AR068527A2 - Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino - Google Patents

Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino

Info

Publication number
AR068527A2
AR068527A2 ARP080104109A ARP080104109A AR068527A2 AR 068527 A2 AR068527 A2 AR 068527A2 AR P080104109 A ARP080104109 A AR P080104109A AR P080104109 A ARP080104109 A AR P080104109A AR 068527 A2 AR068527 A2 AR 068527A2
Authority
AR
Argentina
Prior art keywords
tiotrope
monohidrate
bromide
procedure
prepare crystal
Prior art date
Application number
ARP080104109A
Other languages
English (en)
Inventor
Rolf Banholzer
Michael Trunk
Andreas Mathes
Manfred Graulich
Helmut Meissner
Peter Specht
Christian Kulinna
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR068527(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR068527A2 publication Critical patent/AR068527A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para la preparacion del monohidrato de bromuro de tiotropio cristalino, caracterizado porque: a) se recoge el bromuro de tiotropio en agua, b) la mezcla obtenida se calienta, e) se anade carbon activo, d) después de remover el carbon activo, el monohidrato de bromuro de tiotropio se cristaliza lentamente por enfriamiento lento de la solucion acuosa.
ARP080104109A 2000-10-12 2008-09-19 Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino AR068527A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12

Publications (1)

Publication Number Publication Date
AR068527A2 true AR068527A2 (es) 2009-11-18

Family

ID=7659568

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP010104782A Pending AR034389A1 (es) 2000-10-12 2001-10-12 Monohidrato cristalino de bromuro de tiotropio, procedimiento para su preparacion, su utilización para la preparacion de un medicamento, un medicamento que lo contiene, los hidratos cristalinos del bromuro de tiotropio y un procedimiento para preparacion de estos hidratos cristalinos
ARP080104109A AR068527A2 (es) 2000-10-12 2008-09-19 Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP010104782A Pending AR034389A1 (es) 2000-10-12 2001-10-12 Monohidrato cristalino de bromuro de tiotropio, procedimiento para su preparacion, su utilización para la preparacion de un medicamento, un medicamento que lo contiene, los hidratos cristalinos del bromuro de tiotropio y un procedimiento para preparacion de estos hidratos cristalinos

Country Status (47)

Country Link
EP (2) EP1468998A1 (es)
JP (1) JP3764422B2 (es)
KR (1) KR100823860B1 (es)
CN (2) CN1221549C (es)
AP (1) AP1572A (es)
AR (2) AR034389A1 (es)
AT (1) ATE276253T1 (es)
AU (2) AU2002214996B2 (es)
BG (1) BG66161B1 (es)
BR (1) BR0114584A (es)
CA (1) CA2425539C (es)
CR (1) CR6938A (es)
CZ (1) CZ301841B6 (es)
DE (1) DE50103666D1 (es)
DK (1) DK1326862T3 (es)
DZ (1) DZ3478A1 (es)
EA (1) EA004381B1 (es)
EC (1) ECSP034540A (es)
EE (1) EE04567B1 (es)
EG (1) EG24142A (es)
ES (1) ES2228965T3 (es)
GE (1) GEP20063905B (es)
HK (2) HK1060567A1 (es)
HR (1) HRP20030276B1 (es)
HU (1) HU226830B1 (es)
IL (2) IL155335A0 (es)
IS (1) IS2339B (es)
MA (1) MA25842A1 (es)
ME (2) ME00243B (es)
MX (1) MXPA03003221A (es)
MY (1) MY126931A (es)
NO (1) NO328465B1 (es)
NZ (1) NZ525733A (es)
OA (1) OA12403A (es)
PE (1) PE20020422A1 (es)
PL (1) PL207870B1 (es)
PT (1) PT1326862E (es)
RS (1) RS50218B (es)
SA (1) SA01220412B1 (es)
SI (1) SI1326862T1 (es)
SK (1) SK287009B6 (es)
TR (1) TR200402579T4 (es)
TW (1) TW589313B (es)
UA (1) UA74215C2 (es)
UY (2) UY26962A1 (es)
WO (1) WO2002030928A1 (es)
ZA (1) ZA200302500B (es)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL159238A0 (en) * 2001-06-22 2004-06-01 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
RS20060293A (en) * 2003-11-03 2008-08-07 Boehringer Ingelheim International Gmbh., Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
CN100509809C (zh) * 2003-11-03 2009-07-08 贝林格尔·英格海姆国际有限公司 具有抗胆碱能作用的新颖无水晶体
SI2067779T1 (sl) 2003-11-03 2013-08-30 Boehringer Ingelheim International Gmbh Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
PL2422786T3 (pl) 2004-04-22 2015-02-27 Boehringer Ingelheim Int Nowe kombinacje środków leczniczych do leczenia chorób dróg oddechowych
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE602004020337D1 (de) 2004-08-11 2009-05-14 Boehringer Ingelheim Pharma Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
EP1827541B1 (de) * 2004-10-21 2013-05-29 Boehringer Ingelheim International GmbH Blister für inhalatoren
CA2600636A1 (en) * 2005-03-09 2006-09-14 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
NZ563448A (en) 2005-04-28 2011-01-28 Boehringer Ingelheim Int Benzofuranone derivatives for treating inflammatory diseases
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
DK1881980T3 (da) 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
WO2006134021A2 (en) * 2005-06-15 2006-12-21 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
NZ566399A (en) * 2005-08-06 2011-07-29 Boehringer Ingelheim Int Use of tiotropium salts in the treatment of severe persistant asthma
ES2530991T3 (es) 2005-08-15 2015-03-09 Boehringer Ingelheim Int Procedimiento para la obtención de betamiméticos
US20070086957A1 (en) 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
TW200734333A (en) * 2005-12-19 2007-09-16 Sicor Inc Pure and stable tiotropium bromide
EP2123650B1 (en) 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
KR20080083060A (ko) * 2006-01-04 2008-09-12 베링거 인겔하임 인터내셔날 게엠베하 중등 지속성 천식의 치료에서 티오트로퓸 염의 용도
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
PL1874781T3 (pl) 2006-04-19 2009-12-31 Boehringer Ingelheim Int Dihydrotienopirymidyny do leczenia chorób zapalnych
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
DE502007006951D1 (de) 2006-08-07 2011-05-26 Boehringer Ingelheim Pharma Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
DK2215092T3 (da) 2007-10-19 2012-05-07 Boehringer Ingelheim Int Substitueret piperidino-dihydrothienopyrimidin
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
US20100272811A1 (en) * 2008-07-23 2010-10-28 Alkermes,Inc. Complex of trospium and pharmaceutical compositions thereof
CA2747677C (en) 2008-12-19 2017-05-09 Boehringer Ingelheim International Gmbh Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
EP2201934A1 (en) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
WO2010101538A2 (en) 2009-03-06 2010-09-10 Bilgic Mahmut New crystal forms
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
MY160471A (en) 2009-12-17 2017-03-15 Centrexion Therapeutics Corp New ccr2 receptor antagonists and uses thereof
US20130143905A1 (en) 2009-12-17 2013-06-06 Boehringer Ingelheim International Gmbh Novel antagonists for ccr2 and uses thereof
NZ600857A (en) 2010-01-29 2014-06-27 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5646736B2 (ja) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
WO2012101013A1 (en) 2011-01-28 2012-08-02 Boehringer Ingelheim International Gmbh Substituted pyridinyl-pyrimidines and their use as medicaments
TR201102068A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
EP2721025B1 (en) 2011-06-16 2015-11-25 Boehringer Ingelheim International Gmbh New selective ccr2 antagonists
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
CA2843022C (en) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
SI2914593T1 (sl) 2012-11-05 2017-05-31 Zentiva, K.S. Stabilizacija tiotropijevih solvatov
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
PT3119772T (pt) 2014-03-19 2019-09-05 Boehringer Ingelheim Int Inibidores de syk heteroarilo
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
EP3430011A4 (en) * 2016-11-04 2019-08-14 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI NOVEL ACTIVE SUBSTANCE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
AU6048694A (en) * 1992-12-09 1994-07-04 Paul D. Jager Stabilized medicinal aerosol solution formulations
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
NZ509489A (en) * 1998-08-04 2002-10-25 Jago Res A Medicinal aerosol formulations comprising cromoglycic acid and/or nedocromil

Also Published As

Publication number Publication date
NZ525733A (en) 2005-01-28
HRP20030276B1 (en) 2006-02-28
JP2004526668A (ja) 2004-09-02
KR100823860B1 (ko) 2008-04-21
NO328465B1 (no) 2010-02-22
CZ301841B6 (cs) 2010-07-07
MXPA03003221A (es) 2004-12-03
NO20031694D0 (no) 2003-04-11
MA25842A1 (fr) 2003-07-01
BG107687A (bg) 2003-09-30
ES2228965T3 (es) 2005-04-16
SK4362003A3 (en) 2003-08-05
KR20030042008A (ko) 2003-05-27
BG66161B1 (bg) 2011-09-30
JP3764422B2 (ja) 2006-04-05
HK1086557A1 (en) 2006-09-22
AP1572A (en) 2006-02-13
HK1060567A1 (en) 2004-08-13
UA74215C2 (uk) 2005-11-15
CN1733761A (zh) 2006-02-15
EP1326862A1 (de) 2003-07-16
IL155335A (en) 2009-02-11
DK1326862T3 (da) 2004-11-22
PE20020422A1 (es) 2002-06-28
YU27303A (sh) 2006-05-25
CR6938A (es) 2004-10-28
DZ3478A1 (fr) 2002-04-18
IS2339B (is) 2008-02-15
SI1326862T1 (en) 2005-02-28
ZA200302500B (en) 2004-04-22
DE50103666D1 (de) 2004-10-21
SK287009B6 (sk) 2009-09-07
CA2425539A1 (en) 2003-04-11
AU1499602A (en) 2002-04-22
EA200300457A1 (ru) 2003-10-30
HUP0301022A2 (hu) 2003-10-28
BR0114584A (pt) 2003-08-26
WO2002030928A1 (de) 2002-04-18
TW589313B (en) 2004-06-01
EA004381B1 (ru) 2004-04-29
AU2002214996B2 (en) 2007-03-15
HUP0301022A3 (en) 2005-12-28
RS50218B (sr) 2009-07-15
UY34901A (es) 2015-02-27
CN1469877A (zh) 2004-01-21
CN100519558C (zh) 2009-07-29
TR200402579T4 (tr) 2004-12-21
OA12403A (en) 2006-04-18
MY126931A (en) 2006-10-31
EP1468998A1 (de) 2004-10-20
ME00243B (me) 2011-05-10
GEP20063905B (en) 2006-08-25
PL366041A1 (en) 2005-01-24
SA01220412B1 (ar) 2006-11-05
IL155335A0 (en) 2003-11-23
EE04567B1 (et) 2005-12-15
AP2003002775A0 (en) 2003-03-31
AR034389A1 (es) 2004-02-25
CA2425539C (en) 2007-04-03
ATE276253T1 (de) 2004-10-15
NO20031694L (no) 2003-04-11
ECSP034540A (es) 2003-07-25
MEP40008A (en) 2011-02-10
HU226830B1 (en) 2009-11-30
IS6772A (is) 2003-04-09
HRP20030276A2 (en) 2005-02-28
PL207870B1 (pl) 2011-02-28
EG24142A (en) 2008-08-06
UY26962A1 (es) 2002-06-20
PT1326862E (pt) 2004-11-30
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
EP1326862B1 (de) 2004-09-15

Similar Documents

Publication Publication Date Title
AR068527A2 (es) Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino
PE20060662A1 (es) Procedimiento para producir derivados de amina opticamente activos
AR066130A1 (es) Formas cristalinas de saxagliptina y procesos para preparar las mismas
WO2011049333A3 (en) Method of preparing zsm-5 zeolite using nanocrystalline zsm-5 seeds
PE20030612A1 (es) Benzoimidazoles
CR6888A (es) Sales estables de acido o-acetilsalicilico con aminoacidos basicos
CO6170362A2 (es) Procedimiento de preparacion de halogenuros de n-alquil-naltrexona
PE20081258A1 (es) ANTICUERPOS ANTI-hTNFALFA CRISTALINOS
JO3061B1 (ar) صور بلورية من 3- ( 2، 6- ثانى كلورو – 3، 5- ثانى ميثوكسى فينيل) – 1- { 6- [ 4- (4- ايثيل – بيبرازين – 1- يل) – فينيل أمينو ] – بيريميدين – 4- يل } – 1- ميثيل – يوريا وأملاح منها
ATE416776T1 (de) Stallstaub-extrakt zum schutz vor allergien
PE20011050A1 (es) Compuestos antibioticos de azalida
AR079580A1 (es) Procesos para la fabricacion de un agente farmaceuticamente activo
CO6541539A2 (es) Procesos para preparar las formas cristalinas a y b de ilaprazol y proceso para convertir las formas cristalinas
RU2014153024A (ru) Способ получения простых полиэфирполиолов
PE20081556A1 (es) Formas cristalinas de glyt1
PE20060720A1 (es) Procedimiento para fabricar r-(-)-sertaconazol mononitrato
IL190399A (en) METHOD FOR PREPARING SQUARE ACID AND @ AMONIUM SALTS
CU23171A3 (es) Procedimiento para la preparacion de sal de calcio de zofenopril
PT1272495E (pt) Processo para a preparacao de cefoperazona de sodio altamente cristalina
EA200201236A1 (ru) Новый полиморф v торасемида
UY30798A1 (es) Sales de timo depresores farmacéuticamente aceptables y procesos para su manufactura
ES2267421T1 (es) Procedimiento para la preparacion de acido (6rs)-n(5)-formil-5,6,7,8-tetrahidrofolico cristalino.
AR033030A1 (es) Procedimiento para la produccion de peroxido de hidrogeno
AR014939A1 (es) Proceso para purificar una solucion de un ester profarmaco de ampicilina
BRPI0409930A (pt) cristais de solvato derivado do ácido quinolinacarboxìlico

Legal Events

Date Code Title Description
FB Suspension of granting procedure