AR046229A1 - PROCESSES FOR THE PREPARATION OF CEPHALOSPORINE 3- (2-VINYL REPLACED) HIGHLY PURE - Google Patents

PROCESSES FOR THE PREPARATION OF CEPHALOSPORINE 3- (2-VINYL REPLACED) HIGHLY PURE

Info

Publication number
AR046229A1
AR046229A1 ARP040104059A ARP040104059A AR046229A1 AR 046229 A1 AR046229 A1 AR 046229A1 AR P040104059 A ARP040104059 A AR P040104059A AR P040104059 A ARP040104059 A AR P040104059A AR 046229 A1 AR046229 A1 AR 046229A1
Authority
AR
Argentina
Prior art keywords
pivoxil
cefditoren
highly pure
amorphous
pivoxil cefditoren
Prior art date
Application number
ARP040104059A
Other languages
Spanish (es)
Inventor
Yatendra Kumar
Mohan Prasad
Kaptan Singh
Ashok Prasad
Santosh Richhariya
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR046229A1 publication Critical patent/AR046229A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

La presente se relaciona con un proceso para preparar formas amorfa y cristalina altamente puras de pivoxil cefditoren y composiciones farmacéuticas que comprenden formas amorfa y cristalina altamente puras de pivoxil cefditoren. También se relaciona con un método para tratar infecciones utilizando formas amorfa y cristalina altamente puras de pivoxil cefditoren. El pivoxil cefditoren altamente puro tiene una pureza superior a 98.5% y contiene menos de 1.0% de impurezas de isómero E y menos de 1% de la impureza del isómero D2. Reivindicación 6: Un proceso para preparar pivoxil cefditoren cristalino a partir de pivoxil cefditoren amorfo proceso que comprende: a) i) agregar pivoxil cefditoren amorfo a un solvente orgánico que opcionalmente contenga agua y/o ii) agregar un solvente orgánico que opcionalmente contenga agua a pivoxil cefditoren amorfo; b) cristalizar el producto a partir de la mezcla de la reacción; y c) aislar el pivoxil cefditoren cristalino.This is related to a process for preparing highly pure amorphous and crystalline forms of pivoxil cefditoren and pharmaceutical compositions comprising highly pure amorphous and crystalline forms of pivoxil cefditoren. It is also related to a method of treating infections using highly pure amorphous and crystalline forms of pivoxil cefditoren. The highly pure pivoxil cefditoren has a purity greater than 98.5% and contains less than 1.0% impurities of isomer E and less than 1% of the impurity of the D2 isomer. Claim 6: A process for preparing crystalline pivoxil cefditoren from amorphous pivoxil cefditoren process comprising: a) i) adding amorphous pivoxil cefditoren to an organic solvent that optionally contains water and / or ii) adding an organic solvent that optionally contains water to pivoxil amorphous cefditoren; b) crystallize the product from the reaction mixture; and c) isolate the crystalline pivoxil cefditoren.

ARP040104059A 2003-11-07 2004-11-05 PROCESSES FOR THE PREPARATION OF CEPHALOSPORINE 3- (2-VINYL REPLACED) HIGHLY PURE AR046229A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1368DE2003 2003-11-07

Publications (1)

Publication Number Publication Date
AR046229A1 true AR046229A1 (en) 2005-11-30

Family

ID=34566866

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104059A AR046229A1 (en) 2003-11-07 2004-11-05 PROCESSES FOR THE PREPARATION OF CEPHALOSPORINE 3- (2-VINYL REPLACED) HIGHLY PURE

Country Status (5)

Country Link
EP (1) EP1689755A2 (en)
JP (1) JP2007510709A (en)
CN (1) CN1902207A (en)
AR (1) AR046229A1 (en)
WO (1) WO2005044824A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459550B2 (en) 2003-07-04 2008-12-02 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of Cefditoren
WO2006024900A1 (en) * 2004-08-31 2006-03-09 Ranbaxy Laboratories Limited Highly pure cefditoren pivoxil
US20090111997A1 (en) * 2005-11-23 2009-04-30 Aaron Cote Method of Generating Amorphous Solid for Water-Insoluble Pharmaceuticals
CN101560216B (en) * 2009-05-27 2011-06-15 上海交通大学 Method for preparing cefditoren pivoxil
KR101561963B1 (en) * 2013-05-23 2015-10-22 영진약품공업 주식회사 Novel crystalline from of cefditoren pivoxyl and preparation method thereof
CN106117244B (en) * 2016-06-24 2018-10-19 瑞阳制药有限公司 The process for purification of Cefditoren pivoxil Cephalosporins
CN106243128B (en) * 2016-07-30 2018-09-04 济南康和医药科技有限公司 A kind of process for purification of Cefditoren pivoxil Cephalosporins
CN107422056B (en) * 2017-08-17 2020-04-24 山东裕欣药业有限公司 Gas chromatography detection method of iodomethyl pivalate and preparation method thereof
CN109053768A (en) * 2018-08-07 2018-12-21 中国医药集团总公司四川抗菌素工业研究所 A kind of preparation method of unformed cefditoren
CN109336904B (en) * 2018-11-21 2020-06-09 山东罗欣药业集团股份有限公司 Preparation method of cefditoren pivoxil
CN110251467A (en) * 2019-06-26 2019-09-20 北京济美堂医药研究有限公司 A kind of preparation method of amorphous state Cefditoren pivoxil Cephalosporins composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU224196B1 (en) * 1996-09-20 2005-06-28 Meiji Seika Kaisha Ltd. A crystalline form of cefditoren pivoxyl and process for the production of the same
ID25469A (en) * 1998-01-07 2000-10-05 Meiji Seika Kaisha STORIES OF CHRISTALOGRAPHY AND THE PROCESS OF MAKING AMORF SEFALOSPORINE
JP2001131071A (en) * 1999-10-29 2001-05-15 Meiji Seika Kaisha Ltd Amorphous substance and medical composition containing amorphous substance

Also Published As

Publication number Publication date
WO2005044824A2 (en) 2005-05-19
JP2007510709A (en) 2007-04-26
EP1689755A2 (en) 2006-08-16
CN1902207A (en) 2007-01-24
WO2005044824A3 (en) 2005-07-14

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