HUP0001878A2 - (R)-3-(N,N-diciklobutil-amino)-8-fluor-3,4-dihidro-2H-1-benzopirán-5-karboxamid-hidrogén tartarát, eljárás előállítására és ezt tartalmazó gyógyszerkészítmények - Google Patents
(R)-3-(N,N-diciklobutil-amino)-8-fluor-3,4-dihidro-2H-1-benzopirán-5-karboxamid-hidrogén tartarát, eljárás előállítására és ezt tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0001878A2 HUP0001878A2 HU0001878A HUP0001878A HUP0001878A2 HU P0001878 A2 HUP0001878 A2 HU P0001878A2 HU 0001878 A HU0001878 A HU 0001878A HU P0001878 A HUP0001878 A HU P0001878A HU P0001878 A2 HUP0001878 A2 HU P0001878A2
- Authority
- HU
- Hungary
- Prior art keywords
- benzopyran
- dihydro
- fluoro
- organic solvent
- hydrogen tartrate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 239000003960 organic solvent Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- ZWCZKERDOMOAGZ-BTQNPOSSSA-N (3r)-3-[di(cyclobutyl)amino]-8-fluoro-3,4-dihydro-2h-chromene-5-carboxamide;2,3-dihydroxybutanedioic acid Chemical compound OC(=O)C(O)C(O)C(O)=O.C1CCC1N([C@H]1COC=2C(F)=CC=C(C=2C1)C(=O)N)C1CCC1 ZWCZKERDOMOAGZ-BTQNPOSSSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- MQTUXRKNJYPMCG-CYBMUJFWSA-N robalzotan Chemical compound C1CCC1N([C@H]1COC=2C(F)=CC=C(C=2C1)C(=O)N)C1CCC1 MQTUXRKNJYPMCG-CYBMUJFWSA-N 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya új só, az (R)-3-(N,N-diciklobutil-amino)- 8-fluor-3,4-dihidro-2H-1-benzopirán-5-karboxamid-hidrogén-tartarát, különösen a (2R, 3R)-borkősavval képzett tartarátsó,főképpen ennek egy mól vízzel képzett addíciós vegyülete, azazmonohidrátja, az ilyen sót tartalmazó, a központi idegrendszerrendellenességei ellen hatásos gyógyszerkészítmények és azelőállításukra szolgáló eljárás. A találmány szerinti eljárás során i)az (R)-3-(N,N-diciklobutil-amino)-8-fluor-3,4-dihidro-2H-1-benzopirán-5-karboxamidot szerves oldószerben, adott esetbenmelegítéssel feloldják; ii) hozzáadják a (2R, 3R)-borkősav vizesszerves vagy vízmentes szerves oldószerrel készített oldatát; iii) akapott oldatot hidegen állva hagyják kristályosodni; és iv) adottesetben, ha az ii) lépésben vízmentes szerves oldószert alkalmaztak, aterméket vizes szerves oldószerből átkristályosítják. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702066A SE510305C2 (sv) | 1997-05-30 | 1997-05-30 | Nytt salt |
PCT/SE1998/000907 WO1998054166A1 (en) | 1997-05-30 | 1998-05-15 | A new salt |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0001878A2 true HUP0001878A2 (hu) | 2001-05-28 |
HUP0001878A3 HUP0001878A3 (en) | 2002-04-29 |
Family
ID=20407187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001878A HUP0001878A3 (en) | 1997-05-30 | 1998-05-15 | (r)-3-(n,n-dicyclobutyl-amino)-8-fluoro-3,4-dihydro-2h-1-benzopyran-5-carboxamide hydrogen tartrate, process for its preparation and pharmatceutical compositions of the same |
Country Status (34)
Country | Link |
---|---|
US (2) | US6858645B2 (hu) |
EP (1) | EP0984952B1 (hu) |
JP (1) | JP3554338B2 (hu) |
KR (1) | KR20010013127A (hu) |
CN (1) | CN1198814C (hu) |
AR (1) | AR012751A1 (hu) |
AT (1) | ATE228121T1 (hu) |
AU (1) | AU729301B2 (hu) |
BG (1) | BG64051B1 (hu) |
BR (1) | BR9809519A (hu) |
CA (1) | CA2291732C (hu) |
DE (1) | DE69809547T2 (hu) |
DK (1) | DK0984952T3 (hu) |
EE (1) | EE03874B1 (hu) |
ES (1) | ES2187030T3 (hu) |
HK (1) | HK1025575A1 (hu) |
HU (1) | HUP0001878A3 (hu) |
ID (1) | ID23794A (hu) |
IL (1) | IL133234A (hu) |
IS (1) | IS1943B (hu) |
MY (1) | MY117960A (hu) |
NO (1) | NO995853L (hu) |
NZ (1) | NZ501075A (hu) |
PL (1) | PL337181A1 (hu) |
PT (1) | PT984952E (hu) |
RU (1) | RU2193560C2 (hu) |
SE (1) | SE510305C2 (hu) |
SK (1) | SK282755B6 (hu) |
TR (1) | TR199902926T2 (hu) |
TW (1) | TW510899B (hu) |
UA (1) | UA53720C2 (hu) |
WO (1) | WO1998054166A1 (hu) |
YU (1) | YU62499A (hu) |
ZA (1) | ZA984486B (hu) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102888D0 (sv) * | 2001-08-29 | 2001-08-29 | Astrazeneca Ab | New formulation |
SE0102887D0 (sv) * | 2001-08-29 | 2001-08-29 | Astrazeneca Ab | New formulation |
SE0102886D0 (sv) * | 2001-08-29 | 2001-08-29 | Astrazeneca Ab | New formulation |
SE0301796D0 (sv) * | 2003-06-19 | 2003-06-19 | Astrazeneca Ab | New use II |
SE0301795D0 (sv) * | 2003-06-19 | 2003-06-19 | Astrazeneca Ab | New use I |
EP2022110B1 (en) * | 2006-05-11 | 2011-10-12 | Johnson Controls Saft Advanced Power Solutions LLC | Modular battery system |
JP5163931B2 (ja) * | 2007-03-08 | 2013-03-13 | 株式会社リコー | 定着装置及び画像形成装置 |
EP2065385A1 (en) * | 2007-11-28 | 2009-06-03 | Laboratorios SALVAT, S.A. | Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester |
CN101747305B (zh) * | 2008-11-28 | 2014-06-18 | 中国医学科学院药物研究所 | 硝克柳胺化合物晶v型、其制法和其药物组合物与用途 |
LT2989095T (lt) * | 2013-04-26 | 2019-03-12 | Sanofi | 5-chlortiofen-2-karboksirūgšties [(s)-2-[metil-3-(2-okso-pirolidin-1-il)-benzensulfonilamino]-3-(4-metilpiperazin-1 -il)-3-oksopropil]amido tartrato druska |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5420151A (en) * | 1989-12-22 | 1995-05-30 | Aktiebolaget Astra | Chroman derivatives |
US5616610A (en) * | 1989-12-22 | 1997-04-01 | Astra Aktiebolag | (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans |
US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
IT1282705B1 (it) | 1996-02-28 | 1998-03-31 | Recordati Chem Pharm | Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria |
-
1997
- 1997-05-30 SE SE9702066A patent/SE510305C2/sv not_active IP Right Cessation
-
1998
- 1998-05-13 TW TW087107397A patent/TW510899B/zh active
- 1998-05-15 PL PL98337181A patent/PL337181A1/xx unknown
- 1998-05-15 CN CNB988056631A patent/CN1198814C/zh not_active Expired - Fee Related
- 1998-05-15 HU HU0001878A patent/HUP0001878A3/hu unknown
- 1998-05-15 AU AU77923/98A patent/AU729301B2/en not_active Ceased
- 1998-05-15 NZ NZ501075A patent/NZ501075A/en unknown
- 1998-05-15 EP EP98925993A patent/EP0984952B1/en not_active Expired - Lifetime
- 1998-05-15 YU YU62499A patent/YU62499A/sh unknown
- 1998-05-15 ID IDW991407A patent/ID23794A/id unknown
- 1998-05-15 US US09/077,718 patent/US6858645B2/en not_active Expired - Fee Related
- 1998-05-15 ES ES98925993T patent/ES2187030T3/es not_active Expired - Lifetime
- 1998-05-15 DK DK98925993T patent/DK0984952T3/da active
- 1998-05-15 CA CA002291732A patent/CA2291732C/en not_active Expired - Fee Related
- 1998-05-15 JP JP50056099A patent/JP3554338B2/ja not_active Expired - Fee Related
- 1998-05-15 WO PCT/SE1998/000907 patent/WO1998054166A1/en not_active Application Discontinuation
- 1998-05-15 UA UA99127241A patent/UA53720C2/uk unknown
- 1998-05-15 IL IL13323498A patent/IL133234A/en not_active IP Right Cessation
- 1998-05-15 PT PT98925993T patent/PT984952E/pt unknown
- 1998-05-15 TR TR1999/02926T patent/TR199902926T2/xx unknown
- 1998-05-15 SK SK1594-99A patent/SK282755B6/sk unknown
- 1998-05-15 BR BR9809519-6A patent/BR9809519A/pt not_active IP Right Cessation
- 1998-05-15 KR KR19997011107A patent/KR20010013127A/ko active IP Right Grant
- 1998-05-15 EE EEP199900549A patent/EE03874B1/xx not_active IP Right Cessation
- 1998-05-15 DE DE69809547T patent/DE69809547T2/de not_active Expired - Fee Related
- 1998-05-15 AT AT98925993T patent/ATE228121T1/de not_active IP Right Cessation
- 1998-05-15 RU RU99128026/04A patent/RU2193560C2/ru not_active IP Right Cessation
- 1998-05-26 AR ARP980102434A patent/AR012751A1/es unknown
- 1998-05-26 ZA ZA984486A patent/ZA984486B/xx unknown
- 1998-05-29 MY MYPI98002400A patent/MY117960A/en unknown
-
1999
- 1999-11-24 IS IS5270A patent/IS1943B/is unknown
- 1999-11-29 NO NO995853A patent/NO995853L/no not_active Application Discontinuation
- 1999-12-03 BG BG103949A patent/BG64051B1/bg unknown
-
2000
- 2000-08-08 HK HK00104934A patent/HK1025575A1/xx not_active IP Right Cessation
-
2004
- 2004-10-12 US US10/964,388 patent/US20050085532A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
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FD9A | Lapse of provisional protection due to non-payment of fees |