TR200402579T4 - Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı - Google Patents

Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı

Info

Publication number
TR200402579T4
TR200402579T4 TR2004/02579T TR200402579T TR200402579T4 TR 200402579 T4 TR200402579 T4 TR 200402579T4 TR 2004/02579 T TR2004/02579 T TR 2004/02579T TR 200402579 T TR200402579 T TR 200402579T TR 200402579 T4 TR200402579 T4 TR 200402579T4
Authority
TR
Turkey
Prior art keywords
manufacture
drug substance
crystalline monohydrate
same
monohydrate
Prior art date
Application number
TR2004/02579T
Other languages
English (en)
Inventor
Banholzer Rolf
Sieger Peter
Kulinna Christian
Trunk Michael
Ludwig Manfred Graulich August
Specht Peter
Meissner Helmut
Mathes Andreas
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200402579(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of TR200402579T4 publication Critical patent/TR200402579T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Bulus (1alfa,2 ,4 ,5alfa,7 )-7- [(hidroksidi-2-tienilasetil)oksi]-9 ,9-dimetil-3-oksa-9-azoniatrisiklo [3.3.1.0ÜS(2,4)]nonan-bromid'in bir kristalin monohidrati, aynisinin imalati, ve ayrica aynisinin bir ilaç maddesinin, özellikle de antikolinerjik etkili bir ilaç maddesinin imalati için kullanimi ile ilgilidir.
TR2004/02579T 2000-10-12 2001-09-28 Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı TR200402579T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12

Publications (1)

Publication Number Publication Date
TR200402579T4 true TR200402579T4 (tr) 2004-12-21

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/02579T TR200402579T4 (tr) 2000-10-12 2001-09-28 Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı

Country Status (47)

Country Link
EP (2) EP1326862B1 (tr)
JP (1) JP3764422B2 (tr)
KR (1) KR100823860B1 (tr)
CN (2) CN100519558C (tr)
AP (1) AP1572A (tr)
AR (2) AR034389A1 (tr)
AT (1) ATE276253T1 (tr)
AU (2) AU1499602A (tr)
BG (1) BG66161B1 (tr)
BR (1) BR0114584A (tr)
CA (1) CA2425539C (tr)
CR (1) CR6938A (tr)
CZ (1) CZ301841B6 (tr)
DE (1) DE50103666D1 (tr)
DK (1) DK1326862T3 (tr)
DZ (1) DZ3478A1 (tr)
EA (1) EA004381B1 (tr)
EC (1) ECSP034540A (tr)
EE (1) EE04567B1 (tr)
EG (1) EG24142A (tr)
ES (1) ES2228965T3 (tr)
GE (1) GEP20063905B (tr)
HK (2) HK1060567A1 (tr)
HR (1) HRP20030276B1 (tr)
HU (1) HU226830B1 (tr)
IL (2) IL155335A0 (tr)
IS (1) IS2339B (tr)
MA (1) MA25842A1 (tr)
ME (2) ME00243B (tr)
MX (1) MXPA03003221A (tr)
MY (1) MY126931A (tr)
NO (1) NO328465B1 (tr)
NZ (1) NZ525733A (tr)
OA (1) OA12403A (tr)
PE (1) PE20020422A1 (tr)
PL (1) PL207870B1 (tr)
PT (1) PT1326862E (tr)
RS (1) RS50218B (tr)
SA (1) SA01220412B1 (tr)
SI (1) SI1326862T1 (tr)
SK (1) SK287009B6 (tr)
TR (1) TR200402579T4 (tr)
TW (1) TW589313B (tr)
UA (1) UA74215C2 (tr)
UY (2) UY26962A1 (tr)
WO (1) WO2002030928A1 (tr)
ZA (1) ZA200302500B (tr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
PL208137B1 (pl) * 2001-06-22 2011-03-31 Boehringer Ingelheim Pharma Bezwodny krystaliczny bromek tiotropium, sposób jego wytwarzania i zastosowanie krystalicznego monohydratu bromku tiotropium do wytwarzania krystalicznego bezwodnego bromku tiotropium
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
PL1682542T3 (pl) * 2003-11-03 2010-06-30 Boehringer Ingelheim Int Nowa krystaliczna postać bezwodna o działaniu antycholinergicznym
ATE460414T1 (de) 2003-11-03 2010-03-15 Boehringer Ingelheim Int Verfahren zur herstellung von tiotropiumsalzen
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
EP2322522A1 (de) * 2003-11-03 2011-05-18 Boehringer Ingelheim International Gmbh Neue Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
PT2422786E (pt) 2004-04-22 2014-11-12 Boehringer Ingelheim Int Novas combinações farmacêuticas para o tratamento de doenças respiratórias
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ATE427108T1 (de) 2004-08-11 2009-04-15 Boehringer Ingelheim Pharma Anticholinergika enthaltende arzneimittel zur behandlung von krankheiten der ableitenden harnwege
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
MX2007004768A (es) * 2004-10-21 2007-05-10 Boehringer Ingelheim Int Blister para inhaladores.
WO2006094924A2 (en) * 2005-03-09 2006-09-14 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
BRPI0609899A2 (pt) 2005-04-28 2010-05-11 Boehringer Ingelheim International Gmbh compostos para o tratamento de doenças inflamatórias, uso dos mesmos, formulações farmacêuticas, combinações medicamentosas e produtos intermediários
AU2006243238B2 (en) 2005-05-02 2012-05-24 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
NZ583872A (en) * 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
BRPI0614394A2 (pt) * 2005-08-06 2011-03-29 Boehringer Ingelheim Int uso de sais de tiotrópio
CA2619402C (en) 2005-08-15 2015-02-03 Boehringer Ingelheim International Gmbh Method for producing betamimetics
US20070086957A1 (en) 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
WO2007075838A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Pure and stable tiotropium bromide
CN102731494A (zh) 2005-12-19 2012-10-17 西科尔公司 噻托溴铵的新形式及其制备方法
AU2006334367B2 (en) * 2006-01-04 2012-11-08 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of moderate persistent asthma
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
BRPI0608387A2 (pt) 2006-04-19 2009-12-29 Boehringer Ingelheim Int compostos para o tratamento de doenças inflamatórias
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
JP2010500318A (ja) 2006-08-07 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療用医薬組成物
UY30550A1 (es) 2006-08-22 2008-03-31 Boehringer Ingelheim Int Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
CN101827852B (zh) 2007-10-19 2014-07-30 贝林格尔.英格海姆国际有限公司 取代的哌啶子基-二氢噻吩并嘧啶
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
WO2010011813A1 (en) * 2008-07-23 2010-01-28 Alkermes, Inc. Complex of trospium and pharmaceutical compositions thereof
PL2379525T3 (pl) 2008-12-19 2016-01-29 Centrexion Therapeutics Corp Cykliczne pirymidyno-4-karboksamidy jako antagoniści receptora CCR2 do leczenia stanów zapalnych, astmy oraz COPD
EP2201934A1 (en) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
WO2010101538A2 (en) 2009-03-06 2010-09-10 Bilgic Mahmut New crystal forms
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
JP5822831B2 (ja) 2009-08-07 2015-11-24 ジェネリクス・［ユーケー］・リミテッド チオトロピウム臭化物の無水物
PT2513093E (pt) 2009-12-17 2014-10-22 Boehringer Ingelheim Int Novos antagonistas do receptor ccr2 e suas utilizações
US20130143905A1 (en) 2009-12-17 2013-06-06 Boehringer Ingelheim International Gmbh Novel antagonists for ccr2 and uses thereof
JP5629331B2 (ja) 2010-01-29 2014-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ナフチリジン及びｓｙｋキナーゼ阻害剤としてのその使用
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5647339B2 (ja) 2010-05-17 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２アンタゴニスト及びこれらの使用
WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
JP5959537B2 (ja) 2011-01-28 2016-08-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリジニル−ピリミジン及び医薬としてのその使用
TR201102068A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
JP5786257B2 (ja) 2011-06-16 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の選択的ｃｃｒ２拮抗薬
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
CA2843022C (en) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
EP2914593B1 (en) 2012-11-05 2017-01-11 Zentiva, k.s. Stabilization of tiotropium solvates
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
CN110183440B (zh) 2014-03-19 2022-04-22 勃林格殷格翰国际有限公司 杂芳基syk抑制剂
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
EP3430011A4 (en) * 2016-11-04 2019-08-14 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI NOVEL ACTIVE SUBSTANCE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
PL177078B1 (pl) * 1992-12-09 1999-09-30 Boehringer Ingelheim Pharma Preparaty roztworów aerozolowych
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
ES2193726T3 (es) * 1998-08-04 2003-11-01 Jago Res Ag Formulaciones de aerosol medicinales.

Also Published As

Publication number Publication date
SI1326862T1 (en) 2005-02-28
KR20030042008A (ko) 2003-05-27
CZ301841B6 (cs) 2010-07-07
IS2339B (is) 2008-02-15
ME00243B (me) 2011-05-10
HRP20030276B1 (en) 2006-02-28
SK4362003A3 (en) 2003-08-05
UY34901A (es) 2015-02-27
AU1499602A (en) 2002-04-22
HK1060567A1 (en) 2004-08-13
PT1326862E (pt) 2004-11-30
EG24142A (en) 2008-08-06
YU27303A (sh) 2006-05-25
DZ3478A1 (fr) 2002-04-18
SK287009B6 (sk) 2009-09-07
HK1086557A1 (en) 2006-09-22
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
SA01220412B1 (ar) 2006-11-05
WO2002030928A1 (de) 2002-04-18
BG66161B1 (bg) 2011-09-30
ZA200302500B (en) 2004-04-22
PL207870B1 (pl) 2011-02-28
EE04567B1 (et) 2005-12-15
GEP20063905B (en) 2006-08-25
AP1572A (en) 2006-02-13
NO328465B1 (no) 2010-02-22
MEP40008A (en) 2011-02-10
HU226830B1 (en) 2009-11-30
RS50218B (sr) 2009-07-15
IS6772A (is) 2003-04-09
EP1326862A1 (de) 2003-07-16
PL366041A1 (en) 2005-01-24
HUP0301022A3 (en) 2005-12-28
JP2004526668A (ja) 2004-09-02
CN1733761A (zh) 2006-02-15
ECSP034540A (es) 2003-07-25
NO20031694L (no) 2003-04-11
MY126931A (en) 2006-10-31
CN1469877A (zh) 2004-01-21
CA2425539C (en) 2007-04-03
AR068527A2 (es) 2009-11-18
AU2002214996B2 (en) 2007-03-15
EP1326862B1 (de) 2004-09-15
UA74215C2 (uk) 2005-11-15
HUP0301022A2 (hu) 2003-10-28
ES2228965T3 (es) 2005-04-16
DE50103666D1 (de) 2004-10-21
OA12403A (en) 2006-04-18
CA2425539A1 (en) 2003-04-11
TW589313B (en) 2004-06-01
IL155335A0 (en) 2003-11-23
NZ525733A (en) 2005-01-28
EP1468998A1 (de) 2004-10-20
AR034389A1 (es) 2004-02-25
IL155335A (en) 2009-02-11
DK1326862T3 (da) 2004-11-22
MA25842A1 (fr) 2003-07-01
BG107687A (bg) 2003-09-30
EA004381B1 (ru) 2004-04-29
NO20031694D0 (no) 2003-04-11
AP2003002775A0 (en) 2003-03-31
HRP20030276A2 (en) 2005-02-28
MXPA03003221A (es) 2004-12-03
ATE276253T1 (de) 2004-10-15
KR100823860B1 (ko) 2008-04-21
PE20020422A1 (es) 2002-06-28
CN100519558C (zh) 2009-07-29
CR6938A (es) 2004-10-28
JP3764422B2 (ja) 2006-04-05
UY26962A1 (es) 2002-06-20
BR0114584A (pt) 2003-08-26
EA200300457A1 (ru) 2003-10-30

Similar Documents

Publication Publication Date Title
TR200402579T4 (tr) Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı
BG108440A (en) Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
BR0014818A (pt) Imidazo-3-il-aminas bicìclicas procedimento de preparação e medicamentos que contém como substância ativa pelo menos uma imidazo-3-il-amina bicìclica
TR200103302T2 (tr) Diamorfin etkin maddeli farmasötik preparat
EE200000532A (et) Pürimidiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ningkombineeritud preparaat kasutamiseks HIV nakkusera
BR0014320A (pt) Composições de substâncias terapêuticas solúveis em tocol
HUP0203028A2 (hu) Tolterodint tartalmazó gyógyszerkészítmény és alkalmazása
AR023972A1 (es) Composiciones de medicamentos a base de compuestos anticolinergicamente activos y beta-mimeticos
TR199701018T1 (tr) Oral 2-metil-tieno-benzodiazepin formülasyonu.
BR9912975A (pt) Composto e composições para liberação de agentes ativos, método para sua obtenção e seu uso
NO894887D0 (no) Farmakologisk aktive pyrimidinforbindelser og fremgangsmaate for deres fremstilling.
WO2001019829A3 (en) Pyrazolopyrimidines as therapeutic agents
TR200201058T2 (tr) P38 protein kinaz inhibitörleri olarak, alkilaminoyla ornatılmış bisiklik, azotlu heterosikller
FI962948A (fi) Menetelmä vaikealiukoisten farmaseuttisesti aktiivisten aineiden liuottamiseksi
EE9900086A (et) Bensamidiini derivaadid ja nende kasutamine LTB-4 antagonistliku mõjuga ravimitena
ES2134801T3 (es) Monohidrato de hidrocloruro de tiagabina cristalina, su preparacion y su uso.
HUP0101597A3 (en) Oral medicinal preparations with reproducible release of the active ingredient gatifloxacin or its pharmaceutically suitable salts or hydrates
MX9800408A (es) Sales de derivados de amidina y de inhibidor de ciclooxigenasa, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
MX9708394A (es) Composicion farmaceutica que contiene clorhidrato de tiagabina y el proceso para su preparacion.
EE9400296A (et) Piperidinüültioindooli derivaadid, ravimvormid, aktiivne valuvaigisti, nende valmistamise meetodid
HUP0003836A2 (hu) Lazofoxifent tartalmazó gyógyszerkészítmények
AU7788500A (en) Use of substance p antagonists for influencing the circadian timing system
PL339073A1 (en) Derivatives of benzoxazine and benzothiazine and their application in therapeutic agents
AP2000001937A0 (en) Method for identifying chemical active agents and active agents for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthetic pathway.
DE59910944D1 (de) Transdermales therapeutisches system zur anwendung von candesartan