PE20000477A1 - Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo[4.3.0)nonano - Google Patents

Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo[4.3.0)nonano

Info

Publication number
PE20000477A1
PE20000477A1 PE1999000379A PE00037999A PE20000477A1 PE 20000477 A1 PE20000477 A1 PE 20000477A1 PE 1999000379 A PE1999000379 A PE 1999000379A PE 00037999 A PE00037999 A PE 00037999A PE 20000477 A1 PE20000477 A1 PE 20000477A1
Authority
PE
Peru
Prior art keywords
diazabicyclo
preparation
nonane
benzyl
nonano
Prior art date
Application number
PE1999000379A
Other languages
English (en)
Inventor
Peter Fey
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20000477A1 publication Critical patent/PE20000477A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE (S,S)-8-BENCIL-2,8-DIAZABICICLO[4.3.0]NONANO, CARACTERIZADO PORQUE COMPRENDE HACER REACCIONAR UNA MEZCLA DE ENANTIOMEROS DE (S,S)-8-BENCIL-2,8-DIAZABICICLO[4.3.0]NONANO Y (R,R)-8-BENCIL-2,8-DIAZABICICLO[4.3.0]NONANO EN UNA RELACION MOLAR DE 99:1 A 40:60; CON UN ACIDO L-(+)-TARTARICO EN UNA MEZCLA DE DISOLVENTES ALCOHOL/AGUA Y LA TEMPERATURA DE REACCION ES DE 20°C A 110°C; LUEGO SE PUEDE REALIZAR UNA SIEMBRA CON L-(+)-TARTRATO DE (S,S)-8-BENCIL-2,8-DIAZABICICLO[4.3.0]NONANO; Y SE PUEDE PURIFICAR POR RECRISTALIZACION EN UNA MEZCLA DE ALCOHOL/AGUA. EL COMPUESTO REPRESENTA UN INTERMEDIO PARA LA PREPARACION DEL (S,S)-2,8-DIAZABICICLO[4.3.0]NONANO EL QUE SE UTILIZA PARA LA PREPARACION DEL ANTIBIOTICO MOXIFLOXACINA
PE1999000379A 1998-05-11 1999-05-10 Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo[4.3.0)nonano PE20000477A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19821039A DE19821039A1 (de) 1998-05-11 1998-05-11 Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan

Publications (1)

Publication Number Publication Date
PE20000477A1 true PE20000477A1 (es) 2000-07-07

Family

ID=7867389

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000379A PE20000477A1 (es) 1998-05-11 1999-05-10 Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo[4.3.0)nonano

Country Status (13)

Country Link
US (1) US6235908B1 (es)
EP (1) EP1077979B1 (es)
JP (1) JP4554076B2 (es)
AR (1) AR019123A1 (es)
AU (1) AU3824599A (es)
CA (1) CA2331526C (es)
CO (1) CO4830459A1 (es)
DE (2) DE19821039A1 (es)
ES (1) ES2245101T3 (es)
PE (1) PE20000477A1 (es)
SV (1) SV1999000060A (es)
UY (1) UY25501A1 (es)
WO (1) WO1999058532A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2387016C (en) * 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
US6476046B1 (en) 2000-12-04 2002-11-05 Sepracor, Inc. Diazabicyclo[4.3.0]nonanes, and methods of use thereof
WO2003088897A2 (en) * 2001-04-06 2003-10-30 Affinium Pharmaceuticals, Inc. Fab i inhibitors
EP1575951B1 (en) * 2002-12-06 2014-06-25 Debiopharm International SA Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
PL1828167T3 (pl) * 2004-06-04 2015-02-27 Debiopharm Int Sa Pochodne akryloamidu jako środki antybiotykowe
WO2007067416A2 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
AU2007320997B2 (en) * 2006-11-13 2012-11-08 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
US7692015B2 (en) * 2007-01-05 2010-04-06 Zheqing Wang Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer
EP3255045A1 (en) * 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
WO2009125425A2 (en) * 2008-02-08 2009-10-15 Neuland Laboratories Ltd Improved process for the preparation of (s.s)-2.8-diazabicyclo[4.3.0]nonane
IT1393337B1 (it) 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
CN103044418B (zh) * 2011-10-14 2015-02-04 上海朴颐化学科技有限公司 (s,s)-2,8-二氮杂双环[4,3,0]壬烷的不对称合成方法、相关原料及制备方法
JP6085026B2 (ja) 2012-06-19 2017-02-22 デビオファーム インターナショナル エスエーＤｅｂｉｏｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓａ （ｅ）−ｎ−メチル−ｎ−（（３−メチルベンゾフラン−２−イル）メチル）−３−（７−オキソ−５，６，７，８−テトラヒドロ−１，８−ナフチリジン−３−イル）アクリルアミドのプロドラッグ誘導体
US10751351B2 (en) 2016-02-26 2020-08-25 Debiopharm International S.A. Medicament for treatment of diabetic foot infections
CN112574197B (zh) * 2020-12-07 2021-12-31 泰安汉威集团有限公司 一种化合物c的手性纯化方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB354975A (en) 1929-07-19 1931-08-20 Ig Farbenindustrie Ag Manufacture of optically active phenylpropanol-methylamines
HU194221B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
JPH0285235A (ja) * 1988-09-22 1990-03-26 Kohjin Co Ltd 光学活性アミノアルコール類の製法
JP2995704B2 (ja) * 1989-02-17 1999-12-27 東京化成工業株式会社 光学活性な１ｈ−３−アミノピロリジン化合物の製造法
IT1231158B (it) 1989-07-20 1991-11-19 Dompe Farmaceutici Spa Procedimento per la risoluzione ottica della dropropizina.
JP2609410B2 (ja) 1991-01-31 1997-05-14 ファイザー・インコーポレーテッド （７Ｓ，トランス）−２−（２−ピリミジニル）−７−（ヒドロキシメチル）オクタヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジンの製造
TW209865B (es) * 1992-01-10 1993-07-21 Bayer Ag
DE4234078A1 (de) * 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
DE4234330A1 (de) 1992-10-12 1994-04-14 Bayer Ag Chinoloncarbonsäuren
JP3268098B2 (ja) * 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
US5686614A (en) 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
DE19601745C1 (de) 1996-01-19 1997-10-09 Gruenenthal Gmbh Verfahren zur Racematspaltung von Tramadol

Also Published As

Publication number Publication date
CO4830459A1 (es) 1999-08-30
DE59912242D1 (de) 2005-08-11
UY25501A1 (es) 1999-11-17
JP2002514648A (ja) 2002-05-21
CA2331526C (en) 2011-09-13
CA2331526A1 (en) 1999-11-18
AU3824599A (en) 1999-11-29
SV1999000060A (es) 1999-10-27
US6235908B1 (en) 2001-05-22
WO1999058532A1 (de) 1999-11-18
JP4554076B2 (ja) 2010-09-29
EP1077979B1 (de) 2005-07-06
ES2245101T3 (es) 2005-12-16
AR019123A1 (es) 2001-12-26
EP1077979A1 (de) 2001-02-28
DE19821039A1 (de) 1999-11-18

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