CO4990966A1 - Compuestos de tiourea y benzamida, composiciones y metodos para tratar y prevenir enfermedades inflamatorias y arteros- clerosis - Google Patents

Compuestos de tiourea y benzamida, composiciones y metodos para tratar y prevenir enfermedades inflamatorias y arteros- clerosis

Info

Publication number
CO4990966A1
CO4990966A1 CO98076093A CO98076093A CO4990966A1 CO 4990966 A1 CO4990966 A1 CO 4990966A1 CO 98076093 A CO98076093 A CO 98076093A CO 98076093 A CO98076093 A CO 98076093A CO 4990966 A1 CO4990966 A1 CO 4990966A1
Authority
CO
Colombia
Prior art keywords
alkyl
substituted
aryl
cycloalkyl
heteroaryl
Prior art date
Application number
CO98076093A
Other languages
English (en)
Inventor
David Thomas Connor
William Howard Roark
Karen Sexton
Roderick Sorenson Joseph
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CO4990966A1 publication Critical patent/CO4990966A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compuestos CARACTERIZADOS porque tienen la Fórmula Idondecada n es independientemente 0 a 3;Q es alquilo C1 -C6 ,heteroarilo, heteroarilo sustituido, -NR´, o cicloalquilo; cada R´ es independientemente hidrógeno o alquilo C1 -C6 ;Re es - 2 -heteroarilo sustituido, naftilo, bencilo o dansilo;cada uno de R1 , R2 , R3 , R4 , R5 , R7 , R8 , Ra , Rb , Rc , y Rd es independientemente hidrógeno, -O alquilo, C1 -C6 , -S alquilo C1 -C6 , hidrógeno, alquilo C1 -C6 , -OH, CF3 , -NO2 , -CN, CO2 H, OCF3 , -CO2 , alquilo C1 -C6 , SO3 H, -SO3 -metal alcalino -NH2 , -NH alquilo C1 -C6 O O ½ ½-N(C alquilo C1 -C6 )2 -OC alquilo C1 -C6 , -CO2 alquilo C1 -C6 -SO3 H,-SO3 metal alcalino, -CN -CH2 -halógeno, CH2 -CH2 ½ ½O O ½ ½heteroarilo, heteroarilo sustituido, arilo, arilo sustituido, cicloalquilo, cicloalquilo sustituido, heterocicloalquilo, heterocicloalquilo sustituido, benzoilo, O½C alquilo C1 -C6 O O½ ½ -OCH, -OC alquilo C1 -C6 -SO3 H, -SO3 NR´R´, -CHO, -SO2 NH2 o -NR´R´; o las sales farmacéuticamente aceptables de ellos.O½siempre que cuando Y es -CO-,Q no sea alquilo C1 -C6 ; además siempre que cuando X es O½-CNH- e Y es NH, Rb no sea -OH; además siempre que cuando X e Y sonO½-NHC- Re y Q no sean fenilo sin sustituir; además siempre que O O½ ½ cuando Y es -NHC- y X es -NHCO-, Re y Q no sean ambos arilo; además siempre que cuando Y es SO2 NH- o -SO2 N alquilo C1 -C6 yO O½ ½X es CNH ó CN alquilo C1 -C6 , Q y Re no sean ambos fenilo sin sustituir; además siempre que cuando Y esO O O½ ½ ½-CNH ó -CN alquilo C1 -C6 y X es-NC, ½HRe sea fenilo sin sustituir fenilo di- o tri-sustituido; siempre además que cuando Y esO½-NR´CNR´-,Q no sea arilo sin sustituir.donde heteroarilo ó arilo cicloalquilo o heterocicloalquilo sustituido significa que dichos ciclos tienen uno o más sustituyentes seleccionados entre halógeno, alquilo C1 -C8 , -CN, CF3 , -NO2 -NH2 , -NH(alquilo C1 -C8 ), -N(alquilo C1 -C8 ),-O-(alquilo C1 -C8 ) y -OH.
CO98076093A 1997-12-23 1998-12-22 Compuestos de tiourea y benzamida, composiciones y metodos para tratar y prevenir enfermedades inflamatorias y arteros- clerosis CO4990966A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6860497P 1997-12-23 1997-12-23

Publications (1)

Publication Number Publication Date
CO4990966A1 true CO4990966A1 (es) 2000-12-26

Family

ID=22083601

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98076093A CO4990966A1 (es) 1997-12-23 1998-12-22 Compuestos de tiourea y benzamida, composiciones y metodos para tratar y prevenir enfermedades inflamatorias y arteros- clerosis

Country Status (17)

Country Link
US (2) US6268387B1 (es)
EP (1) EP1042276B1 (es)
JP (1) JP2001526255A (es)
KR (1) KR20010033470A (es)
AR (1) AR024826A1 (es)
AT (1) ATE282591T1 (es)
AU (1) AU1529799A (es)
BR (1) BR9814327A (es)
CA (1) CA2300197A1 (es)
CO (1) CO4990966A1 (es)
DE (1) DE69827664T2 (es)
ES (1) ES2234169T3 (es)
NZ (1) NZ502963A (es)
PE (1) PE20000064A1 (es)
UY (1) UY25322A1 (es)
WO (1) WO1999032433A1 (es)
ZA (1) ZA9811805B (es)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6563802B2 (en) 1998-06-22 2003-05-13 Intel Corporation Echo cancellation with dynamic latency adjustment
DE69908156T2 (de) 1998-09-23 2003-12-24 Tularik Inc Arylsulfonanilid-harnstoffe
WO2001047921A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Pyrimidine and triazine kinase inhibitors
EP1294687A2 (en) 2000-06-14 2003-03-26 Warner-Lambert Company 1,2,4-trisubstituted benzenes as inhibitors of 15-lipoxygenase
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
AU2002331706B2 (en) 2001-08-15 2009-01-22 E.I. Du Pont De Nemours And Company Ortho-substituted aryl amides for controlling invertebrate pests
WO2003062226A1 (en) 2002-01-22 2003-07-31 E. I. Du Pont De Nemours And Company Quinazoline(di) ones for invertebrate pest control
MXPA04007611A (es) * 2002-02-08 2005-05-27 Hoffmann La Roche Metodo para tratar y prevenir perdida osea.
CA2485681C (en) 2002-05-24 2012-10-16 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
KR20040018295A (ko) * 2002-08-22 2004-03-03 임철부 항암 활성을 갖는 티오우레이도 세라마이드 유도체 및 이화합물을 함유하는 약학적 조성물
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
FR2846326A1 (fr) * 2002-10-29 2004-04-30 Isochem Sa Procede de purification des n-carboxyanhydrides
EP2256116A3 (en) 2002-11-18 2011-11-16 ChemoCentryx, Inc. Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
CA2506415A1 (en) 2002-11-19 2004-06-03 Achillion Pharmaceuticals, Inc. Substituted aryl thioureas and releated compounds; inhibitors of viral replication
KR100555655B1 (ko) * 2002-11-20 2006-03-03 임철부 항암 활성을 갖는 우레이도 또는 티오우레이도 유도체 및이 화합물을 함유하는 약학조성물
CA2515544A1 (en) * 2003-02-11 2004-08-26 Kemia Inc. Compounds for the treatment of viral infection
TW200529812A (en) 2003-12-26 2005-09-16 Chugai Pharmaceutical Co Ltd Benzamide derivatives
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
EP1775283A4 (en) * 2004-07-14 2008-12-10 Japan Tobacco Inc 3-AMINOBENZAMIDE COMPOUND AND INHIBITORS OF THE ACTIVITY OF VANILLOID RECEPTOR 1 (VR1)
BRPI0513286A (pt) * 2004-07-15 2008-05-06 Japan Tobacco Inc compostos de benzamida condensada e inibidores de atividade de receptor vanilóide subtipo (vr1), suas composições farmacêuticas, pacote comercial, fármaco e respectivos usos
CN101189210B (zh) * 2005-06-06 2012-06-06 霍夫曼-拉罗奇有限公司 可用作肝肉碱棕榈酰转移酶(l-cpt1)抑制剂的磺酰胺衍生物
ZA200800608B (en) 2005-06-21 2009-06-24 Mitsui Chemicals Inc Amide derivative and insecticide containing the same
US7754717B2 (en) 2005-08-15 2010-07-13 Amgen Inc. Bis-aryl amide compounds and methods of use
US7464565B2 (en) 2005-11-29 2008-12-16 Maytag Corporation Rapid temperature change device for a refrigerator
US20070155746A1 (en) * 2005-12-23 2007-07-05 Kalypsys, Inc. Novel substituted pyridinyloxy and pyrimidinyloxy amides useful as inhibitors of protein kinases
US7906508B2 (en) * 2005-12-28 2011-03-15 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
WO2008031534A1 (en) 2006-09-11 2008-03-20 Syngenta Participations Ag Insecticidal compounds
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
EP2170830B1 (en) 2007-07-17 2014-10-15 Plexxikon, Inc. 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS
FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
FR2930552B1 (fr) * 2008-04-24 2012-10-12 Centre Nat Rech Scient N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog
GB0813403D0 (en) 2008-07-22 2008-08-27 Lectus Therapeutics Ltd Potassium ion channel modulators & uses thereof
CN101367749B (zh) * 2008-09-28 2013-04-24 中国医学科学院医药生物技术研究所 一组胺基苯酰衍生物及其制备方法和应用
MY172424A (en) 2009-04-03 2019-11-25 Hoffmann La Roche Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof
AU2010303270A1 (en) 2009-10-09 2012-05-03 Zafgen Corporation Sulphone compounds for use in the treatment of obesity
BR112012012156A2 (pt) 2009-11-06 2015-09-08 Plexxikon Inc compostos e métodos para modulação de cinase, e indicações para esta
ES2533065T3 (es) 2010-07-09 2015-04-07 Pfizer Limited Bencenosulfonamidas útiles como inhibidores de los canales de sodio
KR20130043207A (ko) 2010-07-22 2013-04-29 자프겐 인크. 트리시클릭 화합물 및 이의 제조 및 사용 방법
TW201216963A (en) * 2010-09-03 2012-05-01 Forma Therapeutics Inc Novel compounds and compositions for the inhibition of NAMPT
JP6058557B2 (ja) 2011-01-26 2017-01-11 ザフゲン，インコーポレイテッド テトラゾール化合物ならびにその作製方法および使用方法
TR201816421T4 (tr) 2011-02-07 2018-11-21 Plexxikon Inc Kinaz modülasyonu için bileşikler ve metotlar ve bunların endikasyonları.
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
EP2505198A1 (en) 2011-04-01 2012-10-03 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity
BR112013028665A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
BR112013028534A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos
BR112013028666A2 (pt) 2011-05-06 2017-08-08 Zafgen Inc compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
JP6035347B2 (ja) 2012-01-18 2016-11-30 ザフゲン，インコーポレイテッド 三環式スルホンアミド化合物ならびにその作製および使用方法
EP2804856B1 (en) 2012-01-18 2017-03-15 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP2925737B1 (en) 2012-11-05 2017-06-14 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
CN104918615B (zh) 2012-11-05 2018-10-12 扎夫根股份有限公司 治疗肝病的方法
CA2890342A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds and methods of making and using same
GB201317609D0 (en) 2013-10-04 2013-11-20 Cancer Rec Tech Ltd Inhibitor compounds
JP6156846B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
WO2015184405A1 (en) * 2014-05-30 2015-12-03 Medivation Technologies, Inc. Aromatic compounds, compositions and uses thereof
WO2016029136A1 (en) * 2014-08-21 2016-02-25 Northwestern University 3-amidobenzamides and uses thereof for increasing cellular levels of a3g
US9597332B2 (en) 2014-12-02 2017-03-21 Novira Therapeutics, Inc. Sulfide alkyl compounds for HBV treatment
DK3227262T3 (da) * 2014-12-02 2020-08-10 Novira Therapeutics Inc Sulfidalkyl og pyridyl-revers-sulfonamidforbindelser til hbv-behandling
US9765050B2 (en) 2014-12-30 2017-09-19 Novira Therapeutics, Inc. Pyridyl reverse sulfonamides for HBV treatment
GB201505658D0 (en) 2015-04-01 2015-05-13 Cancer Rec Tech Ltd Inhibitor compounds
EP3108883A1 (en) * 2015-06-22 2016-12-28 Fundació Institut de Recerca Biomèdica de Bellvitge Therapeutic uses of non-peptide inhibitors of the calcineurin - nfat signalling pathway
GB201617103D0 (en) 2016-10-07 2016-11-23 Cancer Research Technology Limited Compound
CN109503518B (zh) * 2018-11-15 2021-03-30 中国医学科学院医药生物技术研究所 一种取代的双芳香基酰胺化合物及其制备方法和应用
WO2021026257A1 (en) * 2019-08-06 2021-02-11 Empirico Inc. Prodrugs of alox-15 inhibitors and methods of using the same
US20230117592A1 (en) * 2019-12-23 2023-04-20 Sri International Lipoxygenase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH373028A (de) * 1960-08-29 1963-11-15 Geigy Ag J R Verfahren zur Herstellung neuer Aminobenzoesäurederivate
DE3743517A1 (de) 1987-12-22 1989-07-06 Basf Ag Verfahren zur herstellung von aromatischen hydroxycarbonsaeuren
DE3816703A1 (de) 1988-05-17 1989-11-30 Hoechst Ag Heterocyclisch substituierte phenoxysulfonylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als herbizide oder pflanzenwachstumsregulatoren
US5041545A (en) 1989-04-06 1991-08-20 Atochem North America, Inc. 2-hydroxybenzophenone hydrazides and derivatives thereof
US5256686A (en) * 1989-06-27 1993-10-26 Ono Pharmaceutical Co., Ltd. Phenylalkan(en)oic acid
US5177246A (en) 1989-10-02 1993-01-05 Ciba-Geigy Corporation Hydroxphenylcarboxylic acid esters as stabilizers
AU648359B2 (en) 1990-11-22 1994-04-21 Janssen Pharmaceutica N.V. Isonicotinic acid derivatives
US5049496A (en) 1990-12-24 1991-09-17 General Electric Company Method for microbiologically hydroxylating biphenyl and terphenyl compounds
US5382690A (en) 1992-08-11 1995-01-17 Mitsui Toatsu Chemicals, Incorporated Method for preparing aromatic secondary amino compound
DE4238994A1 (de) 1992-11-19 1994-05-26 Basf Ag Aniline als Markierungsmittel für Mineralöle
DE4331416A1 (de) 1993-12-09 1995-06-14 Bayer Ag Verwendung von Phenylcarbonsäure-amiden als Kristallisationsinhibitoren

Also Published As

Publication number Publication date
WO1999032433A1 (en) 1999-07-01
ZA9811805B (en) 1999-06-29
US6268387B1 (en) 2001-07-31
ATE282591T1 (de) 2004-12-15
EP1042276A1 (en) 2000-10-11
EP1042276B1 (en) 2004-11-17
AU1529799A (en) 1999-07-12
KR20010033470A (ko) 2001-04-25
NZ502963A (en) 2002-06-28
DE69827664T2 (de) 2005-12-08
JP2001526255A (ja) 2001-12-18
BR9814327A (pt) 2000-10-03
AR024826A1 (es) 2002-10-30
US6528528B2 (en) 2003-03-04
US20010031874A1 (en) 2001-10-18
CA2300197A1 (en) 1999-07-01
ES2234169T3 (es) 2005-06-16
DE69827664D1 (de) 2004-12-23
UY25322A1 (es) 2004-07-30
PE20000064A1 (es) 2000-02-11

Similar Documents

Publication Publication Date Title
CO4990966A1 (es) Compuestos de tiourea y benzamida, composiciones y metodos para tratar y prevenir enfermedades inflamatorias y arteros- clerosis
NO148884C (no) Trijodert isofthalsyrediamid og anvendelse derav som roentgenkontrastmiddel.
DE3275294D1 (en) N-phenylsulfonyl-n'-pyrimidinyl and ditto triazinyl ureas
MY102027A (en) Leukotriene antagonists
MY100040A (en) Substituted azabicyclo compounds.
CA2047848A1 (en) Azabicyclo derivatives
DK1117297T3 (da) Syntetiske analoger af ecteinascidin-743
PE20000942A1 (es) Derivados de amida, carbamato y urea
ES557582A0 (es) Un procedimiento para preparar derivados de (benzoil-4-piperidinil-1)-2-fenil-1-alcanoles
RS51042B (sr) Derivati benzoksazina kao 5-ht6 modulatori i njihove primene
PT81890B (pt) Processo para a preparacao de composicoes herbicidas que contem um composto do tipo n-(fosfonometilglicil)-sulfonilamina
FI935517A0 (fi) Fenoxi- och fenoxialkylpiperidiner som virusmotverkande medel
FI871360A (fi) Nya fenoxialkylkarboxylsyraderivat foerfarande foer deras framstaellning och laekemedel innehaollande dessa foereningar.
DK276386A (da) Sulfonsyreestere samt deres fremstilling og anvendelse
DK119684A (da) Quinoloncarboxylsyrer og disses anvendelse som baktericider
AR024222A1 (es) Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen
DE60011916D1 (de) Heteroaryloxypropanolamine als beta3-adrenergischer rezeptor-agonisten
DK0719760T3 (da) Naphthalenderivater og deres anvendelse som PGE2-agonister og -antagonister
ES525796A0 (es) Procedimiento para la preparacion de 2-amino-3,5-dibromobencilaminas
GB1368699A (en) Benzoyl ureas and process for their manufacture
SE7608592L (sv) Nya homoftalimider
PT87162A (pt) Process for the preparation of a pyridil alcanoic acid compoundcontainig a sulphonamido group and of pharmaceutical compositions therewith
GB1445595A (en) 4-aminoquinoline derivatives and intermediates for their pre paration
PE20030434A1 (es) COMPUESTO DE ß-CETOAMIDA
PT84161B (pt) Processo para a preparacao de derivados de 3-acilaminometil-imidazo-{1,2-a}-piridinas e de composicoes farmaceuticas que os contem