AR036018A1 - PROCESS FOR ISOLATING PURE CRYSTAL IMIPENEM MONOHIDRATE - Google Patents

PROCESS FOR ISOLATING PURE CRYSTAL IMIPENEM MONOHIDRATE

Info

Publication number
AR036018A1
AR036018A1 ARP020101854A ARP020101854A AR036018A1 AR 036018 A1 AR036018 A1 AR 036018A1 AR P020101854 A ARP020101854 A AR P020101854A AR P020101854 A ARP020101854 A AR P020101854A AR 036018 A1 AR036018 A1 AR 036018A1
Authority
AR
Argentina
Prior art keywords
imipenem
monohidrate
pure crystal
isolating pure
isolating
Prior art date
Application number
ARP020101854A
Other languages
Spanish (es)
Inventor
Yatendra Kumar
Neera Tewari
Ram Chander Aryan
Bishwa Prakash Rai
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR036018A1 publication Critical patent/AR036018A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Abstract

El presente se relaciona con un proceso de efectividad en el costo industrialmente ventajoso para aislar imipenem de alta pureza de la fórmula (1), que comprende cristalizar a temperatura baja monohidrato de imipenem a partir de una solución del mismo que contiene un solvente orgánico miscible en agua, un solvente acuoso o una mezcla de los mismos, sin utilizar liofilización, secado por congelamiento ni técnicas cromatográficas.This is related to an industrially advantageous cost-effectiveness process for isolating high purity imipenem of the formula (1), which comprises crystallizing at low temperature imipenem monohydrate from a solution thereof containing a miscible organic solvent in water, an aqueous solvent or a mixture thereof, without using lyophilization, freeze drying or chromatographic techniques.

ARP020101854A 2001-05-18 2002-05-20 PROCESS FOR ISOLATING PURE CRYSTAL IMIPENEM MONOHIDRATE AR036018A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN595DE2001 2001-05-18

Publications (1)

Publication Number Publication Date
AR036018A1 true AR036018A1 (en) 2004-08-04

Family

ID=11097062

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101854A AR036018A1 (en) 2001-05-18 2002-05-20 PROCESS FOR ISOLATING PURE CRYSTAL IMIPENEM MONOHIDRATE

Country Status (17)

Country Link
US (1) US7241885B2 (en)
EP (1) EP1395588A4 (en)
JP (1) JP2005514323A (en)
KR (1) KR20040010649A (en)
CN (1) CN1522255A (en)
AR (1) AR036018A1 (en)
BR (1) BR0209844A (en)
CA (1) CA2447673A1 (en)
CZ (1) CZ20033351A3 (en)
HU (1) HUP0501093A2 (en)
MX (1) MXPA03010548A (en)
NO (1) NO20035137D0 (en)
OA (1) OA12608A (en)
PL (1) PL373527A1 (en)
SK (1) SK15092003A3 (en)
WO (1) WO2002094773A2 (en)
ZA (1) ZA200309288B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL370705A1 (en) * 2001-05-18 2005-05-30 Ranbaxy Laboratories Limited Process for the preparation of imipenem
WO2003016312A1 (en) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Process for preparation of carbapenem antibiotics
CA2467427A1 (en) * 2001-11-16 2003-05-22 Ranbaxy Laboratories Limited Process for the preparation of crystalline imipenem
EP2209787A4 (en) * 2007-10-08 2011-08-03 Orchid Chemicals & Pharm Ltd Process for the preparation of carbapenem antibiotic
CN103524508B (en) * 2013-09-02 2016-03-30 上海龙翔生物医药开发有限公司 A kind of crystallization method of Imipenem monohydrate
CN108623598A (en) * 2018-05-21 2018-10-09 重庆天地药业有限责任公司 A kind of preparation method of Imipenem intermediate and Imipenem
CN113135916A (en) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 Palladium removing method for imipenem preparation process

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138433A (en) * 1975-06-26 1979-02-06 Hoechst Aktiengesellschaft Process for preparing 1,2-oxa-phospholanes
US4194047A (en) * 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4081455A (en) * 1976-06-02 1978-03-28 Pfizer Inc. 6-Amino-2,2-dimethyl-3-cyanopenams
US4260543A (en) * 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4292436A (en) * 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
US4374772A (en) * 1981-03-19 1983-02-22 Merck & Co., Inc. Process for the preparation of N-formimidoyl thienamycin and reagents therefor
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (en) * 2000-11-03 2004-01-03 Ranbaxy Lab Ltd
CA2467427A1 (en) * 2001-11-16 2003-05-22 Ranbaxy Laboratories Limited Process for the preparation of crystalline imipenem

Also Published As

Publication number Publication date
EP1395588A4 (en) 2004-09-15
KR20040010649A (en) 2004-01-31
NO20035137D0 (en) 2003-11-18
WO2002094773A3 (en) 2003-10-16
MXPA03010548A (en) 2004-05-27
WO2002094773A2 (en) 2002-11-28
US7241885B2 (en) 2007-07-10
CN1522255A (en) 2004-08-18
US20040242865A1 (en) 2004-12-02
EP1395588A2 (en) 2004-03-10
CA2447673A1 (en) 2002-11-28
JP2005514323A (en) 2005-05-19
BR0209844A (en) 2005-04-05
OA12608A (en) 2006-06-08
ZA200309288B (en) 2005-02-28
PL373527A1 (en) 2005-09-05
CZ20033351A3 (en) 2007-12-27
SK15092003A3 (en) 2004-09-08
HUP0501093A2 (en) 2006-03-28

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