JPS5793962A - Carbostyryl derivative - Google Patents

Carbostyryl derivative

Info

Publication number
JPS5793962A
JPS5793962A JP17004080A JP17004080A JPS5793962A JP S5793962 A JPS5793962 A JP S5793962A JP 17004080 A JP17004080 A JP 17004080A JP 17004080 A JP17004080 A JP 17004080A JP S5793962 A JPS5793962 A JP S5793962A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
alkyl
shown
formula ii
etc
group shown
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17004080A
Other versions
JPS6340429B2 (en )
Inventor
Kazuyuki Nakagawa
Takao Nishi
Tatsuyoshi Tanaka
Original Assignee
Otsuka Pharmaceut Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

NEW MATERIAL:A compound shown by the formulaI[R1 is H, alkyl, alkenyl, etc.; R2 is H, a group shown by the formula II (R4 is cycloalkyl which may have alkyl, alkoxy, OH, etc. on the ring, OH-substituted alkyl, etc.; A is alkyelene; Q is C=O, or CH2); R3 is H, alkyl, a group shown by the formula II; with the proviso that only one of R2 and R3 is the group shown by the formula II, and when Q is CH2, R4 must not be unsubstituted alkyl]. The carbon-carbon bond between the 3 position and 4 position of the carbostyryl skeleton is a single or double bond].
EXAMPLE: 6-{3-[4-(4-Fluorophenyl)-1-piperazinylcarbonyl]propoxy}-3,4,-dihydrocarbostyryl.
USE: A preventive and remedy for thrombosis and ischemic heart disease, antiphlogistic, cardiac, phosphodiesterase inhibitor.
PROCESS: A carboxyalkoxycarbostyryl derivative shown by the formula III (R3' is H or alkyl) is reacted with an amine shown by the formula IV, to give a compound shown by the formula II where R2 is a group shown by the formula II and R3 is R3'.
COPYRIGHT: (C)1982,JPO&Japio
JP17004080A 1980-12-01 1980-12-01 Expired JPS6340429B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17004080A JPS6340429B2 (en) 1980-12-01 1980-12-01

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17004080A JPS6340429B2 (en) 1980-12-01 1980-12-01

Publications (2)

Publication Number Publication Date
JPS5793962A true true JPS5793962A (en) 1982-06-11
JPS6340429B2 JPS6340429B2 (en) 1988-08-11

Family

ID=15897492

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17004080A Expired JPS6340429B2 (en) 1980-12-01 1980-12-01

Country Status (1)

Country Link
JP (1) JPS6340429B2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57175168A (en) * 1981-04-17 1982-10-28 Otsuka Pharmaceut Co Ltd Carbostyril derivative
EP0318235A2 (en) * 1987-11-25 1989-05-31 Takeda Chemical Industries, Ltd. PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
WO1992017178A1 (en) * 1991-04-03 1992-10-15 Otsuka Pharmaceutical Company, Limited Remedy for thrombosis and phosphodiesterase inhibitor
WO1993000902A1 (en) * 1991-07-03 1993-01-21 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
WO1996021447A1 (en) * 1995-01-09 1996-07-18 Otsuka Pharmaceutical Company, Limited Use of carbostyril compounds for inhibition of tnf-alpha
JP2002501024A (en) * 1998-01-27 2002-01-15 アベンティス ファーマスーティカルズ プロダクツ インコーポレイテッド Substituted oxo azaheterocyclyl Factor Xa inhibitor

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0546418B2 (en) * 1987-04-14 1993-07-13 Naka Kogyo Kk

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57175168A (en) * 1981-04-17 1982-10-28 Otsuka Pharmaceut Co Ltd Carbostyril derivative
EP0318235A2 (en) * 1987-11-25 1989-05-31 Takeda Chemical Industries, Ltd. PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof
EP0318235A3 (en) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
EP0531548A1 (en) * 1991-04-03 1993-03-17 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as anti-thrombotic agents
US5532253A (en) * 1991-04-03 1996-07-02 Otsuka Pharmaceutical Company, Limited Agent for treating thrombosis and phosphodiesterase inhibitor
WO1992017178A1 (en) * 1991-04-03 1992-10-15 Otsuka Pharmaceutical Company, Limited Remedy for thrombosis and phosphodiesterase inhibitor
US5401754A (en) * 1991-04-03 1995-03-28 Otsuka Pharmaceutical Company, Limited Agent for treating thrombosis and phosphodiesterase inhibitor
EP0531548B1 (en) * 1991-04-03 1995-09-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as anti-thrombotic agents
WO1993000902A1 (en) * 1991-07-03 1993-01-21 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
WO1996021447A1 (en) * 1995-01-09 1996-07-18 Otsuka Pharmaceutical Company, Limited Use of carbostyril compounds for inhibition of tnf-alpha
JP2002501024A (en) * 1998-01-27 2002-01-15 アベンティス ファーマスーティカルズ プロダクツ インコーポレイテッド Substituted oxo azaheterocyclyl Factor Xa inhibitor
JP4676613B2 (en) * 1998-01-27 2011-04-27 アベンティス・ファーマスーティカルズ・インコーポレイテツド Substituted oxo azaheterocyclyl factor Xa inhibitor

Also Published As

Publication number Publication date Type
JPS6340429B2 (en) 1988-08-11 grant

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