AR027021A1 - Procedimiento para preparar y aislar 9-deoxo-9(z)-hidroxiiminoeri-tromicina a - Google Patents

Procedimiento para preparar y aislar 9-deoxo-9(z)-hidroxiiminoeri-tromicina a

Info

Publication number
AR027021A1
AR027021A1 ARP000106764A ARP000106764A AR027021A1 AR 027021 A1 AR027021 A1 AR 027021A1 AR P000106764 A ARP000106764 A AR P000106764A AR P000106764 A ARP000106764 A AR P000106764A AR 027021 A1 AR027021 A1 AR 027021A1
Authority
AR
Argentina
Prior art keywords
deoxo
procedure
mixture
hydroxyiminoeri
thromycin
Prior art date
Application number
ARP000106764A
Other languages
English (en)
Original Assignee
Merial Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas filed Critical Merial Sas
Publication of AR027021A1 publication Critical patent/AR027021A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Unprocedimiento para la preparacion de 9-deoxo-9(Z)-hidroxiiminoeritromicina A que responden a la siguiente formula 1: a partir de la 9-deoxo-9 (E) -hidroxiiminoeritromicina A por reaccion con una base en agua o en una mezcla agua/solvente de tipo di alquilcetona, capáz de formar un solvato cristalizable conla 9 (Z) -oxima deseada; acidificacion de la mezcla reaccionate hasta un pH comprendido entre 9 y 11; agregado a dicha mezcla de un solvente orgánico;eventualmente, concentracion al vacio de la fase orgánica resultante; y aislacion de la 9 (z) -eritromicina-oxima deseada; y el compuesto.
ARP000106764A 1999-12-20 2000-12-20 Procedimiento para preparar y aislar 9-deoxo-9(z)-hidroxiiminoeri-tromicina a AR027021A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9916106A FR2802534B1 (fr) 1999-12-20 1999-12-20 Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a

Publications (1)

Publication Number Publication Date
AR027021A1 true AR027021A1 (es) 2003-03-12

Family

ID=9553516

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106764A AR027021A1 (es) 1999-12-20 2000-12-20 Procedimiento para preparar y aislar 9-deoxo-9(z)-hidroxiiminoeri-tromicina a

Country Status (18)

Country Link
EP (1) EP1242439B1 (es)
JP (1) JP2003518133A (es)
CN (1) CN1215077C (es)
AR (1) AR027021A1 (es)
AT (1) ATE240967T1 (es)
AU (1) AU776674B2 (es)
BR (1) BRPI0016506B8 (es)
CA (1) CA2394623C (es)
DE (1) DE60002922T2 (es)
DK (1) DK1242439T3 (es)
ES (1) ES2202215T3 (es)
FR (1) FR2802534B1 (es)
NZ (1) NZ519802A (es)
PL (2) PL200527B1 (es)
PT (1) PT1242439E (es)
TR (1) TR200300174T3 (es)
WO (1) WO2001046211A1 (es)
ZA (1) ZA200205697B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103713080A (zh) * 2013-12-25 2014-04-09 挑战（天津）动物药业有限公司 一种加米霉素的含量检测方法
CN105461770B (zh) * 2015-12-25 2018-11-06 湖北回盛生物科技有限公司 一种9-脱氧-9-同型红霉素a(z)肟的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
DE69227713D1 (de) * 1991-03-15 1999-01-14 Merck & Co Inc 9-Deoxo-9(Z)-hydroxyiminoerythromycin A und O-Derivate hiervon
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5808017A (en) * 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
US5945405A (en) * 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
DE69824590T2 (de) * 1997-07-08 2005-06-30 Sandoz Industrial Products S.A., Granollers Solvate von erythromycin a oxim

Also Published As

Publication number Publication date
BR0016506B1 (pt) 2013-11-26
FR2802534B1 (fr) 2002-02-01
EP1242439A1 (fr) 2002-09-25
JP2003518133A (ja) 2003-06-03
BRPI0016506B8 (pt) 2021-05-25
DK1242439T3 (da) 2003-09-15
CN1215077C (zh) 2005-08-17
EP1242439B1 (fr) 2003-05-21
PL355573A1 (en) 2004-05-04
DE60002922T2 (de) 2004-05-19
CA2394623C (en) 2012-07-24
BR0016506A (pt) 2002-08-27
AU2687001A (en) 2001-07-03
CA2394623A1 (en) 2001-06-28
FR2802534A1 (fr) 2001-06-22
TR200300174T3 (tr) 2003-07-21
WO2001046211A1 (fr) 2001-06-28
AU776674B2 (en) 2004-09-16
ZA200205697B (en) 2003-09-29
ES2202215T3 (es) 2004-04-01
CN1411465A (zh) 2003-04-16
DE60002922D1 (de) 2003-06-26
PL201837B1 (pl) 2009-05-29
ATE240967T1 (de) 2003-06-15
PT1242439E (pt) 2003-10-31
NZ519802A (en) 2005-03-24
PL200527B1 (pl) 2009-01-30

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