE449764T1 (de) * | 1999-12-28 | 2009-12-15 | Pharmacopeia Inc | Cytokine, insbesondere tnf-alpha, hemmer |
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JP4394953B2 (ja) | 2002-01-22 | 2010-01-06 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除のためのキナゾリン(ジ)オン |
CN1287789C (zh) * | 2002-02-08 | 2006-12-06 | 霍夫曼-拉罗奇有限公司 | 15-脂肪氧化酶抑制剂在制备减少骨损失的药物中的应用 |
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CN109503518B (zh) * | 2018-11-15 | 2021-03-30 | 中国医学科学院医药生物技术研究所 | 一种取代的双芳香基酰胺化合物及其制备方法和应用 |
WO2021026257A1 (en) * | 2019-08-06 | 2021-02-11 | Empirico Inc. | Prodrugs of alox-15 inhibitors and methods of using the same |
EP4081199A4 (en) * | 2019-12-23 | 2024-01-17 | SRI International | LIPOXYGENASE INHIBITORS |
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Publication number | Priority date | Publication date | Assignee | Title |
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CH373028A (de) * | 1960-08-29 | 1963-11-15 | Geigy Ag J R | Verfahren zur Herstellung neuer Aminobenzoesäurederivate |
DE3743517A1 (de) | 1987-12-22 | 1989-07-06 | Basf Ag | Verfahren zur herstellung von aromatischen hydroxycarbonsaeuren |
DE3816703A1 (de) | 1988-05-17 | 1989-11-30 | Hoechst Ag | Heterocyclisch substituierte phenoxysulfonylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als herbizide oder pflanzenwachstumsregulatoren |
US5041545A (en) | 1989-04-06 | 1991-08-20 | Atochem North America, Inc. | 2-hydroxybenzophenone hydrazides and derivatives thereof |
US5256686A (en) * | 1989-06-27 | 1993-10-26 | Ono Pharmaceutical Co., Ltd. | Phenylalkan(en)oic acid |
US5177246A (en) | 1989-10-02 | 1993-01-05 | Ciba-Geigy Corporation | Hydroxphenylcarboxylic acid esters as stabilizers |
CA2095718A1 (en) | 1990-11-22 | 1992-05-23 | Hans-Rudolf Waespe | Isonicotinic acid derivatives and related spiro compounds with herbicidal action |
US5049496A (en) | 1990-12-24 | 1991-09-17 | General Electric Company | Method for microbiologically hydroxylating biphenyl and terphenyl compounds |
US5382690A (en) | 1992-08-11 | 1995-01-17 | Mitsui Toatsu Chemicals, Incorporated | Method for preparing aromatic secondary amino compound |
DE4238994A1 (de) | 1992-11-19 | 1994-05-26 | Basf Ag | Aniline als Markierungsmittel für Mineralöle |
DE4331416A1 (de) | 1993-12-09 | 1995-06-14 | Bayer Ag | Verwendung von Phenylcarbonsäure-amiden als Kristallisationsinhibitoren |
-
1998
- 1998-11-20 AU AU15297/99A patent/AU1529799A/en not_active Abandoned
- 1998-11-20 BR BR9814327-1A patent/BR9814327A/pt not_active IP Right Cessation
- 1998-11-20 DE DE69827664T patent/DE69827664T2/de not_active Expired - Fee Related
- 1998-11-20 AT AT98959510T patent/ATE282591T1/de not_active IP Right Cessation
- 1998-11-20 WO PCT/US1998/024688 patent/WO1999032433A1/en active IP Right Grant
- 1998-11-20 NZ NZ502963A patent/NZ502963A/en unknown
- 1998-11-20 KR KR1020007006971A patent/KR20010033470A/ko not_active Application Discontinuation
- 1998-11-20 ES ES98959510T patent/ES2234169T3/es not_active Expired - Lifetime
- 1998-11-20 US US09/529,135 patent/US6268387B1/en not_active Expired - Fee Related
- 1998-11-20 JP JP2000525370A patent/JP2001526255A/ja not_active Withdrawn
- 1998-11-20 CA CA002300197A patent/CA2300197A1/en not_active Abandoned
- 1998-11-20 EP EP98959510A patent/EP1042276B1/en not_active Expired - Lifetime
- 1998-12-22 PE PE1998001268A patent/PE20000064A1/es not_active Application Discontinuation
- 1998-12-22 AR ARP980106614A patent/AR024826A1/es unknown
- 1998-12-22 CO CO98076093A patent/CO4990966A1/es unknown
- 1998-12-22 ZA ZA9811805A patent/ZA9811805B/xx unknown
- 1998-12-22 UY UY25322A patent/UY25322A1/es unknown
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2001
- 2001-05-15 US US09/858,089 patent/US6528528B2/en not_active Expired - Fee Related
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NZ502963A (en) | 2002-06-28 |
UY25322A1 (es) | 2004-07-30 |
AU1529799A (en) | 1999-07-12 |
US6268387B1 (en) | 2001-07-31 |
PE20000064A1 (es) | 2000-02-11 |
CA2300197A1 (en) | 1999-07-01 |
DE69827664D1 (de) | 2004-12-23 |
DE69827664T2 (de) | 2005-12-08 |
AR024826A1 (es) | 2002-10-30 |
KR20010033470A (ko) | 2001-04-25 |
EP1042276A1 (en) | 2000-10-11 |
ATE282591T1 (de) | 2004-12-15 |
WO1999032433A1 (en) | 1999-07-01 |
ZA9811805B (en) | 1999-06-29 |
ES2234169T3 (es) | 2005-06-16 |
EP1042276B1 (en) | 2004-11-17 |
JP2001526255A (ja) | 2001-12-18 |
CO4990966A1 (es) | 2000-12-26 |
US6528528B2 (en) | 2003-03-04 |
US20010031874A1 (en) | 2001-10-18 |
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