AR068527A2 - Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino - Google Patents
Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalinoInfo
- Publication number
- AR068527A2 AR068527A2 ARP080104109A ARP080104109A AR068527A2 AR 068527 A2 AR068527 A2 AR 068527A2 AR P080104109 A ARP080104109 A AR P080104109A AR P080104109 A ARP080104109 A AR P080104109A AR 068527 A2 AR068527 A2 AR 068527A2
- Authority
- AR
- Argentina
- Prior art keywords
- tiotrope
- monohidrate
- bromide
- procedure
- prepare crystal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Procedimiento para la preparacion del monohidrato de bromuro de tiotropio cristalino, caracterizado porque: a) se recoge el bromuro de tiotropio en agua, b) la mezcla obtenida se calienta, e) se anade carbon activo, d) después de remover el carbon activo, el monohidrato de bromuro de tiotropio se cristaliza lentamente por enfriamiento lento de la solucion acuosa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10050621 | 2000-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR068527A2 true AR068527A2 (es) | 2009-11-18 |
Family
ID=7659568
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010104782A Pending AR034389A1 (es) | 2000-10-12 | 2001-10-12 | Monohidrato cristalino de bromuro de tiotropio, procedimiento para su preparacion, su utilización para la preparacion de un medicamento, un medicamento que lo contiene, los hidratos cristalinos del bromuro de tiotropio y un procedimiento para preparacion de estos hidratos cristalinos |
ARP080104109A AR068527A2 (es) | 2000-10-12 | 2008-09-19 | Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010104782A Pending AR034389A1 (es) | 2000-10-12 | 2001-10-12 | Monohidrato cristalino de bromuro de tiotropio, procedimiento para su preparacion, su utilización para la preparacion de un medicamento, un medicamento que lo contiene, los hidratos cristalinos del bromuro de tiotropio y un procedimiento para preparacion de estos hidratos cristalinos |
Country Status (47)
Families Citing this family (74)
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
PL177078B1 (pl) * | 1992-12-09 | 1999-09-30 | Boehringer Ingelheim Pharma | Preparaty roztworów aerozolowych |
DE19834506A1 (de) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Transmucosales therapeutisches System zur Anwendung von Sildenafil |
ES2193726T3 (es) * | 1998-08-04 | 2003-11-01 | Jago Res Ag | Formulaciones de aerosol medicinales. |
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2001
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/me unknown
- 2001-09-28 AU AU1499602A patent/AU1499602A/xx active Pending
- 2001-09-28 SK SK436-2003A patent/SK287009B6/sk not_active IP Right Cessation
- 2001-09-28 EP EP01983510A patent/EP1326862B1/de not_active Expired - Lifetime
- 2001-09-28 SI SI200130219T patent/SI1326862T1/xx unknown
- 2001-09-28 EP EP04016877A patent/EP1468998A1/de not_active Withdrawn
- 2001-09-28 UA UA2003054185A patent/UA74215C2/uk unknown
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-09-28 IL IL15533501A patent/IL155335A0/xx active IP Right Grant
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/fr active
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/ko active IP Right Grant
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/es active IP Right Grant
- 2001-09-28 HU HU0301022A patent/HU226830B1/hu unknown
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- 2001-09-28 PT PT01983510T patent/PT1326862E/pt unknown
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active Active
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/zh not_active Ceased
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- 2001-09-28 DE DE50103666T patent/DE50103666D1/de not_active Expired - Lifetime
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- 2001-09-28 AT AT01983510T patent/ATE276253T1/de active
- 2001-09-28 PL PL366041A patent/PL207870B1/pl unknown
- 2001-09-28 OA OA1200300107A patent/OA12403A/fr unknown
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/pt active Pending
- 2001-09-28 ES ES01983510T patent/ES2228965T3/es not_active Expired - Lifetime
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/de active IP Right Grant
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-09-28 CN CNB018171435A patent/CN1221549C/zh not_active Ceased
- 2001-09-28 EE EEP200300171A patent/EE04567B1/xx unknown
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/ja not_active Expired - Lifetime
- 2001-10-02 SA SA01220412A patent/SA01220412B1/ar unknown
- 2001-10-09 TW TW090124963A patent/TW589313B/zh active
- 2001-10-09 EG EG20011058A patent/EG24142A/xx active
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/es active IP Right Grant
- 2001-10-10 UY UY26962A patent/UY26962A1/es not_active Application Discontinuation
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-12 AR ARP010104782A patent/AR034389A1/es active Pending
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2003
- 2003-03-26 CR CR6938A patent/CR6938A/es unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/bg active Active
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/es unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/fr unknown
- 2003-04-09 IS IS6772A patent/IS2339B/is unknown
- 2003-04-10 HR HR20030276A patent/HRP20030276B1/xx not_active IP Right Cessation
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-11 NO NO20031694A patent/NO328465B1/no not_active IP Right Cessation
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2004
- 2004-05-20 HK HK04103583A patent/HK1060567A1/xx not_active IP Right Cessation
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2006
- 2006-06-07 HK HK06106478.2A patent/HK1086557A1/xx not_active IP Right Cessation
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2008
- 2008-09-19 AR ARP080104109A patent/AR068527A2/es unknown
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2013
- 2013-07-11 UY UY34901A patent/UY34901A/es not_active Application Discontinuation
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