AR030357A1 - Derivados 4 -, 5 -, 6 - y 7-indol - Google Patents
Derivados 4 -, 5 -, 6 - y 7-indolInfo
- Publication number
- AR030357A1 AR030357A1 ARP010103899A ARP010103899A AR030357A1 AR 030357 A1 AR030357 A1 AR 030357A1 AR P010103899 A ARP010103899 A AR P010103899A AR P010103899 A ARP010103899 A AR P010103899A AR 030357 A1 AR030357 A1 AR 030357A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- amino
- trifluoromethylsulfonyl
- alkylsulfonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invencion se relaciona con derivados indolilo sustituidos con 4-,5-, 6-o 7- metileno de la formula 1 en la cual R es arilo o heteroarilo, donde dicho grupo arilo o heteroarilo pude ser sustituido una o más veces con un sustituyente seleccionado entre halogeno, ciano, nitro, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquilo-C3-8-alquilo C1-6, alcoxi C1-6, alquiltio C1-6, hidroxi, hidroxialquilo C1-6, trifluorometilo, trifluorometilsulfonilo, alquilsulfonilo C1-6, amino, alquilamino C1-6, di-(alquilo C1-6)amino, acilo, aminocarbonilo y un grupo metilendioxi; X es N, C o CH, con la salvedad de que la línea de punto indica un enlace cuando X es C y no indica enlace cuando X es N o CH; R1 es hidrogeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquil-C3-8-alquilo C1-6, arilo, arilalquilo C1-6, acilo, tioacilo, alquilsulfonilo C1-6, trifluorometilsulfonilo o arilsulfonilo y R2 y R3 son independientemente seleccionados entre hidrogeno, halogeno, ciano, nitro, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquil-C3-8-alquilo C1-6, alcoxi C1-6, alquiltio C1-6, hidroxi, hidroxialquilo C1-6, trifluorometilo, trifluorometilsulfonilo, alquilsulfonilo C1-6, amino, alquilamino C1-6, di-(alquilo C1-6)amino, acilo y aminocarbonilo. Los compuestos de la presente invencion son ligados selectivos de dopamina D4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001229 | 2000-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030357A1 true AR030357A1 (es) | 2003-08-20 |
Family
ID=8159658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103899A AR030357A1 (es) | 2000-08-18 | 2001-08-15 | Derivados 4 -, 5 -, 6 - y 7-indol |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6958338B2 (es) |
| EP (1) | EP1309586B1 (es) |
| JP (1) | JP2004506731A (es) |
| KR (1) | KR20030022363A (es) |
| CN (1) | CN1243750C (es) |
| AR (1) | AR030357A1 (es) |
| AT (1) | ATE321040T1 (es) |
| AU (2) | AU2001279611B2 (es) |
| BG (1) | BG107611A (es) |
| BR (1) | BR0113452A (es) |
| CA (1) | CA2419266A1 (es) |
| CZ (1) | CZ2003461A3 (es) |
| DE (1) | DE60118205T2 (es) |
| DK (1) | DK1309586T3 (es) |
| EA (1) | EA006155B1 (es) |
| ES (1) | ES2257424T3 (es) |
| HK (1) | HK1059438A1 (es) |
| HR (1) | HRP20030052A2 (es) |
| HU (1) | HUP0302777A2 (es) |
| IL (1) | IL154051A0 (es) |
| IS (1) | IS6694A (es) |
| MX (1) | MXPA03000838A (es) |
| NO (1) | NO20030522D0 (es) |
| NZ (1) | NZ523786A (es) |
| PL (1) | PL363309A1 (es) |
| PT (1) | PT1309586E (es) |
| SK (1) | SK3212003A3 (es) |
| UA (1) | UA74837C2 (es) |
| WO (1) | WO2002016349A1 (es) |
| ZA (1) | ZA200300562B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2007099828A1 (ja) * | 2006-02-23 | 2009-07-16 | 塩野義製薬株式会社 | 環式基で置換された含窒素複素環誘導体 |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| DK2674428T3 (en) | 2006-04-07 | 2016-04-18 | Vertex Pharma | Modulators of ATP binding cassette transporters |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| TWI404702B (zh) * | 2007-08-31 | 2013-08-11 | Lundbeck & Co As H | 兒茶酚胺衍生物和其前藥 |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| EP2872122A1 (en) | 2012-07-16 | 2015-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| JO3425B1 (ar) | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| PL3424534T3 (pl) | 2014-04-15 | 2021-11-22 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421641A1 (de) * | 1984-06-09 | 1985-12-12 | Merck Patent Gmbh, 6100 Darmstadt | Indolderivate |
| MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| AU6215594A (en) * | 1993-03-18 | 1994-10-11 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
| CA2188949A1 (en) * | 1994-04-28 | 1995-11-09 | Janusz Jozef Kulagowski | Benzofuran derivatives as d4 receptor antagonists |
| DE19500689A1 (de) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
| GB9520731D0 (en) * | 1995-10-10 | 1995-12-13 | Merck Sharp & Dohme | Therapeutic agents |
| GB9604036D0 (en) * | 1996-02-26 | 1996-04-24 | Merck Sharp & Dohme | Therapeutic agents |
| WO1999037304A1 (en) * | 1998-01-27 | 1999-07-29 | Aventis Pharmaceuticals Products Inc. | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
| PL202842B1 (pl) * | 1999-10-19 | 2009-07-31 | Merck & Co Inc | Inhibitory kinazy tyrozynowej, ich zastosowanie i zawierające je kompozycje farmaceutyczne |
| US6727264B1 (en) * | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
-
2001
- 2001-08-15 AR ARP010103899A patent/AR030357A1/es not_active Application Discontinuation
- 2001-08-17 NZ NZ523786A patent/NZ523786A/en unknown
- 2001-08-17 HU HU0302777A patent/HUP0302777A2/hu unknown
- 2001-08-17 CZ CZ2003461A patent/CZ2003461A3/cs unknown
- 2001-08-17 IL IL15405101A patent/IL154051A0/xx unknown
- 2001-08-17 DK DK01957788T patent/DK1309586T3/da active
- 2001-08-17 AU AU2001279611A patent/AU2001279611B2/en not_active Ceased
- 2001-08-17 BR BR0113452-3A patent/BR0113452A/pt not_active IP Right Cessation
- 2001-08-17 CA CA002419266A patent/CA2419266A1/en not_active Abandoned
- 2001-08-17 DE DE60118205T patent/DE60118205T2/de not_active Expired - Fee Related
- 2001-08-17 EA EA200300278A patent/EA006155B1/ru not_active IP Right Cessation
- 2001-08-17 MX MXPA03000838A patent/MXPA03000838A/es active IP Right Grant
- 2001-08-17 SK SK321-2003A patent/SK3212003A3/sk unknown
- 2001-08-17 WO PCT/DK2001/000547 patent/WO2002016349A1/en active IP Right Grant
- 2001-08-17 CN CNB018142400A patent/CN1243750C/zh not_active Expired - Fee Related
- 2001-08-17 PL PL01363309A patent/PL363309A1/xx not_active Application Discontinuation
- 2001-08-17 KR KR10-2003-7001687A patent/KR20030022363A/ko not_active Application Discontinuation
- 2001-08-17 JP JP2002521450A patent/JP2004506731A/ja not_active Withdrawn
- 2001-08-17 PT PT01957788T patent/PT1309586E/pt unknown
- 2001-08-17 AU AU7961101A patent/AU7961101A/xx active Pending
- 2001-08-17 AT AT01957788T patent/ATE321040T1/de not_active IP Right Cessation
- 2001-08-17 UA UA2003010504A patent/UA74837C2/uk unknown
- 2001-08-17 ES ES01957788T patent/ES2257424T3/es not_active Expired - Lifetime
- 2001-08-17 EP EP01957788A patent/EP1309586B1/en not_active Expired - Lifetime
-
2003
- 2003-01-20 IS IS6694A patent/IS6694A/is unknown
- 2003-01-21 ZA ZA200300562A patent/ZA200300562B/en unknown
- 2003-01-27 HR HR20030052A patent/HRP20030052A2/xx not_active Application Discontinuation
- 2003-02-03 NO NO20030522A patent/NO20030522D0/no not_active Application Discontinuation
- 2003-02-04 US US10/359,052 patent/US6958338B2/en not_active Expired - Fee Related
- 2003-03-06 BG BG107611A patent/BG107611A/bg unknown
-
2004
- 2004-03-31 HK HK04102360A patent/HK1059438A1/xx not_active IP Right Cessation
-
2005
- 2005-09-01 US US11/219,544 patent/US7105543B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |