TR200001936T2 - (R)-3-[[(4-fluorofenil) sülfonil]amino]- 1,2,3,4-tetra-hidro-9H-karbazol-9- propanoyik asit (ramatroban)'in termodinamik olarak kararlı biçimi. - Google Patents

(R)-3-[[(4-fluorofenil) sülfonil]amino]- 1,2,3,4-tetra-hidro-9H-karbazol-9- propanoyik asit (ramatroban)'in termodinamik olarak kararlı biçimi.

Info

Publication number
TR200001936T2
TR200001936T2 TR2000/01936T TR200001936T TR200001936T2 TR 200001936 T2 TR200001936 T2 TR 200001936T2 TR 2000/01936 T TR2000/01936 T TR 2000/01936T TR 200001936 T TR200001936 T TR 200001936T TR 200001936 T2 TR200001936 T2 TR 200001936T2
Authority
TR
Turkey
Prior art keywords
thermodynamically stable
ramatroban
stable form
carbazole
fluorophenyl
Prior art date
Application number
TR2000/01936T
Other languages
English (en)
Inventor
Gruenenberg Alfons
Wahl Karl-Heinz
Voges Klaus-Peter
Original Assignee
Bayer Yakuhin, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin, Ltd. filed Critical Bayer Yakuhin, Ltd.
Publication of TR200001936T2 publication Critical patent/TR200001936T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Söz konusu bulus etkin terkip ramatrobanin termodinamik olarak kararli degistirilmesi ile ilgilidir. Termodinamik olarak kararli biçim ya yari-kararli biçimin eritilmesi ve bunu müteakkip tekrar kristalize edilmesi ya da yari-karali etkin terkibin terodinamik olarak kararli bir biçimin kristal çekirdekleri ile tohumlanmasi ile hazirlanir.Termodinamik olarak kararli etkin terkip bir astim maddesi olarak kullanilabilir.
TR2000/01936T 1997-12-24 1998-12-24 (R)-3-[[(4-fluorofenil) sülfonil]amino]- 1,2,3,4-tetra-hidro-9H-karbazol-9- propanoyik asit (ramatroban)'in termodinamik olarak kararlı biçimi. TR200001936T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19757983A DE19757983A1 (de) 1997-12-24 1997-12-24 Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
PCT/JP1998/005844 WO1999033803A1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)

Publications (1)

Publication Number Publication Date
TR200001936T2 true TR200001936T2 (tr) 2001-01-22

Family

ID=7853457

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01936T TR200001936T2 (tr) 1997-12-24 1998-12-24 (R)-3-[[(4-fluorofenil) sülfonil]amino]- 1,2,3,4-tetra-hidro-9H-karbazol-9- propanoyik asit (ramatroban)'in termodinamik olarak kararlı biçimi.

Country Status (37)

Country Link
US (1) US6362214B1 (tr)
EP (1) EP1051398B1 (tr)
JP (2) JP3817668B2 (tr)
KR (1) KR100586350B1 (tr)
CN (1) CN1140510C (tr)
AR (1) AR013803A1 (tr)
AT (1) ATE263152T1 (tr)
AU (1) AU744242B2 (tr)
BG (1) BG65024B1 (tr)
BR (1) BR9814496A (tr)
CA (1) CA2313230A1 (tr)
CO (1) CO4970800A1 (tr)
DE (2) DE19757983A1 (tr)
DK (1) DK1051398T3 (tr)
ES (1) ES2218874T3 (tr)
GT (1) GT199800198A (tr)
HK (1) HK1034517A1 (tr)
HN (1) HN1998000186A (tr)
HU (1) HUP0004432A3 (tr)
ID (1) ID25446A (tr)
IL (1) IL136278A (tr)
IN (1) IN192932B (tr)
MY (1) MY116312A (tr)
NO (1) NO316618B1 (tr)
NZ (1) NZ504741A (tr)
PE (1) PE20000115A1 (tr)
PL (1) PL341359A1 (tr)
PT (1) PT1051398E (tr)
RU (1) RU2220137C2 (tr)
SI (1) SI1051398T1 (tr)
SK (1) SK285109B6 (tr)
TR (1) TR200001936T2 (tr)
TW (1) TW552258B (tr)
UA (1) UA66832C2 (tr)
UY (2) UY25324A1 (tr)
WO (1) WO1999033803A1 (tr)
ZA (1) ZA9811817B (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE543501T1 (de) * 2006-12-20 2012-02-15 Cardoz Ab Kombination von pemirolast und ramatroban zur verwendung bei der behandlung von entzündlichen erkrankungen
AU2007344274A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
CN101434571B (zh) * 2007-11-13 2012-05-30 杭州容立医药科技有限公司 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
CN103054857A (zh) * 2012-12-30 2013-04-24 北京阜康仁生物制药科技有限公司 一种以雷马曲班为活性成分的固体制剂
US20180021302A1 (en) 2015-02-13 2018-01-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1015711B (zh) * 1986-02-21 1992-03-04 拜尔公司 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法
DE3631824A1 (de) 1986-02-21 1988-03-31 Bayer Ag Cycloalkano(1.2-b)indol-sulfonamide
DE19506739A1 (de) 1995-02-27 1996-08-29 Bayer Ag [3-Amino]-tetrahydrocarbazol-propansäureester

Also Published As

Publication number Publication date
CN1282320A (zh) 2001-01-31
BR9814496A (pt) 2000-10-10
CO4970800A1 (es) 2000-11-07
NZ504741A (en) 2002-10-25
NO20003217D0 (no) 2000-06-21
AU744242B2 (en) 2002-02-21
HUP0004432A3 (en) 2002-10-28
IN192932B (tr) 2004-06-12
HK1034517A1 (en) 2001-10-26
PL341359A1 (en) 2001-04-09
UY25575A1 (es) 1999-11-17
US6362214B1 (en) 2002-03-26
DE69822882D1 (en) 2004-05-06
JP2001527067A (ja) 2001-12-25
KR100586350B1 (ko) 2006-06-07
SK285109B6 (sk) 2006-06-01
ZA9811817B (en) 1999-06-29
IL136278A (en) 2005-03-20
DE19757983A1 (de) 1999-07-01
HUP0004432A2 (hu) 2001-06-28
DK1051398T3 (da) 2004-07-19
WO1999033803A1 (en) 1999-07-08
JP3817668B2 (ja) 2006-09-06
NO20003217L (no) 2000-06-21
JP2006151977A (ja) 2006-06-15
MY116312A (en) 2003-12-31
CA2313230A1 (en) 1999-07-08
HN1998000186A (es) 1999-11-03
NO316618B1 (no) 2004-03-08
PE20000115A1 (es) 2000-03-26
EP1051398B1 (en) 2004-03-31
SI1051398T1 (en) 2004-08-31
GT199800198A (es) 1998-12-15
BG104554A (en) 2001-05-31
RU2220137C2 (ru) 2003-12-27
ID25446A (id) 2000-10-05
UA66832C2 (uk) 2004-06-15
AR013803A1 (es) 2001-01-10
IL136278A0 (en) 2001-05-20
CN1140510C (zh) 2004-03-03
AU1687499A (en) 1999-07-19
ES2218874T3 (es) 2004-11-16
JP4411269B2 (ja) 2010-02-10
PT1051398E (pt) 2004-07-30
EP1051398A1 (en) 2000-11-15
ATE263152T1 (de) 2004-04-15
KR20010033529A (ko) 2001-04-25
SK9752000A3 (en) 2001-02-12
UY25324A1 (es) 2000-12-29
BG65024B1 (bg) 2006-12-29
DE69822882T2 (de) 2005-02-03
TW552258B (en) 2003-09-11

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