JPS5767531A - Alpha-hydroxyalkanophenone acetal - Google Patents
Alpha-hydroxyalkanophenone acetalInfo
- Publication number
- JPS5767531A JPS5767531A JP14304180A JP14304180A JPS5767531A JP S5767531 A JPS5767531 A JP S5767531A JP 14304180 A JP14304180 A JP 14304180A JP 14304180 A JP14304180 A JP 14304180A JP S5767531 A JPS5767531 A JP S5767531A
- Authority
- JP
- Japan
- Prior art keywords
- expressed
- acetal
- formula
- hydroxyalkanophenone
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An α-hydroxyalkanophenone acetal expressed by formulaI(R is alkyl or alkoxyl; R1, R2 and R3 lower alkyl; R1 and R2 together may form a cyclic acetal).
EXAMPLE: α-Hydroxyl-p-isobutylpropiophenone dimethyl acetal.
USE: An intermediate for an anti-inflammatory and analgesic agent, etc.
PROCESS: A haloketone expressed by formula II is reacted with an alkaline metallic alkoxide expressed by the formula R1OM (M is alkali metal) in the presence of the corresponding alcohol expressed by the formula ROH. The use of the novel compound provides a compound expressed by formula III (R5 is H or lower alkyl), e.g. ibuprofen, in high yield in a safe and short step.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14304180A JPS5767531A (en) | 1980-10-15 | 1980-10-15 | Alpha-hydroxyalkanophenone acetal |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14304180A JPS5767531A (en) | 1980-10-15 | 1980-10-15 | Alpha-hydroxyalkanophenone acetal |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5767531A true JPS5767531A (en) | 1982-04-24 |
Family
ID=15329525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14304180A Pending JPS5767531A (en) | 1980-10-15 | 1980-10-15 | Alpha-hydroxyalkanophenone acetal |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5767531A (en) |
-
1980
- 1980-10-15 JP JP14304180A patent/JPS5767531A/en active Pending
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