AP1572A - Crystalline monohydrate, method for producing the same and use thereof in the production of a medicament. - Google Patents

Crystalline monohydrate, method for producing the same and use thereof in the production of a medicament.

Info

Publication number
AP1572A
AP1572A APAP/P/2003/002775A AP2003002775A AP1572A AP 1572 A AP1572 A AP 1572A AP 2003002775 A AP2003002775 A AP 2003002775A AP 1572 A AP1572 A AP 1572A
Authority
AP
ARIPO
Prior art keywords
medicament
producing
production
same
crystalline monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
APAP/P/2003/002775A
Other versions
AP2003002775A0 (en
Inventor
Rolf Banholzer
Peter Sieger
Christian Kulinna
Michael Trunk
Manfred Ludwig August Graulich
Peter Specht
Helmut Meissner
Andreas Mathes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AP2003002775A0 publication Critical patent/AP2003002775A0/en
Application granted granted Critical
Publication of AP1572A publication Critical patent/AP1572A/en
Anticipated expiration legal-status Critical
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a crystalline monohydrate of (1a,2ß,4ß,5a,7ß)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatrycyclo[3.3.1.02-4]nonane bromide, to a method for producing the same, and to the use thereof in the J. of Medical Chem. American Chemical Siciety, Washington, US, vol. 37, 1994, pp 3057-61.production of a medicament, especially for producing a medicament that has an anticholinergic effect.
APAP/P/2003/002775A 2000-10-12 2001-09-28 Crystalline monohydrate, method for producing the same and use thereof in the production of a medicament. Active AP1572A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12
PCT/EP2001/011225 WO2002030928A1 (en) 2000-10-12 2001-09-28 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Publications (2)

Publication Number Publication Date
AP2003002775A0 AP2003002775A0 (en) 2003-03-31
AP1572A true AP1572A (en) 2006-02-13

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2003/002775A Active AP1572A (en) 2000-10-12 2001-09-28 Crystalline monohydrate, method for producing the same and use thereof in the production of a medicament.

Country Status (47)

Country Link
EP (2) EP1326862B1 (en)
JP (1) JP3764422B2 (en)
KR (1) KR100823860B1 (en)
CN (2) CN1221549C (en)
AP (1) AP1572A (en)
AR (2) AR034389A1 (en)
AT (1) ATE276253T1 (en)
AU (2) AU1499602A (en)
BG (1) BG66161B1 (en)
BR (1) BR0114584A (en)
CA (1) CA2425539C (en)
CR (1) CR6938A (en)
CZ (1) CZ301841B6 (en)
DE (1) DE50103666D1 (en)
DK (1) DK1326862T3 (en)
DZ (1) DZ3478A1 (en)
EA (1) EA004381B1 (en)
EC (1) ECSP034540A (en)
EE (1) EE04567B1 (en)
EG (1) EG24142A (en)
ES (1) ES2228965T3 (en)
GE (1) GEP20063905B (en)
HK (2) HK1060567A1 (en)
HR (1) HRP20030276B1 (en)
HU (1) HU226830B1 (en)
IL (2) IL155335A0 (en)
IS (1) IS2339B (en)
MA (1) MA25842A1 (en)
ME (2) ME00243B (en)
MX (1) MXPA03003221A (en)
MY (1) MY126931A (en)
NO (1) NO328465B1 (en)
NZ (1) NZ525733A (en)
OA (1) OA12403A (en)
PE (1) PE20020422A1 (en)
PL (1) PL207870B1 (en)
PT (1) PT1326862E (en)
RS (1) RS50218B (en)
SA (1) SA01220412B1 (en)
SI (1) SI1326862T1 (en)
SK (1) SK287009B6 (en)
TR (1) TR200402579T4 (en)
TW (1) TW589313B (en)
UA (1) UA74215C2 (en)
UY (2) UY26962A1 (en)
WO (1) WO2002030928A1 (en)
ZA (1) ZA200302500B (en)

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US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE10214263A1 (en) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (en) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt
KR20060117334A (en) * 2003-11-03 2006-11-16 베링거 인겔하임 인터내셔날 게엠베하 Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
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US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
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PE20020422A1 (en) 2002-06-28
CN1221549C (en) 2005-10-05
EE200300171A (en) 2003-06-16
RS50218B (en) 2009-07-15
EG24142A (en) 2008-08-06
HK1060567A1 (en) 2004-08-13
CN100519558C (en) 2009-07-29
JP3764422B2 (en) 2006-04-05
HUP0301022A2 (en) 2003-10-28
NO20031694L (en) 2003-04-11
IL155335A (en) 2009-02-11
DE50103666D1 (en) 2004-10-21
AU1499602A (en) 2002-04-22
KR20030042008A (en) 2003-05-27
GEP20063905B (en) 2006-08-25
KR100823860B1 (en) 2008-04-21
HK1086557A1 (en) 2006-09-22
AR068527A2 (en) 2009-11-18
IL155335A0 (en) 2003-11-23
SK4362003A3 (en) 2003-08-05
TR200402579T4 (en) 2004-12-21
CN1733761A (en) 2006-02-15
CA2425539A1 (en) 2003-04-11
HUP0301022A3 (en) 2005-12-28
JP2004526668A (en) 2004-09-02
SI1326862T1 (en) 2005-02-28
UA74215C2 (en) 2005-11-15
AR034389A1 (en) 2004-02-25
DK1326862T3 (en) 2004-11-22
CN1469877A (en) 2004-01-21
EP1326862A1 (en) 2003-07-16
ES2228965T3 (en) 2005-04-16
NO328465B1 (en) 2010-02-22
MA25842A1 (en) 2003-07-01
EP1326862B1 (en) 2004-09-15
NZ525733A (en) 2005-01-28
TW589313B (en) 2004-06-01
YU27303A (en) 2006-05-25
BG66161B1 (en) 2011-09-30
EA004381B1 (en) 2004-04-29
MXPA03003221A (en) 2004-12-03
CA2425539C (en) 2007-04-03
HRP20030276A2 (en) 2005-02-28
HRP20030276B1 (en) 2006-02-28
WO2002030928A1 (en) 2002-04-18
IS2339B (en) 2008-02-15
CZ301841B6 (en) 2010-07-07
PT1326862E (en) 2004-11-30
BG107687A (en) 2003-09-30
AU2002214996B2 (en) 2007-03-15
PL366041A1 (en) 2005-01-24
PL207870B1 (en) 2011-02-28
ZA200302500B (en) 2004-04-22
EA200300457A1 (en) 2003-10-30
OA12403A (en) 2006-04-18
ME00243B (en) 2011-05-10
SK287009B6 (en) 2009-09-07
NO20031694D0 (en) 2003-04-11
EP1468998A1 (en) 2004-10-20
DZ3478A1 (en) 2002-04-18
ATE276253T1 (en) 2004-10-15
BR0114584A (en) 2003-08-26
UY34901A (en) 2015-02-27
HU226830B1 (en) 2009-11-30
CR6938A (en) 2004-10-28
MEP40008A (en) 2011-02-10
MY126931A (en) 2006-10-31
SA01220412B1 (en) 2006-11-05
ECSP034540A (en) 2003-07-25
IS6772A (en) 2003-04-09
UY26962A1 (en) 2002-06-20
AP2003002775A0 (en) 2003-03-31
EE04567B1 (en) 2005-12-15

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