HRP20030276B1 - Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament - Google Patents

Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Info

Publication number
HRP20030276B1
HRP20030276B1 HR20030276A HRP20030276A HRP20030276B1 HR P20030276 B1 HRP20030276 B1 HR P20030276B1 HR 20030276 A HR20030276 A HR 20030276A HR P20030276 A HRP20030276 A HR P20030276A HR P20030276 B1 HRP20030276 B1 HR P20030276B1
Authority
HR
Croatia
Prior art keywords
medicament
producing
production
same
crystalline monohydrate
Prior art date
Application number
HR20030276A
Other languages
Croatian (hr)
Inventor
Banholzer Rolf
Sieger Peter
Kulinna Christian
Trunk Michael
Ludwig August Graulich Manfred
Specht Peter
Meissner Helmut
Mathes Andreas
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20030276(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Publication of HRP20030276A2 publication Critical patent/HRP20030276A2/en
Publication of HRP20030276B1 publication Critical patent/HRP20030276B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Spoj, naznačen time, da je to kristaliničan tiotropij bromid monohidrat. Patent sadrži još 11 patentnih zahtjeva.The compound is crystalline tiotropium bromide monohydrate. The patent contains 11 more patent claims.

HR20030276A 2000-10-12 2003-04-10 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament HRP20030276B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12
PCT/EP2001/011225 WO2002030928A1 (en) 2000-10-12 2001-09-28 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Publications (2)

Publication Number Publication Date
HRP20030276A2 HRP20030276A2 (en) 2005-02-28
HRP20030276B1 true HRP20030276B1 (en) 2006-02-28

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030276A HRP20030276B1 (en) 2000-10-12 2003-04-10 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Country Status (47)

Country Link
EP (2) EP1468998A1 (en)
JP (1) JP3764422B2 (en)
KR (1) KR100823860B1 (en)
CN (2) CN100519558C (en)
AP (1) AP1572A (en)
AR (2) AR034389A1 (en)
AT (1) ATE276253T1 (en)
AU (2) AU2002214996B2 (en)
BG (1) BG66161B1 (en)
BR (1) BR0114584A (en)
CA (1) CA2425539C (en)
CR (1) CR6938A (en)
CZ (1) CZ301841B6 (en)
DE (1) DE50103666D1 (en)
DK (1) DK1326862T3 (en)
DZ (1) DZ3478A1 (en)
EA (1) EA004381B1 (en)
EC (1) ECSP034540A (en)
EE (1) EE04567B1 (en)
EG (1) EG24142A (en)
ES (1) ES2228965T3 (en)
GE (1) GEP20063905B (en)
HK (2) HK1060567A1 (en)
HR (1) HRP20030276B1 (en)
HU (1) HU226830B1 (en)
IL (2) IL155335A0 (en)
IS (1) IS2339B (en)
MA (1) MA25842A1 (en)
ME (2) ME00243B (en)
MX (1) MXPA03003221A (en)
MY (1) MY126931A (en)
NO (1) NO328465B1 (en)
NZ (1) NZ525733A (en)
OA (1) OA12403A (en)
PE (1) PE20020422A1 (en)
PL (1) PL207870B1 (en)
PT (1) PT1326862E (en)
RS (1) RS50218B (en)
SA (1) SA01220412B1 (en)
SI (1) SI1326862T1 (en)
SK (1) SK287009B6 (en)
TR (1) TR200402579T4 (en)
TW (1) TW589313B (en)
UA (1) UA74215C2 (en)
UY (2) UY26962A1 (en)
WO (1) WO2002030928A1 (en)
ZA (1) ZA200302500B (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
EP1401445B1 (en) * 2001-06-22 2006-08-23 Boehringer Ingelheim Pharma GmbH & Co.KG Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
DE10212264A1 (en) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214263A1 (en) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA suspension formulations containing an anticholinergic
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (en) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt
AU2004285683C1 (en) 2003-11-03 2011-09-08 Boehringer Ingelheim International Gmbh Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
SG149876A1 (en) * 2003-11-03 2009-02-27 Boehringer Ingelheim Int Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DE502004010602D1 (en) * 2003-11-03 2010-02-11 Boehringer Ingelheim Pharma NEW CRYSTALLINE ANHYDRATE WITH ANTICHOLINERGER EFFICACY
DE102004016179A1 (en) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Compounds for the treatment of proliferative processes
ES2523518T3 (en) 2004-04-22 2014-11-26 Boehringer Ingelheim International Gmbh New pharmacological combinations for the treatment of respiratory diseases
DE102004024454A1 (en) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE602004020337D1 (en) 2004-08-11 2009-05-14 Boehringer Ingelheim Pharma Anticholinergic drugs for the treatment of urinary tract disorders
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (en) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modification of surfaces of lactose as adjuvant for use with powder inhalants
EP1827541B1 (en) * 2004-10-21 2013-05-29 Boehringer Ingelheim International GmbH Blister for inhalers
EP1858554A2 (en) * 2005-03-09 2007-11-28 Boehringer Ingelheim International GmbH New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
ES2328400T3 (en) 2005-04-21 2009-11-12 Boehringer Ingelheim International Gmbh DIHYDROTIENOPIRIMIDINS FOR THE TREATMENT OF INFLAMMATORY DISEASES.
WO2006114371A1 (en) 2005-04-28 2006-11-02 Boehringer Ingelheim International Gmbh Novel compounds for treating inflammatory diseases
CN101203513A (en) * 2005-05-02 2008-06-18 贝林格尔·英格海姆国际有限公司 Novel crystalline forms of tiotropium bromide
AU2006243238B2 (en) 2005-05-02 2012-05-24 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
EP1896026B1 (en) * 2005-06-15 2013-10-09 Boehringer Ingelheim International GmbH Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (en) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
AU2006277968A1 (en) * 2005-08-06 2007-02-15 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of severe persistant asthma
CA2619402C (en) 2005-08-15 2015-02-03 Boehringer Ingelheim International Gmbh Method for producing betamimetics
US20070086957A1 (en) 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (en) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Micronization process
KR101395881B1 (en) 2005-12-19 2014-05-21 시코르, 인크. Novel forms of tiotropium bromide and processes for preparation thereof
WO2007075838A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Pure and stable tiotropium bromide
PT1971332E (en) * 2006-01-04 2011-03-18 Boehringer Ingelheim Int Use of tiotropium salts in the treatment of moderate persistent asthma
EP1847543A1 (en) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidines for the treatment of inflammatory diseases
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CA2660186A1 (en) 2006-08-07 2008-02-14 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of respiratory diseases
UY30550A1 (en) 2006-08-22 2008-03-31 Boehringer Ingelheim Int NEW BETA-AGANISTAS ENANTIOMÉRICAMENTE PUROS, PROCEDURES FOR ITS PREPARATION AND ITS USE AS MEDICATIONS
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (en) 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stable powder formulation containing a new antichinolinergic agent
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
EP2610258B1 (en) 2007-10-19 2014-08-27 Boehringer Ingelheim International Gmbh Substituted piperidino dihydrothieno pyrimidines
EP2093219A1 (en) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Crystalline enantiomer free salt form of a betamimetic and its use as medicine
WO2010011813A1 (en) * 2008-07-23 2010-01-28 Alkermes, Inc. Complex of trospium and pharmaceutical compositions thereof
US20120053164A1 (en) 2008-12-19 2012-03-01 Boehringer Ingelheim International Gmbh Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
EP2201934A1 (en) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
AU2010280497B2 (en) 2009-08-07 2015-10-22 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
KR101530234B1 (en) 2009-12-17 2015-06-19 베링거 인겔하임 인터내셔날 게엠베하 New ccr2 receptor antagonists and uses thereof
US20130143905A1 (en) 2009-12-17 2013-06-06 Boehringer Ingelheim International Gmbh Novel antagonists for ccr2 and uses thereof
BR112012018865A2 (en) 2010-01-29 2016-04-12 Boehringer Ingelheim Int substituted naphthyridines and their use as syk kinase inhibitors
JP5646736B2 (en) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel CCR2 receptor antagonists, methods for their preparation, and their use as drugs
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
JP5721242B2 (en) 2010-06-01 2015-05-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel CCR2 antagonist
JP5959537B2 (en) 2011-01-28 2016-08-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Substituted pyridinyl-pyrimidines and their use as pharmaceuticals
TR201102068A2 (en) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Crystalline substances containing tiotropium bromide
WO2012171863A1 (en) 2011-06-16 2012-12-20 Boehringer Ingelheim International Gmbh New selective ccr2 antagonists
JP5786258B2 (en) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel and selective CCR2 antagonist
BR112014001898A2 (en) 2011-07-26 2017-02-21 Boehringer Ingelheim Int substituted quinolines and their use as medicines
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (en) 2011-11-28 2014-04-02 Zentiva, K.S. Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
DK2914593T3 (en) 2012-11-05 2017-04-18 Zentiva Ks STABILIZATION OF TIOTROPIUM SOLVATES
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
MX2016011784A (en) 2014-03-19 2016-12-02 Boehringer Ingelheim Int Heteroaryl syk inhibitors.
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (en) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович CRYSTALLINE γ-MODIFICATION (1α,2β,4β,5α,7β)-7-[(HYDROXYDI-2-THIENYLACETYL)OXY]-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3,3,1,02,4]NONANE BROMIDE MONOHYDRATE, METHOD OF THEREOF OBTAINING AND THEREOF-BASED PHARMACEUTICAL COMPOSITION
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
WO2018084817A2 (en) * 2016-11-04 2018-05-11 Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ A new form of active agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (en) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them
EP0673240B1 (en) * 1992-12-09 1999-03-24 Boehringer Ingelheim Pharmaceuticals Inc. Stabilized medicinal aerosol solution formulations
DE19834506A1 (en) * 1998-07-31 2000-02-03 Hexal Ag Transmucosal therapeutic system for the use of sildenafil
US6475467B1 (en) * 1998-08-04 2002-11-05 Jago Research Ag Medicinal aerosol formulations

Also Published As

Publication number Publication date
EG24142A (en) 2008-08-06
HUP0301022A2 (en) 2003-10-28
AP1572A (en) 2006-02-13
BR0114584A (en) 2003-08-26
MEP40008A (en) 2011-02-10
IL155335A0 (en) 2003-11-23
SK287009B6 (en) 2009-09-07
NO20031694D0 (en) 2003-04-11
NZ525733A (en) 2005-01-28
JP3764422B2 (en) 2006-04-05
PT1326862E (en) 2004-11-30
AP2003002775A0 (en) 2003-03-31
NO20031694L (en) 2003-04-11
CA2425539A1 (en) 2003-04-11
BG107687A (en) 2003-09-30
CN1221549C (en) 2005-10-05
EE200300171A (en) 2003-06-16
YU27303A (en) 2006-05-25
KR100823860B1 (en) 2008-04-21
MXPA03003221A (en) 2004-12-03
AR068527A2 (en) 2009-11-18
SK4362003A3 (en) 2003-08-05
SA01220412B1 (en) 2006-11-05
TR200402579T4 (en) 2004-12-21
MY126931A (en) 2006-10-31
EE04567B1 (en) 2005-12-15
UA74215C2 (en) 2005-11-15
DZ3478A1 (en) 2002-04-18
PL207870B1 (en) 2011-02-28
WO2002030928A1 (en) 2002-04-18
BG66161B1 (en) 2011-09-30
ME00243B (en) 2011-05-10
OA12403A (en) 2006-04-18
EA004381B1 (en) 2004-04-29
CR6938A (en) 2004-10-28
KR20030042008A (en) 2003-05-27
PE20020422A1 (en) 2002-06-28
PL366041A1 (en) 2005-01-24
EP1468998A1 (en) 2004-10-20
GEP20063905B (en) 2006-08-25
EA200300457A1 (en) 2003-10-30
EP1326862B1 (en) 2004-09-15
JP2004526668A (en) 2004-09-02
DK1326862T3 (en) 2004-11-22
CN100519558C (en) 2009-07-29
EP1326862A1 (en) 2003-07-16
ATE276253T1 (en) 2004-10-15
HU226830B1 (en) 2009-11-30
HK1060567A1 (en) 2004-08-13
SI1326862T1 (en) 2005-02-28
DE50103666D1 (en) 2004-10-21
AU2002214996B2 (en) 2007-03-15
MA25842A1 (en) 2003-07-01
HRP20030276A2 (en) 2005-02-28
ZA200302500B (en) 2004-04-22
CN1733761A (en) 2006-02-15
NO328465B1 (en) 2010-02-22
ES2228965T3 (en) 2005-04-16
RS50218B (en) 2009-07-15
AR034389A1 (en) 2004-02-25
HUP0301022A3 (en) 2005-12-28
HK1086557A1 (en) 2006-09-22
UY26962A1 (en) 2002-06-20
IS2339B (en) 2008-02-15
IS6772A (en) 2003-04-09
ECSP034540A (en) 2003-07-25
CN1469877A (en) 2004-01-21
CA2425539C (en) 2007-04-03
CZ301841B6 (en) 2010-07-07
IL155335A (en) 2009-02-11
UY34901A (en) 2015-02-27
AU1499602A (en) 2002-04-22
TW589313B (en) 2004-06-01

Similar Documents

Publication Publication Date Title
HRP20030276B1 (en) Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
YU69902A (en) New piperazine derivatives
RS50140B (en) Percyquinnin, a process for its production, and its use as a pharmaceutical
HRP20030502B1 (en) Method for producing the anticholinergic agent tiotropium bromide
MXPA05013752A (en) Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof.
HUP0400333A2 (en) Crystalline anticholinergic, method for its production, and use thereof in the production of pharmaceutical composition
AU2002214996A1 (en) Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
CY1111061T1 (en) NEW HYDROCYCLIC UNIONS ACTIVE AS BETA-LACTAMA INHIBITIONS
HK1046374B (en) Camptothecin analogs and methods of preparation thereof
ATE341550T1 (en) QUINOLINYL-PYRROLOPYRAZOLES
RS51146B (en) Novel diphenyl azetidinone with improved phzsiological characteristics, corresponding production method, medicaments containing said compound and use of the latter
YU17301A (en) CRYSTALLINE FORMS EtO2C-CH2-(R)-Cgl-Aze-Pab-OH
ATE303384T1 (en) 1-BIARYL-1,8-NAPHTHYRIDINE-4-ONE AS PHOSPHODIESETERASE INHIBITORS
ATE202483T1 (en) IMMUNTOLERANT PROTHROMBIN COMPLEX PREPARATION
YU30603A (en) Bridged piperazine derivatives
ATE527257T1 (en) TECHNICAL PRODUCTION OF TIOTROPIUM BROMIDE
GB0212410D0 (en) Organic compounds
MY132777A (en) Inhalable formulation of a solution containing a tiotropium salt
MY133169A (en) Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect
BR0213156A (en) Anhydrous crystalline forms of gabapentin
ATE344272T1 (en) URIdine derivatives as antibiotics
AP2002002595A0 (en) Heterocyclic amide derivatives.
DE50010253D1 (en) SUBSTITUTED 1- AND 2-NAPHTHOL MANNICHBASES
MY127328A (en) 5-amino-1-pentene-3-ol substituted derivatives
BR0211733A (en) Salts of substituted 1,2,3,4-tetrahydroquinolin-2-carboxylic acid derivatives

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20190910

Year of fee payment: 19

ODRP Renewal fee for the maintenance of a patent

Payment date: 20200921

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20210928