HUP0101810A3 - Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them - Google Patents
Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing themInfo
- Publication number
- HUP0101810A3 HUP0101810A3 HU0101810A HUP0101810A HUP0101810A3 HU P0101810 A3 HUP0101810 A3 HU P0101810A3 HU 0101810 A HU0101810 A HU 0101810A HU P0101810 A HUP0101810 A HU P0101810A HU P0101810 A3 HUP0101810 A3 HU P0101810A3
- Authority
- HU
- Hungary
- Prior art keywords
- inhibitors
- pharmaceutical compositions
- compositions containing
- factor
- substituted
- Prior art date
Links
- 229940123583 Factor Xa inhibitor Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7270798P | 1998-01-27 | 1998-01-27 | |
| PCT/US1999/001682 WO1999037304A1 (en) | 1998-01-27 | 1999-01-27 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0101810A2 HUP0101810A2 (hu) | 2002-04-29 |
| HUP0101810A3 true HUP0101810A3 (en) | 2002-05-28 |
Family
ID=22109280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101810A HUP0101810A3 (en) | 1998-01-27 | 1999-01-27 | Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7612075B2 (hu) |
| EP (1) | EP1051176B1 (hu) |
| JP (1) | JP4676613B2 (hu) |
| KR (1) | KR20010034442A (hu) |
| CN (1) | CN1291892A (hu) |
| AP (1) | AP2000001889A0 (hu) |
| AT (1) | ATE346050T1 (hu) |
| AU (1) | AU745425B2 (hu) |
| BG (1) | BG104633A (hu) |
| BR (1) | BR9907300A (hu) |
| CA (1) | CA2319198C (hu) |
| DE (1) | DE69934093T2 (hu) |
| EA (1) | EA200000768A1 (hu) |
| EE (1) | EE200000435A (hu) |
| HU (1) | HUP0101810A3 (hu) |
| IL (2) | IL137517A0 (hu) |
| IS (1) | IS5574A (hu) |
| NO (1) | NO20003808L (hu) |
| PL (1) | PL342243A1 (hu) |
| SK (1) | SK11082000A3 (hu) |
| TR (1) | TR200002182T2 (hu) |
| UA (1) | UA59433C2 (hu) |
| WO (1) | WO1999037304A1 (hu) |
| YU (1) | YU47600A (hu) |
| ZA (1) | ZA99607B (hu) |
Families Citing this family (143)
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|---|---|---|---|---|
| IL135180A0 (en) | 1997-09-30 | 2001-05-20 | Daiichi Seiyaku Co | Sulfonyl derivatives |
| CA2317017A1 (en) * | 1998-02-05 | 1999-08-12 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
| US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| CA2340100A1 (en) * | 1998-08-11 | 2000-02-24 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
| JP2003529531A (ja) * | 1998-11-25 | 2003-10-07 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 置換オキソアザへテロシクリルＸａ因子阻害剤 |
| CA2348740A1 (en) * | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Thrombin or factor xa inhibitors |
| DE60027718T2 (de) | 1999-06-22 | 2007-05-16 | Takeda Pharmaceutical Co. Ltd. | Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung |
| AU773227B2 (en) * | 1999-07-28 | 2004-05-20 | Aventis Pharmaceuticals Inc. | Substituted oxoazaheterocyclyl compounds |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| JP2001294572A (ja) * | 2000-02-09 | 2001-10-23 | Dai Ichi Seiyaku Co Ltd | 新規スルホニル誘導体 |
| DE10012732A1 (de) | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
| AR030357A1 (es) * | 2000-08-18 | 2003-08-20 | Lundbeck & Co As H | Derivados 4 -, 5 -, 6 - y 7-indol |
| JP2004509958A (ja) * | 2000-09-29 | 2004-04-02 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 第Ｘａ因子のインヒビターとしてのピペラジン−２−オンアミド |
| DE60116655T2 (de) | 2000-11-08 | 2006-11-16 | Takeda Pharmaceutical Co. Ltd. | Carbamatderivate, verfahren zu deren herstellung und deren verwendung |
| DE10105989A1 (de) | 2001-02-09 | 2002-08-14 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| AU2002307416B2 (en) | 2001-04-18 | 2005-08-11 | Euro-Celtique S.A. | Nociceptin analogs |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0114005D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| ES2258642T3 (es) | 2001-07-02 | 2006-09-01 | Astrazeneca Ab | Derivados de piperidina utiles como moduladores de la actividad del receptor de quimiocina. |
| DE10134482A1 (de) | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
| DE10137163A1 (de) | 2001-07-30 | 2003-02-13 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| WO2003017939A2 (en) | 2001-08-24 | 2003-03-06 | Yale University | Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment |
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| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
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| KR20030084444A (ko) * | 2002-04-26 | 2003-11-01 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
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1999
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- 1999-01-27 PL PL99342243A patent/PL342243A1/xx not_active Application Discontinuation
- 1999-01-27 EE EEP200000435A patent/EE200000435A/xx unknown
- 1999-01-27 ZA ZA9900607A patent/ZA99607B/xx unknown
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- 1999-01-27 IL IL13751799A patent/IL137517A0/xx active IP Right Grant
- 1999-01-27 UA UA2000085034A patent/UA59433C2/uk unknown
- 1999-01-27 AU AU26533/99A patent/AU745425B2/en not_active Ceased
- 1999-01-27 BR BR9907300-5A patent/BR9907300A/pt not_active IP Right Cessation
- 1999-01-27 JP JP2000528286A patent/JP4676613B2/ja not_active Expired - Fee Related
- 1999-01-27 YU YU47600A patent/YU47600A/sh unknown
- 1999-01-27 EP EP99906684A patent/EP1051176B1/en not_active Expired - Lifetime
- 1999-01-27 DE DE69934093T patent/DE69934093T2/de not_active Expired - Lifetime
- 1999-01-27 CN CN99803501A patent/CN1291892A/zh active Pending
- 1999-01-27 TR TR2000/02182T patent/TR200002182T2/xx unknown
- 1999-01-27 SK SK1108-2000A patent/SK11082000A3/sk unknown
- 1999-01-27 AT AT99906684T patent/ATE346050T1/de not_active IP Right Cessation
- 1999-01-27 EA EA200000768A patent/EA200000768A1/ru unknown
- 1999-01-27 KR KR1020007008221A patent/KR20010034442A/ko not_active Application Discontinuation
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- 2000-07-25 BG BG104633A patent/BG104633A/bg unknown
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Also Published As
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| IL137517A (en) | 2006-12-10 |
| US20040102450A1 (en) | 2004-05-27 |
| SK11082000A3 (sk) | 2001-01-18 |
| EE200000435A (et) | 2002-02-15 |
| EP1051176B1 (en) | 2006-11-22 |
| KR20010034442A (ko) | 2001-04-25 |
| EP1051176A4 (en) | 2002-06-12 |
| JP2002501024A (ja) | 2002-01-15 |
| CA2319198A1 (en) | 1999-07-29 |
| DE69934093T2 (de) | 2007-06-21 |
| PL342243A1 (en) | 2001-06-04 |
| IL137517A0 (en) | 2001-07-24 |
| UA59433C2 (uk) | 2003-09-15 |
| US7612075B2 (en) | 2009-11-03 |
| BR9907300A (pt) | 2000-10-24 |
| HUP0101810A2 (hu) | 2002-04-29 |
| ZA99607B (en) | 1999-07-27 |
| CN1291892A (zh) | 2001-04-18 |
| NO20003808L (no) | 2000-09-26 |
| EA200000768A1 (ru) | 2001-06-25 |
| AU2653399A (en) | 1999-08-09 |
| EP1051176A1 (en) | 2000-11-15 |
| BG104633A (bg) | 2001-03-30 |
| JP4676613B2 (ja) | 2011-04-27 |
| WO1999037304A1 (en) | 1999-07-29 |
| AU745425B2 (en) | 2002-03-21 |
| ATE346050T1 (de) | 2006-12-15 |
| NO20003808D0 (no) | 2000-07-25 |
| AP2000001889A0 (en) | 2000-09-30 |
| TR200002182T2 (tr) | 2000-12-21 |
| YU47600A (sh) | 2002-09-19 |
| CA2319198C (en) | 2011-02-22 |
| DE69934093D1 (de) | 2007-01-04 |
| IS5574A (is) | 2000-07-25 |
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