MA25842A1 - Monohydrate cristallin, procede pour sa fabrication et son utilisation pour la fabrication d'un medicament. - Google Patents

Monohydrate cristallin, procede pour sa fabrication et son utilisation pour la fabrication d'un medicament.

Info

Publication number
MA25842A1
MA25842A1 MA27102A MA27102A MA25842A1 MA 25842 A1 MA25842 A1 MA 25842A1 MA 27102 A MA27102 A MA 27102A MA 27102 A MA27102 A MA 27102A MA 25842 A1 MA25842 A1 MA 25842A1
Authority
MA
Morocco
Prior art keywords
manufacture
medicament
crystalline monohydrate
bromide
monohydrate
Prior art date
Application number
MA27102A
Other languages
English (en)
Inventor
Rolf Banholzer
Peter Sieger
Christian Kulinna
Michael Trunk
Manfred Ludwig August Graulich
Peter Specht
Helmut Meissner
Andreas Mathes
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA25842(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MA25842A1 publication Critical patent/MA25842A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/10Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA27102A 2000-10-12 2003-04-08 Monohydrate cristallin, procede pour sa fabrication et son utilisation pour la fabrication d'un medicament. MA25842A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12

Publications (1)

Publication Number Publication Date
MA25842A1 true MA25842A1 (fr) 2003-07-01

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27102A MA25842A1 (fr) 2000-10-12 2003-04-08 Monohydrate cristallin, procede pour sa fabrication et son utilisation pour la fabrication d'un medicament.

Country Status (47)

Country Link
EP (2) EP1326862B1 (fr)
JP (1) JP3764422B2 (fr)
KR (1) KR100823860B1 (fr)
CN (2) CN100519558C (fr)
AP (1) AP1572A (fr)
AR (2) AR034389A1 (fr)
AT (1) ATE276253T1 (fr)
AU (2) AU2002214996B2 (fr)
BG (1) BG66161B1 (fr)
BR (1) BR0114584A (fr)
CA (1) CA2425539C (fr)
CR (1) CR6938A (fr)
CZ (1) CZ301841B6 (fr)
DE (1) DE50103666D1 (fr)
DK (1) DK1326862T3 (fr)
DZ (1) DZ3478A1 (fr)
EA (1) EA004381B1 (fr)
EC (1) ECSP034540A (fr)
EE (1) EE04567B1 (fr)
EG (1) EG24142A (fr)
ES (1) ES2228965T3 (fr)
GE (1) GEP20063905B (fr)
HK (2) HK1060567A1 (fr)
HR (1) HRP20030276B1 (fr)
HU (1) HU226830B1 (fr)
IL (2) IL155335A0 (fr)
IS (1) IS2339B (fr)
MA (1) MA25842A1 (fr)
ME (2) ME00243B (fr)
MX (1) MXPA03003221A (fr)
MY (1) MY126931A (fr)
NO (1) NO328465B1 (fr)
NZ (1) NZ525733A (fr)
OA (1) OA12403A (fr)
PE (1) PE20020422A1 (fr)
PL (1) PL207870B1 (fr)
PT (1) PT1326862E (fr)
RS (1) RS50218B (fr)
SA (1) SA01220412B1 (fr)
SI (1) SI1326862T1 (fr)
SK (1) SK287009B6 (fr)
TR (1) TR200402579T4 (fr)
TW (1) TW589313B (fr)
UA (1) UA74215C2 (fr)
UY (2) UY26962A1 (fr)
WO (1) WO2002030928A1 (fr)
ZA (1) ZA200302500B (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
BR0210537A (pt) * 2001-06-22 2004-06-22 Boehringer Ingelheim Pharma Anticolinérgico cristalino, processo para a sua preparação e sua aplicação para a preparação de um medicamento
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
AU2004285684B2 (en) * 2003-11-03 2011-07-14 Boehringer Ingelheim International Gmbh Novel crystalline anhydride with anticholinergic effect
UY28589A1 (es) * 2003-11-03 2005-06-30 Boehringer Ingelheim Int Nuevas sales de tiotropio, procedimientos para su preparación , así como formulaciones medicamentosas que las contienen
SG137859A1 (en) 2003-11-03 2007-12-28 Boehringer Ingelheim Int Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
BRPI0510080B8 (pt) 2004-04-22 2021-05-25 Boehringer Ingelheim Int combinação farmacêutica e seu uso
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE602004020337D1 (de) 2004-08-11 2009-05-14 Boehringer Ingelheim Pharma Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
JP5566576B2 (ja) * 2004-10-21 2014-08-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 吸入器用ブリスタ
JP2008532973A (ja) * 2005-03-09 2008-08-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬とpde5−阻害剤に基づく新規な医薬組成物
KR20080007645A (ko) 2005-04-28 2008-01-22 베링거 인겔하임 인터내셔날 게엠베하 염증성 질환 치료용 신규 화합물
JP5227790B2 (ja) 2005-05-02 2013-07-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
JP2008540367A (ja) * 2005-05-02 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
EP1896026B1 (fr) * 2005-06-15 2013-10-09 Boehringer Ingelheim International GmbH Procedé de fabrication des sels de tiotropium, des sels de tiotropium et compositions pharmaceutiques
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
NZ566399A (en) * 2005-08-06 2011-07-29 Boehringer Ingelheim Int Use of tiotropium salts in the treatment of severe persistant asthma
RU2412176C2 (ru) 2005-08-15 2011-02-20 Бёрингер Ингельхайм Интернациональ Гмбх Способ получения бетамиметиков
TWI396541B (zh) 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
CN102731494A (zh) 2005-12-19 2012-10-17 西科尔公司 噻托溴铵的新形式及其制备方法
EP1966196A2 (fr) * 2005-12-19 2008-09-10 Sicor, Inc. Bromure de tiotropium pur et stable
ES2362306T3 (es) * 2006-01-04 2011-07-01 Boehringer Ingelheim International Gmbh Uso de sales de tiotropio en el tratamiento de asma persistente moderada.
EP2060575A1 (fr) 2006-04-19 2009-05-20 Boehringer Ingelheim International GmbH Dihydrothienopyrimidines et leur utilisation pour traiter des maladies inflammatoires
EP1847543A1 (fr) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidines pour le traitement de maladies inflammatoires
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CA2660186A1 (fr) 2006-08-07 2008-02-14 Boehringer Ingelheim International Gmbh Combinaisons de medicaments pour le traitement d'affections des voies respiratoires
UY30550A1 (es) 2006-08-22 2008-03-31 Boehringer Ingelheim Int Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos
EP1923393A1 (fr) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Forme cristalline de tiotropium bromide avec urée
EP1925295A1 (fr) 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Formule de poudre stable contenant un nouveau anticholinergique
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
MY153979A (en) 2007-10-19 2015-04-30 Boehringer Ingelheim Int Substituted piperidino-dihydrothienopyrimidine
EP2093219A1 (fr) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Forme de sel à énantiomère pur et cristalline d'un bêtamimétique et son utilisation comme médicament
US20100272811A1 (en) * 2008-07-23 2010-10-28 Alkermes,Inc. Complex of trospium and pharmaceutical compositions thereof
DK2379525T3 (en) 2008-12-19 2015-10-19 Boehringer Ingelheim Int Cyclic pyrimidin-4-carboxamides, as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
EP2201934A1 (fr) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Produits de formule d'aérosol de tiotropium avec stabilité chimique améliorée
EP2403851B1 (fr) 2009-03-06 2015-06-17 Mahmut Bilgic Nouvelles formes cristallines de bromure de tiotropium
WO2011015883A1 (fr) 2009-08-07 2011-02-10 Generics [Uk] Limited Solvate de dichlorométhane du bromure de tiotropium et son utilisation
NZ624602A (en) 2009-08-07 2015-11-27 Generics Uk Ltd Anhydrate of tiotropium bromide
EP2513086B1 (fr) 2009-12-17 2015-04-29 Boehringer Ingelheim International GmbH Nouveaux antagonistes pour CCR2 et utilisations associées
DK2513093T3 (da) 2009-12-17 2014-09-29 Boehringer Ingelheim Int Nye CCR2 receptor antagonister og anvendelser deraf
MX2012008533A (es) 2010-01-29 2012-08-31 Boehringer Ingelheim Int Naftiridinas sustituidas y su uso como inhibidores de syk quinasa.
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8946218B2 (en) 2010-05-12 2015-02-03 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2571870B1 (fr) 2010-05-17 2015-01-21 Boehringer Ingelheim International GmbH Antagonistes de ccr2 et leurs utilisations
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
EP2576538B1 (fr) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH Nouveaux antagonistes de CCR2
WO2012101013A1 (fr) 2011-01-28 2012-08-02 Boehringer Ingelheim International Gmbh Pyridinyl-pyrimidines substituées et leur utilisation en tant que médicaments
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
JP5786257B2 (ja) 2011-06-16 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の選択的ccr2拮抗薬
WO2013010839A1 (fr) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Antagonistes de ccr2 nouveaux et sélectifs
CA2843022C (fr) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Quinoleines substituees et leur utilisation comme medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) * 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
RS55919B1 (sr) 2012-11-05 2017-09-29 Zentiva As Stabilizacija solvata tiotropijuma
EP2913332A1 (fr) * 2014-02-27 2015-09-02 Euticals S.P.A. Forme cristalline de bromure de tiotropium et de lactose
PT3119772T (pt) 2014-03-19 2019-09-05 Boehringer Ingelheim Int Inibidores de syk heteroarilo
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (fr) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Forme cristalline d'anhydrate de bromure de tiotropium
WO2018084817A2 (fr) * 2016-11-04 2018-05-11 Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ Nouvelle forme d'agent actif

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
AU680227B2 (en) * 1992-12-09 1997-07-24 Boehringer Ingelheim Pharmaceuticals, Inc. Stabilized medicinal aerosol solution formulations
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
US6475467B1 (en) * 1998-08-04 2002-11-05 Jago Research Ag Medicinal aerosol formulations

Also Published As

Publication number Publication date
TR200402579T4 (tr) 2004-12-21
PT1326862E (pt) 2004-11-30
DE50103666D1 (de) 2004-10-21
BG66161B1 (bg) 2011-09-30
IS2339B (is) 2008-02-15
HRP20030276B1 (en) 2006-02-28
AR068527A2 (es) 2009-11-18
PE20020422A1 (es) 2002-06-28
UY26962A1 (es) 2002-06-20
EP1326862A1 (fr) 2003-07-16
HUP0301022A2 (hu) 2003-10-28
CN1733761A (zh) 2006-02-15
SK287009B6 (sk) 2009-09-07
AP1572A (en) 2006-02-13
HRP20030276A2 (en) 2005-02-28
DK1326862T3 (da) 2004-11-22
NO20031694D0 (no) 2003-04-11
YU27303A (sh) 2006-05-25
UY34901A (es) 2015-02-27
ME00243B (me) 2011-05-10
AR034389A1 (es) 2004-02-25
IL155335A0 (en) 2003-11-23
HU226830B1 (en) 2009-11-30
IS6772A (is) 2003-04-09
ECSP034540A (es) 2003-07-25
GEP20063905B (en) 2006-08-25
HK1060567A1 (en) 2004-08-13
WO2002030928A1 (fr) 2002-04-18
AU2002214996B2 (en) 2007-03-15
MY126931A (en) 2006-10-31
CA2425539C (fr) 2007-04-03
CA2425539A1 (fr) 2003-04-11
JP2004526668A (ja) 2004-09-02
EA004381B1 (ru) 2004-04-29
HUP0301022A3 (en) 2005-12-28
CN1469877A (zh) 2004-01-21
MEP40008A (en) 2011-02-10
CZ301841B6 (cs) 2010-07-07
EG24142A (en) 2008-08-06
IL155335A (en) 2009-02-11
RS50218B (sr) 2009-07-15
EA200300457A1 (ru) 2003-10-30
OA12403A (en) 2006-04-18
NO20031694L (no) 2003-04-11
CR6938A (es) 2004-10-28
MXPA03003221A (es) 2004-12-03
EP1468998A1 (fr) 2004-10-20
HK1086557A1 (en) 2006-09-22
NZ525733A (en) 2005-01-28
DZ3478A1 (fr) 2002-04-18
SK4362003A3 (en) 2003-08-05
NO328465B1 (no) 2010-02-22
PL207870B1 (pl) 2011-02-28
KR20030042008A (ko) 2003-05-27
PL366041A1 (en) 2005-01-24
BR0114584A (pt) 2003-08-26
BG107687A (bg) 2003-09-30
JP3764422B2 (ja) 2006-04-05
CN100519558C (zh) 2009-07-29
EP1326862B1 (fr) 2004-09-15
UA74215C2 (uk) 2005-11-15
SA01220412B1 (ar) 2006-11-05
KR100823860B1 (ko) 2008-04-21
ZA200302500B (en) 2004-04-22
ES2228965T3 (es) 2005-04-16
SI1326862T1 (en) 2005-02-28
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
AP2003002775A0 (en) 2003-03-31
AU1499602A (en) 2002-04-22
TW589313B (en) 2004-06-01
ATE276253T1 (de) 2004-10-15
EE04567B1 (et) 2005-12-15

Similar Documents

Publication Publication Date Title
MA25842A1 (fr) Monohydrate cristallin, procede pour sa fabrication et son utilisation pour la fabrication d&#39;un medicament.
CY1105210T1 (el) Μεθοδος για την παρασκευη προδρομου ενωσης του αντιχολινενepγου tiotropiumbromid
EE05287B1 (et) Tsklopentanoindoolid, nende kasutamine ravimi valmistamiseks ning neid sisaldav farmatseutiline kompositsioon
CY1105223T1 (el) Κρυσταλλικο αντιχολινepγικο, μεθοδος για την παραγωγη του και τη χρηση του για τη παραγωγη ενος φαρμακου
DK1385519T3 (da) Tiotropiumsalte til behandling af inflammatoriske sygdomme
RS57551B1 (sr) Mikronizovani kristalni tiotropium bromid
BG104329A (en) New method of treatment
FI963450A0 (fi) Morfoliinitakykiniinireseptoriantagonistien lääke-esiastetta
CY1108100T1 (el) Διαδικασια για την παρασκευη εστερων κυκλοπροπυλ καρβοξυλικου οξεος και παραγωγων
NO2013002I1 (no) Aklidinium haogenid (Aklidinium bromid)
CO5011096A1 (es) Medicamentos que contienen antagonistas del receptor 5-ht3 para el tratamiento de la ibs
FR2805339B1 (fr) Procede de production d&#39;oxygene par rectification cryogenique
ITNA20000036A0 (it) Nuovi approcci terapeutici per il trattamento della forfora.
NO870998L (no) FremgangsmŸte for fremstilling av nye, terapeutisk aktive acetamid-derivater.
IT1320192B1 (it) Composizione terapeutica per la cura della psoriasi.
NO20032411L (no) Anvendelse av substituerte 6-dimetylaminometyl-1-fenyl- cykloheksan-forbindelser for behandling av urininkontinens
ITMI911577A1 (it) Procedimento per la preparazione dell&#39;acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2, 3-diidro-7h-pirido (1, 2, 3-de) (1, 4)benzotiadin-6-carbossilico cloridrato.
EA200400382A1 (ru) Применение специфической дозы фондапаринукса натрия для лечения окс
NO20014889D0 (no) Fremgangsmåte for fremstilling av medisinske midler
RU2000114403A (ru) Способ лечения язвенной болезни луковицы двенадцатиперстной кишки, осложненной стенозом
UA3713U (uk) Спосіб корекції порушень імунологічного статусу у дітей
IT8921125A0 (it) Dispositivo per l&#39;eliminazione della riserva di filo avvolta sui fusi di macchine per la filatura.