JPS5793962A - Carbostyryl derivative - Google Patents
Carbostyryl derivativeInfo
- Publication number
- JPS5793962A JPS5793962A JP17004080A JP17004080A JPS5793962A JP S5793962 A JPS5793962 A JP S5793962A JP 17004080 A JP17004080 A JP 17004080A JP 17004080 A JP17004080 A JP 17004080A JP S5793962 A JPS5793962 A JP S5793962A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- group shown
- carbon
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound shown by the formulaI[R1 is H, alkyl, alkenyl, etc.; R2 is H, a group shown by the formula II (R4 is cycloalkyl which may have alkyl, alkoxy, OH, etc. on the ring, OH-substituted alkyl, etc.; A is alkyelene; Q is C=O, or CH2); R3 is H, alkyl, a group shown by the formula II; with the proviso that only one of R2 and R3 is the group shown by the formula II, and when Q is CH2, R4 must not be unsubstituted alkyl]. The carbon-carbon bond between the 3 position and 4 position of the carbostyryl skeleton is a single or double bond].
EXAMPLE: 6-{3-[4-(4-Fluorophenyl)-1-piperazinylcarbonyl]propoxy}-3,4,-dihydrocarbostyryl.
USE: A preventive and remedy for thrombosis and ischemic heart disease, antiphlogistic, cardiac, phosphodiesterase inhibitor.
PROCESS: A carboxyalkoxycarbostyryl derivative shown by the formula III (R3' is H or alkyl) is reacted with an amine shown by the formula IV, to give a compound shown by the formula II where R2 is a group shown by the formula II and R3 is R3'.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17004080A JPS5793962A (en) | 1980-12-01 | 1980-12-01 | Carbostyryl derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17004080A JPS5793962A (en) | 1980-12-01 | 1980-12-01 | Carbostyryl derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5793962A true JPS5793962A (en) | 1982-06-11 |
| JPS6340429B2 JPS6340429B2 (en) | 1988-08-11 |
Family
ID=15897492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17004080A Granted JPS5793962A (en) | 1980-12-01 | 1980-12-01 | Carbostyryl derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5793962A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57175168A (en) * | 1981-04-17 | 1982-10-28 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| EP0318235A2 (en) * | 1987-11-25 | 1989-05-31 | Takeda Chemical Industries, Ltd. | PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof |
| WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| WO1992017178A1 (en) * | 1991-04-03 | 1992-10-15 | Otsuka Pharmaceutical Company, Limited | Remedy for thrombosis and phosphodiesterase inhibitor |
| WO1993000902A1 (en) * | 1991-07-03 | 1993-01-21 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis regulator |
| WO1996021447A1 (en) * | 1995-01-09 | 1996-07-18 | Otsuka Pharmaceutical Company, Limited | Use of carbostyril compounds for inhibition of tnf-alpha |
| JP2002501024A (en) * | 1998-01-27 | 2002-01-15 | アベンティス ファーマスーティカルズ プロダクツ インコーポレイテッド | Substituted oxoazaheterocyclyl factor Xa inhibitors |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63261054A (en) * | 1987-04-14 | 1988-10-27 | ナカ工業株式会社 | Floor panel fixing apparatus |
-
1980
- 1980-12-01 JP JP17004080A patent/JPS5793962A/en active Granted
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57175168A (en) * | 1981-04-17 | 1982-10-28 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| EP0318235A2 (en) * | 1987-11-25 | 1989-05-31 | Takeda Chemical Industries, Ltd. | PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof |
| EP0318235A3 (en) * | 1987-11-25 | 1991-05-02 | Takeda Chemical Industries, Ltd. | Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof |
| WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| EP0531548A1 (en) * | 1991-04-03 | 1993-03-17 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives as anti-thrombotic agents |
| WO1992017178A1 (en) * | 1991-04-03 | 1992-10-15 | Otsuka Pharmaceutical Company, Limited | Remedy for thrombosis and phosphodiesterase inhibitor |
| US5401754A (en) * | 1991-04-03 | 1995-03-28 | Otsuka Pharmaceutical Company, Limited | Agent for treating thrombosis and phosphodiesterase inhibitor |
| EP0531548B1 (en) * | 1991-04-03 | 1995-09-27 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives as anti-thrombotic agents |
| US5532253A (en) * | 1991-04-03 | 1996-07-02 | Otsuka Pharmaceutical Company, Limited | Agent for treating thrombosis and phosphodiesterase inhibitor |
| WO1993000902A1 (en) * | 1991-07-03 | 1993-01-21 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis regulator |
| WO1996021447A1 (en) * | 1995-01-09 | 1996-07-18 | Otsuka Pharmaceutical Company, Limited | Use of carbostyril compounds for inhibition of tnf-alpha |
| JP2002501024A (en) * | 1998-01-27 | 2002-01-15 | アベンティス ファーマスーティカルズ プロダクツ インコーポレイテッド | Substituted oxoazaheterocyclyl factor Xa inhibitors |
| JP4676613B2 (en) * | 1998-01-27 | 2011-04-27 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | Substituted oxoazaheterocyclyl factor Xa inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6340429B2 (en) | 1988-08-11 |
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