HUP0004432A2 - (R)-3-{[(4-Fluorfenil)szulfonil]amino}-1,2,3,4-tetrahidro-9H-karbazol-9-propánsav (ramatroban) termodinamikailag stabil formája és a vegyületet tartalmazó gyógyászati készítmény - Google Patents

(R)-3-{[(4-Fluorfenil)szulfonil]amino}-1,2,3,4-tetrahidro-9H-karbazol-9-propánsav (ramatroban) termodinamikailag stabil formája és a vegyületet tartalmazó gyógyászati készítmény

Info

Publication number
HUP0004432A2
HUP0004432A2 HU0004432A HUP0004432A HUP0004432A2 HU P0004432 A2 HUP0004432 A2 HU P0004432A2 HU 0004432 A HU0004432 A HU 0004432A HU P0004432 A HUP0004432 A HU P0004432A HU P0004432 A2 HUP0004432 A2 HU P0004432A2
Authority
HU
Hungary
Prior art keywords
thermodynamically stable
ramatroban
sulphonyl
carbazole
fluorophenyl
Prior art date
Application number
HU0004432A
Other languages
English (en)
Inventor
Alfons Grunenberg
Klaus-Peter Voges
Karl-Heinz Wahl
Original Assignee
Bayer Yakuhin Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin Ltd. filed Critical Bayer Yakuhin Ltd.
Publication of HUP0004432A2 publication Critical patent/HUP0004432A2/hu
Publication of HUP0004432A3 publication Critical patent/HUP0004432A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A találmány az (I) képletű ramatroban hatóanyag termodinamikailagstabil módosulatára vonatkozik. A termodinamikailag stabil módosulatotúgy állítják elő, hogy a metastabil módosulatot felolvasztják, majdátkristályosítják, vagy a metastabil hatóanyag oldatát atermodinamikailag stabil forma oltókristályával beoltják. Atermodinamikailag stabil hatóanyag asztmaellenes szerkéntalkalmazható. Ó
HU0004432A 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-[[(4-fluorophenyl)sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban) and pharmaceutical composition containing it HUP0004432A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19757983A DE19757983A1 (de) 1997-12-24 1997-12-24 Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
PCT/JP1998/005844 WO1999033803A1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)

Publications (2)

Publication Number Publication Date
HUP0004432A2 true HUP0004432A2 (hu) 2001-06-28
HUP0004432A3 HUP0004432A3 (en) 2002-10-28

Family

ID=7853457

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004432A HUP0004432A3 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-[[(4-fluorophenyl)sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban) and pharmaceutical composition containing it

Country Status (37)

Country Link
US (1) US6362214B1 (hu)
EP (1) EP1051398B1 (hu)
JP (2) JP3817668B2 (hu)
KR (1) KR100586350B1 (hu)
CN (1) CN1140510C (hu)
AR (1) AR013803A1 (hu)
AT (1) ATE263152T1 (hu)
AU (1) AU744242B2 (hu)
BG (1) BG65024B1 (hu)
BR (1) BR9814496A (hu)
CA (1) CA2313230A1 (hu)
CO (1) CO4970800A1 (hu)
DE (2) DE19757983A1 (hu)
DK (1) DK1051398T3 (hu)
ES (1) ES2218874T3 (hu)
GT (1) GT199800198A (hu)
HK (1) HK1034517A1 (hu)
HN (1) HN1998000186A (hu)
HU (1) HUP0004432A3 (hu)
ID (1) ID25446A (hu)
IL (1) IL136278A (hu)
IN (1) IN192932B (hu)
MY (1) MY116312A (hu)
NO (1) NO316618B1 (hu)
NZ (1) NZ504741A (hu)
PE (1) PE20000115A1 (hu)
PL (1) PL341359A1 (hu)
PT (1) PT1051398E (hu)
RU (1) RU2220137C2 (hu)
SI (1) SI1051398T1 (hu)
SK (1) SK285109B6 (hu)
TR (1) TR200001936T2 (hu)
TW (1) TW552258B (hu)
UA (1) UA66832C2 (hu)
UY (2) UY25324A1 (hu)
WO (1) WO1999033803A1 (hu)
ZA (1) ZA9811817B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2395120T3 (es) * 2006-12-20 2013-02-08 Cardoz Ab Combinación de pemirolast y ramotrobán para su uso en el tratamiento de transtornos inflamatorios
AU2007344274A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
CN101434571B (zh) * 2007-11-13 2012-05-30 杭州容立医药科技有限公司 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
CN103054857A (zh) * 2012-12-30 2013-04-24 北京阜康仁生物制药科技有限公司 一种以雷马曲班为活性成分的固体制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631824A1 (de) 1986-02-21 1988-03-31 Bayer Ag Cycloalkano(1.2-b)indol-sulfonamide
CN1015711B (zh) * 1986-02-21 1992-03-04 拜尔公司 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法
DE19506739A1 (de) * 1995-02-27 1996-08-29 Bayer Ag [3-Amino]-tetrahydrocarbazol-propansäureester

Also Published As

Publication number Publication date
JP2006151977A (ja) 2006-06-15
CA2313230A1 (en) 1999-07-08
EP1051398B1 (en) 2004-03-31
AR013803A1 (es) 2001-01-10
DE19757983A1 (de) 1999-07-01
PT1051398E (pt) 2004-07-30
NO20003217L (no) 2000-06-21
NO316618B1 (no) 2004-03-08
UY25575A1 (es) 1999-11-17
HK1034517A1 (en) 2001-10-26
KR100586350B1 (ko) 2006-06-07
SK285109B6 (sk) 2006-06-01
AU1687499A (en) 1999-07-19
CN1282320A (zh) 2001-01-31
HUP0004432A3 (en) 2002-10-28
PL341359A1 (en) 2001-04-09
BG65024B1 (bg) 2006-12-29
DE69822882D1 (en) 2004-05-06
HN1998000186A (es) 1999-11-03
DE69822882T2 (de) 2005-02-03
UY25324A1 (es) 2000-12-29
SI1051398T1 (en) 2004-08-31
RU2220137C2 (ru) 2003-12-27
TR200001936T2 (tr) 2001-01-22
NO20003217D0 (no) 2000-06-21
ES2218874T3 (es) 2004-11-16
DK1051398T3 (da) 2004-07-19
US6362214B1 (en) 2002-03-26
WO1999033803A1 (en) 1999-07-08
MY116312A (en) 2003-12-31
TW552258B (en) 2003-09-11
JP3817668B2 (ja) 2006-09-06
NZ504741A (en) 2002-10-25
IN192932B (hu) 2004-06-12
BG104554A (en) 2001-05-31
IL136278A0 (en) 2001-05-20
KR20010033529A (ko) 2001-04-25
GT199800198A (es) 1998-12-15
UA66832C2 (uk) 2004-06-15
SK9752000A3 (en) 2001-02-12
CO4970800A1 (es) 2000-11-07
BR9814496A (pt) 2000-10-10
ZA9811817B (en) 1999-06-29
PE20000115A1 (es) 2000-03-26
CN1140510C (zh) 2004-03-03
EP1051398A1 (en) 2000-11-15
JP2001527067A (ja) 2001-12-25
AU744242B2 (en) 2002-02-21
ATE263152T1 (de) 2004-04-15
JP4411269B2 (ja) 2010-02-10
ID25446A (id) 2000-10-05
IL136278A (en) 2005-03-20

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