BR9907300A - Inibidores do fator xa oxoaza-heterociclila substituìdos - Google Patents
Inibidores do fator xa oxoaza-heterociclila substituìdosInfo
- Publication number
- BR9907300A BR9907300A BR9907300-5A BR9907300A BR9907300A BR 9907300 A BR9907300 A BR 9907300A BR 9907300 A BR9907300 A BR 9907300A BR 9907300 A BR9907300 A BR 9907300A
- Authority
- BR
- Brazil
- Prior art keywords
- factor
- inhibitors
- substituted
- oxoaza
- heterocyclyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
Patente de Invenção: <B>"INIBIDORES DO FATOR Xa OXOAZAHETEROCICLILA SUBSTITUìDOS"<D>. A presente invenção está dirigida a compostos de oxoazaeterociclica os quais inibem o Fator Xa, a composições farmacêuticas compreendendo esses compostos, a intermediários úteis para o preparo desses compostos e a um método de inibição do Fator Xa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7270798P | 1998-01-27 | 1998-01-27 | |
PCT/US1999/001682 WO1999037304A1 (en) | 1998-01-27 | 1999-01-27 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9907300A true BR9907300A (pt) | 2000-10-24 |
Family
ID=22109280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9907300-5A BR9907300A (pt) | 1998-01-27 | 1999-01-27 | Inibidores do fator xa oxoaza-heterociclila substituìdos |
Country Status (25)
Country | Link |
---|---|
US (1) | US7612075B2 (pt) |
EP (1) | EP1051176B1 (pt) |
JP (1) | JP4676613B2 (pt) |
KR (1) | KR20010034442A (pt) |
CN (1) | CN1291892A (pt) |
AP (1) | AP2000001889A0 (pt) |
AT (1) | ATE346050T1 (pt) |
AU (1) | AU745425B2 (pt) |
BG (1) | BG104633A (pt) |
BR (1) | BR9907300A (pt) |
CA (1) | CA2319198C (pt) |
DE (1) | DE69934093T2 (pt) |
EA (1) | EA200000768A1 (pt) |
EE (1) | EE200000435A (pt) |
HU (1) | HUP0101810A3 (pt) |
IL (2) | IL137517A0 (pt) |
IS (1) | IS5574A (pt) |
NO (1) | NO20003808L (pt) |
PL (1) | PL342243A1 (pt) |
SK (1) | SK11082000A3 (pt) |
TR (1) | TR200002182T2 (pt) |
UA (1) | UA59433C2 (pt) |
WO (1) | WO1999037304A1 (pt) |
YU (1) | YU47600A (pt) |
ZA (1) | ZA99607B (pt) |
Families Citing this family (143)
Publication number | Priority date | Publication date | Assignee | Title |
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AU9280698A (en) * | 1997-09-30 | 1999-04-23 | Daiichi Pharmaceutical Co., Ltd. | Sulfonyl derivatives |
WO1999040075A1 (fr) * | 1998-02-05 | 1999-08-12 | Takeda Chemical Industries, Ltd. | Derives de sulfamide, leur procede de production et leur utilisation |
US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
AU5196399A (en) * | 1998-08-11 | 2000-03-06 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
WO2000032590A1 (en) * | 1998-11-25 | 2000-06-08 | Aventis Pharmaceuticals Products Inc. | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
AU3127900A (en) * | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
AU5566300A (en) | 1999-06-22 | 2001-01-09 | Takeda Chemical Industries Ltd. | Acylhydrazine derivatives, process for preparing the same and use thereof |
HUP0203375A3 (en) * | 1999-07-28 | 2005-03-29 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl compounds |
SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
JP2001294572A (ja) * | 2000-02-09 | 2001-10-23 | Dai Ichi Seiyaku Co Ltd | 新規スルホニル誘導体 |
DE10012732A1 (de) * | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
AR030357A1 (es) | 2000-08-18 | 2003-08-20 | Lundbeck & Co As H | Derivados 4 -, 5 -, 6 - y 7-indol |
WO2002026734A1 (en) * | 2000-09-29 | 2002-04-04 | Cor Therapeutics, Inc. | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR Xa |
WO2002038560A1 (fr) | 2000-11-08 | 2002-05-16 | Takeda Chemical Industries, Ltd. | Derives de carbamate, ainsi que procede de production et utilisation de ceux-ci |
DE10105989A1 (de) | 2001-02-09 | 2002-08-14 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
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GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0114005D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
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1999
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- 1999-01-27 DE DE69934093T patent/DE69934093T2/de not_active Expired - Lifetime
- 1999-01-27 UA UA2000085034A patent/UA59433C2/uk unknown
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DE69934093T2 (de) | 2007-06-21 |
CN1291892A (zh) | 2001-04-18 |
KR20010034442A (ko) | 2001-04-25 |
IL137517A0 (en) | 2001-07-24 |
AU745425B2 (en) | 2002-03-21 |
DE69934093D1 (de) | 2007-01-04 |
IS5574A (is) | 2000-07-25 |
IL137517A (en) | 2006-12-10 |
WO1999037304A1 (en) | 1999-07-29 |
EP1051176B1 (en) | 2006-11-22 |
PL342243A1 (en) | 2001-06-04 |
EP1051176A1 (en) | 2000-11-15 |
EA200000768A1 (ru) | 2001-06-25 |
AU2653399A (en) | 1999-08-09 |
ATE346050T1 (de) | 2006-12-15 |
BG104633A (bg) | 2001-03-30 |
US20040102450A1 (en) | 2004-05-27 |
JP2002501024A (ja) | 2002-01-15 |
US7612075B2 (en) | 2009-11-03 |
TR200002182T2 (tr) | 2000-12-21 |
NO20003808D0 (no) | 2000-07-25 |
HUP0101810A3 (en) | 2002-05-28 |
SK11082000A3 (sk) | 2001-01-18 |
CA2319198A1 (en) | 1999-07-29 |
AP2000001889A0 (en) | 2000-09-30 |
YU47600A (sh) | 2002-09-19 |
HUP0101810A2 (hu) | 2002-04-29 |
EE200000435A (et) | 2002-02-15 |
EP1051176A4 (en) | 2002-06-12 |
ZA99607B (en) | 1999-07-27 |
CA2319198C (en) | 2011-02-22 |
UA59433C2 (uk) | 2003-09-15 |
JP4676613B2 (ja) | 2011-04-27 |
NO20003808L (no) | 2000-09-26 |
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