EA200300457A1 - Кристаллический моногидрат, способ его получения и его применение для получения лекарственного средства - Google Patents

Кристаллический моногидрат, способ его получения и его применение для получения лекарственного средства

Info

Publication number
EA200300457A1
EA200300457A1 EA200300457A EA200300457A EA200300457A1 EA 200300457 A1 EA200300457 A1 EA 200300457A1 EA 200300457 A EA200300457 A EA 200300457A EA 200300457 A EA200300457 A EA 200300457A EA 200300457 A1 EA200300457 A1 EA 200300457A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
application
crystalline monohydrate
preparing medicine
obtaining
Prior art date
Application number
EA200300457A
Other languages
English (en)
Other versions
EA004381B1 (ru
Inventor
Рольф Банхольцер
Петер Зигер
Кристиан Кулинна
Михаель Трунк
Манфред Людвиг Аугуст Граулих
Петер Шпехт
Хельмут Майсснер
Андреас Матес
Original Assignee
Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200300457(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг filed Critical Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Publication of EA200300457A1 publication Critical patent/EA200300457A1/ru
Publication of EA004381B1 publication Critical patent/EA004381B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

В заявке описаны кристаллический моногидрат (1α,2β,4β,5α,7β)-7-[(гидроксиди-2-тиенилацетил)окси]-9,9-диметил-3-окса-9-азониатрицикло[3.3.1.0]нонанбромида, способ его получения, а также его применение для получения лекарственного средства, прежде всего для получения лекарственного средства, обладающего антихолинергическим действием.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300457A 2000-10-12 2001-09-28 Кристаллический моногидрат, способ его получения и его применение для получения лекарственного средства EA004381B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12
PCT/EP2001/011225 WO2002030928A1 (de) 2000-10-12 2001-09-28 Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (2)

Publication Number Publication Date
EA200300457A1 true EA200300457A1 (ru) 2003-10-30
EA004381B1 EA004381B1 (ru) 2004-04-29

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300457A EA004381B1 (ru) 2000-10-12 2001-09-28 Кристаллический моногидрат, способ его получения и его применение для получения лекарственного средства

Country Status (47)

Country Link
EP (2) EP1468998A1 (ru)
JP (1) JP3764422B2 (ru)
KR (1) KR100823860B1 (ru)
CN (2) CN1221549C (ru)
AP (1) AP1572A (ru)
AR (2) AR034389A1 (ru)
AT (1) ATE276253T1 (ru)
AU (2) AU1499602A (ru)
BG (1) BG66161B1 (ru)
BR (1) BR0114584A (ru)
CA (1) CA2425539C (ru)
CR (1) CR6938A (ru)
CZ (1) CZ301841B6 (ru)
DE (1) DE50103666D1 (ru)
DK (1) DK1326862T3 (ru)
DZ (1) DZ3478A1 (ru)
EA (1) EA004381B1 (ru)
EC (1) ECSP034540A (ru)
EE (1) EE04567B1 (ru)
EG (1) EG24142A (ru)
ES (1) ES2228965T3 (ru)
GE (1) GEP20063905B (ru)
HK (2) HK1060567A1 (ru)
HR (1) HRP20030276B1 (ru)
HU (1) HU226830B1 (ru)
IL (2) IL155335A0 (ru)
IS (1) IS2339B (ru)
MA (1) MA25842A1 (ru)
ME (2) MEP40008A (ru)
MX (1) MXPA03003221A (ru)
MY (1) MY126931A (ru)
NO (1) NO328465B1 (ru)
NZ (1) NZ525733A (ru)
OA (1) OA12403A (ru)
PE (1) PE20020422A1 (ru)
PL (1) PL207870B1 (ru)
PT (1) PT1326862E (ru)
RS (1) RS50218B (ru)
SA (1) SA01220412B1 (ru)
SI (1) SI1326862T1 (ru)
SK (1) SK287009B6 (ru)
TR (1) TR200402579T4 (ru)
TW (1) TW589313B (ru)
UA (1) UA74215C2 (ru)
UY (2) UY26962A1 (ru)
WO (1) WO2002030928A1 (ru)
ZA (1) ZA200302500B (ru)

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Also Published As

Publication number Publication date
CA2425539A1 (en) 2003-04-11
CN1733761A (zh) 2006-02-15
EG24142A (en) 2008-08-06
MEP40008A (en) 2011-02-10
UA74215C2 (ru) 2005-11-15
IL155335A (en) 2009-02-11
ZA200302500B (en) 2004-04-22
JP3764422B2 (ja) 2006-04-05
MY126931A (en) 2006-10-31
EP1468998A1 (de) 2004-10-20
MXPA03003221A (es) 2004-12-03
BR0114584A (pt) 2003-08-26
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
AU2002214996B2 (en) 2007-03-15
BG107687A (bg) 2003-09-30
SK4362003A3 (en) 2003-08-05
HRP20030276B1 (en) 2006-02-28
HUP0301022A2 (hu) 2003-10-28
KR20030042008A (ko) 2003-05-27
ME00243B (me) 2011-05-10
EA004381B1 (ru) 2004-04-29
CR6938A (es) 2004-10-28
NO328465B1 (no) 2010-02-22
CN100519558C (zh) 2009-07-29
MA25842A1 (fr) 2003-07-01
KR100823860B1 (ko) 2008-04-21
SA01220412B1 (ar) 2006-11-05
BG66161B1 (bg) 2011-09-30
CA2425539C (en) 2007-04-03
CZ301841B6 (cs) 2010-07-07
DZ3478A1 (fr) 2002-04-18
EP1326862B1 (de) 2004-09-15
AP1572A (en) 2006-02-13
JP2004526668A (ja) 2004-09-02
ES2228965T3 (es) 2005-04-16
NO20031694D0 (no) 2003-04-11
HU226830B1 (en) 2009-11-30
PE20020422A1 (es) 2002-06-28
NO20031694L (no) 2003-04-11
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AR034389A1 (es) 2004-02-25
IS2339B (is) 2008-02-15
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PL207870B1 (pl) 2011-02-28
ATE276253T1 (de) 2004-10-15
HUP0301022A3 (en) 2005-12-28
PL366041A1 (en) 2005-01-24
WO2002030928A1 (de) 2002-04-18
OA12403A (en) 2006-04-18
DK1326862T3 (da) 2004-11-22
TR200402579T4 (tr) 2004-12-21
HK1060567A1 (en) 2004-08-13
SK287009B6 (sk) 2009-09-07
EP1326862A1 (de) 2003-07-16
UY34901A (es) 2015-02-27
SI1326862T1 (en) 2005-02-28
DE50103666D1 (de) 2004-10-21
CN1469877A (zh) 2004-01-21
YU27303A (sh) 2006-05-25
PT1326862E (pt) 2004-11-30
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