HK1060567A1 - Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament. - Google Patents

Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament.

Info

Publication number
HK1060567A1
HK1060567A1 HK04103583A HK04103583A HK1060567A1 HK 1060567 A1 HK1060567 A1 HK 1060567A1 HK 04103583 A HK04103583 A HK 04103583A HK 04103583 A HK04103583 A HK 04103583A HK 1060567 A1 HK1060567 A1 HK 1060567A1
Authority
HK
Hong Kong
Prior art keywords
medicament
producing
production
same
crystalline monohydrate
Prior art date
Application number
HK04103583A
Inventor
Rolf Banholzer
Peter Sieger
Christian Kulinna
Michael Trunk
Manfred Ludwig August Graulich
Peter Specht
Helmut Meissner
Andreas Mathes
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1060567(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of HK1060567A1 publication Critical patent/HK1060567A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Crystalline monohydrate (I) of tiotropium bromide ((1alpha,2beta,4beta,5alpha,7beta)-7-(2-hydroxy-2,2-di(2-thienyl)acetoxy)-9,9-dimethyl-3-oxa-9-azonia-tricyclo(3.3.1.02.4)nonane bromide) is new. An Independent claim is also included for the preparation of (I).
HK04103583A 2000-10-12 2004-05-20 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament. HK1060567A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12
PCT/EP2001/011225 WO2002030928A1 (en) 2000-10-12 2001-09-28 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Publications (1)

Publication Number Publication Date
HK1060567A1 true HK1060567A1 (en) 2004-08-13

Family

ID=7659568

Family Applications (2)

Application Number Title Priority Date Filing Date
HK04103583A HK1060567A1 (en) 2000-10-12 2004-05-20 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament.
HK06106478.2A HK1086557A1 (en) 2000-10-12 2006-06-07 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK06106478.2A HK1086557A1 (en) 2000-10-12 2006-06-07 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Country Status (47)

Country Link
EP (2) EP1468998A1 (en)
JP (1) JP3764422B2 (en)
KR (1) KR100823860B1 (en)
CN (2) CN1221549C (en)
AP (1) AP1572A (en)
AR (2) AR034389A1 (en)
AT (1) ATE276253T1 (en)
AU (2) AU1499602A (en)
BG (1) BG66161B1 (en)
BR (1) BR0114584A (en)
CA (1) CA2425539C (en)
CR (1) CR6938A (en)
CZ (1) CZ301841B6 (en)
DE (1) DE50103666D1 (en)
DK (1) DK1326862T3 (en)
DZ (1) DZ3478A1 (en)
EA (1) EA004381B1 (en)
EC (1) ECSP034540A (en)
EE (1) EE04567B1 (en)
EG (1) EG24142A (en)
ES (1) ES2228965T3 (en)
GE (1) GEP20063905B (en)
HK (2) HK1060567A1 (en)
HR (1) HRP20030276B1 (en)
HU (1) HU226830B1 (en)
IL (2) IL155335A0 (en)
IS (1) IS2339B (en)
MA (1) MA25842A1 (en)
ME (2) ME00243B (en)
MX (1) MXPA03003221A (en)
MY (1) MY126931A (en)
NO (1) NO328465B1 (en)
NZ (1) NZ525733A (en)
OA (1) OA12403A (en)
PE (1) PE20020422A1 (en)
PL (1) PL207870B1 (en)
PT (1) PT1326862E (en)
RS (1) RS50218B (en)
SA (1) SA01220412B1 (en)
SI (1) SI1326862T1 (en)
SK (1) SK287009B6 (en)
TR (1) TR200402579T4 (en)
TW (1) TW589313B (en)
UA (1) UA74215C2 (en)
UY (2) UY26962A1 (en)
WO (1) WO2002030928A1 (en)
ZA (1) ZA200302500B (en)

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CZ301841B6 (en) 2010-07-07
NO20031694L (en) 2003-04-11
DK1326862T3 (en) 2004-11-22
DZ3478A1 (en) 2002-04-18
CN1469877A (en) 2004-01-21
UY34901A (en) 2015-02-27
IL155335A (en) 2009-02-11
ECSP034540A (en) 2003-07-25
BG66161B1 (en) 2011-09-30
AU2002214996B2 (en) 2007-03-15
CN1221549C (en) 2005-10-05
EE200300171A (en) 2003-06-16
IL155335A0 (en) 2003-11-23
TW589313B (en) 2004-06-01
IS6772A (en) 2003-04-09
NZ525733A (en) 2005-01-28
CN100519558C (en) 2009-07-29
UY26962A1 (en) 2002-06-20
EG24142A (en) 2008-08-06
HUP0301022A3 (en) 2005-12-28
PL366041A1 (en) 2005-01-24
BG107687A (en) 2003-09-30
TR200402579T4 (en) 2004-12-21
OA12403A (en) 2006-04-18
CN1733761A (en) 2006-02-15
AR034389A1 (en) 2004-02-25
DE50103666D1 (en) 2004-10-21
AP2003002775A0 (en) 2003-03-31
CA2425539A1 (en) 2003-04-11
EA200300457A1 (en) 2003-10-30
HUP0301022A2 (en) 2003-10-28
SA01220412B1 (en) 2006-11-05
PL207870B1 (en) 2011-02-28
PT1326862E (en) 2004-11-30
CR6938A (en) 2004-10-28
SK4362003A3 (en) 2003-08-05
MA25842A1 (en) 2003-07-01
IS2339B (en) 2008-02-15
UA74215C2 (en) 2005-11-15
NO328465B1 (en) 2010-02-22
HRP20030276A2 (en) 2005-02-28
NO20031694D0 (en) 2003-04-11
EE04567B1 (en) 2005-12-15
EA004381B1 (en) 2004-04-29
PE20020422A1 (en) 2002-06-28
MEP40008A (en) 2011-02-10
KR20030042008A (en) 2003-05-27
AU1499602A (en) 2002-04-22
RS50218B (en) 2009-07-15
MXPA03003221A (en) 2004-12-03
EP1326862B1 (en) 2004-09-15
WO2002030928A1 (en) 2002-04-18
JP3764422B2 (en) 2006-04-05
SI1326862T1 (en) 2005-02-28
GEP20063905B (en) 2006-08-25
HK1086557A1 (en) 2006-09-22
HRP20030276B1 (en) 2006-02-28
JP2004526668A (en) 2004-09-02
ZA200302500B (en) 2004-04-22
KR100823860B1 (en) 2008-04-21
EP1468998A1 (en) 2004-10-20
AR068527A2 (en) 2009-11-18
CA2425539C (en) 2007-04-03
EP1326862A1 (en) 2003-07-16
ME00243B (en) 2011-05-10
MY126931A (en) 2006-10-31
HU226830B1 (en) 2009-11-30
SK287009B6 (en) 2009-09-07
BR0114584A (en) 2003-08-26
YU27303A (en) 2006-05-25
AP1572A (en) 2006-02-13
ES2228965T3 (en) 2005-04-16
ATE276253T1 (en) 2004-10-15

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